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Q148G2

- G6PC3_BOVIN

UniProt

Q148G2 - G6PC3_BOVIN

Protein

Glucose-6-phosphatase 3

Gene

G6PC3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + H2O = D-glucose + phosphate.

    Enzyme regulationi

    Inhibited by vanadate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791SubstrateSequence Analysis
    Active sitei114 – 1141Proton donorSequence Analysis
    Binding sitei161 – 1611SubstrateSequence Analysis
    Active sitei167 – 1671NucleophileBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-UniPathway
    2. glucose-6-phosphate transport Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Gluconeogenesis

    Enzyme and pathway databases

    ReactomeiREACT_204270. Glucose transport.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphatase 3 (EC:3.1.3.9)
    Short name:
    G-6-Pase 3
    Short name:
    G6Pase 3
    Gene namesi
    Name:G6PC3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Glucose-6-phosphatase 3PRO_0000334511Add
    BLAST

    Proteomic databases

    PRIDEiQ148G2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000021621.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424LumenalSequence AnalysisAdd
    BLAST
    Topological domaini46 – 549CytoplasmicSequence Analysis
    Topological domaini76 – 10833LumenalSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 1675LumenalSequence Analysis
    Topological domaini187 – 19711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini219 – 25436LumenalSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28310CytoplasmicSequence Analysis
    Topological domaini305 – 3073LumenalSequence Analysis
    Topological domaini329 – 34618CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18619HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphatase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82628.
    GeneTreeiENSGT00510000046465.
    HOGENOMiHOG000264239.
    HOVERGENiHBG003560.
    InParanoidiQ148G2.
    KOiK01084.
    OMAiKWFLFGD.
    OrthoDBiEOG73NG4N.
    TreeFamiTF324388.

    Family and domain databases

    Gene3Di1.20.144.10. 1 hit.
    InterProiIPR016275. Glucose-6-phosphatase.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view]
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
    SMARTiSM00014. acidPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q148G2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESTLGAGIA MAEALQNQLP WLENVWLWVT FLGDPKSLFL FYFPAAYYAS    50
    RRVGIAVLWI SLITEWLNLV FKWFLFGDRP FWWVHESGYY SQAPAQVHQF 100
    PSSCETGPGS PSGHCMITGA ALWPIMTAVS SQMATRAHSR WVRVIPSLAY 150
    CTFLLAVGLS RVFLLAHFPH QVLAGLITGA VLGWLMTPQV PMERELSFYG 200
    LTSLALLLGA SLIYWTLFTL GLDLSWSINL ASKWCERPEW VHLDSRPFAS 250
    LSRDSGAALG LGIALHSPCY AQVRRAHLGY GQKLVCLVLA MGLLGPLNWL 300
    GYPPQISLFY IFNFLKYTLW PCLVLALVPW LVHMFSAQEA PPIRSS 346
    Length:346
    Mass (Da):38,742
    Last modified:August 22, 2006 - v1
    Checksum:iEBFB51839598E363
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti239 – 2391E → G in AAP40635. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY279358 mRNA. Translation: AAP40635.1.
    BC118357 mRNA. Translation: AAI18358.1.
    RefSeqiNP_899208.2. NM_183364.3.
    UniGeneiBt.23154.

    Genome annotation databases

    EnsembliENSBTAT00000021621; ENSBTAP00000021621; ENSBTAG00000016253.
    GeneIDi369023.
    KEGGibta:369023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY279358 mRNA. Translation: AAP40635.1 .
    BC118357 mRNA. Translation: AAI18358.1 .
    RefSeqi NP_899208.2. NM_183364.3.
    UniGenei Bt.23154.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000021621.

    Proteomic databases

    PRIDEi Q148G2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000021621 ; ENSBTAP00000021621 ; ENSBTAG00000016253 .
    GeneIDi 369023.
    KEGGi bta:369023.

    Organism-specific databases

    CTDi 92579.

    Phylogenomic databases

    eggNOGi NOG82628.
    GeneTreei ENSGT00510000046465.
    HOGENOMi HOG000264239.
    HOVERGENi HBG003560.
    InParanoidi Q148G2.
    KOi K01084.
    OMAi KWFLFGD.
    OrthoDBi EOG73NG4N.
    TreeFami TF324388.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    Reactomei REACT_204270. Glucose transport.

    Miscellaneous databases

    NextBioi 20813337.

    Family and domain databases

    Gene3Di 1.20.144.10. 1 hit.
    InterProi IPR016275. Glucose-6-phosphatase.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view ]
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
    SMARTi SM00014. acidPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Clottes E., Mounier R., Rossignol F., Bonnefont J., Guionie O., Burchell A.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal cerebellum.

    Entry informationi

    Entry nameiG6PC3_BOVIN
    AccessioniPrimary (citable) accession number: Q148G2
    Secondary accession number(s): Q7YSF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3