Q14833 (GRM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metabotropic glutamate receptor 4
Short name=mGluR4

Gene names

Name:	GRM4
Synonyms:	GPRC1D, MGLUR4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	912 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
Subunit structure	Interacts with PICK1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from direct assay PubMed 15102938. Source: UniProtKB adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Inferred from mutant phenotype PubMed 15102938. Source: UniProtKB learning Inferred from electronic annotation. Source: Compara neurotransmitter secretion Traceable author statement PubMed 15102938. Source: UniProtKB regulation of neuron apoptotic process Traceable author statement PubMed 15102938. Source: UniProtKB
Cellular_component	cytoplasmic vesicle Inferred from direct assay PubMed 15102938. Source: UniProtKB dendritic shaft Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from direct assay PubMed 15102938. Source: UniProtKB presynaptic active zone membrane Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.2. Source: UniProtKB glutamate receptor activity Traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14833-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14833-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGK → MVQTLPKLFPHDGAKRKKRTLRTSGPCFGGGGQ
     34-173: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q14833-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MPGKRGLGWW...IMVANILRLF → MSC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 912	880	Metabotropic glutamate receptor 4		PRO_0000012930
Regions
	Topological domain	33 – 587	555	Extracellular Potential
	Transmembrane	588 – 610	23	Helical; Name=1; Potential
	Topological domain	611 – 624	14	Cytoplasmic Potential
	Transmembrane	625 – 645	21	Helical; Name=2; Potential
	Topological domain	646 – 656	11	Extracellular Potential
	Transmembrane	657 – 675	19	Helical; Name=3; Potential
	Topological domain	676 – 699	24	Cytoplasmic Potential
	Transmembrane	700 – 720	21	Helical; Name=4; Potential
	Topological domain	721 – 750	30	Extracellular Potential
	Transmembrane	751 – 772	22	Helical; Name=5; Potential
	Topological domain	773 – 785	13	Cytoplasmic Potential
	Transmembrane	786 – 808	23	Helical; Name=6; Potential
	Topological domain	809 – 821	13	Extracellular Potential
	Transmembrane	822 – 847	26	Helical; Name=7; Potential
	Topological domain	848 – 912	65	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	98	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	454	1	N-linked (GlcNAc...) Potential
	Glycosylation	484	1	N-linked (GlcNAc...) Potential
	Glycosylation	569	1	N-linked (GlcNAc...) Potential
	Disulfide bond	67 ↔ 109		By similarity
	Disulfide bond	249 ↔ 538		By similarity
	Disulfide bond	372 ↔ 388		By similarity
	Disulfide bond	428 ↔ 435		By similarity
	Disulfide bond	520 ↔ 539		By similarity
	Disulfide bond	524 ↔ 542		By similarity
	Disulfide bond	545 ↔ 557		By similarity
	Disulfide bond	560 ↔ 573		By similarity
Natural variations
	Alternative sequence	1 – 172	172	MPGKR…ILRLF → MSC in isoform 3.		VSP_045218
	Alternative sequence	1 – 33	33	MPGKR…SSLGK → MVQTLPKLFPHDGAKRKKRT LRTSGPCFGGGGQ in isoform 2.		VSP_044740
	Alternative sequence	34 – 173	140	Missing in isoform 2.		VSP_044741
	Natural variant	169	1	L → F. Corresponds to variant rs452752 [ dbSNP | Ensembl ].		VAR_049275
	Natural variant	797	1	V → I. Ref.6		VAR_012992
Experimental info
	Sequence conflict	449	1	Y → H in BAH11632. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 4A2F36E63A2EAF5A	FASTA	912	101,868
	10 20 30 40 50 60 MPGKRGLGWW WARLPLCLLL SLYGPWMPSS LGKPKGHPHM NSIRIDGDIT LGGLFPVHGR 70 80 90 100 110 120 GSEGKPCGEL KKEKGIHRLE AMLFALDRIN NDPDLLPNIT LGARILDTCS RDTHALEQSL 130 140 150 160 170 180 TFVQALIEKD GTEVRCGSGG PPIITKPERV VGVIGASGSS VSIMVANILR LFKIPQISYA 190 200 210 220 230 240 STAPDLSDNS RYDFFSRVVP SDTYQAQAMV DIVRALKWNY VSTVASEGSY GESGVEAFIQ 250 260 270 280 290 300 KSREDGGVCI AQSVKIPREP KAGEFDKIIR RLLETSNARA VIIFANEDDI RRVLEAARRA 310 320 330 340 350 360 NQTGHFFWMG SDSWGSKIAP VLHLEEVAEG AVTILPKRMS VRGFDRYFSS RTLDNNRRNI 370 380 390 400 410 420 WFAEFWEDNF HCKLSRHALK KGSHVKKCTN RERIGQDSAY EQEGKVQFVI DAVYAMGHAL 430 440 450 460 470 480 HAMHRDLCPG RVGLCPRMDP VDGTQLLKYI RNVNFSGIAG NPVTFNENGD APGRYDIYQY 490 500 510 520 530 540 QLRNDSAEYK VIGSWTDHLH LRIERMHWPG SGQQLPRSIC SLPCQPGERK KTVKGMPCCW 550 560 570 580 590 600 HCEPCTGYQY QVDRYTCKTC PYDMRPTENR TGCRPIPIIK LEWGSPWAVL PLFLAVVGIA 610 620 630 640 650 660 ATLFVVITFV RYNDTPIVKA SGRELSYVLL AGIFLCYATT FLMIAEPDLG TCSLRRIFLG 670 680 690 700 710 720 LGMSISYAAL LTKTNRIYRI FEQGKRSVSA PRFISPASQL AITFSLISLQ LLGICVWFVV 730 740 750 760 770 780 DPSHSVVDFQ DQRTLDPRFA RGVLKCDISD LSLICLLGYS MLLMVTCTVY AIKTRGVPET 790 800 810 820 830 840 FNEAKPIGFT MYTTCIVWLA FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP 850 860 870 880 890 900 KVYIILFHPE QNVPKRKRSL KAVVTAATMS NKFTQKGNFR PNGEAKSELC ENLEAPALAT 910 KQTYVTYTNH AI
	Isoform 2 [UniParc]. Checksum: 5AEAFC7B26F3CFCF	FASTA	772	86,683
	10 20 30 40 50 60 MVQTLPKLFP HDGAKRKKRT LRTSGPCFGG GGQIPQISYA STAPDLSDNS RYDFFSRVVP 70 80 90 100 110 120 SDTYQAQAMV DIVRALKWNY VSTVASEGSY GESGVEAFIQ KSREDGGVCI AQSVKIPREP 130 140 150 160 170 180 KAGEFDKIIR RLLETSNARA VIIFANEDDI RRVLEAARRA NQTGHFFWMG SDSWGSKIAP 190 200 210 220 230 240 VLHLEEVAEG AVTILPKRMS VRGFDRYFSS RTLDNNRRNI WFAEFWEDNF HCKLSRHALK 250 260 270 280 290 300 KGSHVKKCTN RERIGQDSAY EQEGKVQFVI DAVYAMGHAL HAMHRDLCPG RVGLCPRMDP 310 320 330 340 350 360 VDGTQLLKYI RNVNFSGIAG NPVTFNENGD APGRYDIYQY QLRNDSAEYK VIGSWTDHLH 370 380 390 400 410 420 LRIERMHWPG SGQQLPRSIC SLPCQPGERK KTVKGMPCCW HCEPCTGYQY QVDRYTCKTC 430 440 450 460 470 480 PYDMRPTENR TGCRPIPIIK LEWGSPWAVL PLFLAVVGIA ATLFVVITFV RYNDTPIVKA 490 500 510 520 530 540 SGRELSYVLL AGIFLCYATT FLMIAEPDLG TCSLRRIFLG LGMSISYAAL LTKTNRIYRI 550 560 570 580 590 600 FEQGKRSVSA PRFISPASQL AITFSLISLQ LLGICVWFVV DPSHSVVDFQ DQRTLDPRFA 610 620 630 640 650 660 RGVLKCDISD LSLICLLGYS MLLMVTCTVY AIKTRGVPET FNEAKPIGFT MYTTCIVWLA 670 680 690 700 710 720 FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP KVYIILFHPE QNVPKRKRSL 730 740 750 760 770 KAVVTAATMS NKFTQKGNFR PNGEAKSELC ENLEAPALAT KQTYVTYTNH AI
	Isoform 3 [UniParc]. Checksum: 202C4DC3F806DC8F	FASTA	743	83,580
	10 20 30 40 50 60 MSCKIPQISY ASTAPDLSDN SRYDFFSRVV PSDTYQAQAM VDIVRALKWN YVSTVASEGS 70 80 90 100 110 120 YGESGVEAFI QKSREDGGVC IAQSVKIPRE PKAGEFDKII RRLLETSNAR AVIIFANEDD 130 140 150 160 170 180 IRRVLEAARR ANQTGHFFWM GSDSWGSKIA PVLHLEEVAE GAVTILPKRM SVRGFDRYFS 190 200 210 220 230 240 SRTLDNNRRN IWFAEFWEDN FHCKLSRHAL KKGSHVKKCT NRERIGQDSA YEQEGKVQFV 250 260 270 280 290 300 IDAVYAMGHA LHAMHRDLCP GRVGLCPRMD PVDGTQLLKY IRNVNFSGIA GNPVTFNENG 310 320 330 340 350 360 DAPGRYDIYQ YQLRNDSAEY KVIGSWTDHL HLRIERMHWP GSGQQLPRSI CSLPCQPGER 370 380 390 400 410 420 KKTVKGMPCC WHCEPCTGYQ YQVDRYTCKT CPYDMRPTEN RTGCRPIPII KLEWGSPWAV 430 440 450 460 470 480 LPLFLAVVGI AATLFVVITF VRYNDTPIVK ASGRELSYVL LAGIFLCYAT TFLMIAEPDL 490 500 510 520 530 540 GTCSLRRIFL GLGMSISYAA LLTKTNRIYR IFEQGKRSVS APRFISPASQ LAITFSLISL 550 560 570 580 