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Protein

Migration and invasion enhancer 1

Gene

MIEN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Migration and invasion enhancer 1
Gene namesi
Name:MIEN1
Synonyms:RDX12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002650982 – 112Migration and invasion enhancer 1Add BLAST111
PropeptideiPRO_0000396007113 – 115Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Disulfide bondi30 ↔ 33Redox-activeBy similarity
Lipidationi112S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ148C8.
PRIDEiQ148C8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021802.

Interactioni

Subunit structurei

Interacts with GPX1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029060.

Structurei

3D structure databases

ProteinModelPortaliQ148C8.
SMRiQ148C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410J06V. Eukaryota.
ENOG41127T6. LUCA.
GeneTreeiENSGT00390000010440.
HOGENOMiHOG000275576.
HOVERGENiHBG059755.
InParanoidiQ148C8.
KOiK07401.
OMAiCLAFPQH.
OrthoDBiEOG091G13XN.
TreeFamiTF326627.

Family and domain databases

InterProiView protein in InterPro
IPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF10262. Rdx. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q148C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDTGTTSV APPPGETEPG HGVRIVVEYC EPCGFEATYL ELASAVKEQY
60 70 80 90 100
PGIEIESRLG GTGAFEIEIN GQLVFSKLEN GGFPYEKDLI EAIRRASNGE
110
PLEKITNSRP PCVIL
Length:115
Mass (Da):12,342
Last modified:August 22, 2006 - v1
Checksum:i6580D3266BA6086E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118463 mRNA. Translation: AAI18464.1.
RefSeqiNP_001068689.1. NM_001075221.2.
UniGeneiBt.17107.

Genome annotation databases

EnsembliENSBTAT00000029060; ENSBTAP00000029060; ENSBTAG00000021802.
GeneIDi505710.
KEGGibta:505710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118463 mRNA. Translation: AAI18464.1.
RefSeqiNP_001068689.1. NM_001075221.2.
UniGeneiBt.17107.

3D structure databases

ProteinModelPortaliQ148C8.
SMRiQ148C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029060.

Proteomic databases

PaxDbiQ148C8.
PRIDEiQ148C8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029060; ENSBTAP00000029060; ENSBTAG00000021802.
GeneIDi505710.
KEGGibta:505710.

Organism-specific databases

CTDi84299.

Phylogenomic databases

eggNOGiENOG410J06V. Eukaryota.
ENOG41127T6. LUCA.
GeneTreeiENSGT00390000010440.
HOGENOMiHOG000275576.
HOVERGENiHBG059755.
InParanoidiQ148C8.
KOiK07401.
OMAiCLAFPQH.
OrthoDBiEOG091G13XN.
TreeFamiTF326627.

Gene expression databases

BgeeiENSBTAG00000021802.

Family and domain databases

InterProiView protein in InterPro
IPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF10262. Rdx. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMIEN1_BOVIN
AccessioniPrimary (citable) accession number: Q148C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: May 10, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.