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Protein

Sorting nexin-15

Gene

SNX15

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-15
Gene namesi
Name:SNX15
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Sorting nexin-15PRO_0000290187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei208 – 2081PhosphoserineBy similarity
Modified residuei234 – 2341PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ148E7.
PRIDEiQ148E7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002243.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002897.

Structurei

3D structure databases

ProteinModelPortaliQ148E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 130130PXPROSITE-ProRule annotationAdd
BLAST
Domaini272 – 34574MITAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 MIT domain.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG4111HIS. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154362.
HOVERGENiHBG066336.
InParanoidiQ148E7.
KOiK17927.
OMAiLYNSPQL.
OrthoDBiEOG091G0CNL.
TreeFamiTF323964.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q148E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKRDP EDVKEVVVWK
60 70 80 90 100
RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RGQVFGRFEA SVIEERRKGA
110 120 130 140 150
EDLLRFTVHI PALNNSPQLK EFFRGGEVTR PSEVSGDLHI LPPPLIPTPP
160 170 180 190 200
PDEPRVQPHE TWLPQPLPAE RRGLEELEVP ADPPPSSPAQ EALDLLFNCG
210 220 230 240 250
STEEASSSPA RGPLTEAELA LFDPFSKEEG AGPSPTHIGE LAALEAGSGR
260 270 280 290 300
PDQEPWEPGG QAEEDDEEGE PAPAYLSQAT ELITQALRDE KAGAYPAALQ
310 320 330 340
GYRDGVHILL QGVPGDPSPA RREGVKKKAA EYLKRAEEIL HLHLS
Length:345
Mass (Da):38,403
Last modified:August 22, 2006 - v1
Checksum:i56C0009501B6BE25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118397 mRNA. Translation: AAI18398.1.
RefSeqiNP_001068798.1. NM_001075330.2.
UniGeneiBt.13962.

Genome annotation databases

EnsembliENSBTAT00000002897; ENSBTAP00000002897; ENSBTAG00000002243.
GeneIDi507751.
KEGGibta:507751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118397 mRNA. Translation: AAI18398.1.
RefSeqiNP_001068798.1. NM_001075330.2.
UniGeneiBt.13962.

3D structure databases

ProteinModelPortaliQ148E7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002897.

Proteomic databases

PaxDbiQ148E7.
PRIDEiQ148E7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002897; ENSBTAP00000002897; ENSBTAG00000002243.
GeneIDi507751.
KEGGibta:507751.

Organism-specific databases

CTDi29907.

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG4111HIS. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154362.
HOVERGENiHBG066336.
InParanoidiQ148E7.
KOiK17927.
OMAiLYNSPQL.
OrthoDBiEOG091G0CNL.
TreeFamiTF323964.

Gene expression databases

BgeeiENSBTAG00000002243.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX15_BOVIN
AccessioniPrimary (citable) accession number: Q148E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: August 22, 2006
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.