Q14831 (GRM7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metabotropic glutamate receptor 7
Short name=mGluR7

Gene names

Name:	GRM7
Synonyms:	GPRC1G, MGLUR7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	915 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
Subunit structure	Interacts with PICK1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. Ref.4
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.
Sequence caution	Isoform 3: The sequence AAM47557.1 differs from that shown. Reason: Frameshift at position 904.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult behavior Inferred from electronic annotation. Source: Compara conditioned taste aversion Inferred from electronic annotation. Source: Compara multicellular organismal response to stress Inferred from electronic annotation. Source: Compara negative regulation of adenylate cyclase activity Inferred from direct assay Ref.3Ref.2. Source: UniProtKB negative regulation of glutamate secretion Inferred from sequence or structural similarity. Source: UniProtKB sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of sound Inferred from mutant phenotype PubMed 19047183. Source: UniProtKB short-term memory Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from direct assay Ref.3. Source: UniProtKB
Cellular_component	asymmetric synapse Inferred from sequence or structural similarity. Source: UniProtKB axon Inferred from sequence or structural similarity. Source: UniProtKB cell cortex Inferred from direct assay PubMed 9630572. Source: UniProtKB dendritic shaft Inferred from sequence or structural similarity. Source: UniProtKB integral to plasma membrane Non-traceable author statement Ref.3. Source: UniProtKB postsynaptic membrane Inferred from sequence or structural similarity. Source: UniProtKB presynaptic active zone Inferred from sequence or structural similarity. Source: UniProtKB presynaptic membrane Inferred from electronic annotation. Source: Compara
Molecular_function	PDZ domain binding Non-traceable author statement Ref.4. Source: UniProtKB adenylate cyclase inhibitor activity Inferred from direct assay Ref.3Ref.2. Source: UniProtKB calcium channel regulator activity Inferred from electronic annotation. Source: Compara calcium ion binding Inferred from direct assay PubMed 18599484. Source: UniProtKB glutamate binding Inferred from direct assay Ref.3Ref.2. Source: UniProtKB group III metabotropic glutamate receptor activity Inferred from direct assay Ref.2Ref.3. Source: UniProtKB serine binding Inferred from direct assay Ref.2. Source: UniProtKB voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14831-1)

Also known as: GRM7_v1; mGluR7a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14831-2)

Also known as: GRM7_v2; mGluR7b;

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → NCIPPVRKSVQKSVTWYTIPPTV

Isoform 3 (identifier: Q14831-3)

Also known as: GRM7_v3;

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → NFFFWLYSGTW

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q14831-4)

Also known as: GRM7_v4;

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → ITSEDLSLHKED

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 5 (identifier: Q14831-5)

Also known as: GRM7_v5;

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → SEKCNCY

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 34

34

Potential

Chain

35 – 915

881

Metabotropic glutamate receptor 7

PRO_0000012938

Regions

Topological domain

35 – 590

556

Extracellular Potential

Transmembrane

591 – 615

25

Helical; Name=1; Potential

Topological domain

616 – 627

12

Cytoplasmic Potential

Transmembrane

628 – 648

21

Helical; Name=2; Potential

Topological domain

649 – 654

6

Extracellular Potential

Transmembrane

655 – 675

21

Helical; Name=3; Potential

Topological domain

676 – 702

27

Cytoplasmic Potential

Transmembrane

703 – 723

21

Helical; Name=4; Potential

Topological domain

724 – 753

30

Extracellular Potential

Transmembrane

754 – 775

22

Helical; Name=5; Potential

Topological domain

776 – 788

13

Cytoplasmic Potential

Transmembrane

789 – 810

22

Helical; Name=6; Potential

Topological domain

811 – 825

15

Extracellular Potential

Transmembrane

826 – 850

25

Helical; Name=7; Potential

Topological domain

851 – 915

65

Cytoplasmic Potential

Amino acid modifications

Glycosylation

98

1

N-linked (GlcNAc...) Potential

Glycosylation

458

1

N-linked (GlcNAc...) Potential

Glycosylation

486

1

N-linked (GlcNAc...) Potential

Glycosylation

572

1

N-linked (GlcNAc...) Potential

Disulfide bond

67 ↔ 109

By similarity

Disulfide bond

249 ↔ 541

By similarity

Disulfide bond

374 ↔ 390

By similarity

Disulfide bond

430 ↔ 437

By similarity

Disulfide bond

523 ↔ 542

By similarity

Disulfide bond

527 ↔ 545

By similarity

Disulfide bond

548 ↔ 560

By similarity

Disulfide bond

563 ↔ 576

By similarity

Natural variations

Alternative sequence

900 – 915

16

SPAAK…NNLVI → NCIPPVRKSVQKSVTWYTIP PTV in isoform 2.

VSP_015735

Alternative sequence

900 – 915

16

SPAAK…NNLVI → NFFFWLYSGTW in isoform 3.

VSP_015732

Alternative sequence

900 – 915

16

SPAAK…NNLVI → ITSEDLSLHKED in isoform 4.

VSP_015733

Alternative sequence

900 – 915

16

SPAAK…NNLVI → SEKCNCY in isoform 5.

VSP_015734

Natural variant

433

1

Y → F. Ref.5
Corresponds to variant rs2229902 [ dbSNP | Ensembl ].

VAR_003584

Natural variant

495

1

I → V.
Corresponds to variant rs7634846 [ dbSNP | Ensembl ].

VAR_049276

Natural variant

745

1

G → E.
Corresponds to variant rs1485174 [ dbSNP | Ensembl ].

VAR_049277

Secondary structure

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915

Helix Strand Turn

Details...

Beta strand

43 – 45

3

Beta strand

48 – 55

8

Turn

72 – 75

4

Helix

76 – 89

14

Beta strand

93 – 98

6

Beta strand

101 – 107

7

Helix

112 – 119

8

Helix

120 – 126

7

Beta strand

150 – 154

5

Helix

159 – 169

11

Turn

170 – 173

4

Beta strand

176 – 180

5

Helix

184 – 187

4

Turn

189 – 194

6

Beta strand

195 – 199

5

Helix

203 – 216

14

Beta strand

220 – 223

4

Helix

229 – 240

12

Helix

269 – 272

4

Beta strand

283 – 285

3

Helix

291 – 295

5

Beta strand

310 – 312

3

Beta strand

334 – 338

5

Helix

344 – 351

8

Turn

355 – 357

3

Helix

364 – 372

9

Turn

396 – 398

3

Helix

408 – 429

22

Helix

438 – 441

4

Helix

445 – 453

9

Beta strand

456 – 458

3

Beta strand

462 – 466

5

Beta strand

476 – 483

8

Beta strand

491 – 499

9

Beta strand

502 – 505

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (GRM7_v1) (mGluR7a) [UniParc]. Last modified November 1, 1997. Version 1. Checksum: CFF94E06BF7F4919	FASTA	915	102,251
	10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 910 PAAKKKYVSY NNLVI
	Isoform 2 (GRM7_v2) (mGluR7b) [UniParc]. Checksum: 4D51412B912986D1	FASTA	922	103,070
	10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNN 910 920 CIPPVRKSVQ KSVTWYTIPP TV
	Isoform 3 (GRM7_v3) [UniParc]. Checksum: 1AA5C74733E5FC8F	FASTA	910	101,924
	10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNN 910 FFFWLYSGTW
	Isoform 4 (GRM7_v4) [UniParc]. Checksum: 178DC0821EAD05E5	FASTA	911	101,842
	10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNI 910 TSEDLSLHKE D
	Isoform 5 (GRM7_v5) [UniParc]. Checksum: 53EC7BB83CBCBB61	FASTA	906	101,302
	10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS EKCNCY

References

[1]	"Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS." Makoff A., Pilling C., Harrington K., Emson P. Brain Res. Mol. Brain Res. 40:165-170(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"A novel splice variant of a metabotropic glutamate receptor, human mGluR7b." Flor P.J., Van Der Putten H., Ruegg D., Lukic S., Leonhardt T., Bence M., Sansig G., Knoepfel T., Kuhn R. Neuropharmacology 36:153-159(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]	"Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells." Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M. Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Characterization of three novel isoforms of the metabotropic glutamate receptor 7 (GRM7)." Schulz H.L., Stoehr H., Weber B.H.F. Neurosci. Lett. 326:37-40(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), TISSUE SPECIFICITY.
[5]	"Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia." Bolonna A.A., Kerwin R.W., Munro J., Arranz M.J., Makoff A.J. Schizophr. Res. 47:99-103(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PHE-433.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X94552 mRNA. Translation: CAA64245.1.
U92458 mRNA. Translation: AAB51763.1.
AF458052 mRNA. Translation: AAM47557.1. Frameshift.
AF458053 mRNA. Translation: AAM47558.1.
AF458054 mRNA. Translation: AAM47559.1.

IPI

IPI00292323.
IPI00335261.
IPI00376864.
IPI00651739.
IPI00745954.

RefSeq

NP_000835.1. NM_000844.3.
NP_870989.1. NM_181874.2.

UniGene

Hs.606393.
Hs.660131.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3MQ4	X-ray	2.80	A	37-513	[»]

ProteinModelPortal

Q14831.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000350348.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

Q14831.

Polymorphism databases

DMDM

2495078.

Proteomic databases

PaxDb

Q14831.

PRIDE

Q14831.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000357716; ENSP00000350348; ENSG00000196277.
ENST00000389335; ENSP00000373986; ENSG00000196277.
ENST00000389336; ENSP00000373987; ENSG00000196277.
ENST00000402647; ENSP00000384585; ENSG00000196277.
ENST00000403881; ENSP00000385664; ENSG00000196277.
ENST00000467425; ENSP00000419835; ENSG00000196277.
ENST00000486284; ENSP00000417536; ENSG00000196277.

GeneID

2917.

KEGG

hsa:2917.

UCSC

uc003bql.2. human.
uc003bqm.2. human.
uc010hcg.2. human.

Organism-specific databases

CTD

2917.

GeneCards

GC03P006877.

HGNC

HGNC:4599. GRM7.

HPA

HPA036659.

MIM

604101. gene.

neXtProt

NX_Q14831.

PharmGKB

PA28996.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG295200.

HOGENOM

HOG000218635.

HOVERGEN

HBG107965.

KO

K04608.

OrthoDB

EOG4ZW59D.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q14831.

Bgee

Q14831.

CleanEx

HS_GRM7.

Genevestigator

Q14831.

GermOnline

ENSG00000196277. Homo sapiens.

Family and domain databases

InterPro

IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
[Graphical view]

Pfam

PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]

PRINTS

PR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.

PROSITE

PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q14831.

ChEMBL

CHEMBL3777.

ChiTaRS

GRM7. human.

DrugBank

DB00142. L-Glutamic Acid.

EvolutionaryTrace

Q14831.

GenomeRNAi

2917.

NextBio

11563.

SOURCE

Search...

Entry information

Entry name

GRM7_HUMAN

Accession

Primary (citable) accession number: Q14831
Secondary accession number(s): Q8NFS2, Q8NFS3, Q8NFS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.