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Protein

Signal transducer and activator of transcription 4

Gene

STAT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020591 Interleukin-12 signaling
R-HSA-9020933 Interleukin-23 signaling
R-HSA-9020958 Interleukin-21 signaling
SignaLinkiQ14765
SIGNORiQ14765

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 4
Gene namesi
Name:STAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138378.17
HGNCiHGNC:11365 STAT4
MIMi600558 gene
neXtProtiNX_Q14765

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus 11 (SLEB11)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:612253
Rheumatoid arthritis (RA)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
See also OMIM:180300

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNETi6775
MalaCardsiSTAT4
MIMi180300 phenotype
612253 phenotype
OpenTargetsiENSG00000138378
Orphaneti117 Behcet disease
85408 Juvenile rheumatoid factor-negative polyarthritis
85410 Oligoarticular juvenile arthritis
93552 Pediatric systemic lupus erythematosus
536 Systemic lupus erythematosus
PharmGKBiPA36185

Polymorphism and mutation databases

BioMutaiSTAT4
DMDMi6226158

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824201 – 748Signal transducer and activator of transcription 4Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei693Phosphotyrosine; by JAKBy similarity1

Post-translational modificationi

Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14765
PaxDbiQ14765
PeptideAtlasiQ14765
PRIDEiQ14765

PTM databases

iPTMnetiQ14765
PhosphoSitePlusiQ14765

Expressioni

Gene expression databases

BgeeiENSG00000138378
CleanExiHS_STAT4
ExpressionAtlasiQ14765 baseline and differential
GenevisibleiQ14765 HS

Organism-specific databases

HPAiCAB013108
HPA001860

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi11265211 interactors.
DIPiDIP-39854N
IntActiQ14765 7 interactors.
MINTiQ14765
STRINGi9606.ENSP00000351255

Structurei

3D structure databases

ProteinModelPortaliQ14765
SMRiQ14765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini569 – 664SH2PROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOGENOMiHOG000220792
HOVERGENiHBG055669
InParanoidiQ14765
KOiK11222
OMAiQSDKNSA
OrthoDBiEOG091G03O3
PhylomeDBiQ14765
TreeFamiTF318648

Family and domain databases

CDDicd10375 SH2_STAT4, 1 hit
Gene3Di1.10.532.101 hit
2.60.40.6301 hit
3.30.505.101 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR029839 STAT4
IPR035856 STAT4_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PTHR11801:SF19 PTHR11801:SF19, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q14765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQWNQVQQL EIKFLEQVDQ FYDDNFPMEI RHLLAQWIEN QDWEAASNNE
60 70 80 90 100
TMATILLQNL LIQLDEQLGR VSKEKNLLLI HNLKRIRKVL QGKFHGNPMH
110 120 130 140 150
VAVVISNCLR EERRILAAAN MPVQGPLEKS LQSSSVSERQ RNVEHKVAAI
160 170 180 190 200
KNSVQMTEQD TKYLEDLQDE FDYRYKTIQT MDQSDKNSAM VNQEVLTLQE
210 220 230 240 250
MLNSLDFKRK EALSKMTQII HETDLLMNTM LIEELQDWKR RQQIACIGGP
260 270 280 290 300
LHNGLDQLQN CFTLLAESLF QLRRQLEKLE EQSTKMTYEG DPIPMQRTHM
310 320 330 340 350
LERVTFLIYN LFKNSFVVER QPCMPTHPQR PLVLKTLIQF TVKLRLLIKL
360 370 380 390 400
PELNYQVKVK ASIDKNVSTL SNRRFVLCGT NVKAMSIEES SNGSLSVEFR
410 420 430 440 450
HLQPKEMKSS AGGKGNEGCH MVTEELHSIT FETQICLYGL TIDLETSSLP
460 470 480 490 500
VVMISNVSQL PNAWASIIWY NVSTNDSQNL VFFNNPPPAT LSQLLEVMSW
510 520 530 540 550
QFSSYVGRGL NSDQLHMLAE KLTVQSSYSD GHLTWAKFCK EHLPGKSFTF
560 570 580 590 600
WTWLEAILDL IKKHILPLWI DGYVMGFVSK EKERLLLKDK MPGTFLLRFS
610 620 630 640 650
ESHLGGITFT WVDHSESGEV RFHSVEPYNK GRLSALPFAD ILRDYKVIMA
660 670 680 690 700
ENIPENPLKY LYPDIPKDKA FGKHYSSQPC EVSRPTERGD KGYVPSVFIP
710 720 730 740
ISTIRSDSTE PHSPSDLLPM SPSVYAVLRE NLSPTTIETA MKSPYSAE
Length:748
Mass (Da):85,941
Last modified:November 1, 1996 - v1
Checksum:i11E43803A9AF4FFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti365 – 371KNVSTLS → N in AAL12164 (Ref. 3) Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036002112E → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_020190115I → V. Corresponds to variant dbSNP:rs3024839Ensembl.1
Natural variantiVAR_047939584R → W. Corresponds to variant dbSNP:rs3024933Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78440 mRNA Translation: AAB05605.1
BC031212 mRNA Translation: AAH31212.1
AF423072 Genomic DNA Translation: AAL12164.1
CCDSiCCDS2310.1
RefSeqiNP_001230764.1, NM_001243835.1
NP_003142.1, NM_003151.3
XP_006712782.1, XM_006712719.3
XP_011510007.1, XM_011511705.2
UniGeneiHs.735572
Hs.80642

Genome annotation databases

EnsembliENST00000358470; ENSP00000351255; ENSG00000138378
ENST00000392320; ENSP00000376134; ENSG00000138378
GeneIDi6775
KEGGihsa:6775
UCSCiuc002usm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTAT4_HUMAN
AccessioniPrimary (citable) accession number: Q14765
Secondary accession number(s): Q96NZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome