Q14789 (GOGB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Golgin subfamily B member 1

Alternative name(s):
372 kDa Golgi complex-associated protein
Short name=GCP372
Giantin
Macrogolgin

Gene names

Name:

GOLGB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3259 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in forming intercisternal cross-bridges of the Golgi complex.
Subunit structure	Homodimer; disulfide-linked. Interacts with PLK3. Ref.7
Subcellular location	Golgi apparatus membrane; Single-pass type I membrane protein.
Miscellaneous	Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi organization Traceable author statement PubMed 7691276. Source: ProtInc
Cellular_component	Golgi membrane Traceable author statement Ref.2. Source: ProtInc Golgi stack Traceable author statement PubMed 7691276. Source: ProtInc endoplasmic reticulum-Golgi intermediate compartment Inferred from direct assay PubMed 15308636. Source: UniProtKB integral to membrane Traceable author statement PubMed 7691276. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PFN2	P35080	2	EBI-709973,EBI-473138

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14789-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14789-2)

The sequence of this isoform differs from the canonical sequence as follows:
     215-215: A → AQLSSM
     3102-3102: A → AVSKEK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3259	3259	Golgin subfamily B member 1		PRO_0000190071
Regions
	Topological domain	1 – 3235	3235	Cytoplasmic Potential
	Transmembrane	3236 – 3256	21	Helical; Potential
	Topological domain	3257 – 3259	3	Lumenal Potential
	Coiled coil	48 – 593	546	Potential
	Coiled coil	677 – 1028	352	Potential
	Coiled coil	1062 – 1245	184	Potential
	Coiled coil	1301 – 1779	479	Potential
	Coiled coil	1828 – 3185	1358	Potential
	Compositional bias	2420 – 2423	4	Poly-Glu
	Compositional bias	2993 – 2996	4	Poly-Ser
Amino acid modifications
	Modified residue	6	1	Phosphoserine Ref.9
	Modified residue	17	1	Phosphoserine Ref.8 Ref.9 Ref.10
	Modified residue	138	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	215	1	A → AQLSSM in isoform 2.		VSP_045567
	Alternative sequence	3102	1	A → AVSKEK in isoform 2.		VSP_045568
	Natural variant	348	1	Q → H in a breast cancer sample; somatic mutation. Ref.12		VAR_036096
	Natural variant	911	1	T → S. Ref.4 Corresponds to variant rs3732407 [ dbSNP | Ensembl ].		VAR_020155
	Natural variant	944	1	A → G in a breast cancer sample; somatic mutation. Ref.12		VAR_036097
	Natural variant	1212	1	Y → C. Ref.4 Corresponds to variant rs3732410 [ dbSNP | Ensembl ].		VAR_020156
	Natural variant	1249	1	P → S. Corresponds to variant rs33988592 [ dbSNP | Ensembl ].		VAR_031671
	Natural variant	1713	1	C → F. Corresponds to variant rs35674179 [ dbSNP | Ensembl ].		VAR_031672
	Natural variant	1765	1	G → D. Ref.1 Ref.2 Ref.4 Corresponds to variant rs1127412 [ dbSNP | Ensembl ].		VAR_031673
Experimental info
	Sequence conflict	1 – 39	39	Missing in BAA05025. Ref.3
	Sequence conflict	215	1	A → AQLSSM in BAA05025. Ref.3
	Sequence conflict	2950	1	H → D in BAA05025. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: ED5D043C3A5C6432	FASTA	3,259	376,019
	10 20 30 40 50 60 MLSRLSGLAN VVLHELSGDD DTDQNMRAPL DPELHQESDM EFNNTTQEDV QERLAYAEQL 70 80 90 100 110 120 VVELKDIIRQ KDVQLQQKDE ALQEERKAAD NKIKKLKLHA KAKLTSLNKY IEEMKAQGGT 130 140 150 160 170 180 VLPTEPQSEE QLSKHDKSST EEEMEIEKIK HKLQEKEELI STLQAQLTQA QAEQPAQSST 190 200 210 220 230 240 EMEEFVMMKQ QLQEKEEFIS TLQAQLSQTQ AEQAAQQVVR EKDARFETQV RLHEDELLQL 250 260 270 280 290 300 VTQADVETEM QQKLRVLQRK LEEHEESLVG RAQVVDLLQQ ELTAAEQRNQ ILSQQLQQME 310 320 330 340 350 360 AEHNTLRNTV ETEREESKIL LEKMELEVAE RKLSFHNLQE EMHHLLEQFE QAGQAQAELE 370 380 390 400 410 420 SRYSALEQKH KAEMEEKTSH ILSLQKTGQE LQSACDALKD QNSKLLQDKN EQAVQSAQTI 430 440 450 460 470 480 QQLEDQLQQK SKEISQFLNR LPLQQHETAS QTSFPDVYNE GTQAVTEENI ASLQKRVVEL 490 500 510 520 530 540 ENEKGALLLS SIELEELKAE NEKLSSQITL LEAQNRTGEA DREVSEISIV DIANKRSSSA 550 560 570 580 590 600 EESGQDVLEN TFSQKHKELS VLLLEMKEAQ EEIAFLKLQL QGKRAEEADH EVLDQKEMKQ 610 620 630 640 650 660 MEGEGIAPIK MKVFLEDTGQ DFPLMPNEES SLPAVEKEQA STEHQSRTSE EISLNDAGVE 670 680 690 700 710 720 LKSTKQDGDK SLSAVPDIGQ CHQDELERLK SQILELELNF HKAQEIYEKN LDEKAKEISN 730 740 750 760 770 780 LNQLIEEFKK NADNNSSAFT ALSEERDQLL SQVKELSMVT ELRAQVKQLE MNLAEAERQR 790 800 810 820 830 840 RLDYESQTAH DNLLTEQIHS LSIEAKSKDV KIEVLQNELD DVQLQFSEQS TLIRSLQSQL 850 860 870 880 890 900 QNKESEVLEG AERVRHISSK VEELSQALSQ KELEITKMDQ LLLEKKRDVE TLQQTIEEKD 910 920 930 940 950 960 QQVTEISFSM TEKMVQLNEE KFSLGVEIKT LKEQLNLLSR AEEAKKEQVE EDNEVSSGLK 970 980 990 1000 1010 1020 QNYDEMSPAG QISKEELQHE FDLLKKENEQ RKRKLQAALI NRKELLQRVS RLEEELANLK 1030 1040 1050 1060 1070 1080 DESKKEIPLS ETERGEVEED KENKEYSEKC VTSKCQEIEI YLKQTISEKE VELQHIRKDL 1090 1100 1110 1120 1130 1140 EEKLAAEEQF QALVKQMNQT LQDKTNQIDL LQAEISENQA IIQKLITSNT DASDGDSVAL 1150 1160 1170 1180 1190 1200 VKETVVISPP CTGSSEHWKP ELEEKILALE KEKEQLQKKL QEALTSRKAI LKKAQEKERH 1210 1220 1230 1240 1250 1260 LREELKQQKD DYNRLQEQFD EQSKENENIG DQLRQLQIQV RESIDGKLPS TDQQESCSST 1270 1280 1290 1300 1310 1320 PGLEEPLFKA TEQHHTQPVL ESNLCPDWPS HSEDASALQG GTSVAQIKAQ LKEIEAEKVE 1330 1340 1350 1360 1370 1380 LELKVSSTTS ELTKKSEEVF QLQEQINKQG LEIESLKTVS HEAEVHAESL QQKLESSQLQ 1390 1400 1410 1420 1430 1440 IAGLEHLREL QPKLDELQKL ISKKEEDVSY LSGQLSEKEA ALTKIQTEII EQEDLIKALH 1450 1460 1470 1480 1490 1500 TQLEMQAKEH DERIKQLQVE LCEMKQKPEE IGEESRAKQQ IQRKLQAALI SRKEALKENK 1510 1520 1530 1540 1550 1560 SLQEELSLAR GTIERLTKSL ADVESQVSAQ NKEKDTVLGR LALLQEERDK LITEMDRSLL 1570 1580 1590 1600 1610 1620 ENQSLSSSCE SLKLALEGLT EDKEKLVKEI ESLKSSKIAE STEWQEKHKE LQKEYEILLQ 1630 1640 1650 1660 1670 1680 SYENVSNEAE RIQHVVEAVR QEKQELYGKL RSTEANKKET EKQLQEAEQE MEEMKEKMRK 1690 1700 1710 1720 1730 1740 FAKSKQQKIL ELEEENDRLR AEVHPAGDTA KECMETLLSS NASMKEELER VKMEYETLSK 1750 1760 1770 1780 1790 1800 KFQSLMSEKD SLSEEVQDLK HQIEGNVSKQ ANLEATEKHD NQTNVTEEGT QSIPGETEEQ 1810 1820 1830 1840 1850 1860 DSLSMSTRPT CSESVPSAKS ANPAVSKDFS SHDEINNYLQ QIDQLKERIA GLEEEKQKNK 1870 1880 1890 1900 1910 1920 EFSQTLENEK NTLLSQISTK DGELKMLQEE VTKMNLLNQQ IQEELSRVTK LKETAEEEKD 1930 1940 1950 1960 1970 1980 DLEERLMNQL AELNGSIGNY CQDVTDAQIK NELLESEMKN LKKCVSELEE EKQQLVKEKT 1990 2000 2010 2020 2030 2040 KVESEIRKEY LEKIQGAQKE PGNKSHAKEL QELLKEKQQE VKQLQKDCIR YQEKISALER 2050 2060 2070 2080 2090 2100 TVKALEFVQT ESQKDLEITK ENLAQAVEHR KKAQAELASF KVLLDDTQSE AARVLADNLK 2110 2120 2130 2140 2150 2160 LKKELQSNKE SVKSQMKQKD EDLERRLEQA EEKHLKEKKN MQEKLDALRR EKVHLEETIG 2170 2180 2190 2200 2210 2220 EIQVTLNKKD KEVQQLQENL DSTVTQLAAF TKSMSSLQDD RDRVIDEAKK WERKFSDAIQ 2230 2240 2250 2260 2270 2280 SKEEEIRLKE DNCSVLKDQL RQMSIHMEEL KINISRLEHD KQIWESKAQT EVQLQQKVCD 2290 2300 2310 2320 2330 2340 TLQGENKELL SQLEETRHLY HSSQNELAKL ESELKSLKDQ LTDLSNSLEK CKEQKGNLEG 2350 2360 2370 2380 2390 2400 IIRQQEADIQ NSKFSYEQLE TDLQASRELT SRLHEEINMK EQKIISLLSG KEEAIQVAIA 2410 2420 2430 2440 2450 2460 ELRQQHDKEI KELENLLSQE EEENIVLEEE NKKAVDKTNQ LMETLKTIKK ENIQQKAQLD 2470 2480 2490 2500 2510 2520 SFVKSMSSLQ NDRDRIVGDY QQLEERHLSI ILEKDQLIQE AAAENNKLKE EIRGLRSHMD 2530 2540 2550 2560 2570 2580 DLNSENAKLD AELIQYREDL NQVITIKDSQ QKQLLEVQLQ QNKELENKYA KLEEKLKESE 2590 2600 2610 2620 2630 2640 EANEDLRRSF NALQEEKQDL SKEIESLKVS ISQLTRQVTA LQEEGTLGLY HAQLKVKEEE 2650 2660 2670 2680 2690 2700 VHRLSALFSS SQKRIAELEE ELVCVQKEAA KKVGEIEDKL KKELKHLHHD AGIMRNETET 2710 2720 2730 2740 2750 2760 AEERVAELAR DLVEMEQKLL MVTKENKGLT AQIQSFGRSM SSLQNSRDHA NEELDELKRK 2770 2780 2790 2800 2810 2820 YDASLKELAQ LKEQGLLNRE RDALLSETAF SMNSTEENSL SHLEKLNQQL LSKDEQLLHL 2830 2840 2850 2860 2870 2880 SSQLEDSYNQ VQSFSKAMAS LQNERDHLWN ELEKFRKSEE GKQRSAAQPS TSPAEVQSLK 2890 2900 2910 2920 2930 2940 KAMSSLQNDR DRLLKELKNL QQQYLQINQE ITELHPLKAQ LQEYQDKTKA FQIMQEELRQ 2950 2960 2970 2980 2990 3000 ENLSWQHELH QLRMEKSSWE IHERRMKEQY LMAISDKDQQ LSHLQNLIRE LRSSSSQTQP 3010 3020 3030 3040 3050 3060 LKVQYQRQAS PETSASPDGS QNLVYETELL RTQLNDSLKE IHQKELRIQQ LNSNFSQLLE 3070 3080 3090 3100 3110 3120 EKNTLSIQLC DTSQSLRENQ QHYGDLLNHC AVLEKQVQEL QAGPLNIDVA PGAPQEKNGV 3130 3140 3150 3160 3170 3180 HRKSDPEELR EPQQSFSEAQ QQLCNTRQEV NELRKLLEEE RDQRVAAENA LSVAEEQIRR 3190 3200 3210 3220 3230 3240 LEHSEWDSSR TPIIGSCGTQ EQALLIDLTS NSCRRTRSGV GWKRVLRSLC HSRTRVPLLA 3250 AIYFLMIHVL LILCFTGHL
	Isoform 2 [UniParc]. Checksum: DAF169F5D3CB6EFF	FASTA	3,269	377,137
	10 20 30 40 50 60 MLSRLSGLAN VVLHELSGDD DTDQNMRAPL DPELHQESDM EFNNTTQEDV QERLAYAEQL 70 80 90 100 110 120 VVELKDIIRQ KDVQLQQKDE ALQEERKAAD NKIKKLKLHA KAKLTSLNKY IEEMKAQGGT 130 140 150 160 170 180 VLPTEPQSEE QLSKHDKSST EEEMEIEKIK HKLQEKEELI STLQAQLTQA QAEQPAQSST 190 200 210 220 230 240 EMEEFVMMKQ QLQEKEEFIS TLQAQLSQTQ AEQAAQLSSM QQVVREKDAR FETQVRLHED 250 260 270 280 290 300 ELLQLVTQAD VETEMQQKLR VLQRKLEEHE ESLVGRAQVV DLLQQELTAA EQRNQILSQQ 310 320 330 340 350 360 LQQMEAEHNT LRNTVETERE ESKILLEKME LEVAERKLSF HNLQEEMHHL LEQFEQAGQA 370 380 390 400 410 420 QAELESRYSA LEQKHKAEME EKTSHILSLQ KTGQELQSAC DALKDQNSKL LQDKNEQAVQ 430 