##gff-version 3
Q14765	UniProtKB	Chain	1	748	.	.	.	ID=PRO_0000182420;Note=Signal transducer and activator of transcription 4	
Q14765	UniProtKB	Domain	569	664	.	.	.	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191	
Q14765	UniProtKB	Modified residue	667	667	.	.	.	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35614130;Dbxref=PMID:35614130	
Q14765	UniProtKB	Modified residue	693	693	.	.	.	Note=Phosphotyrosine%3B by JAK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10961885;Dbxref=PMID:10961885	
Q14765	UniProtKB	Modified residue	721	721	.	.	.	Note=Phosphoserine%3B by MAP2K6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10961885;Dbxref=PMID:10961885	
Q14765	UniProtKB	Natural variant	112	112	.	.	.	ID=VAR_036002;Note=In a breast cancer sample%3B somatic mutation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974	
Q14765	UniProtKB	Natural variant	115	115	.	.	.	ID=VAR_020190;Note=I->V;Dbxref=dbSNP:rs3024839	
Q14765	UniProtKB	Natural variant	584	584	.	.	.	ID=VAR_047939;Note=R->W;Dbxref=dbSNP:rs3024933	
Q14765	UniProtKB	Natural variant	623	623	.	.	.	ID=VAR_088806;Note=In DPMC%3B likely pathogenic%3B increased function in receptor signaling pathway via JAK-STAT. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37256972;Dbxref=PMID:37256972	
Q14765	UniProtKB	Natural variant	635	635	.	.	.	ID=VAR_088807;Note=In DPMC%3B likely pathogenic%3B increased function in receptor signaling pathway via JAK-STAT. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37256972;Dbxref=PMID:37256972	
Q14765	UniProtKB	Natural variant	650	650	.	.	.	ID=VAR_088808;Note=In DPMC%3B likely pathogenic%3B increased function in receptor signaling pathway via JAK-STAT. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37256972;Dbxref=PMID:37256972	
Q14765	UniProtKB	Mutagenesis	693	693	.	.	.	Note=Abrogates phosphorylation and transcriptional activity. Y->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10961885,ECO:0000269|PubMed:37256972;Dbxref=PMID:10961885,PMID:37256972	
Q14765	UniProtKB	Mutagenesis	721	721	.	.	.	Note=About 50%25 loss of transcriptional activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10961885;Dbxref=PMID:10961885	
Q14765	UniProtKB	Sequence conflict	365	371	.	.	.	Note=KNVSTLS->N;Ontology_term=ECO:0000305;evidence=ECO:0000305