Reviewed,
UniProtKB/Swiss-Prot Q14789 (GOGB1_HUMAN)
Last modified
February 9, 2010.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (4) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Golgin subfamily B member 1 Alternative name(s): Giantin Macrogolgin 372 kDa Golgi complex-associated protein Short name=GCP372 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 3259 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Subunit structure | Homodimer; disulfide-linked. |
| Subcellular location | Golgi apparatus membrane; Single-pass type I membrane protein. |
| Involvement in disease | Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Coiled coil Transmembrane |
| PTM | Disulfide bond Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | Golgi organization Traceable author statement. Source: ProtInc |
| Cellular component | ER-Golgi intermediate compartment Inferred from direct assay. Source: UniProtKB Golgi membrane Ref.2Traceable author statement. Source: ProtInc Golgi stackTraceable author statement. Source: ProtInc integral to membraneTraceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 3259 | 3259 | Golgin subfamily B member 1 | PRO_0000190071 | |||||
Regions | |||||||||
| Topological domain | 1 – 3235 | 3235 | Cytoplasmic Potential | ||||||
| Transmembrane | 3236 – 3256 | 21 | Potential | ||||||
| Topological domain | 3257 – 3259 | 3 | Lumenal Potential | ||||||
| Coiled coil | 48 – 593 | 546 | Potential | ||||||
| Coiled coil | 677 – 1028 | 352 | Potential | ||||||
| Coiled coil | 1062 – 1245 | 184 | Potential | ||||||
| Coiled coil | 1301 – 1779 | 479 | Potential | ||||||
| Coiled coil | 1828 – 3185 | 1358 | Potential | ||||||
| Compositional bias | 2420 – 2423 | 4 | Poly-Glu | ||||||
| Compositional bias | 2993 – 2996 | 4 | Poly-Ser | ||||||
Amino acid modifications | |||||||||
| Modified residue | 6 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 17 | 1 | Phosphoserine Ref.7 Ref.4 | ||||||
| Modified residue | 38 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 45 | 1 | Phosphothreonine Ref.4 | ||||||
| Modified residue | 46 | 1 | Phosphothreonine Ref.4 | ||||||
| Modified residue | 967 | 1 | Phosphoserine Ref.6 | ||||||
| Modified residue | 2872 | 1 | Phosphoserine Ref.6 | ||||||
Natural variations | |||||||||
| Natural variant | 348 | 1 | Q → H in a breast cancer sample; somatic mutation. Ref.8 | VAR_036096 | |||||
| Natural variant | 911 | 1 | T → S: dbSNP rs3732407. | VAR_020155 | |||||
| Natural variant | 944 | 1 | A → G in a breast cancer sample; somatic mutation. Ref.8 | VAR_036097 | |||||
| Natural variant | 1212 | 1 | Y → C: dbSNP rs3732410. | VAR_020156 | |||||
| Natural variant | 1249 | 1 | P → S: dbSNP rs33988592. | VAR_031671 | |||||
| Natural variant | 1713 | 1 | C → F: dbSNP rs35674179. | VAR_031672 | |||||
| Natural variant | 1765 | 1 | G → D: dbSNP rs1127412. Ref.1 Ref.2 | VAR_031673 | |||||
Experimental info | |||||||||
| Sequence conflict | 1 – 39 | 39 | Missing in BAA05025. Ref.3 | ||||||
| Sequence conflict | 215 | 1 | A → AQLSSM in BAA05025. Ref.3 | ||||||
| Sequence conflict | 2950 | 1 | H → D in BAA05025. Ref.3 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Molecular genetic analyses of a 376-kilodalton Golgi complex membrane protein (giantin)." Seelig H.P., Schranz P., Schroeter H., Wiemann C., Griffiths G., Renz M. Mol. Cell. Biol. 14:2564-2576(1994) [PubMed: 7511208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-1765. |
| [2] | "Macrogolgin -- a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections." Seelig H.P., Schranz P., Schroeter H., Wiemann C., Griffiths G., Renz M. J. Autoimmun. 7:67-91(1994) [PubMed: 8198703] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-1765. |
| [3] | "Molecular cloning and sequence analysis of a human 372-kDa protein localized in the Golgi complex." Sohda M., Misumi Y., Fujiwara T., Nishioka M., Ikehara Y. Biochem. Biophys. Res. Commun. 205:1399-1408(1994) [PubMed: 7802676] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-38; THR-45 AND THR-46, MASS SPECTROMETRY. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [6] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-967 AND SER-2872, MASS SPECTROMETRY. |
| [7] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-17, MASS SPECTROMETRY. Tissue: T-cell. |
| [8] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.  Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-348 AND GLY-944. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X75304 mRNA. Translation: CAA53052.1. D25542 mRNA. Translation: BAA05025.1. |
| IPI | IPI00004671. |
| PIR | A56539. I52300. |
| RefSeq | NP_004478.3. |
| UniGene | Hs.213389 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q14789. 9 interactions. |
| STRING | Q14789. |
PTM databases | |
| PhosphoSite | Q14789. |
Proteomic databases | |
| PRIDE | Q14789. |
Genome annotation databases | |
| Ensembl | ENST00000340645; ENSP00000341848; ENSG00000173230; Homo sapiens. [Genome view] |
| GeneID | 2804. |
| KEGG | hsa:2804. |
| NMPDR | fig|9606.3.peg.23038. |
| UCSC | uc003eei.2. human. |
Organism-specific databases | |
| CTD | 2804. |
| GeneCards | GC03M122865. |
| H-InvDB | HIX0017595. |
| HGNC | HGNC:4429. GOLGB1. |
| HPA | HPA011008. HPA011555. |
| MIM | 602500. gene. |
| PharmGKB | PA28810. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG12494. |
| HOVERGEN | Q14789. |
| InParanoid | Q14789. |
| PhylomeDB | Q14789. |
Gene expression databases | |
| ArrayExpress | Q14789. |
| Bgee | Q14789. |
| CleanEx | HS_GOLGB1. |
| Genevestigator | Q14789. |
| GermOnline | ENSG00000173230. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 11053. |
| SOURCE | Search... |
Entry information
| Entry name | GOGB1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q14789 Secondary accession number(s): Q14398 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
