Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q14831 (GRM7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metabotropic glutamate receptor 7

Short name=mGluR7
Gene names
Name:GRM7
Synonyms:GPRC1G, MGLUR7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length915 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Ref.3

Subunit structure

Interacts with PICK1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. Ref.1 Ref.4

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.

Sequence caution

Isoform 3: The sequence AAM47557.1 differs from that shown. Reason: Frameshift at position 904.

Ontologies

Keywords
   Biological processOlfaction
Sensory transduction
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult behavior

Inferred from electronic annotation. Source: Ensembl

calcium ion transmembrane transport

Inferred from electronic annotation. Source: GOC

conditioned taste aversion

Inferred from electronic annotation. Source: Ensembl

multicellular organismal response to stress

Inferred from electronic annotation. Source: Ensembl

negative regulation of adenylate cyclase activity

Inferred from direct assay Ref.2. Source: UniProtKB

negative regulation of cAMP biosynthetic process

Inferred from direct assay Ref.3Ref.2. Source: UniProtKB

negative regulation of glutamate secretion

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of ion transmembrane transport

Inferred from electronic annotation. Source: GOC

sensory perception of smell

Inferred from electronic annotation. Source: UniProtKB-KW

sensory perception of sound

Inferred from mutant phenotype PubMed 19047183. Source: UniProtKB

short-term memory

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Inferred from direct assay Ref.3. Source: UniProtKB

   Cellular_componentasymmetric synapse

Inferred from sequence or structural similarity. Source: UniProtKB

axon

Inferred from sequence or structural similarity. Source: UniProtKB

cell cortex

Inferred from direct assay PubMed 9630572. Source: UniProtKB

dendritic shaft

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of plasma membrane

Non-traceable author statement Ref.3. Source: UniProtKB

postsynaptic membrane

Inferred from sequence or structural similarity. Source: UniProtKB

presynaptic active zone

Inferred from sequence or structural similarity. Source: UniProtKB

presynaptic membrane

Inferred from electronic annotation. Source: Ensembl

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

   Molecular_functionPDZ domain binding

Non-traceable author statement Ref.4. Source: UniProtKB

adenylate cyclase inhibitor activity

Inferred from direct assay Ref.3Ref.2. Source: UniProtKB

calcium channel regulator activity

Inferred from electronic annotation. Source: Ensembl

calcium ion binding

Inferred from direct assay PubMed 18599484. Source: UniProtKB

glutamate binding

Inferred from direct assay Ref.2. Source: UniProtKB

group III metabotropic glutamate receptor activity

Inferred from direct assay Ref.2Ref.3. Source: UniProtKB

serine binding

Inferred from direct assay Ref.2. Source: UniProtKB

voltage-gated calcium channel activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14831-1)

Also known as: GRM7_v1; mGluR7a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14831-2)

Also known as: GRM7_v2; mGluR7b;

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → NCIPPVRKSVQKSVTWYTIPPTV
Isoform 3 (identifier: Q14831-3)

Also known as: GRM7_v3;

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → NFFFWLYSGTW
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 4 (identifier: Q14831-4)

Also known as: GRM7_v4;

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → ITSEDLSLHKED
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 5 (identifier: Q14831-5)

Also known as: GRM7_v5;

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → SEKCNCY

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 915881Metabotropic glutamate receptor 7
PRO_0000012938

Regions

Topological domain35 – 590556Extracellular Potential
Transmembrane591 – 61525Helical; Name=1; Potential
Topological domain616 – 62712Cytoplasmic Potential
Transmembrane628 – 64821Helical; Name=2; Potential
Topological domain649 – 6546Extracellular Potential
Transmembrane655 – 67521Helical; Name=3; Potential
Topological domain676 – 70227Cytoplasmic Potential
Transmembrane703 – 72321Helical; Name=4; Potential
Topological domain724 – 75330Extracellular Potential
Transmembrane754 – 77522Helical; Name=5; Potential
Topological domain776 – 78813Cytoplasmic Potential
Transmembrane789 – 81022Helical; Name=6; Potential
Topological domain811 – 82515Extracellular Potential
Transmembrane826 – 85025Helical; Name=7; Potential
Topological domain851 – 91565Cytoplasmic Potential
Region180 – 1823Glutamate binding By similarity

Sites

Binding site1591Glutamate By similarity
Binding site2301Glutamate By similarity
Binding site3141Glutamate By similarity
Binding site4071Glutamate By similarity

Amino acid modifications

Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation4581N-linked (GlcNAc...) Potential
Glycosylation4861N-linked (GlcNAc...) Potential
Glycosylation5721N-linked (GlcNAc...) Potential
Disulfide bond67 ↔ 109 By similarity
Disulfide bond249 ↔ 541 By similarity
Disulfide bond374 ↔ 390 By similarity
Disulfide bond430 ↔ 437 By similarity
Disulfide bond523 ↔ 542 By similarity
Disulfide bond527 ↔ 545 By similarity
Disulfide bond548 ↔ 560 By similarity
Disulfide bond563 ↔ 576 By similarity

Natural variations

Alternative sequence900 – 91516SPAAK…NNLVI → NCIPPVRKSVQKSVTWYTIP PTV in isoform 2.
VSP_015735
Alternative sequence900 – 91516SPAAK…NNLVI → NFFFWLYSGTW in isoform 3.
VSP_015732
Alternative sequence900 – 91516SPAAK…NNLVI → ITSEDLSLHKED in isoform 4.
VSP_015733
Alternative sequence900 – 91516SPAAK…NNLVI → SEKCNCY in isoform 5.
VSP_015734
Natural variant4331Y → F. Ref.6
Corresponds to variant rs2229902 [ dbSNP | Ensembl ].
VAR_003584
Natural variant4951I → V.
Corresponds to variant rs7634846 [ dbSNP | Ensembl ].
VAR_049276
Natural variant7451G → E.
Corresponds to variant rs1485174 [ dbSNP | Ensembl ].
VAR_049277

