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Q14789

- GOGB1_HUMAN

UniProt

Q14789 - GOGB1_HUMAN

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Protein

Golgin subfamily B member 1

Gene

GOLGB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May participate in forming intercisternal cross-bridges of the Golgi complex.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. Golgi organization Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily B member 1
Alternative name(s):
372 kDa Golgi complex-associated protein
Short name:
GCP372
Giantin
Macrogolgin
Gene namesi
Name:GOLGB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:4429. GOLGB1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 32353235CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei3236 – 325621HelicalSequence AnalysisAdd
BLAST
Topological domaini3257 – 32593LumenalSequence Analysis

GO - Cellular componenti

  1. cis-Golgi network Source: Ensembl
  2. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
  3. Golgi apparatus Source: HPA
  4. Golgi membrane Source: ProtInc
  5. Golgi stack Source: ProtInc
  6. integral component of membrane Source: ProtInc
  7. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 32593259Golgin subfamily B member 1PRO_0000190071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61Phosphoserine1 Publication
Modified residuei17 – 171Phosphoserine3 Publications
Modified residuei138 – 1381Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ14789.
PaxDbiQ14789.
PRIDEiQ14789.

PTM databases

PhosphoSiteiQ14789.

Expressioni

Gene expression databases

BgeeiQ14789.
CleanExiHS_GOLGB1.
ExpressionAtlasiQ14789. baseline and differential.
GenevestigatoriQ14789.

Organism-specific databases

HPAiHPA011008.
HPA011555.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PLK3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PFN2P350802EBI-709973,EBI-473138

Protein-protein interaction databases

BioGridi109066. 20 interactions.
DIPiDIP-34649N.
IntActiQ14789. 23 interactions.
MINTiMINT-1182261.
STRINGi9606.ENSP00000341848.

Structurei

3D structure databases

ProteinModelPortaliQ14789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili48 – 593546Sequence AnalysisAdd
BLAST
Coiled coili677 – 1028352Sequence AnalysisAdd
BLAST
Coiled coili1062 – 1245184Sequence AnalysisAdd
BLAST
Coiled coili1301 – 1779479Sequence AnalysisAdd
BLAST
Coiled coili1828 – 31851358Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2420 – 24234Poly-Glu
Compositional biasi2993 – 29964Poly-Ser

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111007.
HOGENOMiHOG000112754.
HOVERGENiHBG051756.
InParanoidiQ14789.
OMAiQNLMREL.
OrthoDBiEOG7RFTGC.
PhylomeDBiQ14789.
TreeFamiTF325082.

Family and domain databases

InterProiIPR026202. GOLGB1.
[Graphical view]
PANTHERiPTHR18887. PTHR18887. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14789-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRLSGLAN VVLHELSGDD DTDQNMRAPL DPELHQESDM EFNNTTQEDV
60 70 80 90 100
QERLAYAEQL VVELKDIIRQ KDVQLQQKDE ALQEERKAAD NKIKKLKLHA
110 120 130 140 150
KAKLTSLNKY IEEMKAQGGT VLPTEPQSEE QLSKHDKSST EEEMEIEKIK
160 170 180 190 200
HKLQEKEELI STLQAQLTQA QAEQPAQSST EMEEFVMMKQ QLQEKEEFIS
210 220 230 240 250
TLQAQLSQTQ AEQAAQQVVR EKDARFETQV RLHEDELLQL VTQADVETEM
260 270 280 290 300
QQKLRVLQRK LEEHEESLVG RAQVVDLLQQ ELTAAEQRNQ ILSQQLQQME
310 320 330 340 350
AEHNTLRNTV ETEREESKIL LEKMELEVAE RKLSFHNLQE EMHHLLEQFE
360 370 380 390 400
QAGQAQAELE SRYSALEQKH KAEMEEKTSH ILSLQKTGQE LQSACDALKD
410 420 430 440 450
QNSKLLQDKN EQAVQSAQTI QQLEDQLQQK SKEISQFLNR LPLQQHETAS
460 470 480 490 500
QTSFPDVYNE GTQAVTEENI ASLQKRVVEL ENEKGALLLS SIELEELKAE
510 520 530 540 550
NEKLSSQITL LEAQNRTGEA DREVSEISIV DIANKRSSSA EESGQDVLEN
560 570 580 590 600
TFSQKHKELS VLLLEMKEAQ EEIAFLKLQL QGKRAEEADH EVLDQKEMKQ
610 620 630 640 650
MEGEGIAPIK MKVFLEDTGQ DFPLMPNEES SLPAVEKEQA STEHQSRTSE
660 670 680 690 700
EISLNDAGVE LKSTKQDGDK SLSAVPDIGQ CHQDELERLK SQILELELNF
710 720 730 740 750
HKAQEIYEKN LDEKAKEISN LNQLIEEFKK NADNNSSAFT ALSEERDQLL
760 770 780 790 800
SQVKELSMVT ELRAQVKQLE MNLAEAERQR RLDYESQTAH DNLLTEQIHS
810 820 830 840 850
LSIEAKSKDV KIEVLQNELD DVQLQFSEQS TLIRSLQSQL QNKESEVLEG
860 870 880 890 900
AERVRHISSK VEELSQALSQ KELEITKMDQ LLLEKKRDVE TLQQTIEEKD
910 920 930 940 950
QQVTEISFSM TEKMVQLNEE KFSLGVEIKT LKEQLNLLSR AEEAKKEQVE
960 970 980 990 1000
EDNEVSSGLK QNYDEMSPAG QISKEELQHE FDLLKKENEQ RKRKLQAALI
1010 1020 1030 1040 1050
NRKELLQRVS RLEEELANLK DESKKEIPLS ETERGEVEED KENKEYSEKC
1060 1070 1080 1090 1100
VTSKCQEIEI YLKQTISEKE VELQHIRKDL EEKLAAEEQF QALVKQMNQT
1110 1120 1130 1140 1150
LQDKTNQIDL LQAEISENQA IIQKLITSNT DASDGDSVAL VKETVVISPP
1160 1170 1180 1190 1200
CTGSSEHWKP ELEEKILALE KEKEQLQKKL QEALTSRKAI LKKAQEKERH
1210 1220 1230 1240 1250
LREELKQQKD DYNRLQEQFD EQSKENENIG DQLRQLQIQV RESIDGKLPS
1260 1270 1280 1290 1300
TDQQESCSST PGLEEPLFKA TEQHHTQPVL ESNLCPDWPS HSEDASALQG
1310 1320 1330 1340 1350
GTSVAQIKAQ LKEIEAEKVE LELKVSSTTS ELTKKSEEVF QLQEQINKQG
1360 1370 1380 1390 1400
LEIESLKTVS HEAEVHAESL QQKLESSQLQ IAGLEHLREL QPKLDELQKL
1410 1420 1430 1440 1450
ISKKEEDVSY LSGQLSEKEA ALTKIQTEII EQEDLIKALH TQLEMQAKEH
1460 1470 1480 1490 1500
DERIKQLQVE LCEMKQKPEE IGEESRAKQQ IQRKLQAALI SRKEALKENK
1510 1520 1530 1540 1550
SLQEELSLAR GTIERLTKSL ADVESQVSAQ NKEKDTVLGR LALLQEERDK
1560 1570 1580 1590 1600
LITEMDRSLL ENQSLSSSCE SLKLALEGLT EDKEKLVKEI ESLKSSKIAE
1610 1620 1630 1640 1650
STEWQEKHKE LQKEYEILLQ SYENVSNEAE RIQHVVEAVR QEKQELYGKL
1660 1670 1680 1690 1700
RSTEANKKET EKQLQEAEQE MEEMKEKMRK FAKSKQQKIL ELEEENDRLR
1710 1720 1730 1740 1750
AEVHPAGDTA KECMETLLSS NASMKEELER VKMEYETLSK KFQSLMSEKD
1760 1770 1780 1790 1800
SLSEEVQDLK HQIEGNVSKQ ANLEATEKHD NQTNVTEEGT QSIPGETEEQ
1810 1820 1830 1840 1850
DSLSMSTRPT CSESVPSAKS ANPAVSKDFS SHDEINNYLQ QIDQLKERIA
1860 1870 1880 1890 1900
GLEEEKQKNK EFSQTLENEK NTLLSQISTK DGELKMLQEE VTKMNLLNQQ
1910 1920 1930 1940 1950
IQEELSRVTK LKETAEEEKD DLEERLMNQL AELNGSIGNY CQDVTDAQIK
1960 1970 1980 1990 2000
NELLESEMKN LKKCVSELEE EKQQLVKEKT KVESEIRKEY LEKIQGAQKE
2010 2020 2030 2040 2050
PGNKSHAKEL QELLKEKQQE VKQLQKDCIR YQEKISALER TVKALEFVQT
2060 2070 2080 2090 2100
ESQKDLEITK ENLAQAVEHR KKAQAELASF KVLLDDTQSE AARVLADNLK
2110 2120 2130 2140 2150
LKKELQSNKE SVKSQMKQKD EDLERRLEQA EEKHLKEKKN MQEKLDALRR
2160 2170 2180 2190 2200
EKVHLEETIG EIQVTLNKKD KEVQQLQENL DSTVTQLAAF TKSMSSLQDD
2210 2220 2230 2240 2250
RDRVIDEAKK WERKFSDAIQ SKEEEIRLKE DNCSVLKDQL RQMSIHMEEL
2260 2270 2280 2290 2300
KINISRLEHD KQIWESKAQT EVQLQQKVCD TLQGENKELL SQLEETRHLY
2310 2320 2330 2340 2350
HSSQNELAKL ESELKSLKDQ LTDLSNSLEK CKEQKGNLEG IIRQQEADIQ
2360 2370 2380 2390 2400
NSKFSYEQLE TDLQASRELT SRLHEEINMK EQKIISLLSG KEEAIQVAIA
2410 2420 2430 2440 2450
ELRQQHDKEI KELENLLSQE EEENIVLEEE NKKAVDKTNQ LMETLKTIKK
2460 2470 2480 2490 2500
ENIQQKAQLD SFVKSMSSLQ NDRDRIVGDY QQLEERHLSI ILEKDQLIQE
2510 2520 2530 2540 2550
AAAENNKLKE EIRGLRSHMD DLNSENAKLD AELIQYREDL NQVITIKDSQ
2560 2570 2580 2590 2600
QKQLLEVQLQ QNKELENKYA KLEEKLKESE EANEDLRRSF NALQEEKQDL
2610 2620 2630 2640 2650
SKEIESLKVS ISQLTRQVTA LQEEGTLGLY HAQLKVKEEE VHRLSALFSS
2660 2670 2680 2690 2700
SQKRIAELEE ELVCVQKEAA KKVGEIEDKL KKELKHLHHD AGIMRNETET
2710 2720 2730 2740 2750
AEERVAELAR DLVEMEQKLL MVTKENKGLT AQIQSFGRSM SSLQNSRDHA
2760 2770 2780 2790 2800
NEELDELKRK YDASLKELAQ LKEQGLLNRE RDALLSETAF SMNSTEENSL
2810 2820 2830 2840 2850
SHLEKLNQQL LSKDEQLLHL SSQLEDSYNQ VQSFSKAMAS LQNERDHLWN
2860 2870 2880 2890 2900
ELEKFRKSEE GKQRSAAQPS TSPAEVQSLK KAMSSLQNDR DRLLKELKNL
2910 2920 2930 2940 2950
QQQYLQINQE ITELHPLKAQ LQEYQDKTKA FQIMQEELRQ ENLSWQHELH
2960 2970 2980 2990 3000
QLRMEKSSWE IHERRMKEQY LMAISDKDQQ LSHLQNLIRE LRSSSSQTQP
3010 3020 3030 3040 3050
LKVQYQRQAS PETSASPDGS QNLVYETELL RTQLNDSLKE IHQKELRIQQ
3060 3070 3080 3090 3100
LNSNFSQLLE EKNTLSIQLC DTSQSLRENQ QHYGDLLNHC AVLEKQVQEL
3110 3120 3130 3140 3150
QAGPLNIDVA PGAPQEKNGV HRKSDPEELR EPQQSFSEAQ QQLCNTRQEV
3160 3170 3180 3190 3200
NELRKLLEEE RDQRVAAENA LSVAEEQIRR LEHSEWDSSR TPIIGSCGTQ
3210 3220 3230 3240 3250
EQALLIDLTS NSCRRTRSGV GWKRVLRSLC HSRTRVPLLA AIYFLMIHVL

