UniProtKB - Q14764 (MVP_HUMAN)
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Protein
Major vault protein
Gene
MVP
Organism
Homo sapiens (Human)
Status
Functioni
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.3 Publications
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
GO - Biological processi
- ERBB signaling pathway Source: UniProtKB
- mRNA transport Source: UniProtKB-KW
- negative regulation of protein autophosphorylation Source: UniProtKB
- negative regulation of protein tyrosine kinase activity Source: UniProtKB
- negative regulation of signaling Source: UniProtKB
- neutrophil degranulation Source: Reactome
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ribonucleoprotein |
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-HSA-6798695 Neutrophil degranulation |
SignaLinki | Q14764 |
Protein family/group databases
TCDBi | 1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Major vault proteinShort name: MVP Alternative name(s): Lung resistance-related protein |
Gene namesi | Name:MVP Synonyms:LRP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000013364.18 |
HGNCi | HGNC:7531 MVP |
MIMi | 605088 gene |
neXtProti | NX_Q14764 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9961 |
OpenTargetsi | ENSG00000013364 |
PharmGKBi | PA31332 |
Polymorphism and mutation databases
BioMutai | MVP |
DMDMi | 21542417 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000158980 | 2 – 893 | Major vault proteinAdd BLAST | 892 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Cross-linki | 444 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 445 | PhosphoserineCombined sources | 1 | |
Cross-linki | 704 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Phosphorylated on Tyr residues after EGF stimulation.1 Publication
Dephosphorylated by PTPN11.
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14764 |
PaxDbi | Q14764 |
PeptideAtlasi | Q14764 |
PRIDEi | Q14764 |
2D gel databases
OGPi | Q14764 |
REPRODUCTION-2DPAGEi | IPI00000105 |
PTM databases
iPTMneti | Q14764 |
PhosphoSitePlusi | Q14764 |
SwissPalmi | Q14764 |
Expressioni
Tissue specificityi
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Inductioni
Up-regulated by IFNG/IFN-gamma.1 Publication
Gene expression databases
Bgeei | ENSG00000013364 |
CleanExi | HS_MVP |
ExpressionAtlasi | Q14764 baseline and differential |
Genevisiblei | Q14764 HS |
Organism-specific databases
HPAi | CAB002752 CAB022717 HPA002321 HPA064740 |
Interactioni
Subunit structurei
The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.6 Publications
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
itself | 4 | EBI-2816254,EBI-2816254 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 11528696 interactors. |
IntActi | Q14764 41 interactors. |
MINTi | Q14764 |
STRINGi | 9606.ENSP00000349977 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 120 – 125 | Combined sources | 6 | |
Beta strandi | 137 – 139 | Combined sources | 3 | |
Beta strandi | 141 – 147 | Combined sources | 7 | |
Helixi | 148 – 150 | Combined sources | 3 | |
Beta strandi | 157 – 163 | Combined sources | 7 | |
Beta strandi | 170 – 181 | Combined sources | 12 | |
Beta strandi | 185 – 187 | Combined sources | 3 | |
Beta strandi | 195 – 198 | Combined sources | 4 | |
Beta strandi | 208 – 217 | Combined sources | 10 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Y7X | NMR | - | A | 113-221 | [»] | |
ProteinModelPortali | Q14764 | |||||
SMRi | Q14764 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14764 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 2 – 56 | MVP 1Add BLAST | 55 | |
Repeati | 57 – 111 | MVP 2Add BLAST | 55 | |
Repeati | 112 – 164 | MVP 3Add BLAST | 53 | |
Repeati | 165 – 217 | MVP 4Add BLAST | 53 | |
Repeati | 218 – 272 | MVP 5Add BLAST | 55 | |
Repeati | 273 – 323 | MVP 6Add BLAST | 51 | |
Repeati | 324 – 379 | MVP 7Add BLAST | 56 | |
Repeati | 380 – 457 | MVP 8Add BLAST | 78 | |
Repeati | 458 – 520 | MVP 9Add BLAST | 63 |
Domaini
MVP 3 mediates interaction with PTEN.
MVP 4 mediates interaction with PARP4.
