SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q148G2

- G6PC3_BOVIN

UniProt

Q148G2 - G6PC3_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glucose-6-phosphatase 3
Gene
G6PC3
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function By similarity.

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulationi

Inhibited by vanadate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Substrate Reviewed prediction
Active sitei114 – 1141Proton donor Reviewed prediction
Binding sitei161 – 1611Substrate Reviewed prediction
Active sitei167 – 1671Nucleophile By similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-UniPathway
  2. glucose-6-phosphate transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

ReactomeiREACT_204270. Glucose transport.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Gene namesi
Name:G6PC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Lumenal Reviewed prediction
Add
BLAST
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST
Topological domaini46 – 549Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Reviewed prediction
Add
BLAST
Topological domaini76 – 10833Lumenal Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST
Topological domaini130 – 14011Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei141 – 16222Helical; Reviewed prediction
Add
BLAST
Topological domaini163 – 1675Lumenal Reviewed prediction
Transmembranei168 – 18619Helical; Reviewed prediction
Add
BLAST
Topological domaini187 – 19711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Reviewed prediction
Add
BLAST
Topological domaini219 – 25436Lumenal Reviewed prediction
Add
BLAST
Transmembranei255 – 27319Helical; Reviewed prediction
Add
BLAST
Topological domaini274 – 28310Cytoplasmic Reviewed prediction
Transmembranei284 – 30421Helical; Reviewed prediction
Add
BLAST
Topological domaini305 – 3073Lumenal Reviewed prediction
Transmembranei308 – 32821Helical; Reviewed prediction
Add
BLAST
Topological domaini329 – 34618Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Glucose-6-phosphatase 3
PRO_0000334511Add
BLAST

Proteomic databases

PRIDEiQ148G2.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021621.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ148G2.
KOiK01084.
OMAiKWFLFGD.
OrthoDBiEOG73NG4N.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q148G2-1 [UniParc]FASTAAdd to Basket

« Hide

MESTLGAGIA MAEALQNQLP WLENVWLWVT FLGDPKSLFL FYFPAAYYAS    50
RRVGIAVLWI SLITEWLNLV FKWFLFGDRP FWWVHESGYY SQAPAQVHQF 100
PSSCETGPGS PSGHCMITGA ALWPIMTAVS SQMATRAHSR WVRVIPSLAY 150
CTFLLAVGLS RVFLLAHFPH QVLAGLITGA VLGWLMTPQV PMERELSFYG 200
LTSLALLLGA SLIYWTLFTL GLDLSWSINL ASKWCERPEW VHLDSRPFAS 250
LSRDSGAALG LGIALHSPCY AQVRRAHLGY GQKLVCLVLA MGLLGPLNWL 300
GYPPQISLFY IFNFLKYTLW PCLVLALVPW LVHMFSAQEA PPIRSS 346
Length:346
Mass (Da):38,742
Last modified:August 22, 2006 - v1
Checksum:iEBFB51839598E363
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391E → G in AAP40635. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY279358 mRNA. Translation: AAP40635.1.
BC118357 mRNA. Translation: AAI18358.1.
RefSeqiNP_899208.2. NM_183364.3.
UniGeneiBt.23154.

Genome annotation databases

EnsembliENSBTAT00000021621; ENSBTAP00000021621; ENSBTAG00000016253.
GeneIDi369023.
KEGGibta:369023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY279358 mRNA. Translation: AAP40635.1 .
BC118357 mRNA. Translation: AAI18358.1 .
RefSeqi NP_899208.2. NM_183364.3.
UniGenei Bt.23154.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000021621.

Proteomic databases

PRIDEi Q148G2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021621 ; ENSBTAP00000021621 ; ENSBTAG00000016253 .
GeneIDi 369023.
KEGGi bta:369023.

Organism-specific databases

CTDi 92579.

Phylogenomic databases

eggNOGi NOG82628.
GeneTreei ENSGT00510000046465.
HOGENOMi HOG000264239.
HOVERGENi HBG003560.
InParanoidi Q148G2.
KOi K01084.
OMAi KWFLFGD.
OrthoDBi EOG73NG4N.
TreeFami TF324388.

Enzyme and pathway databases

UniPathwayi UPA00138 .
Reactomei REACT_204270. Glucose transport.

Miscellaneous databases

NextBioi 20813337.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Clottes E., Mounier R., Rossignol F., Bonnefont J., Guionie O., Burchell A.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiG6PC3_BOVIN
AccessioniPrimary (citable) accession number: Q148G2
Secondary accession number(s): Q7YSF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi