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Protein

Metabotropic glutamate receptor 3

Gene

GRM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei151 – 1511GlutamateBy similarity
Binding sitei222 – 2221GlutamateBy similarity
Binding sitei301 – 3011GlutamateBy similarity
Binding sitei389 – 3891GlutamateBy similarity

GO - Molecular functioni

  • calcium channel regulator activity Source: Ensembl
  • glutamate receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB
  • group II metabotropic glutamate receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.
SignaLinkiQ14832.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 3
Short name:
mGluR3
Gene namesi
Name:GRM3
Synonyms:GPRC1C, MGLUR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4595. GRM3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 576554ExtracellularSequence AnalysisAdd
BLAST
Transmembranei577 – 59923Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini600 – 61314CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei614 – 63421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini635 – 64511ExtracellularSequence AnalysisAdd
BLAST
Transmembranei646 – 66419Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini665 – 68824CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei689 – 70921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini710 – 73425ExtracellularSequence AnalysisAdd
BLAST
Transmembranei735 – 75622Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini757 – 76913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei770 – 79223Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini793 – 80210ExtracellularSequence Analysis
Transmembranei803 – 82826Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini829 – 87951CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28992.

Polymorphism and mutation databases

BioMutaiGRM3.
DMDMi76803803.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 879857Metabotropic glutamate receptor 3PRO_0000012927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 991 Publication
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi240 ↔ 527By similarity
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi361 ↔ 3731 Publication
Disulfide bondi412 ↔ 4191 Publication
Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi509 ↔ 528By similarity
Disulfide bondi513 ↔ 531By similarity
Disulfide bondi534 ↔ 546By similarity
Disulfide bondi549 ↔ 562By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14832.
PRIDEiQ14832.

PTM databases

PhosphoSiteiQ14832.

Expressioni

Tissue specificityi

Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.1 Publication

Gene expression databases

BgeeiQ14832.
CleanExiHS_GRM3.
ExpressionAtlasiQ14832. baseline and differential.
GenevisibleiQ14832. HS.

Organism-specific databases

HPAiHPA045227.

Interactioni

Subunit structurei

Interacts with GRASP.By similarity

Protein-protein interaction databases

BioGridi109170. 4 interactions.
STRINGi9606.ENSP00000355316.

Structurei

Secondary structure

1
879
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353Combined sources
Beta strandi38 – 458Combined sources
Beta strandi48 – 503Combined sources
Beta strandi56 – 605Combined sources
Turni62 – 654Combined sources
Helixi66 – 8116Combined sources
Beta strandi83 – 864Combined sources
Beta strandi91 – 977Combined sources
Helixi102 – 11413Combined sources
Beta strandi142 – 1465Combined sources
Helixi151 – 16111Combined sources
Helixi162 – 1643Combined sources
Beta strandi168 – 1725Combined sources
Helixi176 – 1794Combined sources
Turni181 – 1866Combined sources
Beta strandi187 – 1915Combined sources
Helixi195 – 20713Combined sources
Beta strandi212 – 2209Combined sources
Helixi221 – 23515Combined sources
Turni236 – 2383Combined sources
Beta strandi240 – 2478Combined sources
Helixi253 – 26412Combined sources
Beta strandi271 – 2755Combined sources
Helixi278 – 29013Combined sources
Beta strandi296 – 2994Combined sources
Turni301 – 3055Combined sources
Helixi307 – 3104Combined sources
Turni314 – 3196Combined sources
Beta strandi321 – 3255Combined sources
Helixi331 – 3388Combined sources
Turni342 – 3443Combined sources
Helixi351 – 3599Combined sources
Turni381 – 3833Combined sources
Helixi390 – 41122Combined sources
Helixi420 – 4234Combined sources
Helixi427 – 4337Combined sources
Helixi435 – 4373Combined sources
Beta strandi438 – 4403Combined sources
Beta strandi453 – 4553Combined sources
Beta strandi466 – 47611Combined sources
Beta strandi478 – 49215Combined sources
Helixi494 – 4963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S8Mmodel-A30-499[»]
3SM9X-ray2.26A26-504[»]
4XARX-ray2.26A2-508[»]
ProteinModelPortaliQ14832.
SMRiQ14832. Positions 28-670, 686-833.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 1743Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ14832.
KOiK04605.
OMAiCTCIVVT.
OrthoDBiEOG7Z0JXG.
PhylomeDBiQ14832.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14832-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK
60 70 80 90 100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS
110 120 130 140 150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY
160 170 180 190 200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA
210 220 230 240 250
MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS
260 270 280 290 300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS
310 320 330 340 350
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW
360 370 380 390 400
FRDFWEQKFQ CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM
410 420 430 440 450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKDA
460 470 480 490 500
DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY LKVGHWAETL SLDVNSIHWS
510 520 530 540 550
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL ADEFTCMDCG
560 570 580 590 600
SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK
610 620 630 640 650
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS
660 670 680 690 700
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI
710 720 730 740 750
VMVSVWLILE APGTRRYTLA EKRETVILKC NVKDSSMLIS LTYDVILVIL
760 770 780 790 800
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT
810 820 830 840 850
TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH LNRFSVSGTG
860 870
TTYSQSSAST YVPTVCNGRE VLDSTTSSL
Length:879
Mass (Da):98,879
Last modified:September 27, 2005 - v2
Checksum:i7EB84521676E8304
GO
Isoform 2 (identifier: Q14832-2) [UniParc]FASTAAdd to basket

Also known as: GRM3Delta4

The sequence of this isoform differs from the canonical sequence as follows:
     442-537: APFNPNKDAD...CWICIPCEPY → GADDNHVHLC...CSSVLVFLDC
     538-879: Missing.

