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Q148G2

- G6PC3_BOVIN

UniProt

Q148G2 - G6PC3_BOVIN

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Protein

Glucose-6-phosphatase 3

Gene

G6PC3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulationi

Inhibited by vanadate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791SubstrateSequence Analysis
Active sitei114 – 1141Proton donorSequence Analysis
Binding sitei161 – 1611SubstrateSequence Analysis
Active sitei167 – 1671NucleophileBy similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-UniPathway
  2. glucose-6-phosphate transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

ReactomeiREACT_204270. Glucose transport.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Gene namesi
Name:G6PC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424LumenalSequence AnalysisAdd
BLAST
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Topological domaini46 – 549CytoplasmicSequence Analysis
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 10833LumenalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Topological domaini130 – 14011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16222HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 1675LumenalSequence Analysis
Transmembranei168 – 18619HelicalSequence AnalysisAdd
BLAST
Topological domaini187 – 19711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Topological domaini219 – 25436LumenalSequence AnalysisAdd
BLAST
Transmembranei255 – 27319HelicalSequence AnalysisAdd
BLAST
Topological domaini274 – 28310CytoplasmicSequence Analysis
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST
Topological domaini305 – 3073LumenalSequence Analysis
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Topological domaini329 – 34618CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Glucose-6-phosphatase 3PRO_0000334511Add
BLAST

Proteomic databases

PRIDEiQ148G2.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021621.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ148G2.
KOiK01084.
OMAiKWFLFGD.
OrthoDBiEOG73NG4N.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q148G2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESTLGAGIA MAEALQNQLP WLENVWLWVT FLGDPKSLFL FYFPAAYYAS
60 70 80 90 100
RRVGIAVLWI SLITEWLNLV FKWFLFGDRP FWWVHESGYY SQAPAQVHQF
110 120 130 140 150
PSSCETGPGS PSGHCMITGA ALWPIMTAVS SQMATRAHSR WVRVIPSLAY
160 170 180 190 200
CTFLLAVGLS RVFLLAHFPH QVLAGLITGA VLGWLMTPQV PMERELSFYG
210 220 230 240 250
LTSLALLLGA SLIYWTLFTL GLDLSWSINL ASKWCERPEW VHLDSRPFAS
260 270 280 290 300
LSRDSGAALG LGIALHSPCY AQVRRAHLGY GQKLVCLVLA MGLLGPLNWL
310 320 330 340
GYPPQISLFY IFNFLKYTLW PCLVLALVPW LVHMFSAQEA PPIRSS
Length:346
Mass (Da):38,742
Last modified:August 22, 2006 - v1
Checksum:iEBFB51839598E363
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391E → G in AAP40635. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY279358 mRNA. Translation: AAP40635.1.
BC118357 mRNA. Translation: AAI18358.1.
RefSeqiNP_899208.2. NM_183364.3.
UniGeneiBt.23154.

Genome annotation databases

EnsembliENSBTAT00000021621; ENSBTAP00000021621; ENSBTAG00000016253.
GeneIDi369023.
KEGGibta:369023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY279358 mRNA. Translation: AAP40635.1 .
BC118357 mRNA. Translation: AAI18358.1 .
RefSeqi NP_899208.2. NM_183364.3.
UniGenei Bt.23154.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000021621.

Proteomic databases

PRIDEi Q148G2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021621 ; ENSBTAP00000021621 ; ENSBTAG00000016253 .
GeneIDi 369023.
KEGGi bta:369023.

Organism-specific databases

CTDi 92579.

Phylogenomic databases

eggNOGi NOG82628.
GeneTreei ENSGT00510000046465.
HOGENOMi HOG000264239.
HOVERGENi HBG003560.
InParanoidi Q148G2.
KOi K01084.
OMAi KWFLFGD.
OrthoDBi EOG73NG4N.
TreeFami TF324388.

Enzyme and pathway databases

UniPathwayi UPA00138 .
Reactomei REACT_204270. Glucose transport.

Miscellaneous databases

NextBioi 20813337.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Clottes E., Mounier R., Rossignol F., Bonnefont J., Guionie O., Burchell A.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiG6PC3_BOVIN
AccessioniPrimary (citable) accession number: Q148G2
Secondary accession number(s): Q7YSF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3