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Q148G2 (G6PC3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphatase 3

Short name=G-6-Pase 3
Short name=G6Pase 3
EC=3.1.3.9
Gene names
Name:G6PC3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function By similarity.

Catalytic activity

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulation

Inhibited by vanadate By similarity.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glucose-6-phosphatase family.

Ontologies

Keywords
   Biological processGluconeogenesis
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

glucose-6-phosphate transport

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucose-6-phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Glucose-6-phosphatase 3
PRO_0000334511

Regions

Topological domain1 – 2424Lumenal Potential
Transmembrane25 – 4521Helical; Potential
Topological domain46 – 549Cytoplasmic Potential
Transmembrane55 – 7521Helical; Potential
Topological domain76 – 10833Lumenal Potential
Transmembrane109 – 12921Helical; Potential
Topological domain130 – 14011Cytoplasmic Potential
Transmembrane141 – 16222Helical; Potential
Topological domain163 – 1675Lumenal Potential
Transmembrane168 – 18619Helical; Potential
Topological domain187 – 19711Cytoplasmic Potential
Transmembrane198 – 21821Helical; Potential
Topological domain219 – 25436Lumenal Potential
Transmembrane255 – 27319Helical; Potential
Topological domain274 – 28310Cytoplasmic Potential
Transmembrane284 – 30421Helical; Potential
Topological domain305 – 3073Lumenal Potential
Transmembrane308 – 32821Helical; Potential
Topological domain329 – 34618Cytoplasmic Potential

Sites

Active site1141Proton donor Potential
Active site1671Nucleophile By similarity
Binding site791Substrate Potential
Binding site1611Substrate Potential

Experimental info

Sequence conflict2391E → G in AAP40635. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q148G2 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: EBFB51839598E363

FASTA34638,742
        10         20         30         40         50         60 
MESTLGAGIA MAEALQNQLP WLENVWLWVT FLGDPKSLFL FYFPAAYYAS RRVGIAVLWI 

        70         80         90        100        110        120 
SLITEWLNLV FKWFLFGDRP FWWVHESGYY SQAPAQVHQF PSSCETGPGS PSGHCMITGA 

       130        140        150        160        170        180 
ALWPIMTAVS SQMATRAHSR WVRVIPSLAY CTFLLAVGLS RVFLLAHFPH QVLAGLITGA 

       190        200        210        220        230        240 
VLGWLMTPQV PMERELSFYG LTSLALLLGA SLIYWTLFTL GLDLSWSINL ASKWCERPEW 

       250        260        270        280        290        300 
VHLDSRPFAS LSRDSGAALG LGIALHSPCY AQVRRAHLGY GQKLVCLVLA MGLLGPLNWL 

       310        320        330        340 
GYPPQISLFY IFNFLKYTLW PCLVLALVPW LVHMFSAQEA PPIRSS 

« Hide

References

« Hide 'large scale' references
[1]Clottes E., Mounier R., Rossignol F., Bonnefont J., Guionie O., Burchell A.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY279358 mRNA. Translation: AAP40635.1.
BC118357 mRNA. Translation: AAI18358.1.
RefSeqNP_899208.2. NM_183364.3.
UniGeneBt.23154.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000021621.

Proteomic databases

PRIDEQ148G2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000021621; ENSBTAP00000021621; ENSBTAG00000016253.
GeneID369023.
KEGGbta:369023.

Organism-specific databases

CTD92579.

Phylogenomic databases

eggNOGNOG82628.
GeneTreeENSGT00510000046465.
HOGENOMHOG000264239.
HOVERGENHBG003560.
InParanoidQ148G2.
KOK01084.
OMAKWFLFGD.
OrthoDBEOG73NG4N.
TreeFamTF324388.

Enzyme and pathway databases

UniPathwayUPA00138.

Family and domain databases

Gene3D1.20.144.10. 1 hit.
InterProIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. SSF48317. 1 hit.
ProtoNetSearch...

Other

NextBio20813337.

Entry information

Entry nameG6PC3_BOVIN
AccessionPrimary (citable) accession number: Q148G2
Secondary accession number(s): Q7YSF2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 22, 2006
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways