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Protein

Migration and invasion enhancer 1

Gene

MIEN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Migration and invasion enhancer 1
Gene namesi
Name:MIEN1
Synonyms:RDX12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:31468 MIEN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002650982 – 112Migration and invasion enhancer 1Add BLAST111
PropeptideiPRO_0000396007113 – 115Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Disulfide bondi30 ↔ 33Redox-activeBy similarity
Lipidationi112S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ148C8
PRIDEiQ148C8

Expressioni

Gene expression databases

BgeeiENSBTAG00000021802

Interactioni

Subunit structurei

Interacts with GPX1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029060

Structurei

3D structure databases

ProteinModelPortaliQ148C8
SMRiQ148C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410J06V Eukaryota
ENOG41127T6 LUCA
GeneTreeiENSGT00390000010440
HOGENOMiHOG000275576
HOVERGENiHBG059755
InParanoidiQ148C8
KOiK07401
OMAiCLAFPQH
OrthoDBiEOG091G13XN
TreeFamiTF326627

Family and domain databases

InterProiView protein in InterPro
IPR011893 Selenoprotein_Rdx-typ
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF10262 Rdx, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02174 CXXU_selWTH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q148C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDTGTTSV APPPGETEPG HGVRIVVEYC EPCGFEATYL ELASAVKEQY
60 70 80 90 100
PGIEIESRLG GTGAFEIEIN GQLVFSKLEN GGFPYEKDLI EAIRRASNGE
110
PLEKITNSRP PCVIL
Length:115
Mass (Da):12,342
Last modified:August 22, 2006 - v1
Checksum:i6580D3266BA6086E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118463 mRNA Translation: AAI18464.1
RefSeqiNP_001068689.1, NM_001075221.2
UniGeneiBt.17107

Genome annotation databases

EnsembliENSBTAT00000029060; ENSBTAP00000029060; ENSBTAG00000021802
GeneIDi505710
KEGGibta:505710

Entry informationi

Entry nameiMIEN1_BOVIN
AccessioniPrimary (citable) accession number: Q148C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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