Metabotropic glutamate receptor 7 precursor

Names and origin

Protein names

Recommended name:
Metabotropic glutamate receptor 7
Short name=mGluR7

Gene names

Name:	GRM7
Synonyms:	GPRC1G, MGLUR7

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	915 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
Subunit structure	Interacts with PICK1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. Ref.4
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.

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Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of adenylate cyclase activity Ref.3 Inferred from direct assay. Source: UniProtKB negative regulation of cAMP biosynthetic process Ref.3 Inferred from direct assay. Source: UniProtKB negative regulation of glutamate secretion Inferred from sequence or structural similarity. Source: UniProtKB sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of sound Inferred from mutant phenotype. Source: UniProtKB synaptic transmission Ref.3 Inferred from direct assay. Source: UniProtKB
Cellular component	asymmetric synapse Inferred from sequence or structural similarity. Source: UniProtKB axon Inferred from sequence or structural similarity. Source: UniProtKB cell cortex Inferred from direct assay. Source: UniProtKB dendritic shaft Inferred from sequence or structural similarity. Source: UniProtKB integral to plasma membrane Ref.3 Non-traceable author statement. Source: UniProtKB postsynaptic membrane Inferred from sequence or structural similarity. Source: UniProtKB presynaptic active zone Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	PDZ domain binding Non-traceable author statement. Source: UniProtKB adenylate cyclase inhibitor activity Ref.3 Inferred from direct assay. Source: UniProtKB calcium ion binding Inferred from direct assay. Source: UniProtKB glutamate binding Ref.3 Inferred from direct assay. Source: UniProtKB group III metabotropic glutamate receptor activity Ref.2 Ref.3 Inferred from direct assay. Source: UniProtKB serine binding Ref.2 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

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Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14831-1) Also known as: GRM7_v1; mGluR7a; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14831-2) Also known as: GRM7_v2; mGluR7b; The sequence of this isoform differs from the canonical sequence as follows: 900-915: SPAAKKKYVSYNNLVI → NCIPPVRKSVQKSVTWYTIPPTV

Isoform 3 (identifier: Q14831-3) Also known as: GRM7_v3; The sequence of this isoform differs from the canonical sequence as follows: 900-915: SPAAKKKYVSYNNLVI → NFFFGCTVELGLHFKLTFSRNQSNL

Isoform 4 (identifier: Q14831-4) Also known as: GRM7_v4; The sequence of this isoform differs from the canonical sequence as follows: 900-915: SPAAKKKYVSYNNLVI → ITSEDLSLHKED

Isoform 5 (identifier: Q14831-5) Also known as: GRM7_v5; The sequence of this isoform differs from the canonical sequence as follows: 900-915: SPAAKKKYVSYNNLVI → SEKCNCY

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 34

34

Potential

Chain

35 – 915

881

Metabotropic glutamate receptor 7

PRO_0000012938

Regions

Topological domain

35 – 590

556

Extracellular Potential

Transmembrane

591 – 615

25

1 Potential

Topological domain

616 – 627

12

Cytoplasmic Potential

Transmembrane

628 – 648

21

2 Potential

Topological domain

649 – 654

6

Extracellular Potential

Transmembrane

655 – 675

21

3 Potential

Topological domain

676 – 702

27

Cytoplasmic Potential

Transmembrane

703 – 723

21

4 Potential

Topological domain

724 – 753

30

Extracellular Potential

Transmembrane

754 – 775

22

5 Potential

Topological domain

776 – 788

13

Cytoplasmic Potential

Transmembrane

789 – 810

22

6 Potential

Topological domain

811 – 825

15

Extracellular Potential

Transmembrane

826 – 850

25

7 Potential

Topological domain

851 – 915

65

Cytoplasmic Potential

Amino acid modifications

Modified residue

900

1

Phosphoserine By similarity

Glycosylation

98

1

N-linked (GlcNAc...) Potential

Glycosylation

458

1

N-linked (GlcNAc...) Potential

Glycosylation

486

1

N-linked (GlcNAc...) Potential

Glycosylation

572

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

900 – 915

16

SPAAK…NNLVI → NCIPPVRKSVQKSVTWYTIP PTV in isoform 2.

VSP_015735

Alternative sequence

900 – 915

16

SPAAK…NNLVI → NFFFGCTVELGLHFKLTFSR NQSNL in isoform 3.

VSP_015732

Alternative sequence

900 – 915

16

SPAAK…NNLVI → ITSEDLSLHKED in isoform 4.

VSP_015733

Alternative sequence

900 – 915

16

SPAAK…NNLVI → SEKCNCY in isoform 5.

VSP_015734

Natural variant

433

1

Y → F: dbSNP rs2229902. Ref.5

VAR_003584

Natural variant

495

1

I → V: dbSNP rs7634846.

VAR_049276

Natural variant

745

1

G → E: dbSNP rs1485174.

VAR_049277

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 (GRM7_v1) (mGluR7a) [UniParc]. Last modified November 1, 1997. Version 1. Checksum: CFF94E06BF7F4919 Show »	FASTA	915	102,251
10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 910 PAAKKKYVSY NNLVI « Hide
Isoform 2 (GRM7_v2) (mGluR7b). Checksum: 4D51412B912986D1 Show »	FASTA	922	103,070
10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNN 910 920 CIPPVRKSVQ KSVTWYTIPP TV « Hide
Isoform 3 (GRM7_v3). Checksum: 32028B6156A71BFE Show »	FASTA	924	103,376
10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNN 910 920 FFFGCTVELG LHFKLTFSRN QSNL « Hide
Isoform 4 (GRM7_v4). Checksum: 178DC0821EAD05E5 Show »	FASTA	911	101,842
10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNI 910 TSEDLSLHKE D « Hide
Isoform 5 (GRM7_v5). Checksum: 53EC7BB83CBCBB61 Show »	FASTA	906	101,302
10 20 30 40 50 60 MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 70 80 90 100 110 120 GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 130 140 150 160 170 180 TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 190 200 210 220 230 240 STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 250 260 270 280 290 300 ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 310 320 330 340 350 360 RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 370 380 390 400 410 420 NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 430 440 450 460 470 480 ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 490 500 510 520 530 540 QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 550 560 570 580 590 600 CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 610 620 630 640 650 660 GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 670 680 690 700 710 720 FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 730 740 750 760 770 780 FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 790 800 810 820 830 840 PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 850 860 870 880 890 900 YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS EKCNCY « Hide

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References

[1]	"Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS." Makoff A., Pilling C., Harrington K., Emson P. Brain Res. Mol. Brain Res. 40:165-170(1996) [PubMed: 8840028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"A novel splice variant of a metabotropic glutamate receptor, human mGluR7b." Flor P.J., Van Der Putten H., Ruegg D., Lukic S., Leonhardt T., Bence M., Sansig G., Knoepfel T., Kuhn R. Neuropharmacology 36:153-159(1997) [PubMed: 9144652] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]	"Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells." Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Jr., Johnson B.G., Schoepp D.D., Belagaje R.M. Brain Res. Mol. Brain Res. 53:88-97(1998) [PubMed: 9473604] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Characterization of three novel isoforms of the metabotropic glutamate receptor 7 (GRM7)." Schulz H.L., Stoehr H., Weber B.H.F. Neurosci. Lett. 326:37-40(2002) [PubMed: 12052533] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), TISSUE SPECIFICITY.
[5]	"Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia." Bolonna A.A., Kerwin R.W., Munro J., Arranz M.J., Makoff A.J. Schizophr. Res. 47:99-103(2001) [PubMed: 11163549] [Abstract] Cited for: VARIANT PHE-433.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	X94552 mRNA. Translation: CAA64245.1. U92458 mRNA. Translation: AAB51763.1. AF458052 mRNA. Translation: AAM47557.1. AF458053 mRNA. Translation: AAM47558.1. AF458054 mRNA. Translation: AAM47559.1.
IPI	IPI00292323. IPI00335261. IPI00376864. IPI00651739. IPI00745954.
RefSeq	NP_000835.1. NP_870989.1.
UniGene	Hs.606393 Hs.660131
3D structure databases
HSSP	HSSP built from PDB template 1EWK based on UniProtKB P23385.
SMR	Q14831. Positions 40-511.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14831.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q14831.
Proteomic databases
PRIDE	Q14831.
Genome annotation databases
Ensembl	ENST00000357716; ENSP00000350348; ENSG00000196277; Homo sapiens. [Genome view] ENST00000389335; ENSP00000373986; ENSG00000196277; Homo sapiens. [Genome view] ENST00000389336; ENSP00000373987; ENSG00000196277; Homo sapiens. [Genome view] ENST00000402647; ENSP00000384585; ENSG00000196277; Homo sapiens. [Genome view] ENST00000403881; ENSP00000385664; ENSG00000196277; Homo sapiens. [Genome view] ENST00000413492; ENSP00000388238; ENSG00000196277; Homo sapiens. [Genome view] ENST00000435689; ENSP00000405194; ENSG00000196277; Homo sapiens. [Genome view] ENST00000440923; ENSP00000412329; ENSG00000196277; Homo sapiens. [Genome view] ENST00000445087; ENSP00000395035; ENSG00000196277; Homo sapiens. [Genome view] ENST00000448328; ENSP00000393799; ENSG00000196277; Homo sapiens. [Genome view] ENST00000458641; ENSP00000409891; ENSG00000196277; Homo sapiens. [Genome view]
GeneID	2917.
KEGG	hsa:2917.
UCSC	uc003bql.1. human. uc003bqm.1. human. uc010hcg.1. human.
Organism-specific databases
CTD	2917.
GeneCards	GC03P006877.
HGNC	HGNC:4599. GRM7.
MIM	604101. gene.
PharmGKB	PA28996.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q14831.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	Q14831.
Bgee	Q14831.
CleanEx	HS_GRM7.
Genevestigator	Q14831.
GermOnline	ENSG00000196277. Homo sapiens.
Family and domain databases
InterPro	IPR001828. ANF_lig_bd_rcpt. IPR000337. GPCR_3. IPR017978. GPCR_3_C. IPR017979. GPCR_3_CS. IPR000162. GPCR_3_mtglu_rcpt. IPR001883. GPCR_3_mtglu_rcpt_7. IPR011500. GPCR_3_NCR. [Graphical view]
Pfam	PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. [Graphical view]
PRINTS	PR00248. GPCRMGR. PR01057. MTABOTROPC7R. PR00593. MTABOTROPICR.
PROSITE	PS00979. G_PROTEIN_RECEP_F3_1. 1 hit. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. 1 hit. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00142. L-Glutamic Acid.
NextBio	11563.
SOURCE	Search...

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Entry information

Entry name

GRM7_HUMAN

Accession

Primary (citable) accession number: Q14831
Secondary accession number(s): Q8NFS2, Q8NFS3, Q8NFS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	October 13, 2009
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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List of human entries with polymorphisms or disease mutations

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Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents