POU domain, class 6, transcription factor 1

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Q14863 (PO6F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 118. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
POU domain, class 6, transcription factor 1

Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name=Brain-5
Short name=Brn-5
mPOU homeobox protein

Gene names

Name:	POU6F1
Synonyms:	BRN5, MPOU, TCFB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') By similarity.
Subcellular location	Nucleus.
Tissue specificity	In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.
Sequence similarities	Belongs to the POU transcription factor family. Class-6 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Traceable author statement Ref.1. Source: ProtInc heart development Traceable author statement Ref.1. Source: ProtInc muscle organ development Traceable author statement Ref.1. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear membrane Inferred from direct assay. Source: HPA
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 301

301

POU domain, class 6, transcription factor 1

PRO_0000100759

Regions

Domain

139 – 213

POU-specific

DNA binding

234 – 293

Homeobox

Compositional bias

1 – 139

139

Gln/Pro-rich

Experimental info

Sequence conflict

210

N → M in CAA79978. Ref.1

Secondary structure

301

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q14863 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9C552BA84ABAB17A
Show »

FASTA

301

32,645

        10         20         30         40         50         60 
MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN AQGQVIATLA 

        70         80         90        100        110        120 
SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI ASPAPAAKPS ASAPIPITCS 

       130        140        150        160        170        180 
ETPTVSQLVS KPHTPSLDED GINLEEIREF AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY 

       190        200        210        220        230        240 
SQSAICRFEK LDITPKSAQK LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS 

       250        260        270        280        290        300 
FTPQAIEALN AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 


P

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues." Wey E., Lyons G.E., Schaefer B.W. Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[2]	"A novel POU domain protein which binds to the T-cell receptor beta enhancer." Messier H., Brickner H., Gaikwad J., Fotedar A. Mol. Cell. Biol. 13:5450-5460(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z21966 mRNA. Translation: CAA79977.1.
Z21967 mRNA. Translation: CAA79978.1.
L14482 mRNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58180.1.
BC051326 mRNA. Translation: AAH51326.2.
BC074765 mRNA. Translation: AAH74765.3.

IPI

IPI00398955.

PIR

A54687.

RefSeq

NP_002693.3. NM_002702.3.

UniGene

Hs.555886.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3D1N	X-ray	2.51	I/J/K/L/M/N/O/P	142-292	[»]

ProteinModelPortal

Q14863.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000330190.

PTM databases

PhosphoSite

Q14863.

Polymorphism databases

DMDM

2495306.

Proteomic databases

PaxDb

Q14863.

PRIDE

Q14863.

Protocols and materials databases

DNASU

5463.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000333640; ENSP00000330190; ENSG00000184271.
ENST00000389243; ENSP00000373895; ENSG00000184271.
ENST00000550824; ENSP00000448389; ENSG00000184271.

GeneID

5463.

KEGG

hsa:5463.

UCSC

uc001rxy.3. human.

Organism-specific databases

CTD

5463.

GeneCards

GC12M051580.

HGNC

HGNC:9224. POU6F1.

HPA

HPA047021.

neXtProt

NX_Q14863.

PharmGKB

PA33548.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG241882.

HOGENOM

HOG000115597.

HOVERGEN

HBG008230.

K09368.

OMA

KQHESAT.

OrthoDB

EOG4FFD1X.

PhylomeDB

Q14863.

Gene expression databases

ArrayExpress

Q14863.

Bgee

Q14863.

CleanEx

HS_POU6F1.

Genevestigator

Q14863.

GermOnline

ENSG00000184271. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.60. 1 hit.
1.10.260.40. 1 hit.

InterPro

IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]

Pfam

PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]

PRINTS

PR00028. POUDOMAIN.

SMART

SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.
SSF47413. Lambda_like_DNA. 1 hit.

PROSITE

PS00027. HOMEOBOX_1. False negative.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

POU6F1. human.

GenomeRNAi

5463.

NextBio

21144.

Entry information

Entry name

PO6F1_HUMAN

Accession

Primary (citable) accession number: Q14863
Secondary accession number(s): Q15944, Q6DK47, Q7Z7P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents