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Q14789

- GOGB1_HUMAN

UniProt

Q14789 - GOGB1_HUMAN

Protein

Golgin subfamily B member 1

Gene

GOLGB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    May participate in forming intercisternal cross-bridges of the Golgi complex.

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. Golgi organization Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgin subfamily B member 1
    Alternative name(s):
    372 kDa Golgi complex-associated protein
    Short name:
    GCP372
    Giantin
    Macrogolgin
    Gene namesi
    Name:GOLGB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:4429. GOLGB1.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: Ensembl
    2. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
    3. Golgi apparatus Source: HPA
    4. Golgi membrane Source: ProtInc
    5. Golgi stack Source: ProtInc
    6. integral component of membrane Source: ProtInc
    7. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28810.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 32593259Golgin subfamily B member 1PRO_0000190071Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei6 – 61Phosphoserine1 Publication
    Modified residuei17 – 171Phosphoserine3 Publications
    Modified residuei138 – 1381Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiQ14789.
    PaxDbiQ14789.
    PRIDEiQ14789.

    PTM databases

    PhosphoSiteiQ14789.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14789.
    BgeeiQ14789.
    CleanExiHS_GOLGB1.
    GenevestigatoriQ14789.

    Organism-specific databases

    HPAiHPA011008.
    HPA011555.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with PLK3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PFN2P350802EBI-709973,EBI-473138

    Protein-protein interaction databases

    BioGridi109066. 15 interactions.
    DIPiDIP-34649N.
    IntActiQ14789. 23 interactions.
    MINTiMINT-1182261.
    STRINGi9606.ENSP00000341848.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14789.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 32353235CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini3257 – 32593LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3236 – 325621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili48 – 593546Sequence AnalysisAdd
    BLAST
    Coiled coili677 – 1028352Sequence AnalysisAdd
    BLAST
    Coiled coili1062 – 1245184Sequence AnalysisAdd
    BLAST
    Coiled coili1301 – 1779479Sequence AnalysisAdd
    BLAST
    Coiled coili1828 – 31851358Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2420 – 24234Poly-Glu
    Compositional biasi2993 – 29964Poly-Ser

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000112754.
    HOVERGENiHBG051756.
    InParanoidiQ14789.
    OMAiQNLMREL.
    OrthoDBiEOG7RFTGC.
    PhylomeDBiQ14789.
    TreeFamiTF325082.