LILCFTGHL
Length:3,259
Mass (Da):376,019
Last modified:April 17, 2007 - v2
Checksum:iED5D043C3A5C6432
GO
Isoform 2 (identifier: Q14789-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-215: A → AQLSSM
     3102-3102: A → AVSKEK

Note: No experimental confirmation available.

Show »
Length:3,269
Mass (Da):377,137
Checksum:iDAF169F5D3CB6EFF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 3939Missing in BAA05025. (PubMed:7802676)CuratedAdd
BLAST
Sequence conflicti215 – 2151A → AQLSSM in BAA05025. (PubMed:7802676)Curated
Sequence conflicti2950 – 29501H → D in BAA05025. (PubMed:7802676)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti348 – 3481Q → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_036096
Natural varianti911 – 9111T → S.1 Publication
Corresponds to variant rs3732407 [ dbSNP | Ensembl ].
VAR_020155
Natural varianti944 – 9441A → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_036097
Natural varianti1212 – 12121Y → C.1 Publication
Corresponds to variant rs3732410 [ dbSNP | Ensembl ].
VAR_020156
Natural varianti1249 – 12491P → S.
Corresponds to variant rs33988592 [ dbSNP | Ensembl ].
VAR_031671
Natural varianti1713 – 17131C → F.
Corresponds to variant rs35674179 [ dbSNP | Ensembl ].
VAR_031672
Natural varianti1765 – 17651G → D.3 Publications
Corresponds to variant rs1127412 [ dbSNP | Ensembl ].
VAR_031673

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei215 – 2151A → AQLSSM in isoform 2. 1 PublicationVSP_045567
Alternative sequencei3102 – 31021A → AVSKEK in isoform 2. 1 PublicationVSP_045568

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75304 mRNA. Translation: CAA53052.1.
D25542 mRNA. Translation: BAA05025.1.
AB371588 mRNA. Translation: BAG48317.1.
AC119736 Genomic DNA. No translation available.
AC133750 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79502.1.
CH471052 Genomic DNA. Translation: EAW79504.1.
CCDSiCCDS3004.1. [Q14789-1]
CCDS58847.1. [Q14789-2]
PIRiA56539.
I52300.
RefSeqiNP_001243415.1. NM_001256486.1. [Q14789-2]
NP_001243416.1. NM_001256487.1.
NP_001243417.1. NM_001256488.1.
NP_004478.3. NM_004487.4. [Q14789-1]
XP_005247428.1. XM_005247371.2. [Q14789-2]
UniGeneiHs.213389.
Hs.741209.

