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Q14863

- PO6F1_HUMAN

UniProt

Q14863 - PO6F1_HUMAN

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Protein
POU domain, class 6, transcription factor 1
Gene
POU6F1, BRN5, MPOU, TCFB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi234 – 29360Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. brain development Source: ProtInc
  2. heart development Source: ProtInc
  3. muscle organ development Source: ProtInc
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ14863.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name:
Brain-5
Short name:
Brn-5
mPOU homeobox protein
Gene namesi
Name:POU6F1
Synonyms:BRN5, MPOU, TCFB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9224. POU6F1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301POU domain, class 6, transcription factor 1
PRO_0000100759Add
BLAST

Proteomic databases

PaxDbiQ14863.
PRIDEiQ14863.

PTM databases

PhosphoSiteiQ14863.

Expressioni

Tissue specificityi

In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.

Gene expression databases

ArrayExpressiQ14863.
BgeeiQ14863.
CleanExiHS_POU6F1.
GenevestigatoriQ14863.

Organism-specific databases

HPAiHPA047021.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330190.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi144 – 15916
Turni160 – 1623
Helixi165 – 1728
Beta strandi175 – 1773
Helixi182 – 1898
Helixi195 – 21824
Helixi223 – 2275
Helixi243 – 25513
Helixi261 – 27111
Helixi275 – 28915

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D1NX-ray2.51I/J/K/L/M/N/O/P142-292[»]
ProteinModelPortaliQ14863.
SMRiQ14863. Positions 143-291.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 21375POU-specific
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 139139Gln/Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241882.
HOGENOMiHOG000115597.
HOVERGENiHBG008230.
KOiK09368.
OMAiPESHLKE.
OrthoDBiEOG7353Z3.
PhylomeDBiQ14863.
TreeFamiTF350705.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14863-1 [UniParc]FASTAAdd to Basket

« Hide

MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN    50
AQGQVIATLA SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI 100
ASPAPAAKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF 150
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK 200
LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN 250
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 300
P 301
Length:301
Mass (Da):32,645
Last modified:November 1, 1996 - v1
Checksum:i9C552BA84ABAB17A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101N → M in CAA79978. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21966 mRNA. Translation: CAA79977.1.
Z21967 mRNA. Translation: CAA79978.1.
L14482 mRNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58180.1.
BC051326 mRNA. Translation: AAH51326.2.
BC074765 mRNA. Translation: AAH74765.3.
CCDSiCCDS31803.1.
PIRiA54687.
RefSeqiNP_002693.3. NM_002702.3.
UniGeneiHs.555886.

Genome annotation databases

EnsembliENST00000333640; ENSP00000330190; ENSG00000184271.
ENST00000389243; ENSP00000373895; ENSG00000184271.
ENST00000550824; ENSP00000448389; ENSG00000184271.
GeneIDi5463.
KEGGihsa:5463.
UCSCiuc001rxy.3. human.

Polymorphism databases

DMDMi2495306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21966 mRNA. Translation: CAA79977.1 .
Z21967 mRNA. Translation: CAA79978.1 .
L14482 mRNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58180.1 .
BC051326 mRNA. Translation: AAH51326.2 .
BC074765 mRNA. Translation: AAH74765.3 .
CCDSi CCDS31803.1.
PIRi A54687.
RefSeqi NP_002693.3. NM_002702.3.
UniGenei Hs.555886.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3D1N X-ray 2.51 I/J/K/L/M/N/O/P 142-292 [» ]
ProteinModelPortali Q14863.
SMRi Q14863. Positions 143-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000330190.

PTM databases

PhosphoSitei Q14863.

Polymorphism databases

DMDMi 2495306.

Proteomic databases

PaxDbi Q14863.
PRIDEi Q14863.

Protocols and materials databases

DNASUi 5463.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333640 ; ENSP00000330190 ; ENSG00000184271 .
ENST00000389243 ; ENSP00000373895 ; ENSG00000184271 .
ENST00000550824 ; ENSP00000448389 ; ENSG00000184271 .
GeneIDi 5463.
KEGGi hsa:5463.
UCSCi uc001rxy.3. human.

Organism-specific databases

CTDi 5463.
GeneCardsi GC12M051580.
HGNCi HGNC:9224. POU6F1.
HPAi HPA047021.
neXtProti NX_Q14863.
PharmGKBi PA33548.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241882.
HOGENOMi HOG000115597.
HOVERGENi HBG008230.
KOi K09368.
OMAi PESHLKE.
OrthoDBi EOG7353Z3.
PhylomeDBi Q14863.
TreeFami TF350705.

Enzyme and pathway databases

SignaLinki Q14863.

Miscellaneous databases

ChiTaRSi POU6F1. human.
GenomeRNAii 5463.
NextBioi 21144.
PROi Q14863.

Gene expression databases

ArrayExpressi Q14863.
Bgeei Q14863.
CleanExi HS_POU6F1.
Genevestigatori Q14863.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
    Wey E., Lyons G.E., Schaefer B.W.
    Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "A novel POU domain protein which binds to the T-cell receptor beta enhancer."
    Messier H., Brickner H., Gaikwad J., Fotedar A.
    Mol. Cell. Biol. 13:5450-5460(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Salivary gland.

Entry informationi

Entry nameiPO6F1_HUMAN
AccessioniPrimary (citable) accession number: Q14863
Secondary accession number(s): Q15944, Q6DK47, Q7Z7P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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