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Q14847

- LASP1_HUMAN

UniProt

Q14847 - LASP1_HUMAN

Protein

LIM and SH3 domain protein 1

Gene

LASP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types By similarity.By similarity

    GO - Molecular functioni

    1. ion transmembrane transporter activity Source: UniProtKB
    2. protein binding Source: IntAct
    3. SH3/SH2 adaptor activity Source: ProtInc
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ion transport Source: UniProtKB
    2. positive regulation of signal transduction Source: GOC

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Actin-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM and SH3 domain protein 1
    Short name:
    LASP-1
    Alternative name(s):
    Metastatic lymph node gene 50 protein
    Short name:
    MLN 50
    Gene namesi
    Name:LASP1
    Synonyms:MLN50
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6513. LASP1.

    Subcellular locationi

    Cytoplasmcell cortex By similarity. Cytoplasmcytoskeleton By similarity
    Note: Associated with the F-actin rich cortical cytoskeleton.By similarity

    GO - Cellular componenti

    1. cortical actin cytoskeleton Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. focal adhesion Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30298.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261LIM and SH3 domain protein 1PRO_0000075761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei42 – 421N6-acetyllysine1 Publication
    Modified residuei68 – 681Phosphothreonine3 Publications
    Modified residuei104 – 1041Phosphothreonine4 Publications
    Modified residuei112 – 1121N6-succinyllysineBy similarity
    Modified residuei118 – 1181Phosphoserine1 Publication
    Modified residuei146 – 1461Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ14847.
    PaxDbiQ14847.
    PRIDEiQ14847.

    2D gel databases

    OGPiQ14847.
    SWISS-2DPAGEQ14847.

    PTM databases

    PhosphoSiteiQ14847.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14847.
    BgeeiQ14847.
    CleanExiHS_LASP1.
    GenevestigatoriQ14847.

    Organism-specific databases

    HPAiCAB022049.
    HPA012072.

    Interactioni

    Subunit structurei

    Interacts with F-actin By similarity. Interacts with ANKRD54 By similarity. Interacts with KBTBD10.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LPPQ930523EBI-742828,EBI-718388
    MDFIQ997503EBI-742828,EBI-724076
    TJP2Q9UDY29EBI-742828,EBI-1042602
    TRIP13Q156454EBI-742828,EBI-358993
    ZDHHC17Q8IUH53EBI-9088686,EBI-524753
    ZYXQ159425EBI-742828,EBI-444225

    Protein-protein interaction databases

    BioGridi110120. 17 interactions.
    IntActiQ14847. 15 interactions.
    MINTiMINT-5001286.
    STRINGi9606.ENSP00000325240.

    Structurei

    Secondary structure

    1
    261
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi207 – 2115
    Beta strandi228 – 2369
    Beta strandi239 – 2446
    Turni245 – 2484
    Beta strandi249 – 2546
    Helixi255 – 2573
    Beta strandi258 – 2603

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3I35X-ray1.40A202-261[»]
    ProteinModelPortaliQ14847.
    SMRiQ14847. Positions 1-54, 205-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14847.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 5652LIM zinc-bindingPROSITE-ProRule annotationAdd
    BLAST
    Repeati61 – 9535Nebulin 1Add
    BLAST
    Repeati97 – 13135Nebulin 2Add
    BLAST
    Domaini202 – 26160SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi201 – 2044Poly-Gly

    Sequence similaritiesi

    Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
    Contains 2 nebulin repeats.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG259964.
    HOGENOMiHOG000006616.
    HOVERGENiHBG054636.
    InParanoidiQ14847.
    OMAiYWHKACF.
    OrthoDBiEOG771280.
    PhylomeDBiQ14847.
    TreeFamiTF319104.

    Family and domain databases

    Gene3Di2.10.110.10. 1 hit.
    InterProiIPR000900. Nebulin_repeat.
    IPR001452. SH3_domain.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 1 hit.
    PF00880. Nebulin. 2 hits.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00132. LIM. 1 hit.
    SM00227. NEBU. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    PS51216. NEBULIN. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14847-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK    50
    PYCNAHYPKQ SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV 100
    VADTPELQRI KKTQDQISNI KYHEEFEKSR MGPSGGEGME PERRDSQDGS 150
    SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA QSYGGYKEPA APVSIQRSAP 200
    GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM YGTVERTGDT 250
    GMLPANYVEA I 261
    Length:261
    Mass (Da):29,717
    Last modified:January 1, 1998 - v2
    Checksum:i3B89B988605B3639
    GO
    Isoform 2 (identifier: Q14847-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         201-261: GGGGKRYRAV...MLPANYVEAI → ICLQHIPRHR...LTYPHIPGLG

    Note: No experimental confirmation available.

    Show »
    Length:323
    Mass (Da):36,014
    Checksum:iB6A28D1D97AB2C69
    GO
    Isoform 3 (identifier: Q14847-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: MNPNCARCGK...LKQQSELQSQ → MLPLRDLQDDTEHEELQGLREEALLQR

    Note: No experimental confirmation available.

    Show »
    Length:205
    Mass (Da):23,181
    Checksum:i4CD6D2622F74CCF4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791E → R in AAH12460. (PubMed:15489334)Curated
    Sequence conflicti210 – 2101V → A in AAH12460. (PubMed:15489334)Curated
    Sequence conflicti220 – 2201E → A in AAH12460. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8383MNPNC…ELQSQ → MLPLRDLQDDTEHEELQGLR EEALLQR in isoform 3. 1 PublicationVSP_054611Add
    BLAST
    Alternative sequencei201 – 26161GGGGK…YVEAI → ICLQHIPRHRIRPGRDPSIL QCLCFLKPATACDSYPSSSF FCQLKPSSATSAGSLLWQAS PLIDFLVFSLDGTGMGLSGG GRGPWGRAGMGDLLACGPHL PLCSLPSHPPAQLLTYPHIP GLG in isoform 2. 1 PublicationVSP_016554Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82456 mRNA. Translation: CAA57833.1.
    AK294704 mRNA. Translation: BAG57861.1.
    AC006441 Genomic DNA. No translation available.
    AC110749 Genomic DNA. No translation available.
    BC007560 mRNA. Translation: AAH07560.1.
    BC012460 mRNA. Translation: AAH12460.1.
    CCDSiCCDS11331.1. [Q14847-1]
    CCDS62164.1. [Q14847-3]
    PIRiS68234.
    RefSeqiNP_001258537.1. NM_001271608.1. [Q14847-3]
    NP_006139.1. NM_006148.3. [Q14847-1]
    UniGeneiHs.741156.

    Genome annotation databases

    EnsembliENST00000318008; ENSP00000325240; ENSG00000002834. [Q14847-1]
    ENST00000433206; ENSP00000401048; ENSG00000002834. [Q14847-3]
    ENST00000435347; ENSP00000392853; ENSG00000002834. [Q14847-1]
    GeneIDi3927.
    KEGGihsa:3927.
    UCSCiuc002hra.3. human. [Q14847-1]

    Polymorphism databases

    DMDMi3122342.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82456 mRNA. Translation: CAA57833.1 .
    AK294704 mRNA. Translation: BAG57861.1 .
    AC006441 Genomic DNA. No translation available.
    AC110749 Genomic DNA. No translation available.
    BC007560 mRNA. Translation: AAH07560.1 .
    BC012460 mRNA. Translation: AAH12460.1 .
    CCDSi CCDS11331.1. [Q14847-1 ]
    CCDS62164.1. [Q14847-3 ]
    PIRi S68234.
    RefSeqi NP_001258537.1. NM_001271608.1. [Q14847-3 ]
    NP_006139.1. NM_006148.3. [Q14847-1 ]
    UniGenei Hs.741156.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3I35 X-ray 1.40 A 202-261 [» ]
    ProteinModelPortali Q14847.
    SMRi Q14847. Positions 1-54, 205-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110120. 17 interactions.
    IntActi Q14847. 15 interactions.
    MINTi MINT-5001286.
    STRINGi 9606.ENSP00000325240.

    PTM databases

    PhosphoSitei Q14847.

    Polymorphism databases

    DMDMi 3122342.

    2D gel databases

    OGPi Q14847.
    SWISS-2DPAGE Q14847.

    Proteomic databases

    MaxQBi Q14847.
    PaxDbi Q14847.
    PRIDEi Q14847.

    Protocols and materials databases

    DNASUi 3927.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318008 ; ENSP00000325240 ; ENSG00000002834 . [Q14847-1 ]
    ENST00000433206 ; ENSP00000401048 ; ENSG00000002834 . [Q14847-3 ]
    ENST00000435347 ; ENSP00000392853 ; ENSG00000002834 . [Q14847-1 ]
    GeneIDi 3927.
    KEGGi hsa:3927.
    UCSCi uc002hra.3. human. [Q14847-1 ]

    Organism-specific databases

    CTDi 3927.
    GeneCardsi GC17P037026.
    HGNCi HGNC:6513. LASP1.
    HPAi CAB022049.
    HPA012072.
    MIMi 602920. gene.
    neXtProti NX_Q14847.
    PharmGKBi PA30298.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259964.
    HOGENOMi HOG000006616.
    HOVERGENi HBG054636.
    InParanoidi Q14847.
    OMAi YWHKACF.
    OrthoDBi EOG771280.
    PhylomeDBi Q14847.
    TreeFami TF319104.

    Miscellaneous databases

    ChiTaRSi LASP1. human.
    EvolutionaryTracei Q14847.
    GeneWikii LASP1.
    GenomeRNAii 3927.
    NextBioi 15423.
    PROi Q14847.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14847.
    Bgeei Q14847.
    CleanExi HS_LASP1.
    Genevestigatori Q14847.

    Family and domain databases

    Gene3Di 2.10.110.10. 1 hit.
    InterProi IPR000900. Nebulin_repeat.
    IPR001452. SH3_domain.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 1 hit.
    PF00880. Nebulin. 2 hits.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00132. LIM. 1 hit.
    SM00227. NEBU. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    PS51216. NEBULIN. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."
      Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G., Chenard M.-P., Lidereau R., Basset P., Rio M.-C.
      Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary carcinoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Liver and Skin.
    5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-7, ACETYLATION AT MET-1.
      Tissue: Platelet.
    6. "Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains."
      Tomasetto C., Moog-Lutz C., Regnier C.H., Schreiber V., Basset P., Rio M.-C.
      FEBS Lett. 373:245-249(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAINS.
    7. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-68; THR-104 AND SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension."
      Gray C.H., McGarry L.C., Spence H.J., Riboldi-Tunnicliffe A., Ozanne B.W.
      J. Biol. Chem. 284:30498-30507(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KBTBD10.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-68 AND THR-104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-68; THR-104; SER-118 AND SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLASP1_HUMAN
    AccessioniPrimary (citable) accession number: Q14847
    Secondary accession number(s): B4DGQ0, Q96ED2, Q96IG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

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