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Protein

Latent-transforming growth factor beta-binding protein 1

Gene

LTBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • microfibril binding Source: AgBase
  • transforming growth factor beta-activated receptor activity Source: UniProtKB
  • transforming growth factor beta binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049323-MONOMER.
ReactomeiR-HSA-2129379. Molecules associated with elastic fibres.
SIGNORiQ14766.

Names & Taxonomyi

Protein namesi
Recommended name:
Latent-transforming growth factor beta-binding protein 1
Short name:
LTBP-1
Alternative name(s):
Transforming growth factor beta-1-binding protein 1
Short name:
TGF-beta1-BP-1
Gene namesi
Name:LTBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6714. LTBP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: UniProtKB
  • extracellular region Source: Reactome
  • microfibril Source: AgBase
  • proteinaceous extracellular matrix Source: UniProtKB
  • protein complex Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1385 – 1388EIFP → DL: Loss of binding to TGFB1. 1 Publication4

Organism-specific databases

DisGeNETi4052.
OpenTargetsiENSG00000049323.
PharmGKBiPA30477.

Polymorphism and mutation databases

BioMutaiLTBP1.
DMDMi290457687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000763524 – 1721Latent-transforming growth factor beta-binding protein 1Add BLAST1698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 201PROSITE-ProRule annotation
Disulfide bondi195 ↔ 207PROSITE-ProRule annotation
Disulfide bondi209 ↔ 218PROSITE-ProRule annotation
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi378N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi403 ↔ 413PROSITE-ProRule annotation
Disulfide bondi407 ↔ 419PROSITE-ProRule annotation
Disulfide bondi421 ↔ 430PROSITE-ProRule annotation
Glycosylationi424N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi559 ↔ 581PROSITE-ProRule annotation
Disulfide bondi568 ↔ 594PROSITE-ProRule annotation
Disulfide bondi582 ↔ 597PROSITE-ProRule annotation
Glycosylationi620N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi630 ↔ 641PROSITE-ProRule annotation
Disulfide bondi636 ↔ 650PROSITE-ProRule annotation
Disulfide bondi652 ↔ 665PROSITE-ProRule annotation
Disulfide bondi679 ↔ 702PROSITE-ProRule annotation
Disulfide bondi689 ↔ 714PROSITE-ProRule annotation
Disulfide bondi703 ↔ 717PROSITE-ProRule annotation
Disulfide bondi704 ↔ 729PROSITE-ProRule annotation
Disulfide bondi877 ↔ 889PROSITE-ProRule annotation
Disulfide bondi884 ↔ 898PROSITE-ProRule annotation
Disulfide bondi900 ↔ 913PROSITE-ProRule annotation
Disulfide bondi919 ↔ 931PROSITE-ProRule annotation
Disulfide bondi926 ↔ 940PROSITE-ProRule annotation
Disulfide bondi942 ↔ 955PROSITE-ProRule annotation
Disulfide bondi961 ↔ 972PROSITE-ProRule annotation
Disulfide bondi967 ↔ 981PROSITE-ProRule annotation
Modified residuei974(3R)-3-hydroxyasparagine1 Publication1
Disulfide bondi984 ↔ 996PROSITE-ProRule annotation
Disulfide bondi1002 ↔ 1013PROSITE-ProRule annotation
Disulfide bondi1008 ↔ 1022PROSITE-ProRule annotation
Disulfide bondi1025 ↔ 1036PROSITE-ProRule annotation
Disulfide bondi1042 ↔ 1053PROSITE-ProRule annotation
Disulfide bondi1048 ↔ 1062PROSITE-ProRule annotation
Disulfide bondi1064 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1083 ↔ 1094PROSITE-ProRule annotation
Disulfide bondi1089 ↔ 1103PROSITE-ProRule annotation
Disulfide bondi1105 ↔ 1118PROSITE-ProRule annotation
Disulfide bondi1124 ↔ 1135PROSITE-ProRule annotation
Disulfide bondi1130 ↔ 1144PROSITE-ProRule annotation
Modified residuei1137(3R)-3-hydroxyasparagine1 Publication1
Disulfide bondi1146 ↔ 1159PROSITE-ProRule annotation
Disulfide bondi1165 ↔ 1177PROSITE-ProRule annotation
Disulfide bondi1172 ↔ 1186PROSITE-ProRule annotation
Disulfide bondi1188 ↔ 1200PROSITE-ProRule annotation
Glycosylationi1197N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1206 ↔ 1218PROSITE-ProRule annotation
Disulfide bondi1212 ↔ 1227PROSITE-ProRule annotation
Disulfide bondi1229 ↔ 1242PROSITE-ProRule annotation
Disulfide bondi1248 ↔ 1260PROSITE-ProRule annotation
Glycosylationi1250N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1254 ↔ 1269PROSITE-ProRule annotation
Disulfide bondi1349 ↔ 1372PROSITE-ProRule annotation1 Publication
Disulfide bondi1359 ↔ 1384PROSITE-ProRule annotation1 Publication
Disulfide bondi1359Interchain (with C-33 in TGFB1); in linked formPROSITE-ProRule annotation
GlycosylationiCAR_0001841366N-linked (GlcNAc...)1 Publication1
Disulfide bondi1373 ↔ 1389PROSITE-ProRule annotation1 Publication
Disulfide bondi1374 ↔ 1401PROSITE-ProRule annotation1 Publication
Disulfide bondi1384Interchain (with C-33 in TGFB1); in linked formPROSITE-ProRule annotation
Modified residuei1414Phosphoserine; by FAM20C1 Publication1
Disulfide bondi1471 ↔ 1482PROSITE-ProRule annotation
Disulfide bondi1477 ↔ 1491PROSITE-ProRule annotation
Disulfide bondi1526 ↔ 1550PROSITE-ProRule annotation
Disulfide bondi1536 ↔ 1562PROSITE-ProRule annotation
Disulfide bondi1551 ↔ 1565PROSITE-ProRule annotation
Disulfide bondi1552 ↔ 1577PROSITE-ProRule annotation
Modified residuei1597PhosphoserineCombined sources1
Modified residuei1616PhosphoserineBy similarity1
Disulfide bondi1625 ↔ 1636PROSITE-ProRule annotation
Disulfide bondi1631 ↔ 1645PROSITE-ProRule annotation
Disulfide bondi1666 ↔ 1681PROSITE-ProRule annotation
Disulfide bondi1676 ↔ 1690PROSITE-ProRule annotation
Disulfide bondi1692 ↔ 1705PROSITE-ProRule annotation