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG410IF6T Eukaryota ENOG410ZCU8 LUCA |
GeneTreei | ENSGT00390000008969 |
HOGENOMi | HOG000255109 |
HOVERGENi | HBG003499 |
InParanoidi | Q14764 |
KOi | K17266 |
OMAi | VFPQNGL |
OrthoDBi | EOG091G032A |
PhylomeDBi | Q14764 |
TreeFami | TF329353 |
Family and domain databases
CDDi | cd08825 MVP_shoulder, 1 hit |
InterProi | View protein in InterPro IPR021870 MVP_shoulder IPR002499 Vault_N |
Pfami | View protein in Pfam PF11978 MVP_shoulder, 1 hit PF01505 Vault, 4 hits |
PROSITEi | View protein in PROSITE PS51224 MVP, 8 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q14764-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM
60 70 80 90 100
VTVPPRHYCT VANPVSRDAQ GLVLFDVTGQ VRLRHADLEI RLAQDPFPLY
110 120 130 140 150
PGEVLEKDIT PLQVVLPNTA LHLKALLDFE DKDGDKVVAG DEWLFEGPGT
160 170 180 190 200
YIPRKEVEVV EIIQATIIRQ NQALRLRARK ECWDRDGKER VTGEEWLVTT
210 220 230 240 250
VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ARRNFRDFRG VSRRTGEEWL
260 270 280 290 300
VTVQDTEAHV PDVHEEVLGV VPITTLGPHN YCVILDPVGP DGKNQLGQKR
310 320 330 340 350
VVKGEKSFFL QPGEQLEQGI QDVYVLSEQQ GLLLRALQPL EEGEDEEKVS
360 370 380 390 400
HQAGDHWLIR GPLEYVPSAK VEVVEERQAI PLDENEGIYV QDVKTGKVRA
410 420 430 440 450
VIGSTYMLTQ DEVLWEKELP PGVEELLNKG QDPLADRGEK DTAKSLQPLA
460 470 480 490 500
PRNKTRVVSY RVPHNAAVQV YDYREKRARV VFGPELVSLG PEEQFTVLSL
510 520 530 540 550
SAGRPKRPHA RRALCLLLGP DFFTDVITIE TADHARLQLQ LAYNWHFEVN
560 570 580 590 600
DRKDPQETAK LFSVPDFVGD ACKAIASRVR GAVASVTFDD FHKNSARIIR
610 620 630 640 650
TAVFGFETSE AKGPDGMALP RPRDQAVFPQ NGLVVSSVDV QSVEPVDQRT
660 670 680 690 700
RDALQRSVQL AIEITTNSQE AAAKHEAQRL EQEARGRLER QKILDQSEAE
710 720 730 740 750
KARKELLELE ALSMAVESTG TAKAEAESRA EAARIEGEGS VLQAKLKAQA
760 770 780 790 800
LAIETEAELQ RVQKVRELEL VYARAQLELE VSKAQQLAEV EVKKFKQMTE
810 820 830 840 850
AIGPSTIRDL AVAGPEMQVK LLQSLGLKST LITDGSTPIN LFNTAFGLLG
860 870 880 890
MGPEGQPLGR RVASGPSPGE GISPQSAQAP QAPGDNHVVP VLR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079710 | 87 | D → E1 Publication | 1 | |
Natural variantiVAR_050179 | 635 | V → I. Corresponds to variant dbSNP:rs35916172Ensembl. | 1 | |
Natural variantiVAR_050180 | 651 | R → Q. Corresponds to variant dbSNP:rs3764944Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79882 mRNA Translation: CAA56256.2 BC015623 mRNA Translation: AAH15623.1 AJ238512 AJ238518 Genomic DNA Translation: CAB55354.1 AJ238519 AJ238518 Genomic DNA Translation: CAB55355.1 AJ291365 Genomic DNA Translation: CAC35313.1 AJ291366 mRNA Translation: CAC35314.1 AJ291367 mRNA Translation: CAC35316.1 |
CCDSi | CCDS10656.1 |
PIRi | S57723 |
RefSeqi | NP_001280133.1, NM_001293204.1 NP_001280134.1, NM_001293205.1 NP_005106.2, NM_005115.4 NP_059447.2, NM_017458.3 |
UniGenei | Hs.632177 |
Genome annotation databases
Ensembli | ENST00000357402; ENSP00000349977; ENSG00000013364 ENST00000395353; ENSP00000378760; ENSG00000013364 |
GeneIDi | 9961 |
KEGGi | hsa:9961 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | MVP_HUMAN | |
Accessioni | Q14764Primary (citable) accession number: Q14764 Secondary accession number(s): Q96BG4 Q9UBD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 25, 2018 | |
This is version 166 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |