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Q14831

- GRM7_HUMAN

UniProt

Q14831 - GRM7_HUMAN

Protein

Metabotropic glutamate receptor 7

Gene

GRM7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei159 – 1591GlutamateBy similarity
    Binding sitei230 – 2301GlutamateBy similarity
    Binding sitei314 – 3141GlutamateBy similarity
    Binding sitei407 – 4071GlutamateBy similarity

    GO - Molecular functioni

    1. adenylate cyclase inhibitor activity Source: UniProtKB
    2. calcium channel regulator activity Source: RefGenome
    3. calcium ion binding Source: UniProtKB
    4. glutamate binding Source: UniProtKB
    5. glutamate receptor activity Source: UniProtKB
    6. group III metabotropic glutamate receptor activity Source: UniProtKB
    7. PDZ domain binding Source: UniProtKB
    8. serine binding Source: UniProtKB
    9. voltage-gated calcium channel activity Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    2. adult behavior Source: Ensembl
    3. conditioned taste aversion Source: Ensembl
    4. multicellular organismal response to stress Source: Ensembl
    5. negative regulation of adenylate cyclase activity Source: UniProtKB
    6. negative regulation of cAMP biosynthetic process Source: UniProtKB
    7. negative regulation of glutamate secretion Source: UniProtKB
    8. regulation of cyclase activity Source: GOC
    9. regulation of synaptic transmission, glutamatergic Source: RefGenome
    10. sensory perception of smell Source: UniProtKB-KW
    11. sensory perception of sound Source: UniProtKB
    12. short-term memory Source: Ensembl
    13. synaptic transmission Source: UniProtKB
    14. transmission of nerve impulse Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 7
    Short name:
    mGluR7
    Gene namesi
    Name:GRM7
    Synonyms:GPRC1G, MGLUR7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:4599. GRM7.

    Subcellular locationi

    GO - Cellular componenti

    1. asymmetric synapse Source: UniProtKB
    2. axon Source: UniProtKB
    3. cell cortex Source: UniProtKB
    4. dendrite Source: UniProtKB
    5. dendritic shaft Source: UniProtKB
    6. integral component of membrane Source: UniProtKB
    7. integral component of plasma membrane Source: UniProtKB
    8. plasma membrane Source: Reactome
    9. postsynaptic membrane Source: UniProtKB
    10. presynaptic active zone Source: UniProtKB
    11. presynaptic membrane Source: RefGenome
    12. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28996.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 915881Metabotropic glutamate receptor 7PRO_0000012938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi67 ↔ 109By similarity
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi249 ↔ 541By similarity
    Disulfide bondi374 ↔ 390By similarity
    Disulfide bondi430 ↔ 437By similarity
    Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi523 ↔ 542By similarity
    Disulfide bondi527 ↔ 545By similarity
    Disulfide bondi548 ↔ 560By similarity
    Disulfide bondi563 ↔ 576By similarity
    Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ14831.
    PRIDEiQ14831.

    PTM databases

    PhosphoSiteiQ14831.

    Expressioni

    Tissue specificityi

    Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.2 Publications

    Gene expression databases

    ArrayExpressiQ14831.
    BgeeiQ14831.
    CleanExiHS_GRM7.
    GenevestigatoriQ14831.

    Organism-specific databases

    HPAiHPA036659.

    Interactioni

    Subunit structurei

    Interacts with PICK1.By similarity

    Protein-protein interaction databases

    BioGridi109174. 4 interactions.
    STRINGi9606.ENSP00000350348.

    Structurei

    Secondary structure

    1
    915
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi43 – 453
    Beta strandi48 – 558
    Turni72 – 754
    Helixi76 – 8914
    Beta strandi93 – 986
    Beta strandi101 – 1077
    Helixi112 – 1198
    Helixi120 – 1267
    Beta strandi150 – 1545
    Helixi159 – 16911
    Turni170 – 1734
    Beta strandi176 – 1805
    Helixi184 – 1874
    Turni189 – 1946
    Beta strandi195 – 1995
    Helixi203 – 21614
    Beta strandi220 – 2234
    Helixi229 – 24012
    Helixi269 – 2724
    Beta strandi283 – 2853
    Helixi291 – 2955
    Beta strandi310 – 3123
    Beta strandi334 – 3385
    Helixi344 – 3518
    Turni355 – 3573
    Helixi364 – 3729
    Turni396 – 3983
    Helixi408 – 42922
    Helixi438 – 4414
    Helixi445 – 4539
    Beta strandi456 – 4583
    Beta strandi462 – 4665
    Beta strandi476 – 4838
    Beta strandi491 – 4999
    Beta strandi502 – 5054

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3MQ4X-ray2.80A37-513[»]
    ProteinModelPortaliQ14831.
    SMRiQ14831. Positions 40-856.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14831.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 590556ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini616 – 62712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini649 – 6546ExtracellularSequence Analysis
    Topological domaini676 – 70227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini724 – 75330ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini776 – 78813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini811 – 82515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini851 – 91565CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei591 – 61525Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei628 – 64821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei655 – 67521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei703 – 72321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei754 – 77522Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei789 – 81022Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei826 – 85025Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 1823Glutamate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    HOGENOMiHOG000218635.
    HOVERGENiHBG107965.
    KOiK04608.
    OMAiRTGCRSI.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiQ14831.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001883. GPCR_3_mtglu_rcpt_7.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01057. MTABOTROPC7R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14831-1) [UniParc]FASTAAdd to Basket

    Also known as: GRM7_v1, mGluR7a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT    50
    LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT 100
    LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV 150
    VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP 200
    PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI 250
    AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 300
    RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF 350
    TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS 400
    NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK 450
    YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTSNP GYRLIGQWTD 500
    ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG 550
    YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 600
    GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP 650
    DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT 700
    SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD 750
    ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV 800
    WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF 850
    HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 900
    PAAKKKYVSY NNLVI 915
    Length:915
    Mass (Da):102,251
    Last modified:November 1, 1997 - v1
    Checksum:iCFF94E06BF7F4919
    GO
    Isoform 2 (identifier: Q14831-2) [UniParc]FASTAAdd to Basket

    Also known as: GRM7_v2, mGluR7b

    The sequence of this isoform differs from the canonical sequence as follows:
         900-915: SPAAKKKYVSYNNLVI → NCIPPVRKSVQKSVTWYTIPPTV

    Show »
    Length:922
    Mass (Da):103,070
    Checksum:i4D51412B912986D1
    GO
    Isoform 3 (identifier: Q14831-3) [UniParc]FASTAAdd to Basket

    Also known as: GRM7_v3

    The sequence of this isoform differs from the canonical sequence as follows:
         900-915: SPAAKKKYVSYNNLVI → NFFFWLYSGTW

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

    Show »
    Length:910
    Mass (Da):101,924
    Checksum:i1AA5C74733E5FC8F
    GO
    Isoform 4 (identifier: Q14831-4) [UniParc]FASTAAdd to Basket

    Also known as: GRM7_v4

    The sequence of this isoform differs from the canonical sequence as follows:
         900-915: SPAAKKKYVSYNNLVI → ITSEDLSLHKED

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:911
    Mass (Da):101,842
    Checksum:i178DC0821EAD05E5
    GO
    Isoform 5 (identifier: Q14831-5) [UniParc]FASTAAdd to Basket

    Also known as: GRM7_v5

    The sequence of this isoform differs from the canonical sequence as follows:
         900-915: SPAAKKKYVSYNNLVI → SEKCNCY

    Show »
    Length:906
    Mass (Da):101,302
    Checksum:i53EC7BB83CBCBB61
    GO

    Sequence cautioni

    Isoform 3 : The sequence AAM47557.1 differs from that shown. Reason: Frameshift at position 904.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti433 – 4331Y → F.1 Publication
    Corresponds to variant rs2229902 [ dbSNP | Ensembl ].
    VAR_003584
    Natural varianti495 – 4951I → V.
    Corresponds to variant rs7634846 [ dbSNP | Ensembl ].
    VAR_049276
    Natural varianti745 – 7451G → E.
    Corresponds to variant rs1485174 [ dbSNP | Ensembl ].
    VAR_049277

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei900 – 91516SPAAK…NNLVI → NCIPPVRKSVQKSVTWYTIP PTV in isoform 2. 1 PublicationVSP_015735Add
    BLAST
    Alternative sequencei900 – 91516SPAAK…NNLVI → NFFFWLYSGTW in isoform 3. 1 PublicationVSP_015732Add
    BLAST
    Alternative sequencei900 – 91516SPAAK…NNLVI → ITSEDLSLHKED in isoform 4. 1 PublicationVSP_015733Add
    BLAST
    Alternative sequencei900 – 91516SPAAK…NNLVI → SEKCNCY in isoform 5. 1 PublicationVSP_015734Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94552 mRNA. Translation: CAA64245.1.
    U92458 mRNA. Translation: AAB51763.1.
    AF458052 mRNA. Translation: AAM47557.1. Frameshift.
    AF458053 mRNA. Translation: AAM47558.1.
    AF458054 mRNA. Translation: AAM47559.1.
    CCDSiCCDS43042.1. [Q14831-1]
    RefSeqiNP_000835.1. NM_000844.3. [Q14831-1]
    NP_870989.1. NM_181874.2. [Q14831-2]
    XP_005265152.1. XM_005265095.2. [Q14831-4]
    UniGeneiHs.606393.
    Hs.660131.

    Genome annotation databases

    EnsembliENST00000357716; ENSP00000350348; ENSG00000196277. [Q14831-1]
    ENST00000389335; ENSP00000373986; ENSG00000196277. [Q14831-4]
    ENST00000389336; ENSP00000373987; ENSG00000196277. [Q14831-5]
    ENST00000402647; ENSP00000384585; ENSG00000196277. [Q14831-2]
    ENST00000467425; ENSP00000419835; ENSG00000196277. [Q14831-2]
    ENST00000486284; ENSP00000417536; ENSG00000196277. [Q14831-2]
    GeneIDi2917.
    KEGGihsa:2917.
    UCSCiuc003bql.2. human. [Q14831-2]
    uc003bqm.2. human. [Q14831-1]
    uc010hcg.2. human. [Q14831-5]

    Polymorphism databases

    DMDMi2495078.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94552 mRNA. Translation: CAA64245.1 .
    U92458 mRNA. Translation: AAB51763.1 .
    AF458052 mRNA. Translation: AAM47557.1 . Frameshift.
    AF458053 mRNA. Translation: AAM47558.1 .
    AF458054 mRNA. Translation: AAM47559.1 .
    CCDSi CCDS43042.1. [Q14831-1 ]
    RefSeqi NP_000835.1. NM_000844.3. [Q14831-1 ]
    NP_870989.1. NM_181874.2. [Q14831-2 ]
    XP_005265152.1. XM_005265095.2. [Q14831-4 ]
    UniGenei Hs.606393.
    Hs.660131.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3MQ4 X-ray 2.80 A 37-513 [» ]
    ProteinModelPortali Q14831.
    SMRi Q14831. Positions 40-856.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109174. 4 interactions.
    STRINGi 9606.ENSP00000350348.

    Chemistry

    BindingDBi Q14831.
    ChEMBLi CHEMBL3777.
    DrugBanki DB00142. L-Glutamic Acid.
    GuidetoPHARMACOLOGYi 295.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q14831.

    Polymorphism databases

    DMDMi 2495078.

    Proteomic databases

    PaxDbi Q14831.
    PRIDEi Q14831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357716 ; ENSP00000350348 ; ENSG00000196277 . [Q14831-1 ]
    ENST00000389335 ; ENSP00000373986 ; ENSG00000196277 . [Q14831-4 ]
    ENST00000389336 ; ENSP00000373987 ; ENSG00000196277 . [Q14831-5 ]
    ENST00000402647 ; ENSP00000384585 ; ENSG00000196277 . [Q14831-2 ]
    ENST00000467425 ; ENSP00000419835 ; ENSG00000196277 . [Q14831-2 ]
    ENST00000486284 ; ENSP00000417536 ; ENSG00000196277 . [Q14831-2 ]
    GeneIDi 2917.
    KEGGi hsa:2917.
    UCSCi uc003bql.2. human. [Q14831-2 ]
    uc003bqm.2. human. [Q14831-1 ]
    uc010hcg.2. human. [Q14831-5 ]

    Organism-specific databases

    CTDi 2917.
    GeneCardsi GC03P006877.
    HGNCi HGNC:4599. GRM7.
    HPAi HPA036659.
    MIMi 604101. gene.
    neXtProti NX_Q14831.
    PharmGKBi PA28996.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295200.
    HOGENOMi HOG000218635.
    HOVERGENi HBG107965.
    KOi K04608.
    OMAi RTGCRSI.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi Q14831.
    TreeFami TF313240.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi GRM7. human.
    EvolutionaryTracei Q14831.
    GeneWikii Metabotropic_glutamate_receptor_7.
    GenomeRNAii 2917.
    NextBioi 11563.
    PROi Q14831.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14831.
    Bgeei Q14831.
    CleanExi HS_GRM7.
    Genevestigatori Q14831.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001883. GPCR_3_mtglu_rcpt_7.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01057. MTABOTROPC7R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS."
      Makoff A., Pilling C., Harrington K., Emson P.
      Brain Res. Mol. Brain Res. 40:165-170(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "A novel splice variant of a metabotropic glutamate receptor, human mGluR7b."
      Flor P.J., Van Der Putten H., Ruegg D., Lukic S., Leonhardt T., Bence M., Sansig G., Knoepfel T., Kuhn R.
      Neuropharmacology 36:153-159(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."
      Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.
      Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    4. "Characterization of three novel isoforms of the metabotropic glutamate receptor 7 (GRM7)."
      Schulz H.L., Stoehr H., Weber B.H.F.
      Neurosci. Lett. 326:37-40(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), TISSUE SPECIFICITY.
    5. "MGluR7 complexed with LY341495."
      Structural genomics consortium (SGC)
      Submitted (JUN-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 37-513.
    6. "Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia."
      Bolonna A.A., Kerwin R.W., Munro J., Arranz M.J., Makoff A.J.
      Schizophr. Res. 47:99-103(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PHE-433.

    Entry informationi

    Entry nameiGRM7_HUMAN
    AccessioniPrimary (citable) accession number: Q14831
    Secondary accession number(s): Q8NFS2, Q8NFS3, Q8NFS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3