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Q14863 (PO6F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name=Brain-5
Short name=Brn-5
mPOU homeobox protein
Gene names
Name:POU6F1
Synonyms:BRN5, MPOU, TCFB1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') By similarity.

Subcellular location

Nucleus.

Tissue specificity

In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.

Sequence similarities

Belongs to the POU transcription factor family. Class-6 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301POU domain, class 6, transcription factor 1
PRO_0000100759

Regions

Domain139 – 21375POU-specific
DNA binding234 – 29360Homeobox
Compositional bias1 – 139139Gln/Pro-rich

Experimental info

Sequence conflict2101N → M in CAA79978. Ref.1

Secondary structure

.................... 301
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q14863 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9C552BA84ABAB17A

FASTA30132,645
        10         20         30         40         50         60 
MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN AQGQVIATLA 

        70         80         90        100        110        120 
SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI ASPAPAAKPS ASAPIPITCS 

       130        140        150        160        170        180 
ETPTVSQLVS KPHTPSLDED GINLEEIREF AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY 

       190        200        210        220        230        240 
SQSAICRFEK LDITPKSAQK LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS 

       250        260        270        280        290        300 
FTPQAIEALN AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 


P 

« Hide

References

« Hide 'large scale' references
[1]"A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
Wey E., Lyons G.E., Schaefer B.W.
Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"A novel POU domain protein which binds to the T-cell receptor beta enhancer."
Messier H., Brickner H., Gaikwad J., Fotedar A.
Mol. Cell. Biol. 13:5450-5460(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z21966 mRNA. Translation: CAA79977.1.
Z21967 mRNA. Translation: CAA79978.1.
L14482 mRNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58180.1.
BC051326 mRNA. Translation: AAH51326.2.
BC074765 mRNA. Translation: AAH74765.3.
PIRA54687.
RefSeqNP_002693.3. NM_002702.3.
UniGeneHs.555886.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3D1NX-ray2.51I/J/K/L/M/N/O/P142-292[»]
ProteinModelPortalQ14863.
SMRQ14863. Positions 143-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000330190.

PTM databases

PhosphoSiteQ14863.

Polymorphism databases

DMDM2495306.

Proteomic databases

PaxDbQ14863.
PRIDEQ14863.

Protocols and materials databases

DNASU5463.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333640; ENSP00000330190; ENSG00000184271.
ENST00000389243; ENSP00000373895; ENSG00000184271.
ENST00000550824; ENSP00000448389; ENSG00000184271.
GeneID5463.
KEGGhsa:5463.
UCSCuc001rxy.3. human.

Organism-specific databases

CTD5463.
GeneCardsGC12M051580.
HGNCHGNC:9224. POU6F1.
HPAHPA047021.
neXtProtNX_Q14863.
PharmGKBPA33548.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241882.
HOGENOMHOG000115597.
HOVERGENHBG008230.
KOK09368.
OMALKQHESA.
OrthoDBEOG7353Z3.
PhylomeDBQ14863.
TreeFamTF350705.

Enzyme and pathway databases

SignaLinkQ14863.

Gene expression databases

ArrayExpressQ14863.
BgeeQ14863.
CleanExHS_POU6F1.
GenevestigatorQ14863.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPOU6F1. human.
GenomeRNAi5463.
NextBio21144.
PROQ14863.

Entry information

Entry namePO6F1_HUMAN
AccessionPrimary (citable) accession number: Q14863
Secondary accession number(s): Q15944, Q6DK47, Q7Z7P6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM