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Q14872

- MTF1_HUMAN

UniProt

Q14872 - MTF1_HUMAN

Protein

Metal regulatory transcription factor 1

Gene

MTF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri140 – 16425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri170 – 19425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22425C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri229 – 25325C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri259 – 28325C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31325C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter binding Source: UniProtKB
    2. DNA binding Source: ProtInc
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    7. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    8. sequence-specific DNA binding transcription factor activity Source: ProtInc
    9. transcription coactivator activity Source: ProtInc

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    2. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    3. response to cadmium ion Source: Ensembl
    4. response to metal ion Source: ProtInc
    5. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metal regulatory transcription factor 1
    Alternative name(s):
    MRE-binding transcription factor
    Transcription factor MTF-1
    Gene namesi
    Name:MTF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7428. MTF1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31235.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 753752Metal regulatory transcription factor 1PRO_0000047220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei5 – 51PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ14872.
    PaxDbiQ14872.
    PRIDEiQ14872.

    PTM databases

    PhosphoSiteiQ14872.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14872.
    BgeeiQ14872.
    CleanExiHS_MTF1.
    GenevestigatoriQ14872.

    Organism-specific databases

    HPAiHPA028604.
    HPA028689.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AP1M1Q9BXS53EBI-747024,EBI-541426

    Protein-protein interaction databases

    BioGridi110620. 3 interactions.
    IntActiQ14872. 1 interaction.
    MINTiMINT-1456332.
    STRINGi9606.ENSP00000362127.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14872.
    SMRiQ14872. Positions 102-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi133 – 1386Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi420 – 49778Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri140 – 16425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri170 – 19425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22425C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri229 – 25325C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri259 – 28325C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31325C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000059609.
    HOVERGENiHBG006412.
    InParanoidiQ14872.
    OMAiEDTNHSL.
    OrthoDBiEOG76T9QH.
    PhylomeDBiQ14872.
    TreeFamiTF106493.

    Family and domain databases

    Gene3Di3.30.160.60. 6 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL    50
    IEQDPGTLED EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP 100
    DQIHLTINPG STPMPRNIEG ATLTLQSECP ETKRKEVKRY QCTFEGCPRT 150
    YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA FLTSYSLRIH VRVHTKEKPF 200
    ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF TTLSDLRKHI 250
    RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF 300
    STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL 350
    RENSSTTQGQ DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD 400
    AESVSDVPPS TGNSASLSLP LVLQPGLSEP PQPLLPASAP SAPPPAPSLG 450
    PGSQQAAFGN PPALLQPPEV PVPHSTQFAA NHQEFLPHPQ APQPIVPGLS 500
    VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI 550
    TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF 600
    TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR 650
    KGCSSPPPPE PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ 700
    AETPSDPQTE TLSAMDVSEF LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS 750
    FSK 753
    Length:753
    Mass (Da):80,957
    Last modified:June 21, 2005 - v2
    Checksum:iCC96518824170E98
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti185 – 1851Y → H in CAA55363. (PubMed:8065932)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78710 mRNA. Translation: CAA55363.1.
    AK314233 mRNA. Translation: BAG36903.1.
    AL929472 Genomic DNA. Translation: CAH70087.1.
    CH471059 Genomic DNA. Translation: EAX07312.1.
    BC014454 mRNA. Translation: AAH14454.1.
    CCDSiCCDS30676.1.
    PIRiS48059.
    RefSeqiNP_005946.2. NM_005955.2.
    UniGeneiHs.471991.

    Genome annotation databases

    EnsembliENST00000373036; ENSP00000362127; ENSG00000188786.
    GeneIDi4520.
    KEGGihsa:4520.
    UCSCiuc001cce.1. human.

    Polymorphism databases

    DMDMi68052403.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78710 mRNA. Translation: CAA55363.1 .
    AK314233 mRNA. Translation: BAG36903.1 .
    AL929472 Genomic DNA. Translation: CAH70087.1 .
    CH471059 Genomic DNA. Translation: EAX07312.1 .
    BC014454 mRNA. Translation: AAH14454.1 .
    CCDSi CCDS30676.1.
    PIRi S48059.
    RefSeqi NP_005946.2. NM_005955.2.
    UniGenei Hs.471991.

    3D structure databases

    ProteinModelPortali Q14872.
    SMRi Q14872. Positions 102-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110620. 3 interactions.
    IntActi Q14872. 1 interaction.
    MINTi MINT-1456332.
    STRINGi 9606.ENSP00000362127.

    PTM databases

    PhosphoSitei Q14872.

    Polymorphism databases

    DMDMi 68052403.

    Proteomic databases

    MaxQBi Q14872.
    PaxDbi Q14872.
    PRIDEi Q14872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373036 ; ENSP00000362127 ; ENSG00000188786 .
    GeneIDi 4520.
    KEGGi hsa:4520.
    UCSCi uc001cce.1. human.

    Organism-specific databases

    CTDi 4520.
    GeneCardsi GC01M038275.
    HGNCi HGNC:7428. MTF1.
    HPAi HPA028604.
    HPA028689.
    MIMi 600172. gene.
    neXtProti NX_Q14872.
    PharmGKBi PA31235.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000059609.
    HOVERGENi HBG006412.
    InParanoidi Q14872.
    OMAi EDTNHSL.
    OrthoDBi EOG76T9QH.
    PhylomeDBi Q14872.
    TreeFami TF106493.

    Miscellaneous databases

    ChiTaRSi MTF1. human.
    GeneWikii MTF1.
    GenomeRNAii 4520.
    NextBioi 17448.
    PROi Q14872.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14872.
    Bgeei Q14872.
    CleanExi HS_MTF1.
    Genevestigatori Q14872.

    Family and domain databases

    Gene3Di 3.30.160.60. 6 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1."
      Brugnera E., Georgiev O., Radtke F., Heuchel R., Baker E., Sutherland G., Schaffner W.
      Nucleic Acids Res. 22:3167-3173(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiMTF1_HUMAN
    AccessioniPrimary (citable) accession number: Q14872
    Secondary accession number(s): B2RAK6, Q96CB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3