440 450 460 470 480 SAQTIQQLED QLQQKSKEIS QFLNRLPLQQ HETASQTSFP DVYNEGTQAV TEENIASLQK 490 500 510 520 530 540 RVVELENEKG ALLLSSIELE ELKAENEKLS SQITLLEAQN RTGEADREVS EISIVDIANK 550 560 570 580 590 600 RSSSAEESGQ DVLENTFSQK HKELSVLLLE MKEAQEEIAF LKLQLQGKRA EEADHEVLDQ 610 620 630 640 650 660 KEMKQMEGEG IAPIKMKVFL EDTGQDFPLM PNEESSLPAV EKEQASTEHQ SRTSEEISLN 670 680 690 700 710 720 DAGVELKSTK QDGDKSLSAV PDIGQCHQDE LERLKSQILE LELNFHKAQE IYEKNLDEKA 730 740 750 760 770 780 KEISNLNQLI EEFKKNADNN SSAFTALSEE RDQLLSQVKE LSMVTELRAQ VKQLEMNLAE 790 800 810 820 830 840 AERQRRLDYE SQTAHDNLLT EQIHSLSIEA KSKDVKIEVL QNELDDVQLQ FSEQSTLIRS 850 860 870 880 890 900 LQSQLQNKES EVLEGAERVR HISSKVEELS QALSQKELEI TKMDQLLLEK KRDVETLQQT 910 920 930 940 950 960 IEEKDQQVTE ISFSMTEKMV QLNEEKFSLG VEIKTLKEQL NLLSRAEEAK KEQVEEDNEV 970 980 990 1000 1010 1020 SSGLKQNYDE MSPAGQISKE ELQHEFDLLK KENEQRKRKL QAALINRKEL LQRVSRLEEE 1030 1040 1050 1060 1070 1080 LANLKDESKK EIPLSETERG EVEEDKENKE YSEKCVTSKC QEIEIYLKQT ISEKEVELQH 1090 1100 1110 1120 1130 1140 IRKDLEEKLA AEEQFQALVK QMNQTLQDKT NQIDLLQAEI SENQAIIQKL ITSNTDASDG 1150 1160 1170 1180 1190 1200 DSVALVKETV VISPPCTGSS EHWKPELEEK ILALEKEKEQ LQKKLQEALT SRKAILKKAQ 1210 1220 1230 1240 1250 1260 EKERHLREEL KQQKDDYNRL QEQFDEQSKE NENIGDQLRQ LQIQVRESID GKLPSTDQQE 1270 1280 1290 1300 1310 1320 SCSSTPGLEE PLFKATEQHH TQPVLESNLC PDWPSHSEDA SALQGGTSVA QIKAQLKEIE 1330 1340 1350 1360 1370 1380 AEKVELELKV SSTTSELTKK SEEVFQLQEQ INKQGLEIES LKTVSHEAEV HAESLQQKLE 1390 1400 1410 1420 1430 1440 SSQLQIAGLE HLRELQPKLD ELQKLISKKE EDVSYLSGQL SEKEAALTKI QTEIIEQEDL 1450 1460 1470 1480 1490 1500 IKALHTQLEM QAKEHDERIK QLQVELCEMK QKPEEIGEES RAKQQIQRKL QAALISRKEA 1510 1520 1530 1540 1550 1560 LKENKSLQEE LSLARGTIER LTKSLADVES QVSAQNKEKD TVLGRLALLQ EERDKLITEM 1570 1580 1590 1600 1610 1620 DRSLLENQSL SSSCESLKLA LEGLTEDKEK LVKEIESLKS SKIAESTEWQ EKHKELQKEY 1630 1640 1650 1660 1670 1680 EILLQSYENV SNEAERIQHV VEAVRQEKQE LYGKLRSTEA NKKETEKQLQ EAEQEMEEMK 1690 1700 1710 1720 1730 1740 EKMRKFAKSK QQKILELEEE NDRLRAEVHP AGDTAKECME TLLSSNASMK EELERVKMEY 1750 1760 1770 1780 1790 1800 ETLSKKFQSL MSEKDSLSEE VQDLKHQIEG NVSKQANLEA TEKHDNQTNV TEEGTQSIPG 1810 1820 1830 1840 1850 1860 ETEEQDSLSM STRPTCSESV PSAKSANPAV SKDFSSHDEI NNYLQQIDQL KERIAGLEEE 1870 1880 1890 1900 1910 1920 KQKNKEFSQT LENEKNTLLS QISTKDGELK MLQEEVTKMN LLNQQIQEEL SRVTKLKETA 1930 1940 1950 1960 1970 1980 EEEKDDLEER LMNQLAELNG SIGNYCQDVT DAQIKNELLE SEMKNLKKCV SELEEEKQQL 1990 2000 2010 2020 2030 2040 VKEKTKVESE IRKEYLEKIQ GAQKEPGNKS HAKELQELLK EKQQEVKQLQ KDCIRYQEKI 2050 2060 2070 2080 2090 2100 SALERTVKAL EFVQTESQKD LEITKENLAQ AVEHRKKAQA ELASFKVLLD DTQSEAARVL 2110 2120 2130 2140 2150 2160 ADNLKLKKEL QSNKESVKSQ MKQKDEDLER RLEQAEEKHL KEKKNMQEKL DALRREKVHL 2170 2180 2190 2200 2210 2220 EETIGEIQVT LNKKDKEVQQ LQENLDSTVT QLAAFTKSMS SLQDDRDRVI DEAKKWERKF 2230 2240 2250 2260 2270 2280 SDAIQSKEEE IRLKEDNCSV LKDQLRQMSI HMEELKINIS RLEHDKQIWE SKAQTEVQLQ 2290 2300 2310 2320 2330 2340 QKVCDTLQGE NKELLSQLEE TRHLYHSSQN ELAKLESELK SLKDQLTDLS NSLEKCKEQK 2350 2360 2370 2380 2390 2400 GNLEGIIRQQ EADIQNSKFS YEQLETDLQA SRELTSRLHE EINMKEQKII SLLSGKEEAI 2410 2420 2430 2440 2450 2460 QVAIAELRQQ HDKEIKELEN LLSQEEEENI VLEEENKKAV DKTNQLMETL KTIKKENIQQ 2470 2480 2490 2500 2510 2520 KAQLDSFVKS MSSLQNDRDR IVGDYQQLEE RHLSIILEKD QLIQEAAAEN NKLKEEIRGL 2530 2540 2550 2560 2570 2580 RSHMDDLNSE NAKLDAELIQ YREDLNQVIT IKDSQQKQLL EVQLQQNKEL ENKYAKLEEK 2590 2600 2610 2620 2630 2640 LKESEEANED LRRSFNALQE EKQDLSKEIE SLKVSISQLT RQVTALQEEG TLGLYHAQLK 2650 2660 2670 2680 2690 2700 VKEEEVHRLS ALFSSSQKRI AELEEELVCV QKEAAKKVGE IEDKLKKELK HLHHDAGIMR 2710 2720 2730 2740 2750 2760 NETETAEERV AELARDLVEM EQKLLMVTKE NKGLTAQIQS FGRSMSSLQN SRDHANEELD 2770 2780 2790 2800 2810 2820 ELKRKYDASL KELAQLKEQG LLNRERDALL SETAFSMNST EENSLSHLEK LNQQLLSKDE 2830 2840 2850 2860 2870 2880 QLLHLSSQLE DSYNQVQSFS KAMASLQNER DHLWNELEKF RKSEEGKQRS AAQPSTSPAE 2890 2900 2910 2920 2930 2940 VQSLKKAMSS LQNDRDRLLK ELKNLQQQYL QINQEITELH PLKAQLQEYQ DKTKAFQIMQ 2950 2960 2970 2980 2990 3000 EELRQENLSW QHELHQLRME KSSWEIHERR MKEQYLMAIS DKDQQLSHLQ NLIRELRSSS 3010 3020 3030 3040 3050 3060 SQTQPLKVQY QRQASPETSA SPDGSQNLVY ETELLRTQLN DSLKEIHQKE LRIQQLNSNF 3070 3080 3090 3100 3110 3120 SQLLEEKNTL SIQLCDTSQS LRENQQHYGD LLNHCAVLEK QVQELQAVSK EKGPLNIDVA 3130 3140 3150 3160 3170 3180 PGAPQEKNGV HRKSDPEELR EPQQSFSEAQ QQLCNTRQEV NELRKLLEEE RDQRVAAENA 3190 3200 3210 3220 3230 3240 LSVAEEQIRR LEHSEWDSSR TPIIGSCGTQ EQALLIDLTS NSCRRTRSGV GWKRVLRSLC 3250 3260 HSRTRVPLLA AIYFLMIHVL LILCFTGHL