590 600 QLLGICVWFV VDPSHSVVDF QDQRTLDPRF ARGVLKCDIS DLSLICLLGY SMLLMVTCTV 610 620 630 640 650 660 YAIKTRGVPE TFNEAKPIGF TMYTTCIVWL AFIPIFFGTS QSADKLYIQT TTLTVSVSLS 670 680 690 700 710 720 ASVSLGMLYM PKVYIILFHP EQNVPKRKRS LKAVVTAATM SNKFTQKGNF RPNGEAKSEL 730 740 CENLEAPALA TKQTYVTYTN HAI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization and localization of human metabotropic glutamate receptor type 4." Makoff A., Lelchuk R., Oxer M., Harrington K., Emson P. Brain Res. Mol. Brain Res. 37:239-248(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells." Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M. Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4." Flor P.J., Lukic S., Rueegg D., Leonhardt T., Knoepfel T., Kuhn R. Neuropharmacology 34:149-155(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Cerebellum.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia." Ohtsuki T., Toru M., Arinami T. Psychiatr. Genet. 11:79-83(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ILE-797.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80818 mRNA. Translation: CAA56784.1. U92457 mRNA. Translation: AAB51762.1. AK293913 mRNA. Translation: BAH11625.1. AK293949 mRNA. Translation: BAH11632.1. AL354740 Genomic DNA. No translation available. AL590403 Genomic DNA. Translation: CAI17348.1.
IPI	IPI00000839. IPI01013349.
RefSeq	NP_000832.1. NM_000841.2. NP_001243741.1. NM_001256812.1. NP_001243743.1. NM_001256814.1.
UniGene	Hs.429018. Hs.736330.
3D structure databases
ProteinModelPortal	Q14833.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363296.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q14833.
Polymorphism databases
DMDM	2495077.
Proteomic databases
PaxDb	Q14833.
PRIDE	Q14833.
Protocols and materials databases
DNASU	2914.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374181; ENSP00000363296; ENSG00000124493. ENST00000455714; ENSP00000398456; ENSG00000124493. ENST00000538487; ENSP00000440556; ENSG00000124493. ENST00000544773; ENSP00000437730; ENSG00000124493.
GeneID	2914.
KEGG	hsa:2914.
UCSC	uc003oio.3. human. uc011dsl.2. human. uc011dsm.2. human.
Organism-specific databases
CTD	2914.
GeneCards	GC06M034203.
HGNC	HGNC:4596. GRM4.
HPA	CAB022096.
MIM	604100. gene.
neXtProt	NX_Q14833.
PharmGKB	PA28993.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG295200.
HOGENOM	HOG000218635.
HOVERGEN	HBG107965.
InParanoid	Q14833.
KO	K04607.
OMA	GWGWWWA.
OrthoDB	EOG4ZW59D.
PhylomeDB	Q14833.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q14833.
Bgee	Q14833.
CleanEx	HS_GRM4.
Genevestigator	Q14833.
GermOnline	ENSG00000124493. Homo sapiens.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR000337. GPCR_3. IPR011500. GPCR_3_9-Cys_dom. IPR017978. GPCR_3_C. IPR017979. GPCR_3_CS. IPR000162. GPCR_3_mtglu_rcpt. IPR001786. GPCR_3_mtglu_rcpt_4. [Graphical view]
Pfam	PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. [Graphical view]
PRINTS	PR00248. GPCRMGR. PR01054. MTABOTROPC4R. PR00593. MTABOTROPICR.
PROSITE	PS00979. G_PROTEIN_RECEP_F3_1. 1 hit. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. 1 hit. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q14833.
ChEMBL	CHEMBL2736.
ChiTaRS	GRM4. human.
DrugBank	DB00142. L-Glutamic Acid.
GenomeRNAi	2914.
NextBio	11551.
SOURCE	Search...

Entry information

Entry name

GRM4_HUMAN

Accession

Primary (citable) accession number: Q14833
Secondary accession number(s): B7Z1T9 , B7Z1U6, F5GXM5, Q5SZ84

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 29, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.