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Protein

Major vault protein

Gene

MVP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.3 Publications

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein phosphatase binding Source: UniProtKB

GO - Biological processi

  • ERBB signaling pathway Source: UniProtKB
  • mRNA transport Source: UniProtKB-KW
  • negative regulation of protein autophosphorylation Source: UniProtKB
  • negative regulation of protein tyrosine kinase activity Source: UniProtKB
  • negative regulation of signaling Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013364-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
SignaLinkiQ14764.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Major vault protein
Short name:
MVP
Alternative name(s):
Lung resistance-related protein
Gene namesi
Name:MVP
Synonyms:LRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7531. MVP.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • nuclear pore Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9961.
OpenTargetsiENSG00000013364.
PharmGKBiPA31332.

Polymorphism and mutation databases

BioMutaiMVP.
DMDMi21542417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001589802 – 893Major vault proteinAdd BLAST892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei445PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on Tyr residues after EGF stimulation.1 Publication
Dephosphorylated by PTPN11.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ14764.
PaxDbiQ14764.
PeptideAtlasiQ14764.
PRIDEiQ14764.

2D gel databases

OGPiQ14764.
REPRODUCTION-2DPAGEIPI00000105.

PTM databases

iPTMnetiQ14764.
PhosphoSitePlusiQ14764.
SwissPalmiQ14764.

Expressioni

Tissue specificityi

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Inductioni

Up-regulated by IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiENSG00000013364.
CleanExiHS_MVP.
ExpressionAtlasiQ14764. baseline and differential.
GenevisibleiQ14764. HS.

Organism-specific databases

HPAiCAB002752.
CAB022717.
HPA002321.

Interactioni

Subunit structurei

The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-2816254,EBI-2816254

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115286. 92 interactors.
IntActiQ14764. 36 interactors.
MINTiMINT-5004583.
STRINGi9606.ENSP00000349977.

Structurei

Secondary structure

1893
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi120 – 125Combined sources6
Beta strandi137 – 139Combined sources3
Beta strandi141 – 147Combined sources7
Helixi148 – 150Combined sources3
Beta strandi157 – 163Combined sources7
Beta strandi170 – 181Combined sources12
Beta strandi185 – 187Combined sources3
Beta strandi195 – 198Combined sources4
Beta strandi208 – 217Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y7XNMR-A113-221[»]
ProteinModelPortaliQ14764.
SMRiQ14764.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14764.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 56MVP 1Add BLAST55
Repeati57 – 111MVP 2Add BLAST55
Repeati112 – 164MVP 3Add BLAST53
Repeati165 – 217MVP 4Add BLAST53
Repeati218 – 272MVP 5Add BLAST55
Repeati273 – 323MVP 6Add BLAST51
Repeati324 – 379MVP 7Add BLAST56
Repeati380 – 457MVP 8Add BLAST78
Repeati458 – 520MVP 9Add BLAST63

Domaini

MVP 3 mediates interaction with PTEN.
MVP 4 mediates interaction with PARP4.

Sequence similaritiesi

Contains 9 MVP (vault) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF6T. Eukaryota.
ENOG410ZCU8. LUCA.
GeneTreeiENSGT00390000008969.
HOGENOMiHOG000255109.
HOVERGENiHBG003499.
InParanoidiQ14764.
KOiK17266.
OMAiNKGQDPL.
OrthoDBiEOG091G032A.
PhylomeDBiQ14764.
TreeFamiTF329353.

Family and domain databases

CDDicd08825. MVP_shoulder. 1 hit.
InterProiIPR021870. MVP_shoulder.
IPR002499. Vault_N.
[Graphical view]
PfamiPF11978. MVP_shoulder. 1 hit.
PF01505. Vault. 4 hits.
[Graphical view]
PROSITEiPS51224. MVP. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM
60 70 80 90 100
VTVPPRHYCT VANPVSRDAQ GLVLFDVTGQ VRLRHADLEI RLAQDPFPLY
110 120 130 140 150
PGEVLEKDIT PLQVVLPNTA LHLKALLDFE DKDGDKVVAG DEWLFEGPGT
160 170 180 190 200
YIPRKEVEVV EIIQATIIRQ NQALRLRARK ECWDRDGKER VTGEEWLVTT
210 220 230 240 250
VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ARRNFRDFRG VSRRTGEEWL
260 270 280 290 300
VTVQDTEAHV PDVHEEVLGV VPITTLGPHN YCVILDPVGP DGKNQLGQKR
310 320 330 340 350
VVKGEKSFFL QPGEQLEQGI QDVYVLSEQQ GLLLRALQPL EEGEDEEKVS
360 370 380 390 400
HQAGDHWLIR GPLEYVPSAK VEVVEERQAI PLDENEGIYV QDVKTGKVRA
410 420 430 440 450
VIGSTYMLTQ DEVLWEKELP PGVEELLNKG QDPLADRGEK DTAKSLQPLA
460 470 480 490 500
PRNKTRVVSY RVPHNAAVQV YDYREKRARV VFGPELVSLG PEEQFTVLSL
510 520 530 540 550
SAGRPKRPHA RRALCLLLGP DFFTDVITIE TADHARLQLQ LAYNWHFEVN
560 570 580 590 600
DRKDPQETAK LFSVPDFVGD ACKAIASRVR GAVASVTFDD FHKNSARIIR
610 620 630 640 650
TAVFGFETSE AKGPDGMALP RPRDQAVFPQ NGLVVSSVDV QSVEPVDQRT
660 670 680 690 700
RDALQRSVQL AIEITTNSQE AAAKHEAQRL EQEARGRLER QKILDQSEAE
710 720 730 740 750
KARKELLELE ALSMAVESTG TAKAEAESRA EAARIEGEGS VLQAKLKAQA
760 770 780 790 800
LAIETEAELQ RVQKVRELEL VYARAQLELE VSKAQQLAEV EVKKFKQMTE
810 820 830 840 850
AIGPSTIRDL AVAGPEMQVK LLQSLGLKST LITDGSTPIN LFNTAFGLLG
860 870 880 890
MGPEGQPLGR RVASGPSPGE GISPQSAQAP QAPGDNHVVP VLR
Length:893
Mass (Da):99,327
Last modified:January 23, 2007 - v4
Checksum:i6FEE5545B0A3FE65
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050179635V → I.Corresponds to variant rs35916172dbSNPEnsembl.1
Natural variantiVAR_050180651R → Q.Corresponds to variant rs3764944dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79882 mRNA. Translation: CAA56256.2.
BC015623 mRNA. Translation: AAH15623.1.
AJ238512
, AJ238514, AJ238516, AJ238518 Genomic DNA. Translation: CAB55354.1.
AJ238519
, AJ238514, AJ238516, AJ238518 Genomic DNA. Translation: CAB55355.1.
AJ291365 Genomic DNA. Translation: CAC35313.1.
AJ291366 mRNA. Translation: CAC35314.1.
AJ291367 mRNA. Translation: CAC35316.1.
CCDSiCCDS10656.1.
PIRiS57723.
RefSeqiNP_001280133.1. NM_001293204.1.
NP_001280134.1. NM_001293205.1.
NP_005106.2. NM_005115.4.
NP_059447.2. NM_017458.3.
UniGeneiHs.632177.

Genome annotation databases

EnsembliENST00000357402; ENSP00000349977; ENSG00000013364.
ENST00000395353; ENSP00000378760; ENSG00000013364.
GeneIDi9961.
KEGGihsa:9961.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79882 mRNA. Translation: CAA56256.2.
BC015623 mRNA. Translation: AAH15623.1.
AJ238512
, AJ238514, AJ238516, AJ238518 Genomic DNA. Translation: CAB55354.1.
AJ238519
, AJ238514, AJ238516, AJ238518 Genomic DNA. Translation: CAB55355.1.
AJ291365 Genomic DNA. Translation: CAC35313.1.
AJ291366 mRNA. Translation: CAC35314.1.
AJ291367 mRNA. Translation: CAC35316.1.
CCDSiCCDS10656.1.
PIRiS57723.
RefSeqiNP_001280133.1. NM_001293204.1.
NP_001280134.1. NM_001293205.1.
NP_005106.2. NM_005115.4.
NP_059447.2. NM_017458.3.
UniGeneiHs.632177.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y7XNMR-A113-221[»]
ProteinModelPortaliQ14764.
SMRiQ14764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115286. 92 interactors.
IntActiQ14764. 36 interactors.
MINTiMINT-5004583.
STRINGi9606.ENSP00000349977.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ14764.
PhosphoSitePlusiQ14764.
SwissPalmiQ14764.

Polymorphism and mutation databases

BioMutaiMVP.
DMDMi21542417.

2D gel databases

OGPiQ14764.
REPRODUCTION-2DPAGEIPI00000105.

Proteomic databases

EPDiQ14764.
PaxDbiQ14764.
PeptideAtlasiQ14764.
PRIDEiQ14764.

Protocols and materials databases

DNASUi9961.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357402; ENSP00000349977; ENSG00000013364.
ENST00000395353; ENSP00000378760; ENSG00000013364.
GeneIDi9961.
KEGGihsa:9961.

Organism-specific databases

CTDi9961.
DisGeNETi9961.
GeneCardsiMVP.
HGNCiHGNC:7531. MVP.
HPAiCAB002752.
CAB022717.
HPA002321.
MIMi605088. gene.
neXtProtiNX_Q14764.
OpenTargetsiENSG00000013364.
PharmGKBiPA31332.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF6T. Eukaryota.
ENOG410ZCU8. LUCA.
GeneTreeiENSGT00390000008969.
HOGENOMiHOG000255109.
HOVERGENiHBG003499.
InParanoidiQ14764.
KOiK17266.
OMAiNKGQDPL.
OrthoDBiEOG091G032A.
PhylomeDBiQ14764.
TreeFamiTF329353.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013364-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
SignaLinkiQ14764.

Miscellaneous databases

EvolutionaryTraceiQ14764.
GeneWikiiMajor_vault_protein.
GenomeRNAii9961.
PROiQ14764.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000013364.
CleanExiHS_MVP.
ExpressionAtlasiQ14764. baseline and differential.
GenevisibleiQ14764. HS.

Family and domain databases

CDDicd08825. MVP_shoulder. 1 hit.
InterProiIPR021870. MVP_shoulder.
IPR002499. Vault_N.
[Graphical view]
PfamiPF11978. MVP_shoulder. 1 hit.
PF01505. Vault. 4 hits.
[Graphical view]
PROSITEiPS51224. MVP. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMVP_HUMAN
AccessioniPrimary (citable) accession number: Q14764
Secondary accession number(s): Q96BG4
, Q9BPW6, Q9BQT1, Q9UBD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 155 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.