References

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[1]	"Molecular genetic analyses of a 376-kilodalton Golgi complex membrane protein (giantin)." Seelig H.P., Schranz P., Schroeter H., Wiemann C., Griffiths G., Renz M. Mol. Cell. Biol. 14:2564-2576(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-1765.
[2]	"Macrogolgin -- a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections." Seelig H.P., Schranz P., Schroeter H., Wiemann C., Griffiths G., Renz M. J. Autoimmun. 7:67-91(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-1765.
[3]	"Molecular cloning and sequence analysis of a human 372-kDa protein localized in the Golgi complex." Sohda M., Misumi Y., Fujiwara T., Nishioka M., Ikehara Y. Biochem. Biophys. Res. Commun. 205:1399-1408(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method." Oshikawa M., Sugai Y., Usami R., Ohtoko K., Toyama S., Kato S. DNA Res. 15:123-136(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-911; CYS-1212 AND ASP-1765. Tissue: Retinal pigment epithelium.
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle." Ruan Q., Wang Q., Xie S., Fang Y., Darzynkiewicz Z., Guan K., Jhanwar-Uniyal M., Dai W. Exp. Cell Res. 294:51-59(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PLK3.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-17, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-138, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-348 AND GLY-944.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X75304 mRNA. Translation: CAA53052.1. D25542 mRNA. Translation: BAA05025.1. AB371588 mRNA. Translation: BAG48317.1. AC119736 Genomic DNA. No translation available. AC133750 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW79502.1. CH471052 Genomic DNA. Translation: EAW79504.1.
IPI	IPI00004671. IPI00796891.
PIR	A56539. I52300.
RefSeq	NP_001243415.1. NM_001256486.1. NP_001243416.1. NM_001256487.1. NP_001243417.1. NM_001256488.1. NP_004478.3. NM_004487.4.
UniGene	Hs.213389. Hs.741209.
3D structure databases
ProteinModelPortal	Q14789.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-34649N.
IntAct	Q14789. 14 interactions.
MINT	MINT-1182261.
STRING	9606.ENSP00000341848.
PTM databases
PhosphoSite	Q14789.
Polymorphism databases
DMDM	145559478.
Proteomic databases
PaxDb	Q14789.
PRIDE	Q14789.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340645; ENSP00000341848; ENSG00000173230. ENST00000393667; ENSP00000377275; ENSG00000173230.
GeneID	2804.
KEGG	hsa:2804.
UCSC	uc003eei.4. human.
Organism-specific databases
CTD	2804.
GeneCards	GC03M121382.
H-InvDB	HIX0017595.
HGNC	HGNC:4429. GOLGB1.
HPA	HPA011008. HPA011555.
MIM	602500. gene.
neXtProt	NX_Q14789.
PharmGKB	PA28810.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000112754.
HOVERGEN	HBG051756.
InParanoid	Q14789.
OrthoDB	EOG43R3KV.
PhylomeDB	Q14789.
Gene expression databases
ArrayExpress	Q14789.
Bgee	Q14789.
CleanEx	HS_GOLGB1.
Genevestigator	Q14789.
GermOnline	ENSG00000173230. Homo sapiens.
Family and domain databases
InterPro	IPR026202. GOLGB1. [Graphical view]
PANTHER	PTHR18887. PTHR18887. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	GOLGB1. human.
GenomeRNAi	2804.
NextBio	11053.
SOURCE	Search...

Entry information

Entry name

GOGB1_HUMAN

Accession

Primary (citable) accession number: Q14789
Secondary accession number(s): B2ZZ91 , D3DN92, E7EP74, Q14398

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.