Note: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain.
Show »
Length:537
Mass (Da):60,749
Checksum:i47F5D3ED1DF5A9E1
GO

Sequence cautioni

The sequence AAD15616.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence ABC47402.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA54796.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961L → F in AAH41407 (PubMed:15489334).Curated
Sequence conflicti446 – 4461P → T in AAH22496 (PubMed:15489334).Curated
Sequence conflicti512 – 5121P → A in AAH22496 (PubMed:15489334).Curated
Sequence conflicti856 – 8561S → Y in AAH22496 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti475 – 4751G → D.
Corresponds to variant rs17161026 [ dbSNP | Ensembl ].
VAR_049274

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei442 – 53796APFNP…PCEPY → GADDNHVHLCQPEWLCGLGL FVCTQGSHHPVSTPEECCHT QTAPQQVQCQWNWDHILSVL CKHVCANGVQWAGSPRLHHL ISVIVNCSSVLVFLDC in isoform 2. 1 PublicationVSP_047679Add
BLAST
Alternative sequencei538 – 879342Missing in isoform 2. 1 PublicationVSP_047680Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77748 mRNA. Translation: CAA54796.1. Different initiation.
DQ315361 mRNA. Translation: ABC47402.1. Different initiation.
AC004829 Genomic DNA. No translation available.
AC005009 Genomic DNA. Translation: AAD15616.1. Different initiation.
AC002081 Genomic DNA. Translation: AAC60379.2.
BC022496 mRNA. Translation: AAH22496.2.
BC041407 mRNA. Translation: AAH41407.1.
CCDSiCCDS5600.1. [Q14832-1]
RefSeqiNP_000831.2. NM_000840.2. [Q14832-1]
UniGeneiHs.590575.

Genome annotation databases

EnsembliENST00000361669; ENSP00000355316; ENSG00000198822. [Q14832-1]
ENST00000439827; ENSP00000398767; ENSG00000198822. [Q14832-2]
GeneIDi2913.
KEGGihsa:2913.
UCSCiuc003uid.3. human. [Q14832-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77748 mRNA. Translation: CAA54796.1. Different initiation.
DQ315361 mRNA. Translation: ABC47402.1. Different initiation.
AC004829 Genomic DNA. No translation available.
AC005009 Genomic DNA. Translation: AAD15616.1. Different initiation.
AC002081 Genomic DNA. Translation: AAC60379.2.
BC022496 mRNA. Translation: AAH22496.2.
BC041407 mRNA. Translation: AAH41407.1.
CCDSiCCDS5600.1. [Q14832-1]
RefSeqiNP_000831.2. NM_000840.2. [Q14832-1]
UniGeneiHs.590575.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S8Mmodel-A30-499[»]
3SM9X-ray2.26A26-504[»]
4XARX-ray2.26A2-508[»]
ProteinModelPortaliQ14832.
SMRiQ14832. Positions 28-670, 686-833.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109170. 4 interactions.
STRINGi9606.ENSP00000355316.

Chemistry

BindingDBiQ14832.
ChEMBLiCHEMBL2888.
GuidetoPHARMACOLOGYi291.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ14832.

Polymorphism and mutation databases

BioMutaiGRM3.
DMDMi76803803.

Proteomic databases

PaxDbiQ14832.
PRIDEiQ14832.

Protocols and materials databases

DNASUi2913.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361669; ENSP00000355316; ENSG00000198822. [Q14832-1]
ENST00000439827; ENSP00000398767; ENSG00000198822. [Q14832-2]
GeneIDi2913.
KEGGihsa:2913.
UCSCiuc003uid.3. human. [Q14832-1]

Organism-specific databases

CTDi2913.
GeneCardsiGC07P086274.
HGNCiHGNC:4595. GRM3.
HPAiHPA045227.
MIMi601115. gene.
neXtProtiNX_Q14832.
PharmGKBiPA28992.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ14832.
KOiK04605.
OMAiCTCIVVT.
OrthoDBiEOG7Z0JXG.
PhylomeDBiQ14832.
TreeFamiTF313240.

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.
SignaLinkiQ14832.

Miscellaneous databases

ChiTaRSiGRM3. human.
GeneWikiiMetabotropic_glutamate_receptor_3.
GenomeRNAii2913.
NextBioi11547.
PROiQ14832.
SOURCEiSearch...

Gene expression databases

BgeeiQ14832.
CleanExiHS_GRM3.
ExpressionAtlasiQ14832. baseline and differential.
GenevisibleiQ14832. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization and localization of human metabotropic glutamate receptor type 3."
    Makoff A., Volpe F., Lelchuk R., Harrington K., Emson P.
    Brain Res. Mol. Brain Res. 40:55-63(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    Tissue: Lymphoblast.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Crystal structure of metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist."
    Structural genomics consortium (SGC)
    Submitted (JUL-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 26-504 OF MUTANT SER-240, DISULFIDE BONDS.

Entry informationi

Entry nameiGRM3_HUMAN
AccessioniPrimary (citable) accession number: Q14832
Secondary accession number(s): Q2PNZ6
, Q75MV4, Q75N17, Q86YG6, Q8TBH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2005
Last modified: June 24, 2015
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.