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Q14872

- MTF1_HUMAN

UniProt

Q14872 - MTF1_HUMAN

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Protein
Metal regulatory transcription factor 1
Gene
MTF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16425C2H2-type 1
Add
BLAST
Zinc fingeri170 – 19425C2H2-type 2
Add
BLAST
Zinc fingeri200 – 22425C2H2-type 3
Add
BLAST
Zinc fingeri229 – 25325C2H2-type 4
Add
BLAST
Zinc fingeri259 – 28325C2H2-type 5
Add
BLAST
Zinc fingeri289 – 31325C2H2-type 6
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  3. core promoter binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: IntAct
  6. sequence-specific DNA binding transcription factor activity Source: ProtInc
  7. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  3. response to cadmium ion Source: Ensembl
  4. response to metal ion Source: ProtInc
  5. response to oxidative stress Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metal regulatory transcription factor 1
Alternative name(s):
MRE-binding transcription factor
Transcription factor MTF-1
Gene namesi
Name:MTF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7428. MTF1.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 753752Metal regulatory transcription factor 1
PRO_0000047220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity
Modified residuei5 – 51Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ14872.
PaxDbiQ14872.
PRIDEiQ14872.

PTM databases

PhosphoSiteiQ14872.

Expressioni

Gene expression databases

ArrayExpressiQ14872.
BgeeiQ14872.
CleanExiHS_MTF1.
GenevestigatoriQ14872.

Organism-specific databases

HPAiHPA028604.
HPA028689.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AP1M1Q9BXS53EBI-747024,EBI-541426

Protein-protein interaction databases

BioGridi110620. 3 interactions.
IntActiQ14872. 1 interaction.
MINTiMINT-1456332.
STRINGi9606.ENSP00000362127.

Structurei

3D structure databases

ProteinModelPortaliQ14872.
SMRiQ14872. Positions 102-316.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi133 – 1386Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi420 – 49778Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000059609.
HOVERGENiHBG006412.
InParanoidiQ14872.
OMAiEDTNHSL.
OrthoDBiEOG76T9QH.
PhylomeDBiQ14872.
TreeFamiTF106493.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14872-1 [UniParc]FASTAAdd to Basket

« Hide

MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL    50
IEQDPGTLED EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP 100
DQIHLTINPG STPMPRNIEG ATLTLQSECP ETKRKEVKRY QCTFEGCPRT 150
YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA FLTSYSLRIH VRVHTKEKPF 200
ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF TTLSDLRKHI 250
RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF 300
STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL 350
RENSSTTQGQ DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD 400
AESVSDVPPS TGNSASLSLP LVLQPGLSEP PQPLLPASAP SAPPPAPSLG 450
PGSQQAAFGN PPALLQPPEV PVPHSTQFAA NHQEFLPHPQ APQPIVPGLS 500
VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI 550
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF 600
TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR 650
KGCSSPPPPE PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ 700
AETPSDPQTE TLSAMDVSEF LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS 750
FSK 753
Length:753
Mass (Da):80,957
Last modified:June 21, 2005 - v2
Checksum:iCC96518824170E98
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851Y → H in CAA55363. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78710 mRNA. Translation: CAA55363.1.
AK314233 mRNA. Translation: BAG36903.1.
AL929472 Genomic DNA. Translation: CAH70087.1.
CH471059 Genomic DNA. Translation: EAX07312.1.
BC014454 mRNA. Translation: AAH14454.1.
CCDSiCCDS30676.1.
PIRiS48059.
RefSeqiNP_005946.2. NM_005955.2.
UniGeneiHs.471991.

Genome annotation databases

EnsembliENST00000373036; ENSP00000362127; ENSG00000188786.
GeneIDi4520.
KEGGihsa:4520.
UCSCiuc001cce.1. human.

Polymorphism databases

DMDMi68052403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78710 mRNA. Translation: CAA55363.1 .
AK314233 mRNA. Translation: BAG36903.1 .
AL929472 Genomic DNA. Translation: CAH70087.1 .
CH471059 Genomic DNA. Translation: EAX07312.1 .
BC014454 mRNA. Translation: AAH14454.1 .
CCDSi CCDS30676.1.
PIRi S48059.
RefSeqi NP_005946.2. NM_005955.2.
UniGenei Hs.471991.

3D structure databases

ProteinModelPortali Q14872.
SMRi Q14872. Positions 102-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110620. 3 interactions.
IntActi Q14872. 1 interaction.
MINTi MINT-1456332.
STRINGi 9606.ENSP00000362127.

PTM databases

PhosphoSitei Q14872.

Polymorphism databases

DMDMi 68052403.

Proteomic databases

MaxQBi Q14872.
PaxDbi Q14872.
PRIDEi Q14872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373036 ; ENSP00000362127 ; ENSG00000188786 .
GeneIDi 4520.
KEGGi hsa:4520.
UCSCi uc001cce.1. human.

Organism-specific databases

CTDi 4520.
GeneCardsi GC01M038275.
HGNCi HGNC:7428. MTF1.
HPAi HPA028604.
HPA028689.
MIMi 600172. gene.
neXtProti NX_Q14872.
PharmGKBi PA31235.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000059609.
HOVERGENi HBG006412.
InParanoidi Q14872.
OMAi EDTNHSL.
OrthoDBi EOG76T9QH.
PhylomeDBi Q14872.
TreeFami TF106493.

Miscellaneous databases

ChiTaRSi MTF1. human.
GeneWikii MTF1.
GenomeRNAii 4520.
NextBioi 17448.
PROi Q14872.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14872.
Bgeei Q14872.
CleanExi HS_MTF1.
Genevestigatori Q14872.

Family and domain databases

Gene3Di 3.30.160.60. 6 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1."
    Brugnera E., Georgiev O., Radtke F., Heuchel R., Baker E., Sutherland G., Schaffner W.
    Nucleic Acids Res. 22:3167-3173(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiMTF1_HUMAN
AccessioniPrimary (citable) accession number: Q14872
Secondary accession number(s): B2RAK6, Q96CB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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