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Protein

Cyclin-A2-2

Gene

CYCA2-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cell proliferation Source: TAIR
  • positive regulation of stomatal complex development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-ATH-113510. E2F mediated regulation of DNA replication.
R-ATH-1538133. G0 and Early G1.
R-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-68911. G2 Phase.
R-ATH-68949. Orc1 removal from chromatin.
R-ATH-69205. G1/S-Specific Transcription.
R-ATH-69273. Cyclin A/B1 associated events during G2/M transition.
R-ATH-69656. Cyclin A:Cdk2-associated events at S phase entry.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A2-2
Alternative name(s):
Cyc3b-At
Cyclin-3b
G2/mitotic-specific cyclin-A2-2
Short name:
CycA2;2
Gene namesi
Name:CYCA2-2
Synonyms:CYC3B
Ordered Locus Names:At5g11300
ORF Names:F2I11.190
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G11300.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Cyclin-A2-2PRO_0000286994Add
BLAST

Proteomic databases

PaxDbiQ147G5.
PRIDEiQ147G5.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Gene expression databases

GenevisibleiQ147G5. AT.

Interactioni

Protein-protein interaction databases

BioGridi16279. 15 interactions.
IntActiQ147G5. 4 interactions.
STRINGi3702.AT5G11300.1.

Structurei

3D structure databases

ProteinModelPortaliQ147G5.
SMRiQ147G5. Positions 172-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
InParanoidiQ147G5.
KOiK06627.
OMAiMHTEKSK.
PhylomeDBiQ147G5.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q147G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYCSSSMHPN ANKENISTSD VQESFVRITR SRAKKAMGRG VSIPPTKPSF
60 70 80 90 100
KQQKRRAVLK DVSNTSADII YSELRKGGNI KANRKCLKEP KKAAKEGANS
110 120 130 140 150
AMDILVDMHT EKSKLAEDLS KIRMAEAQDV SLSNFKDEEI TEQQEDGSGV
160 170 180 190 200
MELLQVVDID SNVEDPQCCS LYAADIYDNI HVAELQQRPL ANYMELVQRD
210 220 230 240 250
IDPDMRKILI DWLVEVSDDY KLVPDTLYLT VNLIDRFLSN SYIERQRLQL
260 270 280 290 300
LGVSCMLIAS KYEELSAPGV EEFCFITANT YTRPEVLSME IQILNFVHFR
310 320 330 340 350
LSVPTTKTFL RRFIKAAQAS YKVPFIELEY LANYLAELTL VEYSFLRFLP
360 370 380 390 400
SLIAASAVFL ARWTLDQTDH PWNPTLQHYT RYEVAELKNT VLAMEDLQLN
410 420 430
TSGCTLAATR EKYNQPKFKS VAKLTSPKRV TSLFSR
Length:436
Mass (Da):49,694
Last modified:August 22, 2006 - v1
Checksum:iE8971BD931AA25EF
GO

Sequence cautioni

The sequence CAB96665.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841P → R in CAA83277 (PubMed:7972055).Curated
Sequence conflicti432 – 4321S → L in CAA83277 (PubMed:7972055).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31402 mRNA. Translation: CAA83277.1.
AL360314 Genomic DNA. Translation: CAB96665.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91657.1.
BT026128 mRNA. Translation: ABG48484.1.
RefSeqiNP_568248.2. NM_121168.4.
UniGeneiAt.1678.

Genome annotation databases

EnsemblPlantsiAT5G11300.1; AT5G11300.1; AT5G11300.
GeneIDi831001.
GrameneiAT5G11300.1; AT5G11300.1; AT5G11300.
KEGGiath:AT5G11300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31402 mRNA. Translation: CAA83277.1.
AL360314 Genomic DNA. Translation: CAB96665.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91657.1.
BT026128 mRNA. Translation: ABG48484.1.
RefSeqiNP_568248.2. NM_121168.4.
UniGeneiAt.1678.

3D structure databases

ProteinModelPortaliQ147G5.
SMRiQ147G5. Positions 172-428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16279. 15 interactions.
IntActiQ147G5. 4 interactions.
STRINGi3702.AT5G11300.1.

Proteomic databases

PaxDbiQ147G5.
PRIDEiQ147G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G11300.1; AT5G11300.1; AT5G11300.
GeneIDi831001.
GrameneiAT5G11300.1; AT5G11300.1; AT5G11300.
KEGGiath:AT5G11300.

Organism-specific databases

TAIRiAT5G11300.

Phylogenomic databases

eggNOGiKOG0654. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
InParanoidiQ147G5.
KOiK06627.
OMAiMHTEKSK.
PhylomeDBiQ147G5.

Enzyme and pathway databases

ReactomeiR-ATH-113510. E2F mediated regulation of DNA replication.
R-ATH-1538133. G0 and Early G1.
R-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-68911. G2 Phase.
R-ATH-68949. Orc1 removal from chromatin.
R-ATH-69205. G1/S-Specific Transcription.
R-ATH-69273. Cyclin A/B1 associated events during G2/M transition.
R-ATH-69656. Cyclin A:Cdk2-associated events at S phase entry.

Miscellaneous databases

PROiQ147G5.

Gene expression databases

GenevisibleiQ147G5. AT.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three discrete classes of Arabidopsis cyclins are expressed during different intervals of the cell cycle."
    Ferreira P., Hemerly A., de Almeida Engler J., Bergounioux C., Burssens S., van Montagu M., Engler G., Inze D.
    Proc. Natl. Acad. Sci. U.S.A. 91:11313-11317(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
    Tissue: Callus.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Genome-wide analysis of the cyclin family in Arabidopsis and comparative phylogenetic analysis of plant cyclin-like proteins."
    Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W., Ma H.
    Plant Physiol. 135:1084-1099(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiCCA22_ARATH
AccessioniPrimary (citable) accession number: Q147G5
Secondary accession number(s): Q39073, Q9LFM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 22, 2006
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.