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Protein

Zinc finger protein 846

Gene

ZNF846

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 13623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri170 – 19223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 846
Gene namesi
Name:ZNF846
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27260. ZNF846.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410876.

Polymorphism and mutation databases

BioMutaiZNF846.
DMDMi187671939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Zinc finger protein 846PRO_0000332245Add
BLAST

Proteomic databases

MaxQBiQ147U1.
PaxDbiQ147U1.
PeptideAtlasiQ147U1.
PRIDEiQ147U1.

PTM databases

iPTMnetiQ147U1.
PhosphoSiteiQ147U1.

Expressioni

Gene expression databases

BgeeiENSG00000196605.
CleanExiHS_ZNF846.
ExpressionAtlasiQ147U1. baseline and differential.
GenevisibleiQ147U1. HS.

Organism-specific databases

HPAiHPA034617.
HPA034618.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10234020,EBI-10172290

Protein-protein interaction databases

BioGridi127839. 2 interactions.
IntActiQ147U1. 1 interaction.
STRINGi9606.ENSP00000380999.

Structurei

3D structure databases

ProteinModelPortaliQ147U1.
SMRiQ147U1. Positions 8-44, 94-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8073KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 13623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri170 – 19223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ147U1.
KOiK09228.
OMAiSMLSQHV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ147U1.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR003656. Znf_BED.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 1 hit.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00614. ZnF_BED. 3 hits.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q147U1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSSQHLVTF EDVAVDFTQE EWTLLDQAQR DLYRDVMLEN YKNLIILAGS
60 70 80 90 100
ELFKRSLMSG LEQMEELRTG VTGVLQELDL QLKTKGSPLL QDISAERSPN
110 120 130 140 150
GVQLERSNTA EKLYDSNHSG KVFNEHPFLM THMITHIGEK TSEDNQSGKA
160 170 180 190 200
LRKNFPHSFY KKSHAEGKMP KCVKHEKAFN QFPNLTRQNK THTQEKLCEC
210 220 230 240 250
KDCWRTFLNQ SSLKLHIRSH NGDKHYVCKE CGKAFSNSSH LIGHGRIHSG
260 270 280 290 300
EKPYVCKECG KAFTQSTGLK LHIRTHSGEK PYKCKECGKA FTHSSYLTDH
310 320 330 340 350
TRIHSGKKPY VCMECGKAFT RSTGLILHMR IHTGEKPYEC KECGKAFIHS
360 370 380 390 400
SYLTKHVRIH SGEKLYLCKA CGKAFTRSSG LVLHMRTHTG EKPYECKECG
410 420 430 440 450
KAFNNSSMLS QHVRIHTGEK PYECKECGKA FTQSSGLSTH LRTHTGEKAC
460 470 480 490 500
ECKECGKAFA RSTNLNMHMR THTGEKPYAC KECGKAFRYS TYLNVHTRTH
510 520 530
TGAKPYECKK CGKNFTQSSA LAKHLRTKAC EKT
Length:533
Mass (Da):60,552
Last modified:April 29, 2008 - v2
Checksum:i08BE40F6CA55405F
GO
Isoform 2 (identifier: Q147U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     340-533: Missing.

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):24,076
Checksum:iCC531EB5A67E61A8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti450 – 4501C → Y.
Corresponds to variant rs10414485 [ dbSNP | Ensembl ].
VAR_052911
Natural varianti492 – 4921Y → C.
Corresponds to variant rs10420364 [ dbSNP | Ensembl ].
VAR_052912

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 129129Missing in isoform 2. 1 PublicationVSP_033362Add
BLAST
Alternative sequencei340 – 533194Missing in isoform 2. 1 PublicationVSP_033363Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097652 mRNA. Translation: BAG53503.1.
AK289536 mRNA. Translation: BAF82225.1.
AC008752 Genomic DNA. No translation available.
BC118576 mRNA. Translation: AAI18577.2.
CCDSiCCDS42496.1. [Q147U1-1]
RefSeqiNP_001071092.1. NM_001077624.1. [Q147U1-1]
XP_005259829.1. XM_005259772.3. [Q147U1-1]
XP_011526019.1. XM_011527717.2. [Q147U1-1]
UniGeneiHs.665717.

Genome annotation databases

EnsembliENST00000397902; ENSP00000380999; ENSG00000196605. [Q147U1-1]
ENST00000588267; ENSP00000465467; ENSG00000196605. [Q147U1-3]
ENST00000592859; ENSP00000467891; ENSG00000196605. [Q147U1-3]
GeneIDi162993.
KEGGihsa:162993.
UCSCiuc002mmb.2. human. [Q147U1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097652 mRNA. Translation: BAG53503.1.
AK289536 mRNA. Translation: BAF82225.1.
AC008752 Genomic DNA. No translation available.
BC118576 mRNA. Translation: AAI18577.2.
CCDSiCCDS42496.1. [Q147U1-1]
RefSeqiNP_001071092.1. NM_001077624.1. [Q147U1-1]
XP_005259829.1. XM_005259772.3. [Q147U1-1]
XP_011526019.1. XM_011527717.2. [Q147U1-1]
UniGeneiHs.665717.

3D structure databases

ProteinModelPortaliQ147U1.
SMRiQ147U1. Positions 8-44, 94-532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127839. 2 interactions.
IntActiQ147U1. 1 interaction.
STRINGi9606.ENSP00000380999.

PTM databases

iPTMnetiQ147U1.
PhosphoSiteiQ147U1.

Polymorphism and mutation databases

BioMutaiZNF846.
DMDMi187671939.

Proteomic databases

MaxQBiQ147U1.
PaxDbiQ147U1.
PeptideAtlasiQ147U1.
PRIDEiQ147U1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397902; ENSP00000380999; ENSG00000196605. [Q147U1-1]
ENST00000588267; ENSP00000465467; ENSG00000196605. [Q147U1-3]
ENST00000592859; ENSP00000467891; ENSG00000196605. [Q147U1-3]
GeneIDi162993.
KEGGihsa:162993.
UCSCiuc002mmb.2. human. [Q147U1-1]

Organism-specific databases

CTDi162993.
GeneCardsiZNF846.
HGNCiHGNC:27260. ZNF846.
HPAiHPA034617.
HPA034618.
neXtProtiNX_Q147U1.
PharmGKBiPA162410876.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ147U1.
KOiK09228.
OMAiSMLSQHV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ147U1.
TreeFamiTF341817.

Miscellaneous databases

GenomeRNAii162993.
PROiQ147U1.

Gene expression databases

BgeeiENSG00000196605.
CleanExiHS_ZNF846.
ExpressionAtlasiQ147U1. baseline and differential.
GenevisibleiQ147U1. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR003656. Znf_BED.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 1 hit.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00614. ZnF_BED. 3 hits.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN846_HUMAN
AccessioniPrimary (citable) accession number: Q147U1
Secondary accession number(s): A8K0H1, B3KUP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.