Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q14863

- PO6F1_HUMAN

UniProt

Q14863 - PO6F1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

POU domain, class 6, transcription factor 1

Gene

POU6F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi234 – 29360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. brain development Source: ProtInc
  2. heart development Source: ProtInc
  3. muscle organ development Source: ProtInc
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ14863.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name:
Brain-5
Short name:
Brn-5
mPOU homeobox protein
Gene namesi
Name:POU6F1
Synonyms:BRN5, MPOU, TCFB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9224. POU6F1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301POU domain, class 6, transcription factor 1PRO_0000100759Add
BLAST

Proteomic databases

PaxDbiQ14863.
PRIDEiQ14863.

PTM databases

PhosphoSiteiQ14863.

Expressioni

Tissue specificityi

In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.

Gene expression databases

BgeeiQ14863.
CleanExiHS_POU6F1.
ExpressionAtlasiQ14863. baseline and differential.
GenevestigatoriQ14863.

Organism-specific databases

HPAiHPA047021.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330190.

Structurei

Secondary structure

1
301
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi144 – 15916Combined sources
Turni160 – 1623Combined sources
Helixi165 – 1728Combined sources
Beta strandi175 – 1773Combined sources
Helixi182 – 1898Combined sources
Helixi195 – 21824Combined sources
Helixi223 – 2275Combined sources
Helixi243 – 25513Combined sources
Helixi261 – 27111Combined sources
Helixi275 – 28915Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D1NX-ray2.51I/J/K/L/M/N/O/P142-292[»]
ProteinModelPortaliQ14863.
SMRiQ14863. Positions 143-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 21375POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 139139Gln/Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241882.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000115597.
HOVERGENiHBG008230.
InParanoidiQ14863.
KOiK09368.
OMAiPESHLKE.
OrthoDBiEOG7353Z3.
PhylomeDBiQ14863.
TreeFamiTF350705.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14863-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN
60 70 80 90 100
AQGQVIATLA SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI
110 120 130 140 150
ASPAPAAKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF
160 170 180 190 200
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK
210 220 230 240 250
LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN
260 270 280 290 300
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI

P
Length:301
Mass (Da):32,645
Last modified:November 1, 1996 - v1
Checksum:i9C552BA84ABAB17A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101N → M in CAA79978. (PubMed:7908264)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21966 mRNA. Translation: CAA79977.1.
Z21967 mRNA. Translation: CAA79978.1.
L14482 mRNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58180.1.
BC051326 mRNA. Translation: AAH51326.2.
BC074765 mRNA. Translation: AAH74765.3.
CCDSiCCDS31803.1.
PIRiA54687.
RefSeqiNP_002693.3. NM_002702.3.
UniGeneiHs.555886.

Genome annotation databases

EnsembliENST00000333640; ENSP00000330190; ENSG00000184271.
ENST00000389243; ENSP00000373895; ENSG00000184271.
ENST00000550824; ENSP00000448389; ENSG00000184271.
GeneIDi5463.
KEGGihsa:5463.
UCSCiuc001rxy.3. human.

Polymorphism databases

DMDMi2495306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21966 mRNA. Translation: CAA79977.1 .
Z21967 mRNA. Translation: CAA79978.1 .
L14482 mRNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58180.1 .
BC051326 mRNA. Translation: AAH51326.2 .
BC074765 mRNA. Translation: AAH74765.3 .
CCDSi CCDS31803.1.
PIRi A54687.
RefSeqi NP_002693.3. NM_002702.3.
UniGenei Hs.555886.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3D1N X-ray 2.51 I/J/K/L/M/N/O/P 142-292 [» ]
ProteinModelPortali Q14863.
SMRi Q14863. Positions 143-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000330190.

PTM databases

PhosphoSitei Q14863.

Polymorphism databases

DMDMi 2495306.

Proteomic databases

PaxDbi Q14863.
PRIDEi Q14863.

Protocols and materials databases

DNASUi 5463.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333640 ; ENSP00000330190 ; ENSG00000184271 .
ENST00000389243 ; ENSP00000373895 ; ENSG00000184271 .
ENST00000550824 ; ENSP00000448389 ; ENSG00000184271 .
GeneIDi 5463.
KEGGi hsa:5463.
UCSCi uc001rxy.3. human.

Organism-specific databases

CTDi 5463.
GeneCardsi GC12M051580.
HGNCi HGNC:9224. POU6F1.
HPAi HPA047021.
neXtProti NX_Q14863.
PharmGKBi PA33548.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241882.
GeneTreei ENSGT00760000118935.
HOGENOMi HOG000115597.
HOVERGENi HBG008230.
InParanoidi Q14863.
KOi K09368.
OMAi PESHLKE.
OrthoDBi EOG7353Z3.
PhylomeDBi Q14863.
TreeFami TF350705.

Enzyme and pathway databases

SignaLinki Q14863.

Miscellaneous databases

ChiTaRSi POU6F1. human.
GenomeRNAii 5463.
NextBioi 21144.
PROi Q14863.

Gene expression databases

Bgeei Q14863.
CleanExi HS_POU6F1.
ExpressionAtlasi Q14863. baseline and differential.
Genevestigatori Q14863.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
    Wey E., Lyons G.E., Schaefer B.W.
    Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "A novel POU domain protein which binds to the T-cell receptor beta enhancer."
    Messier H., Brickner H., Gaikwad J., Fotedar A.
    Mol. Cell. Biol. 13:5450-5460(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Salivary gland.

Entry informationi

Entry nameiPO6F1_HUMAN
AccessioniPrimary (citable) accession number: Q14863
Secondary accession number(s): Q15944, Q6DK47, Q7Z7P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3