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Reviewed, UniProtKB/Swiss-Prot Q14773 (ICAM4_HUMAN)

Last modified January 19, 2010. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Intercellular adhesion molecule 4
      Short name=ICAM-4
Alternative name(s):
    Landsteiner-Wiener blood group glycoprotein
      Short name=LW blood group protein
    CD_antigen=CD242
Gene names
Name: ICAM4
Synonyms: LW
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. Ref.6

Subcellular location

Isoform Long: Cell membrane; Single-pass type I membrane protein.

Isoform Short: Secreted.

Tissue specificity

Erythrocytes.

Post-translational modification

N- and O-glycosylated.

Polymorphism

Responsible for the Landsteiner-Wiener blood group system. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B).

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
   Molecular functionBlood group antigen
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell-cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Traceable author statement. Source: ProtInc

plasma membrane

Inferred from Experiment. Source: Reactome

   Molecular functionintegrin binding

Traceable author statement. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q14773-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q14773-2)

The sequence of this isoform differs from the canonical sequence as follows:
     233-271: AWSPAPTALASGSIAALVGILLTVGAAYLCKCLAMKSQA → GEAPL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 271249Intercellular adhesion molecule 4
PRO_0000014796

Regions

Topological domain23 – 240218Extracellular Potential
Transmembrane241 – 26121 Potential
Topological domain262 – 27110Cytoplasmic Potential
Domain62 – 12463Ig-like C2-type 1
Domain146 – 21772Ig-like C2-type 2

Amino acid modifications

Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Disulfide bond69 ↔ 117 By similarity
Disulfide bond153 ↔ 210 By similarity

Natural variations

Alternative sequence233 – 27139AWSPA…MKSQA → GEAPL in isoform Short.
VSP_002519
Natural variant1001Q → R in LW(B). Ref.5
VAR_003912
Natural variant2081V → L
VAR_038721

Experimental info

Sequence conflict14 – 2916AAAYP…GRRTK → RPPTRELGARWDAGL in AAA59538. Ref.1
Sequence conflict14 – 2916AAAYP…GRRTK → RPPTRELGARWDAGL in AAA59537. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 2F6BC8BABD79E615

FASTA27129,265
        10         20         30         40         50         60 
MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ 

        70         80         90        100        110        120 
PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK 

       130        140        150        160        170        180 
TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL 

       190        200        210        220        230        240 
ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSPAPTA 

       250        260        270 
LASGSIAALV GILLTVGAAY LCKCLAMKSQ A 

« Hide

Isoform Short.

Checksum: F74416D3FB52ADB2
Show »

FASTA23725,931

References

« Hide 'large scale' references
[1]"The LW blood group glycoprotein is homologous to intercellular adhesion molecules."
Bailly P., Hermand P., Callebaut I., Sonneborn H.H., Khamlichi S., Mornon J.-P., Cartron J.-P.
Proc. Natl. Acad. Sci. U.S.A. 91:5306-5310(1994) [PubMed: 8202485] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
[2]"Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes."
Hermand P., le Pennec P.Y., Rouger P., Cartron J.-P., Bailly P.
Blood 87:2962-2967(1996) [PubMed: 8639917] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG).
[3]SeattleSNPs variation discovery resource
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-208.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
Tissue: Lung.
[5]"Molecular basis and expression of the LWa/LWb blood group polymorphism."
Hermand P., Gane P., Mattei M.-G., Sistonen P., Cartron J.-P., Bailly P.
Blood 86:1590-1594(1995) [PubMed: 7632968] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-130, VARIANT BLOOD GROUP LW(B) ARG-100.
[6]"Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms."
Spring F.A., Parsons S.F., Ortlepp S., Olsson M.L., Sessions R., Brady R.L., Anstee D.J.
Blood 98:458-466(2001) [PubMed: 11435317] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L27671 mRNA. Translation: AAA59538.1.
L27670 mRNA. Translation: AAA59537.1.
X93093 Genomic DNA. Translation: CAA63646.1.
DQ011692 Genomic DNA. Translation: AAY16986.1.
BC029364 mRNA. Translation: AAH29364.1.
S78852 mRNA. Translation: AAB35046.1.
IPIIPI00000118.
IPI00396335.
PIRI52612.
I59300.
I80159.
RefSeqNP_001034221.1.
NP_001535.1.
NP_071772.1.
UniGeneHs.706750

3D structure databases

SMRQ14773. Positions 47-132.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ14773.

Proteomic databases

PRIDEQ14773.

Genome annotation databases

EnsemblENST00000380770; ENSP00000370147; ENSG00000105371; Homo sapiens. [Genome view]
GeneID3386.
KEGGhsa:3386.
UCSCuc002mns.1. human.
uc002mnt.1. human.

Organism-specific databases

CTD3386.
GeneCardsGC19P010258.
H-InvDBHIX0014739.
HGNCHGNC:5347. ICAM4.
MIM111250. gene+phenotype.
PharmGKBPA29595.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20381.
HOVERGENQ14773.
OMAVIYSESL.
PhylomeDBQ14773.

Enzyme and pathway databases

ReactomeREACT_13552. Integrin cell surface interactions.
REACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpressQ14773.
BgeeQ14773.
CleanExHS_ICAM4.
GenevestigatorQ14773.
GermOnlineENSG00000105371. Homo sapiens.

Family and domain databases

InterProIPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 2 hits.
PfamPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSPR01472. ICAMVCAM1.
PROSITEPS50835. IG_LIKE. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio13396.
SOURCESearch...

Entry information

Entry nameICAM4_HUMAN
AccessionPrimary (citable) accession number: Q14773
Secondary accession number(s): A0M8X2 expand/collapse secondary AC list , Q14771, Q14772, Q16375
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 19, 2010
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Blood group antigen proteins

Nomenclature of blood group antigens and list of entries

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents