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Q14831

- GRM7_HUMAN

UniProt

Q14831 - GRM7_HUMAN

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Protein

Metabotropic glutamate receptor 7

Gene

GRM7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591GlutamateBy similarity
Binding sitei230 – 2301GlutamateBy similarity
Binding sitei314 – 3141GlutamateBy similarity
Binding sitei407 – 4071GlutamateBy similarity

GO - Molecular functioni

  1. adenylate cyclase inhibitor activity Source: UniProtKB
  2. calcium channel regulator activity Source: RefGenome
  3. calcium ion binding Source: UniProtKB
  4. glutamate binding Source: UniProtKB
  5. glutamate receptor activity Source: UniProtKB
  6. group III metabotropic glutamate receptor activity Source: UniProtKB
  7. PDZ domain binding Source: UniProtKB
  8. serine binding Source: UniProtKB
  9. voltage-gated calcium channel activity Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  2. adult behavior Source: Ensembl
  3. conditioned taste aversion Source: Ensembl
  4. multicellular organismal response to stress Source: Ensembl
  5. negative regulation of adenylate cyclase activity Source: UniProtKB
  6. negative regulation of cAMP biosynthetic process Source: UniProtKB
  7. negative regulation of glutamate secretion Source: UniProtKB
  8. regulation of cyclase activity Source: GOC
  9. regulation of synaptic transmission, glutamatergic Source: RefGenome
  10. sensory perception of smell Source: UniProtKB-KW
  11. sensory perception of sound Source: UniProtKB
  12. short-term memory Source: Ensembl
  13. synaptic transmission Source: UniProtKB
  14. transmission of nerve impulse Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 7
Short name:
mGluR7
Gene namesi
Name:GRM7
Synonyms:GPRC1G, MGLUR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:4599. GRM7.

Subcellular locationi

GO - Cellular componenti

  1. asymmetric synapse Source: UniProtKB
  2. axon Source: UniProtKB
  3. cell cortex Source: UniProtKB
  4. dendrite Source: UniProtKB
  5. dendritic shaft Source: UniProtKB
  6. integral component of membrane Source: UniProtKB
  7. integral component of plasma membrane Source: UniProtKB
  8. plasma membrane Source: Reactome
  9. postsynaptic membrane Source: UniProtKB
  10. presynaptic active zone Source: UniProtKB
  11. presynaptic membrane Source: RefGenome
  12. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 915881Metabotropic glutamate receptor 7PRO_0000012938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 109By similarity
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi249 ↔ 541By similarity
Disulfide bondi374 ↔ 390By similarity
Disulfide bondi430 ↔ 437By similarity
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi523 ↔ 542By similarity
Disulfide bondi527 ↔ 545By similarity
Disulfide bondi548 ↔ 560By similarity
Disulfide bondi563 ↔ 576By similarity
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14831.
PRIDEiQ14831.

PTM databases

PhosphoSiteiQ14831.

Expressioni

Tissue specificityi

Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.2 Publications

Gene expression databases

BgeeiQ14831.
CleanExiHS_GRM7.
ExpressionAtlasiQ14831. baseline and differential.
GenevestigatoriQ14831.

Organism-specific databases

HPAiHPA036659.

Interactioni

Subunit structurei

Interacts with PICK1.By similarity

Protein-protein interaction databases

BioGridi109174. 4 interactions.
STRINGi9606.ENSP00000350348.

Structurei

Secondary structure

1
915
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi43 – 453
Beta strandi48 – 558
Turni72 – 754
Helixi76 – 8914
Beta strandi93 – 986
Beta strandi101 – 1077
Helixi112 – 1198
Helixi120 – 1267
Beta strandi150 – 1545
Helixi159 – 16911
Turni170 – 1734
Beta strandi176 – 1805
Helixi184 – 1874
Turni189 – 1946
Beta strandi195 – 1995
Helixi203 – 21614
Beta strandi220 – 2234
Helixi229 – 24012
Helixi269 – 2724
Beta strandi283 – 2853
Helixi291 – 2955
Beta strandi310 – 3123
Beta strandi334 – 3385
Helixi344 – 3518
Turni355 – 3573
Helixi364 – 3729
Turni396 – 3983
Helixi408 – 42922
Helixi438 – 4414
Helixi445 – 4539
Beta strandi456 – 4583
Beta strandi462 – 4665
Beta strandi476 – 4838
Beta strandi491 – 4999
Beta strandi502 – 5054

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MQ4X-ray2.80A37-513[»]
ProteinModelPortaliQ14831.
SMRiQ14831. Positions 40-855.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14831.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 590556ExtracellularSequence AnalysisAdd
BLAST
Topological domaini616 – 62712CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini649 – 6546ExtracellularSequence Analysis
Topological domaini676 – 70227CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini724 – 75330ExtracellularSequence AnalysisAdd
BLAST
Topological domaini776 – 78813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini811 – 82515ExtracellularSequence AnalysisAdd
BLAST
Topological domaini851 – 91565CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei591 – 61525Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei628 – 64821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei655 – 67521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei703 – 72321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei754 – 77522Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei789 – 81022Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei826 – 85025Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1823Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ14831.
KOiK04608.
OMAiRTGCRSI.
OrthoDBiEOG7Z0JXG.
PhylomeDBiQ14831.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14831-1) [UniParc]FASTAAdd to Basket

Also known as: GRM7_v1, mGluR7a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT
60 70 80 90 100
LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT
110 120 130 140 150
LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV
160 170 180 190 200
VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP
210 220 230 240 250
PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI
260 270 280 290 300
AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK
310 320 330 340 350
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF
360 370 380 390 400
TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS
410 420 430 440 450
NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK
460 470 480 490 500
YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTSNP GYRLIGQWTD
510 520 530 540 550
ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG
560 570 580 590 600
YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML
610 620 630 640 650
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP
660 670 680 690 700
DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT
710 720 730 740 750
SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD
760 770 780 790 800
ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV
810 820 830 840 850
WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF
860 870 880 890 900
HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS
910
PAAKKKYVSY NNLVI
Length:915
Mass (Da):102,251
Last modified:November 1, 1997 - v1
Checksum:iCFF94E06BF7F4919
GO
Isoform 2 (identifier: Q14831-2) [UniParc]FASTAAdd to Basket

Also known as: GRM7_v2, mGluR7b

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → NCIPPVRKSVQKSVTWYTIPPTV

Show »
Length:922
Mass (Da):103,070
Checksum:i4D51412B912986D1
GO
Isoform 3 (identifier: Q14831-3) [UniParc]FASTAAdd to Basket

Also known as: GRM7_v3

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → NFFFWLYSGTW

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Show »
Length:910
Mass (Da):101,924
Checksum:i1AA5C74733E5FC8F
GO
Isoform 4 (identifier: Q14831-4) [UniParc]FASTAAdd to Basket

Also known as: GRM7_v4

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → ITSEDLSLHKED

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:911
Mass (Da):101,842
Checksum:i178DC0821EAD05E5
GO
Isoform 5 (identifier: Q14831-5) [UniParc]FASTAAdd to Basket

Also known as: GRM7_v5

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → SEKCNCY

Show »
Length:906
Mass (Da):101,302
Checksum:i53EC7BB83CBCBB61
GO

Sequence cautioni

Isoform 3 : The sequence AAM47557.1 differs from that shown. Reason: Frameshift at position 904.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti433 – 4331Y → F.1 Publication
Corresponds to variant rs2229902 [ dbSNP | Ensembl ].
VAR_003584
Natural varianti495 – 4951I → V.
Corresponds to variant rs7634846 [ dbSNP | Ensembl ].
VAR_049276
Natural varianti745 – 7451G → E.
Corresponds to variant rs1485174 [ dbSNP | Ensembl ].
VAR_049277

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei900 – 91516SPAAK…NNLVI → NCIPPVRKSVQKSVTWYTIP PTV in isoform 2. 1 PublicationVSP_015735Add
BLAST
Alternative sequencei900 – 91516SPAAK…NNLVI → NFFFWLYSGTW in isoform 3. 1 PublicationVSP_015732Add
BLAST
Alternative sequencei900 – 91516SPAAK…NNLVI → ITSEDLSLHKED in isoform 4. 1 PublicationVSP_015733Add
BLAST
Alternative sequencei900 – 91516SPAAK…NNLVI → SEKCNCY in isoform 5. 1 PublicationVSP_015734Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94552 mRNA. Translation: CAA64245.1.
U92458 mRNA. Translation: AAB51763.1.
AF458052 mRNA. Translation: AAM47557.1. Frameshift.
AF458053 mRNA. Translation: AAM47558.1.
AF458054 mRNA. Translation: AAM47559.1.
CCDSiCCDS43042.1. [Q14831-1]
RefSeqiNP_000835.1. NM_000844.3. [Q14831-1]
NP_870989.1. NM_181874.2. [Q14831-2]
XP_005265152.1. XM_005265095.2. [Q14831-4]
UniGeneiHs.606393.
Hs.660131.

Genome annotation databases

EnsembliENST00000357716; ENSP00000350348; ENSG00000196277. [Q14831-1]
ENST00000389335; ENSP00000373986; ENSG00000196277. [Q14831-4]
ENST00000389336; ENSP00000373987; ENSG00000196277. [Q14831-5]
ENST00000467425; ENSP00000419835; ENSG00000196277. [Q14831-2]
ENST00000486284; ENSP00000417536; ENSG00000196277. [Q14831-2]
GeneIDi2917.
KEGGihsa:2917.
UCSCiuc003bql.2. human. [Q14831-2]
uc003bqm.2. human. [Q14831-1]
uc010hcg.2. human. [Q14831-5]

Polymorphism databases

DMDMi2495078.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94552 mRNA. Translation: CAA64245.1 .
U92458 mRNA. Translation: AAB51763.1 .
AF458052 mRNA. Translation: AAM47557.1 . Frameshift.
AF458053 mRNA. Translation: AAM47558.1 .
AF458054 mRNA. Translation: AAM47559.1 .
CCDSi CCDS43042.1. [Q14831-1 ]
RefSeqi NP_000835.1. NM_000844.3. [Q14831-1 ]
NP_870989.1. NM_181874.2. [Q14831-2 ]
XP_005265152.1. XM_005265095.2. [Q14831-4 ]
UniGenei Hs.606393.
Hs.660131.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3MQ4 X-ray 2.80 A 37-513 [» ]
ProteinModelPortali Q14831.
SMRi Q14831. Positions 40-855.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109174. 4 interactions.
STRINGi 9606.ENSP00000350348.

Chemistry

BindingDBi Q14831.
ChEMBLi CHEMBL3777.
GuidetoPHARMACOLOGYi 295.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q14831.

Polymorphism databases

DMDMi 2495078.

Proteomic databases

PaxDbi Q14831.
PRIDEi Q14831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357716 ; ENSP00000350348 ; ENSG00000196277 . [Q14831-1 ]
ENST00000389335 ; ENSP00000373986 ; ENSG00000196277 . [Q14831-4 ]
ENST00000389336 ; ENSP00000373987 ; ENSG00000196277 . [Q14831-5 ]
ENST00000467425 ; ENSP00000419835 ; ENSG00000196277 . [Q14831-2 ]
ENST00000486284 ; ENSP00000417536 ; ENSG00000196277 . [Q14831-2 ]
GeneIDi 2917.
KEGGi hsa:2917.
UCSCi uc003bql.2. human. [Q14831-2 ]
uc003bqm.2. human. [Q14831-1 ]
uc010hcg.2. human. [Q14831-5 ]

Organism-specific databases

CTDi 2917.
GeneCardsi GC03P006877.
HGNCi HGNC:4599. GRM7.
HPAi HPA036659.
MIMi 604101. gene.
neXtProti NX_Q14831.
PharmGKBi PA28996.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00760000118884.
HOGENOMi HOG000218635.
HOVERGENi HBG107965.
InParanoidi Q14831.
KOi K04608.
OMAi RTGCRSI.
OrthoDBi EOG7Z0JXG.
PhylomeDBi Q14831.
TreeFami TF313240.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi GRM7. human.
EvolutionaryTracei Q14831.
GeneWikii Metabotropic_glutamate_receptor_7.
GenomeRNAii 2917.
NextBioi 11563.
PROi Q14831.
SOURCEi Search...

Gene expression databases

Bgeei Q14831.
CleanExi HS_GRM7.
ExpressionAtlasi Q14831. baseline and differential.
Genevestigatori Q14831.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS."
    Makoff A., Pilling C., Harrington K., Emson P.
    Brain Res. Mol. Brain Res. 40:165-170(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "A novel splice variant of a metabotropic glutamate receptor, human mGluR7b."
    Flor P.J., Van Der Putten H., Ruegg D., Lukic S., Leonhardt T., Bence M., Sansig G., Knoepfel T., Kuhn R.
    Neuropharmacology 36:153-159(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."
    Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.
    Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  4. "Characterization of three novel isoforms of the metabotropic glutamate receptor 7 (GRM7)."
    Schulz H.L., Stoehr H., Weber B.H.F.
    Neurosci. Lett. 326:37-40(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), TISSUE SPECIFICITY.
  5. "MGluR7 complexed with LY341495."
    Structural genomics consortium (SGC)
    Submitted (JUN-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 37-513.
  6. "Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia."
    Bolonna A.A., Kerwin R.W., Munro J., Arranz M.J., Makoff A.J.
    Schizophr. Res. 47:99-103(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PHE-433.

Entry informationi

Entry nameiGRM7_HUMAN
AccessioniPrimary (citable) accession number: Q14831
Secondary accession number(s): Q8NFS2, Q8NFS3, Q8NFS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3