Genome annotation databases

EnsembliENST00000340645; ENSP00000341848; ENSG00000173230. [Q14789-1]
ENST00000393667; ENSP00000377275; ENSG00000173230. [Q14789-2]
GeneIDi2804.
KEGGihsa:2804.
UCSCiuc003eei.5. human. [Q14789-1]

Polymorphism databases

DMDMi145559478.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75304 mRNA. Translation: CAA53052.1 .
D25542 mRNA. Translation: BAA05025.1 .
AB371588 mRNA. Translation: BAG48317.1 .
AC119736 Genomic DNA. No translation available.
AC133750 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79502.1 .
CH471052 Genomic DNA. Translation: EAW79504.1 .
CCDSi CCDS3004.1. [Q14789-1 ]
CCDS58847.1. [Q14789-2 ]
PIRi A56539.
I52300.
RefSeqi NP_001243415.1. NM_001256486.1. [Q14789-2 ]
NP_001243416.1. NM_001256487.1.
NP_001243417.1. NM_001256488.1.
NP_004478.3. NM_004487.4. [Q14789-1 ]
XP_005247428.1. XM_005247371.2. [Q14789-2 ]
UniGenei Hs.213389.
Hs.741209.

3D structure databases

ProteinModelPortali Q14789.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109066. 20 interactions.
DIPi DIP-34649N.
IntActi Q14789. 23 interactions.
MINTi MINT-1182261.
STRINGi 9606.ENSP00000341848.

PTM databases

PhosphoSitei Q14789.

Polymorphism databases

DMDMi 145559478.

Proteomic databases

MaxQBi Q14789.
PaxDbi Q14789.
PRIDEi Q14789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340645 ; ENSP00000341848 ; ENSG00000173230 . [Q14789-1 ]
ENST00000393667 ; ENSP00000377275 ; ENSG00000173230 . [Q14789-2 ]
GeneIDi 2804.
KEGGi hsa:2804.
UCSCi uc003eei.5. human. [Q14789-1 ]

Organism-specific databases

CTDi 2804.
GeneCardsi GC03M121382.
H-InvDB HIX0017595.
HGNCi HGNC:4429. GOLGB1.
HPAi HPA011008.
HPA011555.
MIMi 602500. gene.
neXtProti NX_Q14789.
PharmGKBi PA28810.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000111007.
HOGENOMi HOG000112754.
HOVERGENi HBG051756.
InParanoidi Q14789.
OMAi QNLMREL.
OrthoDBi EOG7RFTGC.
PhylomeDBi Q14789.
TreeFami TF325082.

Miscellaneous databases

ChiTaRSi GOLGB1. human.
GeneWikii GOLGB1.
GenomeRNAii 2804.
NextBioi 11053.
PROi Q14789.
SOURCEi Search...

Gene expression databases

Bgeei Q14789.
CleanExi HS_GOLGB1.
ExpressionAtlasi Q14789. baseline and differential.
Genevestigatori Q14789.

Family and domain databases

InterProi IPR026202. GOLGB1.
[Graphical view ]
PANTHERi PTHR18887. PTHR18887. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular genetic analyses of a 376-kilodalton Golgi complex membrane protein (giantin)."
    Seelig H.P., Schranz P., Schroeter H., Wiemann C., Griffiths G., Renz M.
    Mol. Cell. Biol. 14:2564-2576(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-1765.
  2. "Macrogolgin -- a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections."
    Seelig H.P., Schranz P., Schroeter H., Wiemann C., Griffiths G., Renz M.
    J. Autoimmun. 7:67-91(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-1765.
  3. "Molecular cloning and sequence analysis of a human 372-kDa protein localized in the Golgi complex."
    Sohda M., Misumi Y., Fujiwara T., Nishioka M., Ikehara Y.
    Biochem. Biophys. Res. Commun. 205:1399-1408(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method."
    Oshikawa M., Sugai Y., Usami R., Ohtoko K., Toyama S., Kato S.
    DNA Res. 15:123-136(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-911; CYS-1212 AND ASP-1765.
    Tissue: Retinal pigment epithelium.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle."
    Ruan Q., Wang Q., Xie S., Fang Y., Darzynkiewicz Z., Guan K., Jhanwar-Uniyal M., Dai W.
    Exp. Cell Res. 294:51-59(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLK3.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-348 AND GLY-944.

Entry informationi

Entry nameiGOGB1_HUMAN
AccessioniPrimary (citable) accession number: Q14789
Secondary accession number(s): B2ZZ91
, D3DN92, E7EP74, Q14398
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3