Q14802 (FXYD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FXYD domain-containing ion transport regulator 3

Alternative name(s):
Chloride conductance inducer protein Mat-8
Mammary tumor 8 kDa protein
Phospholemman-like

Gene names

Name:	FXYD3
Synonyms:	MAT8, PLML

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in a subset of human breast tumors.
Miscellaneous	Marker of a cell type preferentially transformed by neu or ras oncoprotein.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ionic channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	chloride channel activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14802-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14802-2)

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: S → SEWRSSGEQAGRGWGSPPLTTQLSPTG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 87	67	FXYD domain-containing ion transport regulator 3		PRO_0000010362
Regions
	Topological domain	21 – 38	18	Extracellular Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Topological domain	60 – 87	28	Cytoplasmic Potential
Natural variations
	Alternative sequence	58	1	S → SEWRSSGEQAGRGWGSPPLT TQLSPTG in isoform 2.		VSP_034598
	Natural variant	40	1	G → S. Corresponds to variant rs35578165 [ dbSNP | Ensembl ].		VAR_049109
Experimental info
	Sequence conflict	36 – 37	2	Missing in AAA73922. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 6D674D668EB32493	FASTA	87	9,263
	10 20 30 40 50 60 MQKVTLGLLV FLAGFPVLDA NDLEDKNSPF YYDWHSLQVG GLICAGVLCA MGIIIVMSAK 70 80 CKCKFGQKSG HHPGETPPLI TPGSAQS
	Isoform 2 [UniParc]. Checksum: 76E2065D324DD3FB	FASTA	113	11,988
	10 20 30 40 50 60 MQKVTLGLLV FLAGFPVLDA NDLEDKNSPF YYDWHSLQVG GLICAGVLCA MGIIIVMSEW 70 80 90 100 110 RSSGEQAGRG WGSPPLTTQL SPTGAKCKCK FGQKSGHHPG ETPPLITPGS AQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes." Morrison B.W., Moorman J.R., Kowdley G.C., Kobayashi Y.M., Jones L.R., Leder P. J. Biol. Chem. 270:2176-2182(1995) [PubMed: 7836447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Mammary gland.
[2]	"Two novel cDNAs express specifically in RA-treated human lung adenocarcinoma cell line GLC-82." Lei W., Wu M. Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Lung carcinoma.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Urinary bladder.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X93036 mRNA. Translation: CAA63604.1. U28249 mRNA. Translation: AAA73922.1. BT006712 mRNA. Translation: AAP35358.1. CR456945 mRNA. Translation: CAG33226.1. CR542197 mRNA. Translation: CAG46994.1. AC020907 Genomic DNA. No translation available. BC005238 mRNA. Translation: AAH05238.1. BC090044 mRNA. Translation: AAH90044.1.
IPI	IPI00336173. IPI00414913.
PIR	A55571.
RefSeq	NP_001129479.1. NM_001136007.1. NP_001129483.1. NM_001136011.1. NP_001129484.1. NM_001136012.1. NP_005962.1. NM_005971.3. NP_068710.1. NM_021910.2.
UniGene	Hs.301350.
3D structure databases
ProteinModelPortal	Q14802.
SMR	Q14802. Positions 21-87.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14802. 3 interactions.
MINT	MINT-5004597.
STRING	Q14802.
Polymorphism databases
DMDM	3024101.
Proteomic databases
PRIDE	Q14802.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000406988; ENSP00000385200; ENSG00000089356. ENST00000435734; ENSP00000389770; ENSG00000089356.
GeneID	5349.
KEGG	hsa:5349.
UCSC	uc002nxv.1. human. uc002nxw.1. human.
Organism-specific databases
CTD	5349.
GeneCards	GC19P035606.
H-InvDB	HIX0015019.
HGNC	HGNC:4027. FXYD3.
HPA	HPA010856.
MIM	604996. gene.
neXtProt	NX_Q14802.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21180.
GeneTree	ENSGT00530000063998.
HOVERGEN	HBG008212.
OMA	PGSAHNC.
OrthoDB	EOG4W0XFT.
Gene expression databases
ArrayExpress	Q14802.
Bgee	Q14802.
CleanEx	HS_FXYD3.
Genevestigator	Q14802.
GermOnline	ENSG00000089356. Homo sapiens.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K13361.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20732.
SOURCE	Search...

Entry information

Entry name

FXYD3_HUMAN

Accession

Primary (citable) accession number: Q14802
Secondary accession number(s): A6NDE0, Q13211, Q6IB59

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.