StAR-related lipid transfer protein 3

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Reviewed, UniProtKB/Swiss-Prot Q14849 (STAR3_HUMAN)

Last modified June 16, 2009. Version 90. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    StAR-related lipid transfer protein 3
Alternative name(s):
    START domain-containing protein 3
      Short name=StARD3
    Metastatic lymph node protein 64
      Short name=Protein MLN 64
    Protein CAB1

Gene names

Name:	STARD3
Synonyms:	CAB1, MLN64

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function

Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain.

Subcellular location

Late endosome membrane; Multi-pass membrane protein.

Sequence similarities

Contains 1 MENTAL domain.

Contains 1 START domain.

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Ontologies

Keywords
Biological process	Lipid transport Steroidogenesis Transport
Cellular component	Endosome Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	C21-steroid hormone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW cholesterol metabolic process Ref.2 Traceable author statement. Source: ProtInc lipid transport Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial transport Ref.2 Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cholesterol binding Inferred from direct assay. Source: MGI cholesterol transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 445

445

StAR-related lipid transfer protein 3

PRO_0000220653

Regions

Topological domain

1 – 51

Cytoplasmic Potential

Transmembrane

52 – 72

Potential

Topological domain

73 – 94

Extracellular Potential

Transmembrane

95 – 115

Potential

Topological domain

116 – 120

Cytoplasmic Potential

Transmembrane

121 – 141

Potential

Topological domain

142 – 148

Extracellular Potential

Transmembrane

149 – 169

Potential

Topological domain

170 – 445

276

Cytoplasmic Potential

Domain

46 – 217

172

MENTAL

Domain

230 – 443

214

START

Amino acid modifications

Modified residue

209

Phosphoserine By similarity

Modified residue

213

Phosphoserine By similarity

Modified residue

217

Phosphoserine By similarity

Modified residue

221

Phosphoserine By similarity

Natural variations

Natural variant

117

R → Q: dbSNP rs1877031. Ref.1 Ref.2 Ref.3 Ref.4

VAR_027877

Natural variant

216

G → A: dbSNP rs11556624. Ref.4

VAR_027878

Secondary structure

445

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q14849-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 8EBFBAF013CFDC7E
Show »

FASTA

445

50,502

        10         20         30         40         50         60 
MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR RTFCLFVTFD 

        70         80         90        100        110        120 
LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV LAFFRFSGLL LGYAVLRLRH 

       130        140        150        160        170        180 
WWVIAVTTLV SSAFLIVKVI LSELLSKGAF GYLLPIVSFV LAWLETWFLD FKVLPQEAEE 

       190        200        210        220        230        240 
ERWYLAAQVA VARGPLLFSG ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR 

       250        260        270        280        290        300 
QGKEATAVVD QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV 

       310        320        330        340        350        360 
ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV RRIERRRDRY 

       370        380        390        400        410        420 
LSSGIATSHS AKPPTHKYVR GENGPGGFIV LKSASNPRVC TFVWILNTDL KGRLPRYLIH 

       430        440 
QSLAATMFEF AFHLRQRISE LGARA

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17." Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G., Chenard M.-P., Lidereau R., Basset P., Rio M.-C. Genomics 28:367-376(1995) [PubMed: 7490069] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-117. Tissue: Mammary carcinoma.
[2]	"Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method." Akiyama N., Sasaki H., Ishizuka T., Kishi T., Sakamoto H., Onda M., Hirai H., Yazaki Y., Sugimura T., Terada M. Cancer Res. 57:3548-3553(1997) [PubMed: 9270027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-117. Tissue: Oesophageal carcinoma.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-117.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-117 AND ALA-216. Tissue: Lung, Skin and Spleen.
[5]	"Structure and lipid transport mechanism of a StAR-related domain." Tsujishita Y., Hurley J.H. Nat. Struct. Biol. 7:408-414(2000) [PubMed: 10802740] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 216-445.
[6]	"The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein." Alpy F., Stoeckel M.-E., Dierich A., Escola J.-M., Wendling C., Chenard M.-P., Vanier M.T., Gruenberg J., Tomasetto C., Rio M.-C. J. Biol. Chem. 276:4261-4269(2001) [PubMed: 11053434] [Abstract] Cited for: TOPOLOGY.
+	Additional computationally mapped references.

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Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Cross-references

Sequence databases

X80198 mRNA. Translation: CAA56489.1.
D38255 mRNA. Translation: BAA22525.1.
BT006964 mRNA. Translation: AAP35610.1.
BC008356 mRNA. Translation: AAH08356.1.
BC008747 mRNA. Translation: AAH08747.1.
BC025679 mRNA. Translation: AAH25679.1.

IPI

IPI00000865.

PIR

I38027.

RefSeq

NP_006795.2.

UniGene

Hs.77628

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EM2	X-ray	2.20	A	216-444	[»]
2I92	model	-	A	230-443	[»]

ModBase

Search...

Protein family/group databases

TCDB

9.B.64.1.1. putative cholesterol transporter (Start1) family.

Proteomic databases

PRIDE

Q14849.

Genome annotation databases

Ensembl

ENSG00000131748. Homo sapiens. [Contig view]

GeneID

10948.

KEGG

hsa:10948.

Organism-specific databases

GeneCards

GC17P035046.

H-InvDB

HIX0013780.

HGNC

HGNC:17579. STARD3.

HPA

CAB017021.

MIM

607048. gene.

PharmGKB

PA134981867.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q14849.

OMA

Q14849. AEEERWY.

Gene expression databases

ArrayExpress

Q14849.

CleanEx

HS_STARD3.

GermOnline

ENSG00000131748. Homo sapiens.

Family and domain databases

InterPro

IPR019498. Cholesterol-capturing_domain.
IPR000799. StAR.
IPR002913. START_lipid_bd.
[Graphical view]

Pfam

PF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
[Graphical view]

PRINTS

PR00978. STARPROTEIN.

SMART

SM00234. START. 1 hit.
[Graphical view]

PROSITE

PS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

41597.

SOURCE

Search...

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Entry information

Entry name

STAR3_HUMAN

Accession

Primary (citable) accession number: Q14849
Secondary accession number(s): Q53Y53, Q96HM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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