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Protein

Zinc finger protein 846

Gene

ZNF846

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 846
Gene namesi
Name:ZNF846
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196605.7
HGNCiHGNC:27260 ZNF846
neXtProtiNX_Q147U1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196605
PharmGKBiPA162410876

Polymorphism and mutation databases

BioMutaiZNF846
DMDMi187671939

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322451 – 533Zinc finger protein 846Add BLAST533

Proteomic databases

MaxQBiQ147U1
PaxDbiQ147U1
PeptideAtlasiQ147U1
PRIDEiQ147U1

PTM databases

iPTMnetiQ147U1
PhosphoSitePlusiQ147U1

Expressioni

Gene expression databases

BgeeiENSG00000196605
CleanExiHS_ZNF846
ExpressionAtlasiQ147U1 baseline and differential
GenevisibleiQ147U1 HS

Organism-specific databases

HPAiHPA034617
HPA034618

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10234020,EBI-10172290

Protein-protein interaction databases

BioGridi127839, 2 interactors
IntActiQ147U1, 2 interactors
STRINGi9606.ENSP00000380999

Structurei

3D structure databases

ProteinModelPortaliQ147U1
SMRiQ147U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 80KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144146
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ147U1
KOiK09228
OMAiSMLSQHV
OrthoDBiEOG091G02KC
PhylomeDBiQ147U1
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00614 ZnF_BED, 3 hits
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q147U1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSSQHLVTF EDVAVDFTQE EWTLLDQAQR DLYRDVMLEN YKNLIILAGS
60 70 80 90 100
ELFKRSLMSG LEQMEELRTG VTGVLQELDL QLKTKGSPLL QDISAERSPN
110 120 130 140 150
GVQLERSNTA EKLYDSNHSG KVFNEHPFLM THMITHIGEK TSEDNQSGKA
160 170 180 190 200
LRKNFPHSFY KKSHAEGKMP KCVKHEKAFN QFPNLTRQNK THTQEKLCEC
210 220 230 240 250
KDCWRTFLNQ SSLKLHIRSH NGDKHYVCKE CGKAFSNSSH LIGHGRIHSG
260 270 280 290 300
EKPYVCKECG KAFTQSTGLK LHIRTHSGEK PYKCKECGKA FTHSSYLTDH
310 320 330 340 350
TRIHSGKKPY VCMECGKAFT RSTGLILHMR IHTGEKPYEC KECGKAFIHS
360 370 380 390 400
SYLTKHVRIH SGEKLYLCKA CGKAFTRSSG LVLHMRTHTG EKPYECKECG
410 420 430 440 450
KAFNNSSMLS QHVRIHTGEK PYECKECGKA FTQSSGLSTH LRTHTGEKAC
460 470 480 490 500
ECKECGKAFA RSTNLNMHMR THTGEKPYAC KECGKAFRYS TYLNVHTRTH
510 520 530
TGAKPYECKK CGKNFTQSSA LAKHLRTKAC EKT
Length:533
Mass (Da):60,552
Last modified:April 29, 2008 - v2
Checksum:i08BE40F6CA55405F
GO
Isoform 2 (identifier: Q147U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     340-533: Missing.

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):24,076
Checksum:iCC531EB5A67E61A8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052911450C → Y. Corresponds to variant dbSNP:rs10414485Ensembl.1
Natural variantiVAR_052912492Y → C. Corresponds to variant dbSNP:rs10420364Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0333621 – 129Missing in isoform 2. 1 PublicationAdd BLAST129
Alternative sequenceiVSP_033363340 – 533Missing in isoform 2. 1 PublicationAdd BLAST194

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097652 mRNA Translation: BAG53503.1
AK289536 mRNA Translation: BAF82225.1
AC008752 Genomic DNA No translation available.
BC118576 mRNA Translation: AAI18577.2
CCDSiCCDS42496.1 [Q147U1-1]
RefSeqiNP_001071092.1, NM_001077624.1 [Q147U1-1]
XP_005259829.1, XM_005259772.3 [Q147U1-1]
XP_011526019.1, XM_011527717.2 [Q147U1-1]
UniGeneiHs.665717

Genome annotation databases

EnsembliENST00000397902; ENSP00000380999; ENSG00000196605 [Q147U1-1]
ENST00000588267; ENSP00000465467; ENSG00000196605 [Q147U1-3]
ENST00000592859; ENSP00000467891; ENSG00000196605 [Q147U1-3]
GeneIDi162993
KEGGihsa:162993
UCSCiuc002mmb.2 human [Q147U1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN846_HUMAN
AccessioniPrimary (citable) accession number: Q147U1
Secondary accession number(s): A8K0H1, B3KUP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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