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Protein

Glucose-6-phosphatase 3

Gene

G6PC3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Enzyme regulationi

Inhibited by vanadate.By similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79SubstrateSequence analysis1
Active sitei114Proton donorSequence analysis1
Binding sitei161SubstrateSequence analysis1
Active sitei167NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

ReactomeiR-BTA-70153. Glucose transport.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Gene namesi
Name:G6PC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24LumenalSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 54CytoplasmicSequence analysis9
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 108LumenalSequence analysisAdd BLAST33
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 140CytoplasmicSequence analysisAdd BLAST11
Transmembranei141 – 162HelicalSequence analysisAdd BLAST22
Topological domaini163 – 167LumenalSequence analysis5
Transmembranei168 – 186HelicalSequence analysisAdd BLAST19
Topological domaini187 – 197CytoplasmicSequence analysisAdd BLAST11
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 254LumenalSequence analysisAdd BLAST36
Transmembranei255 – 273HelicalSequence analysisAdd BLAST19
Topological domaini274 – 283CytoplasmicSequence analysis10
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 307LumenalSequence analysis3
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 346CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003345111 – 346Glucose-6-phosphatase 3Add BLAST346

Proteomic databases

PaxDbiQ148G2.
PRIDEiQ148G2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016253.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021621.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXG. Eukaryota.
ENOG4110AJ7. LUCA.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ148G2.
KOiK01084.
OMAiHMFSAQE.
OrthoDBiEOG091G0AXF.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q148G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTLGAGIA MAEALQNQLP WLENVWLWVT FLGDPKSLFL FYFPAAYYAS
60 70 80 90 100
RRVGIAVLWI SLITEWLNLV FKWFLFGDRP FWWVHESGYY SQAPAQVHQF
110 120 130 140 150
PSSCETGPGS PSGHCMITGA ALWPIMTAVS SQMATRAHSR WVRVIPSLAY
160 170 180 190 200
CTFLLAVGLS RVFLLAHFPH QVLAGLITGA VLGWLMTPQV PMERELSFYG
210 220 230 240 250
LTSLALLLGA SLIYWTLFTL GLDLSWSINL ASKWCERPEW VHLDSRPFAS
260 270 280 290 300
LSRDSGAALG LGIALHSPCY AQVRRAHLGY GQKLVCLVLA MGLLGPLNWL
310 320 330 340
GYPPQISLFY IFNFLKYTLW PCLVLALVPW LVHMFSAQEA PPIRSS
Length:346
Mass (Da):38,742
Last modified:August 22, 2006 - v1
Checksum:iEBFB51839598E363
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239E → G in AAP40635 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY279358 mRNA. Translation: AAP40635.1.
BC118357 mRNA. Translation: AAI18358.1.
RefSeqiNP_899208.2. NM_183364.3.
UniGeneiBt.23154.

Genome annotation databases

EnsembliENSBTAT00000021621; ENSBTAP00000021621; ENSBTAG00000016253.
GeneIDi369023.
KEGGibta:369023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY279358 mRNA. Translation: AAP40635.1.
BC118357 mRNA. Translation: AAI18358.1.
RefSeqiNP_899208.2. NM_183364.3.
UniGeneiBt.23154.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021621.

Proteomic databases

PaxDbiQ148G2.
PRIDEiQ148G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021621; ENSBTAP00000021621; ENSBTAG00000016253.
GeneIDi369023.
KEGGibta:369023.

Organism-specific databases

CTDi92579.

Phylogenomic databases

eggNOGiENOG410IDXG. Eukaryota.
ENOG4110AJ7. LUCA.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiQ148G2.
KOiK01084.
OMAiHMFSAQE.
OrthoDBiEOG091G0AXF.
TreeFamiTF324388.

Enzyme and pathway databases

UniPathwayiUPA00138.
ReactomeiR-BTA-70153. Glucose transport.

Gene expression databases

BgeeiENSBTAG00000016253.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG6PC3_BOVIN
AccessioniPrimary (citable) accession number: Q148G2
Secondary accession number(s): Q7YSF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 22, 2006
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.