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Protein

Metabotropic glutamate receptor 7

Gene

GRM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

Caution

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159GlutamateBy similarity1
Binding sitei230GlutamateBy similarity1
Binding sitei314GlutamateBy similarity1
Binding sitei407GlutamateBy similarity1

GO - Molecular functioni

  • adenylate cyclase inhibitor activity Source: UniProtKB
  • calcium channel regulator activity Source: GO_Central
  • calcium ion binding Source: UniProtKB
  • glutamate binding Source: UniProtKB
  • glutamate receptor activity Source: UniProtKB
  • group III metabotropic glutamate receptor activity Source: UniProtKB
  • PDZ domain binding Source: UniProtKB
  • serine binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 7
Short name:
mGluR7
Gene namesi
Name:GRM7
Synonyms:GPRC1G, MGLUR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196277.15
HGNCiHGNC:4599 GRM7
MIMi604101 gene
neXtProtiNX_Q14831

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 590ExtracellularSequence analysisAdd BLAST556
Transmembranei591 – 615Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini616 – 627CytoplasmicSequence analysisAdd BLAST12
Transmembranei628 – 648Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini649 – 654ExtracellularSequence analysis6
Transmembranei655 – 675Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini676 – 702CytoplasmicSequence analysisAdd BLAST27
Transmembranei703 – 723Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini724 – 753ExtracellularSequence analysisAdd BLAST30
Transmembranei754 – 775Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini776 – 788CytoplasmicSequence analysisAdd BLAST13
Transmembranei789 – 810Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini811 – 825ExtracellularSequence analysisAdd BLAST15
Transmembranei826 – 850Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini851 – 915CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2917
OpenTargetsiENSG00000196277
PharmGKBiPA28996

Chemistry databases

ChEMBLiCHEMBL3777
DrugBankiDB00142 L-Glutamic Acid
GuidetoPHARMACOLOGYi295

Polymorphism and mutation databases

BioMutaiGRM7
DMDMi2495078

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001293835 – 915Metabotropic glutamate receptor 7Add BLAST881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi67 ↔ 109By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 541By similarity
Disulfide bondi374 ↔ 390By similarity
Disulfide bondi430 ↔ 437By similarity
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi523 ↔ 542By similarity
Disulfide bondi527 ↔ 545By similarity
Disulfide bondi548 ↔ 560By similarity
Disulfide bondi563 ↔ 576By similarity
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei900PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ14831
PeptideAtlasiQ14831
PRIDEiQ14831

PTM databases

iPTMnetiQ14831
PhosphoSitePlusiQ14831

Expressioni

Tissue specificityi

Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.2 Publications

Gene expression databases

BgeeiENSG00000196277
CleanExiHS_GRM7
ExpressionAtlasiQ14831 baseline and differential
GenevisibleiQ14831 HS

Organism-specific databases

HPAiHPA015964

Interactioni

Subunit structurei

Interacts with PICK1.By similarity

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi1091746 interactors.
CORUMiQ14831
STRINGi9606.ENSP00000350348

Chemistry databases

BindingDBiQ14831

Structurei

Secondary structure

1915
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 45Combined sources4
Beta strandi48 – 55Combined sources8
Beta strandi58 – 60Combined sources3
Beta strandi62 – 64Combined sources3
Beta strandi66 – 70Combined sources5
Turni72 – 75Combined sources4
Helixi76 – 90Combined sources15
Beta strandi93 – 98Combined sources6
Beta strandi101 – 107Combined sources7
Helixi112 – 119Combined sources8
Helixi120 – 123Combined sources4
Turni124 – 126Combined sources3
Beta strandi150 – 154Combined sources5
Helixi159 – 171Combined sources13
Beta strandi176 – 180Combined sources5
Helixi184 – 187Combined sources4
Turni189 – 191Combined sources3
Beta strandi195 – 199Combined sources5
Helixi202 – 215Combined sources14
Beta strandi220 – 228Combined sources9
Helixi229 – 245Combined sources17
Beta strandi249 – 256Combined sources8
Helixi267 – 275Combined sources9
Beta strandi277 – 279Combined sources3
Beta strandi282 – 287Combined sources6
Helixi289 – 301Combined sources13
Beta strandi302 – 304Combined sources3
Beta strandi308 – 314Combined sources7
Beta strandi334 – 338Combined sources5
Helixi344 – 351Combined sources8
Turni355 – 357Combined sources3
Helixi364 – 371Combined sources8
Turni396 – 398Combined sources3
Helixi408 – 429Combined sources22
Helixi438 – 453Combined sources16
Beta strandi456 – 458Combined sources3
Beta strandi462 – 465Combined sources4
Beta strandi477 – 483Combined sources7
Beta strandi491 – 504Combined sources14
Helixi506 – 508Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MQ4X-ray2.80A37-513[»]
5C5CX-ray1.86A37-513[»]
ProteinModelPortaliQ14831
SMRiQ14831
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14831

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 182Glutamate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000218635
HOVERGENiHBG107965
InParanoidiQ14831
KOiK04608
OMAiKMVKGMP
OrthoDBiEOG091G177R
PhylomeDBiQ14831
TreeFamiTF313240

Family and domain databases

Gene3Di2.10.50.301 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001883 GPCR_3_mtglu_rcpt_7
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01057 MTABOTROPC7R
PR00593 MTABOTROPICR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14831-1) [UniParc]FASTAAdd to basket
Also known as: GRM7_v1, mGluR7a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT
60 70 80 90 100
LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT
110 120 130 140 150
LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV
160 170 180 190 200
VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP
210 220 230 240 250
PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI
260 270 280 290 300
AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK
310 320 330 340 350
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF
360 370 380 390 400
TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS
410 420 430 440 450
NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK
460 470 480 490 500
YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTSNP GYRLIGQWTD
510 520 530 540 550
ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG
560 570 580 590 600
YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML
610 620 630 640 650
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP
660 670 680 690 700
DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT
710 720 730 740 750
SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD
760 770 780 790 800
ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV
810 820 830 840 850
WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF
860 870 880 890 900
HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS
910
PAAKKKYVSY NNLVI
Length:915
Mass (Da):102,251
Last modified:November 1, 1997 - v1
Checksum:iCFF94E06BF7F4919
GO
Isoform 2 (identifier: Q14831-2) [UniParc]FASTAAdd to basket
Also known as: GRM7_v2, mGluR7b

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → NCIPPVRKSVQKSVTWYTIPPTV

Show »
Length:922
Mass (Da):103,070
Checksum:i4D51412B912986D1
GO
Isoform 3 (identifier: Q14831-3) [UniParc]FASTAAdd to basket
Also known as: GRM7_v3

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → NFFFWLYSGTW

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:910
Mass (Da):101,924
Checksum:i1AA5C74733E5FC8F
GO
Isoform 4 (identifier: Q14831-4) [UniParc]FASTAAdd to basket
Also known as: GRM7_v4

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → ITSEDLSLHKED

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:911
Mass (Da):101,842
Checksum:i178DC0821EAD05E5
GO
Isoform 5 (identifier: Q14831-5) [UniParc]FASTAAdd to basket
Also known as: GRM7_v5

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: SPAAKKKYVSYNNLVI → SEKCNCY

Show »
Length:906
Mass (Da):101,302
Checksum:i53EC7BB83CBCBB61
GO

Sequence cautioni

Isoform 3 : The sequence AAM47557 differs from that shown. Reason: Frameshift at position 904.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003584433Y → F1 PublicationCorresponds to variant dbSNP:rs2229902Ensembl.1
Natural variantiVAR_049276495I → V. Corresponds to variant dbSNP:rs7634846Ensembl.1
Natural variantiVAR_049277745G → E. Corresponds to variant dbSNP:rs1485174Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015735900 – 915SPAAK…NNLVI → NCIPPVRKSVQKSVTWYTIP PTV in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_015732900 – 915SPAAK…NNLVI → NFFFWLYSGTW in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_015733900 – 915SPAAK…NNLVI → ITSEDLSLHKED in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_015734900 – 915SPAAK…NNLVI → SEKCNCY in isoform 5. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94552 mRNA Translation: CAA64245.1
U92458 mRNA Translation: AAB51763.1
AF458052 mRNA Translation: AAM47557.1 Frameshift.
AF458053 mRNA Translation: AAM47558.1
AF458054 mRNA Translation: AAM47559.1
CCDSiCCDS43042.1 [Q14831-1]
RefSeqiNP_000835.1, NM_000844.3 [Q14831-1]
NP_870989.1, NM_181874.2 [Q14831-2]
UniGeneiHs.606393
Hs.660131

Genome annotation databases

EnsembliENST00000357716; ENSP00000350348; ENSG00000196277 [Q14831-1]
ENST00000389335; ENSP00000373986; ENSG00000196277 [Q14831-4]
ENST00000389336; ENSP00000373987; ENSG00000196277 [Q14831-5]
ENST00000467425; ENSP00000419835; ENSG00000196277 [Q14831-2]
ENST00000486284; ENSP00000417536; ENSG00000196277 [Q14831-2]
GeneIDi2917
KEGGihsa:2917
UCSCiuc003bql.3 human [Q14831-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGRM7_HUMAN
AccessioniPrimary (citable) accession number: Q14831
Secondary accession number(s): Q8NFS2, Q8NFS3, Q8NFS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome