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Protein
Submitted name:

Fumarate hydratase

Gene

FH

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-71403. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Submitted name:
Fumarate hydrataseImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:FHImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSBTAG00000021688.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028902.

Structurei

3D structure databases

SMRiQ148D3. Positions 49-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 389332Lyase_1InterPro annotationAdd
BLAST
Domaini455 – 50753FumaraseC_CInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1317. Eukaryota.
COG0114. LUCA.
GeneTreeiENSGT00390000002779.
HOGENOMiHOG000061736.
HOVERGENiHBG002183.
KOiK01679.
OMAiFAYLKKA.
OrthoDBiEOG091G05UL.
TreeFamiTF300441.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00743. FumaraseC. 1 hit.
InterProiIPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00979. fumC_II. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q148D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRALRLLAR SRLLSRNPGS APKPGLGPGG PAVLLLRPPN AARMASQNSF
60 70 80 90 100
RIEYDTFGEL KVPNDKYYGA QTVRSTMNFK IGGMTERMPI PVIKAFGILK
110 120 130 140 150
RAAAEVNQDY GLDPKIANAI MKAADEVAEG KLNDHFPLVV WQTGSGTQTN
160 170 180 190 200
MNVNEVISNR AIEILGGELG SKKPVHPNDH VNKSQSSNDT FPTAMHIAAA
210 220 230 240 250
IEVHEVLLPG LQKLHDALEA KSKEFDQIIK IGRTHTQDAV PLTLGQEFSG
260 270 280 290 300
YVQQVKYATT RIKAAMPRIY ELAAGGTAVG TGLNTRIGFA EKVAAKVAVL
310 320 330 340 350
TGLPFVTAPN KFEALAAHDA LVELSGAMNT TACSLMKIAN DIRFLGSGPR
360 370 380 390 400
SGLGELILPE NEPGSSIMPG KVNPTQCEAM TMVAAQVMGN HVAVTVGGSN
410 420 430 440 450
GHFELNVFKP MMIKNVLHSA RLLGDASVSF TENCVVGIQA NTERISKLMN
460 470 480 490 500
ESLMLVTALN PHIGYDKAAK IAKTAHKNGS TLKATAIELG YLTAEQFDEW
510
VKPKDMLGPK
Length:510
Mass (Da):54,691
Last modified:August 22, 2006 - v1
Checksum:iFF5AD14825691745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02042810 Genomic DNA. No translation available.
BC118450 mRNA. Translation: AAI18451.1.
RefSeqiNP_001069271.1. NM_001075803.2.
UniGeneiBt.45986.

Genome annotation databases

EnsembliENSBTAT00000028902; ENSBTAP00000028902; ENSBTAG00000021688.
GeneIDi520260.
KEGGibta:520260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02042810 Genomic DNA. No translation available.
BC118450 mRNA. Translation: AAI18451.1.
RefSeqiNP_001069271.1. NM_001075803.2.
UniGeneiBt.45986.

3D structure databases

SMRiQ148D3. Positions 49-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028902; ENSBTAP00000028902; ENSBTAG00000021688.
GeneIDi520260.
KEGGibta:520260.

Organism-specific databases

CTDi2271.

Phylogenomic databases

eggNOGiKOG1317. Eukaryota.
COG0114. LUCA.
GeneTreeiENSGT00390000002779.
HOGENOMiHOG000061736.
HOVERGENiHBG002183.
KOiK01679.
OMAiFAYLKKA.
OrthoDBiEOG091G05UL.
TreeFamiTF300441.

Enzyme and pathway databases

ReactomeiR-BTA-71403. Citric acid cycle (TCA cycle).

Gene expression databases

BgeeiENSBTAG00000021688.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00743. FumaraseC. 1 hit.
InterProiIPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00979. fumC_II. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ148D3_BOVIN
AccessioniPrimary (citable) accession number: Q148D3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.