    Family and domain databases

    InterProiIPR026202. GOLGB1.
    [Graphical view]
    PANTHERiPTHR18887. PTHR18887. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14789-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSRLSGLAN VVLHELSGDD DTDQNMRAPL DPELHQESDM EFNNTTQEDV     50
    QERLAYAEQL VVELKDIIRQ KDVQLQQKDE ALQEERKAAD NKIKKLKLHA 100
    KAKLTSLNKY IEEMKAQGGT VLPTEPQSEE QLSKHDKSST EEEMEIEKIK 150
    HKLQEKEELI STLQAQLTQA QAEQPAQSST EMEEFVMMKQ QLQEKEEFIS 200
    TLQAQLSQTQ AEQAAQQVVR EKDARFETQV RLHEDELLQL VTQADVETEM 250
    QQKLRVLQRK LEEHEESLVG RAQVVDLLQQ ELTAAEQRNQ ILSQQLQQME 300
    AEHNTLRNTV ETEREESKIL LEKMELEVAE RKLSFHNLQE EMHHLLEQFE 350
    QAGQAQAELE SRYSALEQKH KAEMEEKTSH ILSLQKTGQE LQSACDALKD 400
    QNSKLLQDKN EQAVQSAQTI QQLEDQLQQK SKEISQFLNR LPLQQHETAS 450
    QTSFPDVYNE GTQAVTEENI ASLQKRVVEL ENEKGALLLS SIELEELKAE 500
    NEKLSSQITL LEAQNRTGEA DREVSEISIV DIANKRSSSA EESGQDVLEN 550
    TFSQKHKELS VLLLEMKEAQ EEIAFLKLQL QGKRAEEADH EVLDQKEMKQ 600
    MEGEGIAPIK MKVFLEDTGQ DFPLMPNEES SLPAVEKEQA STEHQSRTSE 650
    EISLNDAGVE LKSTKQDGDK SLSAVPDIGQ CHQDELERLK SQILELELNF 700
    HKAQEIYEKN LDEKAKEISN LNQLIEEFKK NADNNSSAFT ALSEERDQLL 750
    SQVKELSMVT ELRAQVKQLE MNLAEAERQR RLDYESQTAH DNLLTEQIHS 800
    LSIEAKSKDV KIEVLQNELD DVQLQFSEQS TLIRSLQSQL QNKESEVLEG 850
    AERVRHISSK VEELSQALSQ KELEITKMDQ LLLEKKRDVE TLQQTIEEKD 900
    QQVTEISFSM TEKMVQLNEE KFSLGVEIKT LKEQLNLLSR AEEAKKEQVE 950
    EDNEVSSGLK QNYDEMSPAG QISKEELQHE FDLLKKENEQ RKRKLQAALI 1000
    NRKELLQRVS RLEEELANLK DESKKEIPLS ETERGEVEED KENKEYSEKC 1050
    VTSKCQEIEI YLKQTISEKE VELQHIRKDL EEKLAAEEQF QALVKQMNQT 1100
    LQDKTNQIDL LQAEISENQA IIQKLITSNT DASDGDSVAL VKETVVISPP 1150
    CTGSSEHWKP ELEEKILALE KEKEQLQKKL QEALTSRKAI LKKAQEKERH 1200
    LREELKQQKD DYNRLQEQFD EQSKENENIG DQLRQLQIQV RESIDGKLPS 1250
    TDQQESCSST PGLEEPLFKA TEQHHTQPVL ESNLCPDWPS HSEDASALQG 1300
    GTSVAQIKAQ LKEIEAEKVE LELKVSSTTS ELTKKSEEVF QLQEQINKQG 1350
    LEIESLKTVS HEAEVHAESL QQKLESSQLQ IAGLEHLREL QPKLDELQKL 1400
    ISKKEEDVSY LSGQLSEKEA ALTKIQTEII EQEDLIKALH TQLEMQAKEH 1450
    DERIKQLQVE LCEMKQKPEE IGEESRAKQQ IQRKLQAALI SRKEALKENK 1500
    SLQEELSLAR GTIERLTKSL ADVESQVSAQ NKEKDTVLGR LALLQEERDK 1550
    LITEMDRSLL ENQSLSSSCE SLKLALEGLT EDKEKLVKEI ESLKSSKIAE 1600
    STEWQEKHKE LQKEYEILLQ SYENVSNEAE RIQHVVEAVR QEKQELYGKL 1650
    RSTEANKKET EKQLQEAEQE MEEMKEKMRK FAKSKQQKIL ELEEENDRLR 1700
    AEVHPAGDTA KECMETLLSS NASMKEELER VKMEYETLSK KFQSLMSEKD 1750
    SLSEEVQDLK HQIEGNVSKQ ANLEATEKHD NQTNVTEEGT QSIPGETEEQ 1800
    DSLSMSTRPT CSESVPSAKS ANPAVSKDFS SHDEINNYLQ QIDQLKERIA 1850
    GLEEEKQKNK EFSQTLENEK NTLLSQISTK DGELKMLQEE VTKMNLLNQQ 1900
    IQEELSRVTK LKETAEEEKD DLEERLMNQL AELNGSIGNY CQDVTDAQIK 1950
    NELLESEMKN LKKCVSELEE EKQQLVKEKT KVESEIRKEY LEKIQGAQKE 2000
    PGNKSHAKEL QELLKEKQQE VKQLQKDCIR YQEKISALER TVKALEFVQT 2050
    ESQKDLEITK ENLAQAVEHR KKAQAELASF KVLLDDTQSE AARVLADNLK 2100
    LKKELQSNKE SVKSQMKQKD EDLERRLEQA EEKHLKEKKN MQEKLDALRR 2150
    EKVHLEETIG EIQVTLNKKD KEVQQLQENL DSTVTQLAAF TKSMSSLQDD 2200
    RDRVIDEAKK WERKFSDAIQ SKEEEIRLKE DNCSVLKDQL RQMSIHMEEL 2250
    KINISRLEHD KQIWESKAQT EVQLQQKVCD TLQGENKELL SQLEETRHLY 2300
    HSSQNELAKL ESELKSLKDQ LTDLSNSLEK CKEQKGNLEG IIRQQEADIQ 2350
    NSKFSYEQLE TDLQASRELT SRLHEEINMK EQKIISLLSG KEEAIQVAIA 2400
    ELRQQHDKEI KELENLLSQE EEENIVLEEE NKKAVDKTNQ LMETLKTIKK 2450
    ENIQQKAQLD SFVKSMSSLQ NDRDRIVGDY QQLEERHLSI ILEKDQLIQE 2500
    AAAENNKLKE EIRGLRSHMD DLNSENAKLD AELIQYREDL NQVITIKDSQ 2550
    QKQLLEVQLQ QNKELENKYA KLEEKLKESE EANEDLRRSF NALQEEKQDL 2600
    SKEIESLKVS ISQLTRQVTA LQEEGTLGLY HAQLKVKEEE VHRLSALFSS 2650
    SQKRIAELEE ELVCVQKEAA KKVGEIEDKL KKELKHLHHD AGIMRNETET 2700
    AEERVAELAR DLVEMEQKLL MVTKENKGLT AQIQSFGRSM SSLQNSRDHA 2750
    NEELDELKRK YDASLKELAQ LKEQGLLNRE RDALLSETAF SMNSTEENSL 2800
    SHLEKLNQQL LSKDEQLLHL SSQLEDSYNQ VQSFSKAMAS LQNERDHLWN 2850
    ELEKFRKSEE GKQRSAAQPS TSPAEVQSLK KAMSSLQNDR DRLLKELKNL 2900
    QQQYLQINQE ITELHPLKAQ LQEYQDKTKA FQIMQEELRQ ENLSWQHELH 2950
    QLRMEKSSWE IHERRMKEQY LMAISDKDQQ LSHLQNLIRE LRSSSSQTQP 3000
    LKVQYQRQAS PETSASPDGS QNLVYETELL RTQLNDSLKE IHQKELRIQQ 3050
    LNSNFSQLLE EKNTLSIQLC DTSQSLRENQ QHYGDLLNHC AVLEKQVQEL 3100
    QAGPLNIDVA PGAPQEKNGV HRKSDPEELR EPQQSFSEAQ QQLCNTRQEV 3150
    NELRKLLEEE RDQRVAAENA LSVAEEQIRR LEHSEWDSSR TPIIGSCGTQ 3200
    EQALLIDLTS NSCRRTRSGV GWKRVLRSLC HSRTRVPLLA AIYFLMIHVL 3250
    LILCFTGHL 3259
    Length:3,259
    Mass (Da):376,019
    Last modified:April 17, 2007 - v2
    Checksum:iED5D043C3A5C6432
    GO
    Isoform 2 (identifier: Q14789-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         215-215: A → AQLSSM
         3102-3102: A → AVSKEK

    Note: No experimental confirmation available.

    Show »
    Length:3,269
    Mass (Da):377,137
    Checksum:iDAF169F5D3CB6EFF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 3939Missing in BAA05025. (PubMed:7802676)CuratedAdd
    BLAST
    Sequence conflicti215 – 2151A → AQLSSM in BAA05025. (PubMed:7802676)Curated
    Sequence conflicti2950 – 29501H → D in BAA05025. (PubMed:7802676)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti348 – 3481Q → H in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036096
    Natural varianti911 – 9111T → S.1 Publication
    Corresponds to variant rs3732407 [ dbSNP | Ensembl ].
    VAR_020155
    Natural varianti944 – 9441A → G in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036097
    Natural varianti1212 – 12121Y → C.1 Publication
    Corresponds to variant rs3732410 [ dbSNP | Ensembl ].
    VAR_020156
    Natural varianti1249 – 12491P → S.
    Corresponds to variant rs33988592 [ dbSNP | Ensembl ].
    VAR_031671
    Natural varianti1713 – 17131C → F.
    Corresponds to variant rs35674179 [ dbSNP | Ensembl ].
    VAR_031672
    Natural varianti1765 – 17651G → D.3 Publications
    Corresponds to variant rs1127412 [ dbSNP | Ensembl ].
    VAR_031673

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei215 – 2151A → AQLSSM in isoform 2. 1 PublicationVSP_045567
    Alternative sequencei3102 – 31021A → AVSKEK in isoform 2. 1 PublicationVSP_045568

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75304 mRNA. Translation: CAA53052.1.
    D25542 mRNA. Translation: BAA05025.1.
    AB371588 mRNA. Translation: BAG48317.1.
    AC119736 Genomic DNA. No translation available.
    AC133750 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79502.1.
    CH471052 Genomic DNA. Translation: EAW79504.1.
    CCDSiCCDS3004.1. [Q14789-1]
    CCDS58847.1. [Q14789-2]
    PIRiA56539.
    I52300.
    RefSeqiNP_001243415.1. NM_001256486.1. [Q14789-2]
    NP_001243416.1. NM_001256487.1.
    NP_001243417.1. NM_001256488.1.
    NP_004478.3. NM_004487.4. [Q14789-1]
    XP_005247428.1. XM_005247371.2. [Q14789-2]
    UniGeneiHs.213389.
    Hs.741209.

    Genome annotation databases

    EnsembliENST00000340645; ENSP00000341848; ENSG00000173230. [Q14789-1]
    ENST00000393667; ENSP00000377275; ENSG00000173230. [Q14789-2]
    GeneIDi2804.
    KEGGihsa:2804.
    UCSCiuc003eei.5. human. [Q14789-1]

    Polymorphism databases

    DMDMi145559478.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75304 mRNA. Translation: CAA53052.1 .
    D25542 mRNA. Translation: BAA05025.1 .
    AB371588 mRNA. Translation: BAG48317.1 .
    AC119736 Genomic DNA. No translation available.
    AC133750 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79502.1 .
    CH471052 Genomic DNA. Translation: EAW79504.1 .
    CCDSi CCDS3004.1. [Q14789-1 ]
    CCDS58847.1. [Q14789-2 ]
    PIRi A56539.
    I52300.
    RefSeqi NP_001243415.1. NM_001256486.1. [Q14789-2 ]
    NP_001243416.1. NM_001256487.1.
    NP_001243417.1. NM_001256488.1.
    NP_004478.3. NM_004487.4. [Q14789-1 ]
    XP_005247428.1. XM_005247371.2. [Q14789-2 ]
    UniGenei Hs.213389.
    Hs.741209.

    3D structure databases

    ProteinModelPortali Q14789.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109066. 15 interactions.
    DIPi DIP-34649N.
    IntActi Q14789. 23 interactions.
    MINTi MINT-1182261.
    STRINGi 9606.ENSP00000341848.

    PTM databases

    PhosphoSitei Q14789.

    Polymorphism databases

    DMDMi 145559478.

    Proteomic databases

    MaxQBi Q14789.
    PaxDbi Q14789.
    PRIDEi Q14789.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340645 ; ENSP00000341848 ; ENSG00000173230 . [Q14789-1 ]
    ENST00000393667 ; ENSP00000377275 ; ENSG00000173230 . [Q14789-2 ]
    GeneIDi 2804.
    KEGGi hsa:2804.
    UCSCi uc003eei.5. human. [Q14789-1 ]

    Organism-specific databases

    CTDi 2804.
    GeneCardsi GC03M121382.
    H-InvDB HIX0017595.
    HGNCi HGNC:4429. GOLGB1.
    HPAi HPA011008.
    HPA011555.
    MIMi 602500. gene.
    neXtProti NX_Q14789.
    PharmGKBi PA28810.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000112754.
    HOVERGENi HBG051756.
    InParanoidi Q14789.
    OMAi QNLMREL.
    OrthoDBi EOG7RFTGC.
    PhylomeDBi Q14789.
    TreeFami TF325082.

    Miscellaneous databases

    ChiTaRSi GOLGB1. human.
    GeneWikii GOLGB1.
    GenomeRNAii 2804.
    NextBioi 11053.
    PROi Q14789.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14789.
    Bgeei Q14789.
    CleanExi HS_GOLGB1.
    Genevestigatori Q14789.

    Family and domain databases

    InterProi IPR026202. GOLGB1.
    [Graphical view ]
    PANTHERi PTHR18887. PTHR18887. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic analyses of a 376-kilodalton Golgi complex membrane protein (giantin)."
      Seelig H.P., Schranz P., Schroeter H., Wiemann C., Griffiths G., Renz M.
      Mol. Cell. Biol. 14:2564-2576(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-1765.
    2. "Macrogolgin -- a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections."
      Seelig H.P., Schranz P., Schroeter H., Wiemann C., Griffiths G., Renz M.
      J. Autoimmun. 7:67-91(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-1765.
    3. "Molecular cloning and sequence analysis of a human 372-kDa protein localized in the Golgi complex."
      Sohda M., Misumi Y., Fujiwara T., Nishioka M., Ikehara Y.
      Biochem. Biophys. Res. Commun. 205:1399-1408(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method."
      Oshikawa M., Sugai Y., Usami R., Ohtoko K., Toyama S., Kato S.
      DNA Res. 15:123-136(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-911; CYS-1212 AND ASP-1765.
      Tissue: Retinal pigment epithelium.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle."
      Ruan Q., Wang Q., Xie S., Fang Y., Darzynkiewicz Z., Guan K., Jhanwar-Uniyal M., Dai W.
      Exp. Cell Res. 294:51-59(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLK3.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-348 AND GLY-944.

    Entry informationi

    Entry nameiGOGB1_HUMAN
    AccessioniPrimary (citable) accession number: Q14789
    Secondary accession number(s): B2ZZ91
    , D3DN92, E7EP74, Q14398
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3