Post-translational modificationi

Contains hydroxylated asparagine residues.1 Publication
Isoform Short N-terminus is blocked.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity
Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

EPDiQ14766.
MaxQBiQ14766.
PaxDbiQ14766.
PeptideAtlasiQ14766.
PRIDEiQ14766.

PTM databases

iPTMnetiQ14766.
PhosphoSitePlusiQ14766.
UniCarbKBiQ14766.

Expressioni

Tissue specificityi

Expressed in the aorta (at protein level). Isoform Long is found in fibroblasts.1 Publication

Gene expression databases

BgeeiENSG00000049323.
CleanExiHS_LTBP1.
ExpressionAtlasiQ14766. baseline and differential.
GenevisibleiQ14766. HS.

Organism-specific databases

HPAiCAB025428.
HPA005707.
HPA006221.

Interactioni

Subunit structurei

The large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1 (PubMed:10930463). Interacts with FBN2 (PubMed:12429738). Interacts with ADAMTSL2 (PubMed:18677313). Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) (PubMed:17293099, PubMed:12429738).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FBN1P355552EBI-11173832,EBI-2505934

GO - Molecular functioni

  • transforming growth factor beta binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110230. 32 interactors.
DIPiDIP-50011N.
IntActiQ14766. 6 interactors.
MINTiMINT-1522113.
STRINGi9606.ENSP00000386043.

Structurei

Secondary structure

11721
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1340 – 1342Combined sources3
Beta strandi1346 – 1353Combined sources8
Turni1355 – 1358Combined sources4
Beta strandi1366 – 1368Combined sources3
Helixi1369 – 1374Combined sources6
Beta strandi1378 – 1382Combined sources5
Beta strandi1385 – 1388Combined sources4
Beta strandi1392 – 1394Combined sources3
Helixi1395 – 1400Combined sources6
Beta strandi1408 – 1410Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KSQNMR-A1340-1412[»]
ProteinModelPortaliQ14766.
SMRiQ14766.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14766.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 219EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini399 – 431EGF-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini557 – 609TB 1PROSITE-ProRule annotationAdd BLAST53
Domaini626 – 663EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini677 – 729TB 2PROSITE-ProRule annotationAdd BLAST53
Domaini873 – 910EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini915 – 956EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini957 – 997EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini998 – 1037EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1038 – 1078EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1079 – 1119EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1120 – 1160EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1161 – 1201EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1202 – 1243EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1244 – 1281EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini1286 – 1328EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1347 – 1401TB 3PROSITE-ProRule annotationAdd BLAST55
Domaini1424 – 1466EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1467 – 1503EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1524 – 1577TB 4PROSITE-ProRule annotationAdd BLAST54
Domaini1621 – 1657EGF-like 17PROSITE-ProRule annotationAdd BLAST37
Domaini1662 – 1706EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1507 – 1721C-terminal domain1 PublicationAdd BLAST215

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1174 – 1176Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 130Pro-richAdd BLAST31

Domaini

Associates covalently with small latent TGF-beta complex via domain TB 3.

Sequence similaritiesi

Belongs to the LTBP family.Curated
Contains 18 EGF-like domains.PROSITE-ProRule annotation
Contains 4 TB (TGF-beta binding) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410Z7XK. LUCA.
GeneTreeiENSGT00760000118806.
InParanoidiQ14766.
KOiK19559.
OMAiTQLGRCF.
OrthoDBiEOG091G008S.
PhylomeDBiQ14766.
TreeFamiTF317514.

Family and domain databases

Gene3Di3.90.290.10. 5 hits.
InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR017878. TB_dom.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 13 hits.
PF00683. TB. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 18 hits.
SM00179. EGF_CA. 16 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 5 hits.
SSF57581. SSF57581. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 13 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 14 hits.
PS01187. EGF_CA. 15 hits.
PS51364. TB. 4 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q14766-1) [UniParc]FASTAAdd to basket
Also known as: LTBP-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAWLRWGL LLWAGLLASS AHGRLRRITY VVHPGPGLAA GALPLSGPPR
60 70 80 90 100
SRTFNVALNA RYSRSSAAAG APSRASPGVP SERTRRTSKP GGAALQGLRP
110 120 130 140 150
PPPPPPEPAR PAVPGGQLHP NPGGHPAAAP FTKQGRQVVR SKVPQETQSG
160 170 180 190 200
GGSRLQVHQK QQLQGVNVCG GRCCHGWSKA PGSQRCTKPS CVPPCQNGGM
210 220 230 240 250
CLRPQLCVCK PGTKGKACET IAAQDTSSPV FGGQSPGAAS SWGPPEQAAK
260 270 280 290 300
HTSSKKADTL PRVSPVAQMT LTLKPKPSVG LPQQIHSQVT PLSSQSVVIH
310 320 330 340 350
HGQTQEYVLK PKYFPAQKGI SGEQSTEGSF PLRYVQDQVA APFQLSNHTG
360 370 380 390 400
RIKVVFTPSI CKVTCTKGSC QNSCEKGNTT TLISENGHAA DTLTATNFRV
410 420 430 440 450
VICHLPCMNG GQCSSRDKCQ CPPNFTGKLC QIPVHGASVP KLYQHSQQPG
460 470 480 490 500
KALGTHVIHS THTLPLTVTS QQGVKVKFPP NIVNIHVKHP PEASVQIHQV
510 520 530 540 550
SRIDGPTGQK TKEAQPGQSQ VSYQGLPVQK TQTIHSTYSH QQVIPHVYPV
560 570 580 590 600
AAKTQLGRCF QETIGSQCGK ALPGLSKQED CCGTVGTSWG FNKCQKCPKK
610 620 630 640 650
PSYHGYNQMM ECLPGYKRVN NTFCQDINEC QLQGVCPNGE CLNTMGSYRC
660 670 680 690 700
TCKIGFGPDP TFSSCVPDPP VISEEKGPCY RLVSSGRQCM HPLSVHLTKQ
710 720 730 740 750
LCCCSVGKAW GPHCEKCPLP GTAAFKEICP GGMGYTVSGV HRRRPIHHHV
760 770 780 790 800
GKGPVFVKPK NTQPVAKSTH PPPLPAKEEP VEALTFSREH GPGVAEPEVA
810 820 830 840 850
TAPPEKEIPS LDQEKTKLEP GQPQLSPGIS TIHLHPQFPV VIEKTSPPVP
860 870 880 890 900
VEVAPEASTS SASQVIAPTQ VTEINECTVN PDICGAGHCI NLPVRYTCIC
910 920 930 940 950
YEGYRFSEQQ RKCVDIDECT QVQHLCSQGR CENTEGSFLC ICPAGFMASE
960 970 980 990 1000
EGTNCIDVDE CLRPDVCGEG HCVNTVGAFR CEYCDSGYRM TQRGRCEDID
1010 1020 1030 1040 1050
ECLNPSTCPD EQCVNSPGSY QCVPCTEGFR GWNGQCLDVD ECLEPNVCAN
1060 1070 1080 1090 1100
GDCSNLEGSY MCSCHKGYTR TPDHKHCRDI DECQQGNLCV NGQCKNTEGS
1110 1120 1130 1140 1150
FRCTCGQGYQ LSAAKDQCED IDECQHRHLC AHGQCRNTEG SFQCVCDQGY
1160 1170 1180 1190 1200
RASGLGDHCE DINECLEDKS VCQRGDCINT AGSYDCTCPD GFQLDDNKTC
1210 1220 1230 1240 1250
QDINECEHPG LCGPQGECLN TEGSFHCVCQ QGFSISADGR TCEDIDECVN
1260 1270 1280 1290 1300
NTVCDSHGFC DNTAGSFRCL CYQGFQAPQD GQGCVDVNEC ELLSGVCGEA
1310 1320 1330 1340 1350
FCENVEGSFL CVCADENQEY SPMTGQCRSR TSTDLDVDVD QPKEEKKECY
1360 1370 1380 1390 1400
YNLNDASLCD NVLAPNVTKQ ECCCTSGVGW GDNCEIFPCP VLGTAEFTEM
1410 1420 1430 1440 1450
CPKGKGFVPA GESSSEAGGE NYKDADECLL FGQEICKNGF CLNTRPGYEC
1460 1470 1480 1490 1500
YCKQGTYYDP VKLQCFDMDE CQDPSSCIDG QCVNTEGSYN CFCTHPMVLD
1510 1520 1530 1540 1550
ASEKRCIRPA ESNEQIEETD VYQDLCWEHL SDEYVCSRPL VGKQTTYTEC
1560 1570 1580 1590 1600
CCLYGEAWGM QCALCPLKDS DDYAQLCNIP VTGRRQPYGR DALVDFSEQY
1610 1620 1630 1640 1650
TPEADPYFIQ DRFLNSFEEL QAEECGILNG CENGRCVRVQ EGYTCDCFDG
1660 1670 1680 1690 1700
YHLDTAKMTC VDVNECDELN NRMSLCKNAK CINTDGSYKC LCLPGYVPSD
1710 1720
KPNYCTPLNT ALNLEKDSDL E
Length:1,721
Mass (Da):186,796
Last modified:March 2, 2010 - v4
Checksum:i432489CAC3023754
GO
Isoform Short (identifier: Q14766-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: LTBP-1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.
     327-345: EGSFPLRYVQDQVAAPFQL → MDTKLMCLLFFFSLPPLLV

Show »
Length:1,395
Mass (Da):152,935
Checksum:i69C41A7EC71FE8D2
GO
Isoform 3 (identifier: Q14766-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.
     327-345: EGSFPLRYVQDQVAAPFQL → MDTKLMCLLFFFSLPPLLV
     724-776: Missing.

Note: No experimental confirmation available.
Show »
Length:1,342
Mass (Da):147,235
Checksum:i616E9947D00D3200
GO
Isoform 4 (identifier: Q14766-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-840: PV → PGI

Show »
Length:1,722
Mass (Da):186,867
Checksum:iD59CED455F79E348
GO
Isoform 5 (identifier: Q14766-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.
     327-345: EGSFPLRYVQDQVAAPFQL → MDTKLMCLLFFFSLPPLLV
     839-840: PV → PGI

Note: No experimental confirmation available.
Show »
Length:1,396
Mass (Da):153,006
Checksum:i08160DD6EB7DFE97
GO

Sequence cautioni

The sequence BAD92038 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50R → AS in AAA96327 (PubMed:8537398).Curated1
Sequence conflicti691H → Y in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti694S → P in BP291349 (Ref. 8) Curated1
Sequence conflicti710Missing in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti710Missing in AAM03124 (Ref. 2) Curated1
Sequence conflicti744R → M in BP291349 (Ref. 8) Curated1
Sequence conflicti792 – 794PGV → ARS in AAA61160 (PubMed:2350783).Curated3
Sequence conflicti792 – 794PGV → ARS in AAM03124 (Ref. 2) Curated3
Sequence conflicti831T → A in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti1378V → A in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti1378V → A in AAM03124 (Ref. 2) Curated1
Sequence conflicti1378V → A in BAD92038 (Ref. 3) Curated1
Sequence conflicti1378V → A in EAX00437 (Ref. 5) Curated1
Sequence conflicti1378V → A in AAI30290 (PubMed:15489334).Curated1
Sequence conflicti1648F → L in AAA61160 (PubMed:2350783).Curated1
Sequence conflicti1648F → L in AAM03124 (Ref. 2) Curated1
Sequence conflicti1661V → F in AAA61160 (PubMed:2350783).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0369631 – 326Missing in isoform Short, isoform 3 and isoform 5. 5 PublicationsAdd BLAST326
Alternative sequenceiVSP_036964327 – 345EGSFP…APFQL → MDTKLMCLLFFFSLPPLLV in isoform Short, isoform 3 and isoform 5. 5 PublicationsAdd BLAST19
Alternative sequenceiVSP_036965724 – 776Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_040125839 – 840PV → PGI in isoform 4 and isoform 5. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34057 mRNA. Translation: AAA61160.1.
AF489528 mRNA. Translation: AAM03124.1.
AB208801 mRNA. Translation: BAD92038.1. Different initiation.
AC019195 Genomic DNA. Translation: AAY14953.1.
AC019127 Genomic DNA. Translation: AAY24260.1.
AC020594 Genomic DNA. Translation: AAY15036.1.
CH471053 Genomic DNA. Translation: EAX00437.1.
BC130289 mRNA. Translation: AAI30290.1.
L48925 Genomic DNA. Translation: AAA96327.1.
BP291349 mRNA. No translation available.
CCDSiCCDS33177.2. [Q14766-1]
CCDS33178.2. [Q14766-2]
CCDS54345.1. [Q14766-3]
PIRiA35626.
RefSeqiNP_000618.3. NM_000627.3.
NP_001159736.1. NM_001166264.1.
NP_001159737.1. NM_001166265.1.
NP_001159738.1. NM_001166266.1.
NP_996826.2. NM_206943.2.
XP_011531155.1. XM_011532853.2. [Q14766-4]
UniGeneiHs.619315.

Genome annotation databases

EnsembliENST00000404525; ENSP00000385359; ENSG00000049323. [Q14766-3]
ENST00000404816; ENSP00000386043; ENSG00000049323. [Q14766-1]
ENST00000407925; ENSP00000384091; ENSG00000049323. [Q14766-2]
GeneIDi4052.
KEGGihsa:4052.
UCSCiuc002rou.4. human. [Q14766-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34057 mRNA. Translation: AAA61160.1.
AF489528 mRNA. Translation: AAM03124.1.
AB208801 mRNA. Translation: BAD92038.1. Different initiation.
AC019195 Genomic DNA. Translation: AAY14953.1.
AC019127 Genomic DNA. Translation: AAY24260.1.
AC020594 Genomic DNA. Translation: AAY15036.1.
CH471053 Genomic DNA. Translation: EAX00437.1.
BC130289 mRNA. Translation: AAI30290.1.
L48925 Genomic DNA. Translation: AAA96327.1.
BP291349 mRNA. No translation available.
CCDSiCCDS33177.2. [Q14766-1]
CCDS33178.2. [Q14766-2]
CCDS54345.1. [Q14766-3]
PIRiA35626.
RefSeqiNP_000618.3. NM_000627.3.
NP_001159736.1. NM_001166264.1.
NP_001159737.1. NM_001166265.1.
NP_001159738.1. NM_001166266.1.
NP_996826.2. NM_206943.2.
XP_011531155.1. XM_011532853.2. [Q14766-4]
UniGeneiHs.619315.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KSQNMR-A1340-1412[»]
ProteinModelPortaliQ14766.
SMRiQ14766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110230. 32 interactors.
DIPiDIP-50011N.
IntActiQ14766. 6 interactors.
MINTiMINT-1522113.
STRINGi9606.ENSP00000386043.

PTM databases

iPTMnetiQ14766.
PhosphoSitePlusiQ14766.
UniCarbKBiQ14766.

Polymorphism and mutation databases

BioMutaiLTBP1.
DMDMi290457687.

Proteomic databases

EPDiQ14766.
MaxQBiQ14766.
PaxDbiQ14766.
PeptideAtlasiQ14766.
PRIDEiQ14766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404525; ENSP00000385359; ENSG00000049323. [Q14766-3]
ENST00000404816; ENSP00000386043; ENSG00000049323. [Q14766-1]
ENST00000407925; ENSP00000384091; ENSG00000049323. [Q14766-2]
GeneIDi4052.
KEGGihsa:4052.
UCSCiuc002rou.4. human. [Q14766-1]

Organism-specific databases

CTDi4052.
DisGeNETi4052.
GeneCardsiLTBP1.
HGNCiHGNC:6714. LTBP1.
HPAiCAB025428.
HPA005707.
HPA006221.
MIMi150390. gene.
neXtProtiNX_Q14766.
OpenTargetsiENSG00000049323.
PharmGKBiPA30477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410Z7XK. LUCA.
GeneTreeiENSGT00760000118806.
InParanoidiQ14766.
KOiK19559.
OMAiTQLGRCF.
OrthoDBiEOG091G008S.
PhylomeDBiQ14766.
TreeFamiTF317514.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049323-MONOMER.
ReactomeiR-HSA-2129379. Molecules associated with elastic fibres.
SIGNORiQ14766.

Miscellaneous databases

ChiTaRSiLTBP1. human.
EvolutionaryTraceiQ14766.
GeneWikiiLTBP1_(gene).
GenomeRNAii4052.
PROiQ14766.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049323.
CleanExiHS_LTBP1.
ExpressionAtlasiQ14766. baseline and differential.
GenevisibleiQ14766. HS.

Family and domain databases

Gene3Di3.90.290.10. 5 hits.
InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR017878. TB_dom.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 13 hits.
PF00683. TB. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 18 hits.
SM00179. EGF_CA. 16 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 5 hits.
SSF57581. SSF57581. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 13 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 14 hits.
PS01187. EGF_CA. 15 hits.
PS51364. TB. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLTBP1_HUMAN
AccessioniPrimary (citable) accession number: Q14766
Secondary accession number(s): A1L3V1
, P22064, Q53SD8, Q53SF3, Q53SG1, Q59HF7, Q8TD95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 2, 2010
Last modified: November 30, 2016
This is version 164 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.