Secondary structure

................................................................... 915
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (GRM7_v1) (mGluR7a) [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: CFF94E06BF7F4919

FASTA915102,251
        10         20         30         40         50         60 
MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 

        70         80         90        100        110        120 
GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 

       130        140        150        160        170        180 
TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 

       190        200        210        220        230        240 
STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 

       250        260        270        280        290        300 
ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 

       310        320        330        340        350        360 
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 

       370        380        390        400        410        420 
NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 

       430        440        450        460        470        480 
ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 

       490        500        510        520        530        540 
QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 

       550        560        570        580        590        600 
CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 

       610        620        630        640        650        660 
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 

       670        680        690        700        710        720 
FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 

       730        740        750        760        770        780 
FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 

       790        800        810        820        830        840 
PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 

       850        860        870        880        890        900 
YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 

       910 
PAAKKKYVSY NNLVI 

« Hide

Isoform 2 (GRM7_v2) (mGluR7b) [UniParc].

Checksum: 4D51412B912986D1
Show »

FASTA922103,070
Isoform 3 (GRM7_v3) [UniParc].

Checksum: 1AA5C74733E5FC8F
Show »

FASTA910101,924
Isoform 4 (GRM7_v4) [UniParc].

Checksum: 178DC0821EAD05E5
Show »

FASTA911101,842
Isoform 5 (GRM7_v5) [UniParc].

Checksum: 53EC7BB83CBCBB61
Show »

FASTA906101,302

References

[1]"Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS."
Makoff A., Pilling C., Harrington K., Emson P.
Brain Res. Mol. Brain Res. 40:165-170(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Brain.
[2]"A novel splice variant of a metabotropic glutamate receptor, human mGluR7b."
Flor P.J., Van Der Putten H., Ruegg D., Lukic S., Leonhardt T., Bence M., Sansig G., Knoepfel T., Kuhn R.
Neuropharmacology 36:153-159(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]"Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells."
Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M.
Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
[4]"Characterization of three novel isoforms of the metabotropic glutamate receptor 7 (GRM7)."
Schulz H.L., Stoehr H., Weber B.H.F.
Neurosci. Lett. 326:37-40(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), TISSUE SPECIFICITY.
[5]"MGluR7 complexed with LY341495."
Structural genomics consortium (SGC)
Submitted (JUN-2010) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 37-513.
[6]"Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia."
Bolonna A.A., Kerwin R.W., Munro J., Arranz M.J., Makoff A.J.
Schizophr. Res. 47:99-103(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PHE-433.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X94552 mRNA. Translation: CAA64245.1.
U92458 mRNA. Translation: AAB51763.1.
AF458052 mRNA. Translation: AAM47557.1. Frameshift.
AF458053 mRNA. Translation: AAM47558.1.
AF458054 mRNA. Translation: AAM47559.1.
RefSeqNP_000835.1. NM_000844.3.
NP_870989.1. NM_181874.2.
XP_005265152.1. XM_005265095.1.
UniGeneHs.606393.
Hs.660131.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3MQ4X-ray2.80A37-513[»]
ProteinModelPortalQ14831.
SMRQ14831. Positions 40-580.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109174. 4 interactions.
STRING9606.ENSP00000350348.

Chemistry

BindingDBQ14831.
ChEMBLCHEMBL3777.
DrugBankDB00142. L-Glutamic Acid.
GuidetoPHARMACOLOGY295.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ14831.

Polymorphism databases

DMDM2495078.

Proteomic databases

PaxDbQ14831.
PRIDEQ14831.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357716; ENSP00000350348; ENSG00000196277. [Q14831-1]
ENST00000389335; ENSP00000373986; ENSG00000196277. [Q14831-4]
ENST00000389336; ENSP00000373987; ENSG00000196277. [Q14831-5]
ENST00000402647; ENSP00000384585; ENSG00000196277. [Q14831-2]
ENST00000403881; ENSP00000385664; ENSG00000196277. [Q14831-4]
ENST00000467425; ENSP00000419835; ENSG00000196277. [Q14831-2]
ENST00000486284; ENSP00000417536; ENSG00000196277. [Q14831-2]
GeneID2917.
KEGGhsa:2917.
UCSCuc003bql.2. human. [Q14831-2]
uc003bqm.2. human. [Q14831-1]
uc010hcg.2. human. [Q14831-5]

Organism-specific databases

CTD2917.
GeneCardsGC03P006877.
HGNCHGNC:4599. GRM7.
HPAHPA036659.
MIM604101. gene.
neXtProtNX_Q14831.
PharmGKBPA28996.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295200.
HOGENOMHOG000218635.
HOVERGENHBG107965.
KOK04608.
OMAANDEDIX.
OrthoDBEOG7Z0JXG.
TreeFamTF313240.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ14831.
BgeeQ14831.
CleanExHS_GRM7.
GenevestigatorQ14831.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMSSF53822. SSF53822. 1 hit.
PROSITEPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGRM7. human.
EvolutionaryTraceQ14831.
GeneWikiMetabotropic_glutamate_receptor_7.
GenomeRNAi2917.
NextBio11563.
PROQ14831.
SOURCESearch...

Entry information

Entry nameGRM7_HUMAN
AccessionPrimary (citable) accession number: Q14831
Secondary accession number(s): Q8NFS2, Q8NFS3, Q8NFS4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries