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Protein

POU domain, class 6, transcription factor 1

Gene

POU6F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi234 – 293HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • brain development Source: ProtInc
  • heart development Source: ProtInc
  • muscle organ development Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30942-MONOMER.
SignaLinkiQ14863.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name:
Brain-5
Short name:
Brn-5
mPOU homeobox protein
Gene namesi
Name:POU6F1
Synonyms:BRN5, MPOU, TCFB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9224. POU6F1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5463.
OpenTargetsiENSG00000184271.
PharmGKBiPA33548.

Polymorphism and mutation databases

BioMutaiPOU6F1.
DMDMi2495306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007591 – 301POU domain, class 6, transcription factor 1Add BLAST301

Proteomic databases

PaxDbiQ14863.
PeptideAtlasiQ14863.
PRIDEiQ14863.

PTM databases

iPTMnetiQ14863.
PhosphoSitePlusiQ14863.

Expressioni

Tissue specificityi

In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.

Gene expression databases

BgeeiENSG00000184271.
CleanExiHS_POU6F1.
GenevisibleiQ14863. HS.

Organism-specific databases

HPAiHPA047021.
HPA050411.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330190.

Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi144 – 159Combined sources16
Turni160 – 162Combined sources3
Helixi165 – 172Combined sources8
Beta strandi175 – 177Combined sources3
Helixi182 – 189Combined sources8
Helixi195 – 218Combined sources24
Helixi223 – 227Combined sources5
Helixi243 – 255Combined sources13
Helixi261 – 271Combined sources11
Helixi275 – 289Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D1NX-ray2.51I/J/K/L/M/N/O/P142-292[»]
ProteinModelPortaliQ14863.
SMRiQ14863.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 213POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 139Gln/Pro-richAdd BLAST139

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000115597.
HOVERGENiHBG008230.
InParanoidiQ14863.
KOiK09368.
OMAiERWMEEA.
OrthoDBiEOG091G04YJ.
PhylomeDBiQ14863.
TreeFamiTF350705.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN
60 70 80 90 100
AQGQVIATLA SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI
110 120 130 140 150
ASPAPAAKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF
160 170 180 190 200
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK
210 220 230 240 250
LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN
260 270 280 290 300
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI

P
Length:301
Mass (Da):32,645
Last modified:November 1, 1996 - v1
Checksum:i9C552BA84ABAB17A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210N → M in CAA79978 (PubMed:7908264).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21966 mRNA. Translation: CAA79977.1.
Z21967 mRNA. Translation: CAA79978.1.
L14482 mRNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58180.1.
BC051326 mRNA. Translation: AAH51326.2.
BC074765 mRNA. Translation: AAH74765.3.
CCDSiCCDS31803.1.
PIRiA54687.
RefSeqiNP_001317351.1. NM_001330422.1.
NP_002693.3. NM_002702.3.
XP_016875013.1. XM_017019524.1.
XP_016875014.1. XM_017019525.1.
XP_016875015.1. XM_017019526.1.
XP_016875016.1. XM_017019527.1.
XP_016875017.1. XM_017019528.1.
XP_016875018.1. XM_017019529.1.
XP_016875019.1. XM_017019530.1.
UniGeneiHs.555886.

Genome annotation databases

EnsembliENST00000389243; ENSP00000373895; ENSG00000184271.
GeneIDi5463.
KEGGihsa:5463.
UCSCiuc001rxy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21966 mRNA. Translation: CAA79977.1.
Z21967 mRNA. Translation: CAA79978.1.
L14482 mRNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58180.1.
BC051326 mRNA. Translation: AAH51326.2.
BC074765 mRNA. Translation: AAH74765.3.
CCDSiCCDS31803.1.
PIRiA54687.
RefSeqiNP_001317351.1. NM_001330422.1.
NP_002693.3. NM_002702.3.
XP_016875013.1. XM_017019524.1.
XP_016875014.1. XM_017019525.1.
XP_016875015.1. XM_017019526.1.
XP_016875016.1. XM_017019527.1.
XP_016875017.1. XM_017019528.1.
XP_016875018.1. XM_017019529.1.
XP_016875019.1. XM_017019530.1.
UniGeneiHs.555886.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D1NX-ray2.51I/J/K/L/M/N/O/P142-292[»]
ProteinModelPortaliQ14863.
SMRiQ14863.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330190.

PTM databases

iPTMnetiQ14863.
PhosphoSitePlusiQ14863.

Polymorphism and mutation databases

BioMutaiPOU6F1.
DMDMi2495306.

Proteomic databases

PaxDbiQ14863.
PeptideAtlasiQ14863.
PRIDEiQ14863.

Protocols and materials databases

DNASUi5463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389243; ENSP00000373895; ENSG00000184271.
GeneIDi5463.
KEGGihsa:5463.
UCSCiuc001rxy.4. human.

Organism-specific databases

CTDi5463.
DisGeNETi5463.
GeneCardsiPOU6F1.
HGNCiHGNC:9224. POU6F1.
HPAiHPA047021.
HPA050411.
neXtProtiNX_Q14863.
OpenTargetsiENSG00000184271.
PharmGKBiPA33548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000115597.
HOVERGENiHBG008230.
InParanoidiQ14863.
KOiK09368.
OMAiERWMEEA.
OrthoDBiEOG091G04YJ.
PhylomeDBiQ14863.
TreeFamiTF350705.

Enzyme and pathway databases

BioCyciZFISH:G66-30942-MONOMER.
SignaLinkiQ14863.

Miscellaneous databases

ChiTaRSiPOU6F1. human.
GenomeRNAii5463.
PROiQ14863.

Gene expression databases

BgeeiENSG00000184271.
CleanExiHS_POU6F1.
GenevisibleiQ14863. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPO6F1_HUMAN
AccessioniPrimary (citable) accession number: Q14863
Secondary accession number(s): Q15944, Q6DK47, Q7Z7P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.