Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q14832

- GRM3_HUMAN

UniProt

Q14832 - GRM3_HUMAN

Protein

Metabotropic glutamate receptor 3

Gene

GRM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei151 – 1511GlutamateBy similarity
    Binding sitei222 – 2221GlutamateBy similarity
    Binding sitei301 – 3011GlutamateBy similarity
    Binding sitei389 – 3891GlutamateBy similarity

    GO - Molecular functioni

    1. calcium channel regulator activity Source: Ensembl
    2. glutamate receptor activity Source: UniProtKB
    3. G-protein coupled receptor activity Source: UniProtKB
    4. group II metabotropic glutamate receptor activity Source: RefGenome

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: RefGenome
    2. negative regulation of adenylate cyclase activity Source: ProtInc
    3. regulation of synaptic transmission, glutamatergic Source: RefGenome
    4. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiQ14832.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 3
    Short name:
    mGluR3
    Gene namesi
    Name:GRM3
    Synonyms:GPRC1C, MGLUR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4595. GRM3.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. astrocyte projection Source: Ensembl
    2. axon Source: Ensembl
    3. dendritic spine Source: Ensembl
    4. integral component of plasma membrane Source: RefGenome
    5. plasma membrane Source: Reactome
    6. postsynaptic density Source: Ensembl
    7. postsynaptic membrane Source: Ensembl
    8. presynaptic membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28992.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 879857Metabotropic glutamate receptor 3PRO_0000012927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 991 Publication
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi240 ↔ 527By similarity
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi361 ↔ 3731 Publication
    Disulfide bondi412 ↔ 4191 Publication
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi509 ↔ 528By similarity
    Disulfide bondi513 ↔ 531By similarity
    Disulfide bondi534 ↔ 546By similarity
    Disulfide bondi549 ↔ 562By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ14832.
    PRIDEiQ14832.

    PTM databases

    PhosphoSiteiQ14832.

    Expressioni

    Tissue specificityi

    Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.1 Publication

    Gene expression databases

    ArrayExpressiQ14832.
    BgeeiQ14832.
    CleanExiHS_GRM3.
    GenevestigatoriQ14832.

    Organism-specific databases

    HPAiHPA045227.

    Interactioni

    Subunit structurei

    Interacts with GRASP.By similarity

    Protein-protein interaction databases

    BioGridi109170. 4 interactions.
    STRINGi9606.ENSP00000355316.

    Structurei

    Secondary structure

    1
    879
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi33 – 353
    Beta strandi38 – 458
    Beta strandi48 – 503
    Beta strandi56 – 605
    Turni62 – 654
    Helixi66 – 8116
    Beta strandi83 – 864
    Beta strandi91 – 977
    Helixi102 – 11413
    Beta strandi142 – 1465
    Helixi151 – 16111
    Helixi162 – 1643
    Beta strandi168 – 1725
    Helixi176 – 1794
    Turni181 – 1866
    Beta strandi187 – 1915
    Helixi195 – 20713
    Beta strandi212 – 2209
    Helixi221 – 23515
    Turni236 – 2383
    Beta strandi240 – 2478
    Helixi253 – 26412
    Beta strandi271 – 2755
    Helixi278 – 29013
    Beta strandi296 – 2994
    Turni301 – 3055
    Helixi307 – 3104
    Turni314 – 3196
    Beta strandi321 – 3255
    Helixi331 – 3388
    Turni342 – 3443
    Helixi351 – 3599
    Turni381 – 3833
    Helixi390 – 41122
    Helixi420 – 4234
    Helixi427 – 4337
    Helixi435 – 4373
    Beta strandi466 – 47611
    Beta strandi478 – 49215
    Helixi494 – 4963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1S8Mmodel-A30-499[»]
    3SM9X-ray2.26A26-504[»]
    ProteinModelPortaliQ14832.
    SMRiQ14832. Positions 28-834.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 576554ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini600 – 61314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini635 – 64511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini665 – 68824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini710 – 73425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini757 – 76913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini793 – 80210ExtracellularSequence Analysis
    Topological domaini829 – 87951CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei577 – 59923Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei614 – 63421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei646 – 66419Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei689 – 70921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei735 – 75622Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei770 – 79223Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei803 – 82826Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni172 – 1743Glutamate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    HOGENOMiHOG000218635.
    HOVERGENiHBG107965.
    InParanoidiQ14832.
    KOiK04605.
    OMAiCTCIVVT.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiQ14832.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001234. GPCR_3_mtglu_rcpt_3.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01053. MTABOTROPC3R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14832-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK    50
    GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS 100
    RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY 150
    SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA 200
    MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS 250
    NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS 300
    DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW 350
    FRDFWEQKFQ CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM 400
    AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKDA 450
    DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY LKVGHWAETL SLDVNSIHWS 500
    RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL ADEFTCMDCG 550
    SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK 600
    HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS 650
    SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI 700
    VMVSVWLILE APGTRRYTLA EKRETVILKC NVKDSSMLIS LTYDVILVIL 750
    CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT 800
    TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH LNRFSVSGTG 850
    TTYSQSSAST YVPTVCNGRE VLDSTTSSL 879
    Length:879
    Mass (Da):98,879
    Last modified:September 27, 2005 - v2
    Checksum:i7EB84521676E8304
    GO
    Isoform 2 (identifier: Q14832-2) [UniParc]FASTAAdd to Basket

    Also known as: GRM3Delta4

    The sequence of this isoform differs from the canonical sequence as follows:
         442-537: APFNPNKDAD...CWICIPCEPY → GADDNHVHLC...CSSVLVFLDC
         538-879: Missing.

    Note: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain.

    Show »
    Length:537
    Mass (Da):60,749
    Checksum:i47F5D3ED1DF5A9E1
    GO

    Sequence cautioni

    The sequence AAD15616.1 differs from that shown. Reason: Erroneous initiation.
    The sequence ABC47402.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAA54796.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961L → F in AAH41407. (PubMed:15489334)Curated
    Sequence conflicti446 – 4461P → T in AAH22496. (PubMed:15489334)Curated
    Sequence conflicti512 – 5121P → A in AAH22496. (PubMed:15489334)Curated
    Sequence conflicti856 – 8561S → Y in AAH22496. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti475 – 4751G → D.
    Corresponds to variant rs17161026 [ dbSNP | Ensembl ].
    VAR_049274

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei442 – 53796APFNP…PCEPY → GADDNHVHLCQPEWLCGLGL FVCTQGSHHPVSTPEECCHT QTAPQQVQCQWNWDHILSVL CKHVCANGVQWAGSPRLHHL ISVIVNCSSVLVFLDC in isoform 2. 1 PublicationVSP_047679Add
    BLAST
    Alternative sequencei538 – 879342Missing in isoform 2. 1 PublicationVSP_047680Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77748 mRNA. Translation: CAA54796.1. Different initiation.
    DQ315361 mRNA. Translation: ABC47402.1. Different initiation.
    AC004829 Genomic DNA. No translation available.
    AC005009 Genomic DNA. Translation: AAD15616.1. Different initiation.
    AC002081 Genomic DNA. Translation: AAC60379.2.
    BC022496 mRNA. Translation: AAH22496.2.
    BC041407 mRNA. Translation: AAH41407.1.
    CCDSiCCDS5600.1. [Q14832-1]
    RefSeqiNP_000831.2. NM_000840.2. [Q14832-1]
    UniGeneiHs.590575.

    Genome annotation databases

    EnsembliENST00000361669; ENSP00000355316; ENSG00000198822. [Q14832-1]
    ENST00000439827; ENSP00000398767; ENSG00000198822. [Q14832-2]
    GeneIDi2913.
    KEGGihsa:2913.
    UCSCiuc003uid.3. human. [Q14832-1]

    Polymorphism databases

    DMDMi76803803.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77748 mRNA. Translation: CAA54796.1 . Different initiation.
    DQ315361 mRNA. Translation: ABC47402.1 . Different initiation.
    AC004829 Genomic DNA. No translation available.
    AC005009 Genomic DNA. Translation: AAD15616.1 . Different initiation.
    AC002081 Genomic DNA. Translation: AAC60379.2 .
    BC022496 mRNA. Translation: AAH22496.2 .
    BC041407 mRNA. Translation: AAH41407.1 .
    CCDSi CCDS5600.1. [Q14832-1 ]
    RefSeqi NP_000831.2. NM_000840.2. [Q14832-1 ]
    UniGenei Hs.590575.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1S8M model - A 30-499 [» ]
    3SM9 X-ray 2.26 A 26-504 [» ]
    ProteinModelPortali Q14832.
    SMRi Q14832. Positions 28-834.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109170. 4 interactions.
    STRINGi 9606.ENSP00000355316.

    Chemistry

    BindingDBi Q14832.
    ChEMBLi CHEMBL2888.
    DrugBanki DB00659. Acamprosate.
    DB00184. Nicotine.
    GuidetoPHARMACOLOGYi 291.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q14832.

    Polymorphism databases

    DMDMi 76803803.

    Proteomic databases

    PaxDbi Q14832.
    PRIDEi Q14832.

    Protocols and materials databases

    DNASUi 2913.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361669 ; ENSP00000355316 ; ENSG00000198822 . [Q14832-1 ]
    ENST00000439827 ; ENSP00000398767 ; ENSG00000198822 . [Q14832-2 ]
    GeneIDi 2913.
    KEGGi hsa:2913.
    UCSCi uc003uid.3. human. [Q14832-1 ]

    Organism-specific databases

    CTDi 2913.
    GeneCardsi GC07P086274.
    HGNCi HGNC:4595. GRM3.
    HPAi HPA045227.
    MIMi 601115. gene.
    neXtProti NX_Q14832.
    PharmGKBi PA28992.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295200.
    HOGENOMi HOG000218635.
    HOVERGENi HBG107965.
    InParanoidi Q14832.
    KOi K04605.
    OMAi CTCIVVT.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi Q14832.
    TreeFami TF313240.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.
    SignaLinki Q14832.

    Miscellaneous databases

    GeneWikii Metabotropic_glutamate_receptor_3.
    GenomeRNAii 2913.
    NextBioi 11547.
    PROi Q14832.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14832.
    Bgeei Q14832.
    CleanExi HS_GRM3.
    Genevestigatori Q14832.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001234. GPCR_3_mtglu_rcpt_3.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01053. MTABOTROPC3R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and localization of human metabotropic glutamate receptor type 3."
      Makoff A., Volpe F., Lelchuk R., Harrington K., Emson P.
      Brain Res. Mol. Brain Res. 40:55-63(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
      Tissue: Lymphoblast.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Crystal structure of metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist."
      Structural genomics consortium (SGC)
      Submitted (JUL-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 26-504 OF MUTANT SER-240, DISULFIDE BONDS.

    Entry informationi

    Entry nameiGRM3_HUMAN
    AccessioniPrimary (citable) accession number: Q14832
    Secondary accession number(s): Q2PNZ6
    , Q75MV4, Q75N17, Q86YG6, Q8TBH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3