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Protein

StAR-related lipid transfer protein 3

Gene

STARD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain.

GO - Molecular functioni

  • cholesterol binding Source: MGI

GO - Biological processi

  • cholesterol metabolic process Source: ProtInc
  • lipid metabolic process Source: ProtInc
  • lipid transport Source: UniProtKB-KW
  • mitochondrial transport Source: ProtInc
  • progesterone biosynthetic process Source: Ensembl
  • steroid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Steroidogenesis, Transport

Keywords - Ligandi

Lipid-binding

Protein family/group databases

TCDBi9.B.64.1.1. the putative cholesterol transporter (start1) family.

Chemistry

SwissLipidsiSLP:000000712.

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 3
Alternative name(s):
Metastatic lymph node gene 64 protein
Short name:
MLN 64
Protein CAB1
START domain-containing protein 3
Short name:
StARD3
Gene namesi
Name:STARD3
Synonyms:CAB1, MLN64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17579. STARD3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini73 – 9422ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini116 – 1205CytoplasmicSequence analysis
Transmembranei121 – 14121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini142 – 1487ExtracellularSequence analysis
Transmembranei149 – 16921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini170 – 445276CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • integral component of membrane Source: UniProtKB-KW
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981867.

Polymorphism and mutation databases

BioMutaiSTARD3.
DMDMi116242802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445StAR-related lipid transfer protein 3PRO_0000220653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei209 – 2091PhosphoserineBy similarity
Modified residuei217 – 2171PhosphoserineBy similarity
Modified residuei221 – 2211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14849.
PaxDbiQ14849.
PeptideAtlasiQ14849.
PRIDEiQ14849.

PTM databases

iPTMnetiQ14849.
PhosphoSiteiQ14849.

Expressioni

Gene expression databases

BgeeiENSG00000131748.
CleanExiHS_STARD3.
ExpressionAtlasiQ14849. baseline and differential.
GenevisibleiQ14849. HS.

Organism-specific databases

HPAiCAB017021.

Interactioni

Subunit structurei

Can form homodimers. Interacts with STARD3NL.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GOPCQ9HD263EBI-9819324,EBI-349832
VAPAQ9P0L04EBI-9819369,EBI-1059156

Protein-protein interaction databases

BioGridi116148. 16 interactions.
IntActiQ14849. 3 interactions.
STRINGi9606.ENSP00000337446.

Structurei

Secondary structure

1
445
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi233 – 25422Combined sources
Helixi255 – 2584Combined sources
Beta strandi260 – 2645Combined sources
Beta strandi270 – 2767Combined sources
Turni277 – 2793Combined sources
Beta strandi280 – 29112Combined sources
Helixi293 – 3008Combined sources
Helixi304 – 3107Combined sources
Beta strandi314 – 32310Combined sources
Turni324 – 3263Combined sources
Beta strandi327 – 3348Combined sources
Beta strandi340 – 3423Combined sources
Beta strandi345 – 35511Combined sources
Beta strandi357 – 36610Combined sources
Beta strandi378 – 3803Combined sources
Beta strandi385 – 3928Combined sources
Beta strandi400 – 4067Combined sources
Beta strandi412 – 4143Combined sources
Helixi416 – 44328Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EM2X-ray2.20A216-444[»]
2I92model-A230-443[»]
5I9JX-ray1.74A216-444[»]
ProteinModelPortaliQ14849.
SMRiQ14849. Positions 230-443.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14849.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 217172MENTALPROSITE-ProRule annotationAdd
BLAST
Domaini230 – 443214STARTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MENTAL domain.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000015362.
HOVERGENiHBG052482.
InParanoidiQ14849.
PhylomeDBiQ14849.
TreeFamiTF313869.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR019498. MENTAL.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14849-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR
60 70 80 90 100
RTFCLFVTFD LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV
110 120 130 140 150
LAFFRFSGLL LGYAVLRLRH WWVIAVTTLV SSAFLIVKVI LSELLSKGAF
160 170 180 190 200
GYLLPIVSFV LAWLETWFLD FKVLPQEAEE ERWYLAAQVA VARGPLLFSG
210 220 230 240 250
ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR QGKEATAVVD
260 270 280 290 300
QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV
310 320 330 340 350
ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV
360 370 380 390 400
RRIERRRDRY LSSGIATSHS AKPPTHKYVR GENGPGGFIV LKSASNPRVC
410 420 430 440
TFVWILNTDL KGRLPRYLIH QSLAATMFEF AFHLRQRISE LGARA
Length:445
Mass (Da):50,502
Last modified:October 17, 2006 - v2
Checksum:i8EBFBAF013CFDC7E
GO
Isoform 2 (identifier: Q14849-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-143: Missing.

Note: No experimental confirmation available.
Show »
Length:427
Mass (Da):48,601
Checksum:i2B97748DBDD1C4CE
GO
Isoform 3 (identifier: Q14849-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-183: WVIAVTTLVS...LPQEAEEERW → SRRWCPVHSS...LKRSDSAPPG

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):49,960
Checksum:iF5A010E90FC97121
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171R → Q.5 Publications
Corresponds to variant rs1877031 [ dbSNP | Ensembl ].
VAR_027877
Natural varianti216 – 2161G → A.1 Publication
Corresponds to variant rs11556624 [ dbSNP | Ensembl ].
VAR_027878

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 18362WVIAV…EEERW → SRRWCPVHSSLSRSSSLSCS AKGHLATCSPSSLLSSPGWR PGSLTSKSYPRKLKRSDSAP PG in isoform 3. 1 PublicationVSP_045361Add
BLAST
Alternative sequencei126 – 14318Missing in isoform 2. 1 PublicationVSP_042710Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80198 mRNA. Translation: CAA56489.1.
D38255 mRNA. Translation: BAA22525.1.
BT006964 mRNA. Translation: AAP35610.1.
AK300176 mRNA. Translation: BAG61955.1.
AK300842 mRNA. Translation: BAG62493.1.
AC087491 Genomic DNA. No translation available.
BC008356 mRNA. Translation: AAH08356.1.
BC008747 mRNA. Translation: AAH08747.1.
BC025679 mRNA. Translation: AAH25679.1.
CCDSiCCDS11341.1. [Q14849-1]
CCDS54117.1. [Q14849-3]
CCDS54118.1. [Q14849-2]
PIRiI38027.
RefSeqiNP_001159409.1. NM_001165937.1. [Q14849-3]
NP_001159410.1. NM_001165938.1. [Q14849-2]
NP_006795.3. NM_006804.3. [Q14849-1]
UniGeneiHs.728838.

Genome annotation databases

EnsembliENST00000336308; ENSP00000337446; ENSG00000131748. [Q14849-1]
ENST00000394250; ENSP00000377794; ENSG00000131748. [Q14849-2]
ENST00000544210; ENSP00000439869; ENSG00000131748. [Q14849-3]
GeneIDi10948.
KEGGihsa:10948.
UCSCiuc002hsd.4. human. [Q14849-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80198 mRNA. Translation: CAA56489.1.
D38255 mRNA. Translation: BAA22525.1.
BT006964 mRNA. Translation: AAP35610.1.
AK300176 mRNA. Translation: BAG61955.1.
AK300842 mRNA. Translation: BAG62493.1.
AC087491 Genomic DNA. No translation available.
BC008356 mRNA. Translation: AAH08356.1.
BC008747 mRNA. Translation: AAH08747.1.
BC025679 mRNA. Translation: AAH25679.1.
CCDSiCCDS11341.1. [Q14849-1]
CCDS54117.1. [Q14849-3]
CCDS54118.1. [Q14849-2]
PIRiI38027.
RefSeqiNP_001159409.1. NM_001165937.1. [Q14849-3]
NP_001159410.1. NM_001165938.1. [Q14849-2]
NP_006795.3. NM_006804.3. [Q14849-1]
UniGeneiHs.728838.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EM2X-ray2.20A216-444[»]
2I92model-A230-443[»]
5I9JX-ray1.74A216-444[»]
ProteinModelPortaliQ14849.
SMRiQ14849. Positions 230-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116148. 16 interactions.
IntActiQ14849. 3 interactions.
STRINGi9606.ENSP00000337446.

Chemistry

SwissLipidsiSLP:000000712.

Protein family/group databases

TCDBi9.B.64.1.1. the putative cholesterol transporter (start1) family.

PTM databases

iPTMnetiQ14849.
PhosphoSiteiQ14849.

Polymorphism and mutation databases

BioMutaiSTARD3.
DMDMi116242802.

Proteomic databases

MaxQBiQ14849.
PaxDbiQ14849.
PeptideAtlasiQ14849.
PRIDEiQ14849.

Protocols and materials databases

DNASUi10948.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336308; ENSP00000337446; ENSG00000131748. [Q14849-1]
ENST00000394250; ENSP00000377794; ENSG00000131748. [Q14849-2]
ENST00000544210; ENSP00000439869; ENSG00000131748. [Q14849-3]
GeneIDi10948.
KEGGihsa:10948.
UCSCiuc002hsd.4. human. [Q14849-1]

Organism-specific databases

CTDi10948.
GeneCardsiSTARD3.
HGNCiHGNC:17579. STARD3.
HPAiCAB017021.
MIMi607048. gene.
neXtProtiNX_Q14849.
PharmGKBiPA134981867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000015362.
HOVERGENiHBG052482.
InParanoidiQ14849.
PhylomeDBiQ14849.
TreeFamiTF313869.

Miscellaneous databases

ChiTaRSiSTARD3. human.
EvolutionaryTraceiQ14849.
GenomeRNAii10948.
PROiQ14849.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131748.
CleanExiHS_STARD3.
ExpressionAtlasiQ14849. baseline and differential.
GenevisibleiQ14849. HS.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR019498. MENTAL.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAR3_HUMAN
AccessioniPrimary (citable) accession number: Q14849
Secondary accession number(s): A8MXA4
, B4DUY1, F5H0G2, Q53Y53, Q96HM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.