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Protein

Migration and invasion enhancer 1

Gene

MIEN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Migration and invasion enhancer 1
Gene namesi
Name:MIEN1
Synonyms:RDX12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002650982 – 112Migration and invasion enhancer 1Add BLAST111
PropeptideiPRO_0000396007113 – 115Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Disulfide bondi30 ↔ 33Redox-activeBy similarity
Lipidationi112S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ148C8.
PRIDEiQ148C8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021802.

Interactioni

Subunit structurei

Interacts with GPX1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029060.

Structurei

3D structure databases

ProteinModelPortaliQ148C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410J06V. Eukaryota.
ENOG41127T6. LUCA.
GeneTreeiENSGT00390000010440.
HOGENOMiHOG000275576.
HOVERGENiHBG059755.
InParanoidiQ148C8.
KOiK07401.
OMAiCLAFPQH.
OrthoDBiEOG091G13XN.
TreeFamiTF326627.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q148C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDTGTTSV APPPGETEPG HGVRIVVEYC EPCGFEATYL ELASAVKEQY
60 70 80 90 100
PGIEIESRLG GTGAFEIEIN GQLVFSKLEN GGFPYEKDLI EAIRRASNGE
110
PLEKITNSRP PCVIL
Length:115
Mass (Da):12,342
Last modified:August 22, 2006 - v1
Checksum:i6580D3266BA6086E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118463 mRNA. Translation: AAI18464.1.
RefSeqiNP_001068689.1. NM_001075221.2.
UniGeneiBt.17107.

Genome annotation databases

EnsembliENSBTAT00000029060; ENSBTAP00000029060; ENSBTAG00000021802.
GeneIDi505710.
KEGGibta:505710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118463 mRNA. Translation: AAI18464.1.
RefSeqiNP_001068689.1. NM_001075221.2.
UniGeneiBt.17107.

3D structure databases

ProteinModelPortaliQ148C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029060.

Proteomic databases

PaxDbiQ148C8.
PRIDEiQ148C8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029060; ENSBTAP00000029060; ENSBTAG00000021802.
GeneIDi505710.
KEGGibta:505710.

Organism-specific databases

CTDi84299.

Phylogenomic databases

eggNOGiENOG410J06V. Eukaryota.
ENOG41127T6. LUCA.
GeneTreeiENSGT00390000010440.
HOGENOMiHOG000275576.
HOVERGENiHBG059755.
InParanoidiQ148C8.
KOiK07401.
OMAiCLAFPQH.
OrthoDBiEOG091G13XN.
TreeFamiTF326627.

Gene expression databases

BgeeiENSBTAG00000021802.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMIEN1_BOVIN
AccessioniPrimary (citable) accession number: Q148C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.