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Q14863

- PO6F1_HUMAN

UniProt

Q14863 - PO6F1_HUMAN

Protein

POU domain, class 6, transcription factor 1

Gene

POU6F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi234 – 29360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. brain development Source: ProtInc
    2. heart development Source: ProtInc
    3. muscle organ development Source: ProtInc
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ14863.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 6, transcription factor 1
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 5
    Short name:
    Brain-5
    Short name:
    Brn-5
    mPOU homeobox protein
    Gene namesi
    Name:POU6F1
    Synonyms:BRN5, MPOU, TCFB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9224. POU6F1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33548.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301POU domain, class 6, transcription factor 1PRO_0000100759Add
    BLAST

    Proteomic databases

    PaxDbiQ14863.
    PRIDEiQ14863.

    PTM databases

    PhosphoSiteiQ14863.

    Expressioni

    Tissue specificityi

    In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.

    Gene expression databases

    ArrayExpressiQ14863.
    BgeeiQ14863.
    CleanExiHS_POU6F1.
    GenevestigatoriQ14863.

    Organism-specific databases

    HPAiHPA047021.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000330190.

    Structurei

    Secondary structure

    1
    301
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi144 – 15916
    Turni160 – 1623
    Helixi165 – 1728
    Beta strandi175 – 1773
    Helixi182 – 1898
    Helixi195 – 21824
    Helixi223 – 2275
    Helixi243 – 25513
    Helixi261 – 27111
    Helixi275 – 28915

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3D1NX-ray2.51I/J/K/L/M/N/O/P142-292[»]
    ProteinModelPortaliQ14863.
    SMRiQ14863. Positions 143-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini139 – 21375POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 139139Gln/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241882.
    HOGENOMiHOG000115597.
    HOVERGENiHBG008230.
    KOiK09368.
    OMAiPESHLKE.
    OrthoDBiEOG7353Z3.
    PhylomeDBiQ14863.
    TreeFamiTF350705.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14863-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN    50
    AQGQVIATLA SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI 100
    ASPAPAAKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF 150
    AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK 200
    LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN 250
    AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 300
    P 301
    Length:301
    Mass (Da):32,645
    Last modified:November 1, 1996 - v1
    Checksum:i9C552BA84ABAB17A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti210 – 2101N → M in CAA79978. (PubMed:7908264)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21966 mRNA. Translation: CAA79977.1.
    Z21967 mRNA. Translation: CAA79978.1.
    L14482 mRNA. No translation available.
    CH471111 Genomic DNA. Translation: EAW58180.1.
    BC051326 mRNA. Translation: AAH51326.2.
    BC074765 mRNA. Translation: AAH74765.3.
    CCDSiCCDS31803.1.
    PIRiA54687.
    RefSeqiNP_002693.3. NM_002702.3.
    UniGeneiHs.555886.

    Genome annotation databases

    EnsembliENST00000333640; ENSP00000330190; ENSG00000184271.
    ENST00000389243; ENSP00000373895; ENSG00000184271.
    ENST00000550824; ENSP00000448389; ENSG00000184271.
    GeneIDi5463.
    KEGGihsa:5463.
    UCSCiuc001rxy.3. human.

    Polymorphism databases

    DMDMi2495306.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21966 mRNA. Translation: CAA79977.1 .
    Z21967 mRNA. Translation: CAA79978.1 .
    L14482 mRNA. No translation available.
    CH471111 Genomic DNA. Translation: EAW58180.1 .
    BC051326 mRNA. Translation: AAH51326.2 .
    BC074765 mRNA. Translation: AAH74765.3 .
    CCDSi CCDS31803.1.
    PIRi A54687.
    RefSeqi NP_002693.3. NM_002702.3.
    UniGenei Hs.555886.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3D1N X-ray 2.51 I/J/K/L/M/N/O/P 142-292 [» ]
    ProteinModelPortali Q14863.
    SMRi Q14863. Positions 143-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000330190.

    PTM databases

    PhosphoSitei Q14863.

    Polymorphism databases

    DMDMi 2495306.

    Proteomic databases

    PaxDbi Q14863.
    PRIDEi Q14863.

    Protocols and materials databases

    DNASUi 5463.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333640 ; ENSP00000330190 ; ENSG00000184271 .
    ENST00000389243 ; ENSP00000373895 ; ENSG00000184271 .
    ENST00000550824 ; ENSP00000448389 ; ENSG00000184271 .
    GeneIDi 5463.
    KEGGi hsa:5463.
    UCSCi uc001rxy.3. human.

    Organism-specific databases

    CTDi 5463.
    GeneCardsi GC12M051580.
    HGNCi HGNC:9224. POU6F1.
    HPAi HPA047021.
    neXtProti NX_Q14863.
    PharmGKBi PA33548.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241882.
    HOGENOMi HOG000115597.
    HOVERGENi HBG008230.
    KOi K09368.
    OMAi PESHLKE.
    OrthoDBi EOG7353Z3.
    PhylomeDBi Q14863.
    TreeFami TF350705.

    Enzyme and pathway databases

    SignaLinki Q14863.

    Miscellaneous databases

    ChiTaRSi POU6F1. human.
    GenomeRNAii 5463.
    NextBioi 21144.
    PROi Q14863.

    Gene expression databases

    ArrayExpressi Q14863.
    Bgeei Q14863.
    CleanExi HS_POU6F1.
    Genevestigatori Q14863.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
      Wey E., Lyons G.E., Schaefer B.W.
      Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "A novel POU domain protein which binds to the T-cell receptor beta enhancer."
      Messier H., Brickner H., Gaikwad J., Fotedar A.
      Mol. Cell. Biol. 13:5450-5460(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Salivary gland.

    Entry informationi

    Entry nameiPO6F1_HUMAN
    AccessioniPrimary (citable) accession number: Q14863
    Secondary accession number(s): Q15944, Q6DK47, Q7Z7P6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3