ID   PTCA_HUMAN              Reviewed;         206 AA.
AC   Q14761; B2R512; O00643; Q6I9S6;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=Protein tyrosine phosphatase receptor type C-associated protein;
DE            Short=PTPRC-associated protein;
DE   AltName: Full=CD45-associated protein;
DE            Short=CD45-AP;
DE   AltName: Full=Lymphocyte phosphatase-associated phosphoprotein;
GN   Name=PTPRCAP; Synonyms=LPAP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7961877; DOI=10.1016/s0021-9258(19)62018-1;
RA   Schraven B., Schoenhaut D., Bruyns E., Koretzky G., Eckerskorn C.,
RA   Wallich R., Kirchgessner H., Sakorafas P., Labkovsky B., Ratnofsky S.,
RA   Meuer S.;
RT   "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human
RT   lymphocytes.";
RL   J. Biol. Chem. 269:29102-29111(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8954783; DOI=10.1006/geno.1996.0595;
RA   Bruyns E., Mincheva A., Bruyns R.M., Kirchgessner H., Weitz S., Lichter P.,
RA   Meuer S., Schraven B.;
RT   "Sequence, genomic organization, and chromosomal localization of the human
RT   LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.";
RL   Genomics 38:79-83(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INTERACTION WITH CD45.
RX   PubMed=8537410; DOI=10.1074/jbc.270.52.31372;
RA   Bruyns E., Hendricks-Taylor L.R., Meuer S., Koretzky G.A., Schraven B.;
RT   "Identification of the sites of interaction between lymphocyte phosphatase-
RT   associated phosphoprotein (LPAP) and CD45.";
RL   J. Biol. Chem. 270:31372-31376(1995).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=T-cell;
RX   PubMed=19367720; DOI=10.1021/pr800500r;
RA   Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
RT   "Phosphorylation analysis of primary human T lymphocytes using sequential
RT   IMAC and titanium oxide enrichment.";
RL   J. Proteome Res. 7:5167-5176(2008).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-153, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SUBUNIT: Interacts with CD45/PTPRC. {ECO:0000269|PubMed:8537410}.
CC   -!- INTERACTION:
CC       Q14761; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-722217, EBI-10303987;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Phosphorylated on tyrosine residues.
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DR   EMBL; X81422; CAA57182.1; -; mRNA.
DR   EMBL; X97267; CAA65922.1; -; Genomic_DNA.
DR   EMBL; CR457429; CAG33710.1; -; mRNA.
DR   EMBL; AK312022; BAG34959.1; -; mRNA.
DR   EMBL; BC113859; AAI13860.1; -; mRNA.
DR   EMBL; BC114467; AAI14468.1; -; mRNA.
DR   CCDS; CCDS8163.1; -.
DR   PIR; A55412; A55412.
DR   RefSeq; NP_005599.1; NM_005608.2.
DR   AlphaFoldDB; Q14761; -.
DR   BioGRID; 111754; 15.
DR   IntAct; Q14761; 6.
DR   STRING; 9606.ENSP00000325589; -.
DR   BindingDB; Q14761; -.
DR   ChEMBL; CHEMBL4806; -.
DR   iPTMnet; Q14761; -.
DR   PhosphoSitePlus; Q14761; -.
DR   BioMuta; PTPRCAP; -.
DR   DMDM; 22001841; -.
DR   EPD; Q14761; -.
DR   jPOST; Q14761; -.
DR   MassIVE; Q14761; -.
DR   MaxQB; Q14761; -.
DR   PaxDb; 9606-ENSP00000325589; -.
DR   PeptideAtlas; Q14761; -.
DR   ProteomicsDB; 60156; -.
DR   Antibodypedia; 16508; 149 antibodies from 27 providers.
DR   DNASU; 5790; -.
DR   Ensembl; ENST00000326294.4; ENSP00000325589.3; ENSG00000213402.3.
DR   GeneID; 5790; -.
DR   KEGG; hsa:5790; -.
DR   MANE-Select; ENST00000326294.4; ENSP00000325589.3; NM_005608.3; NP_005599.1.
DR   UCSC; uc001oli.2; human.
DR   AGR; HGNC:9667; -.
DR   CTD; 5790; -.
DR   DisGeNET; 5790; -.
DR   GeneCards; PTPRCAP; -.
DR   HGNC; HGNC:9667; PTPRCAP.
DR   HPA; ENSG00000213402; Group enriched (intestine, lymphoid tissue).
DR   MIM; 601577; gene.
DR   neXtProt; NX_Q14761; -.
DR   OpenTargets; ENSG00000213402; -.
DR   PharmGKB; PA34012; -.
DR   VEuPathDB; HostDB:ENSG00000213402; -.
DR   eggNOG; ENOG502SG9X; Eukaryota.
DR   GeneTree; ENSGT00390000017041; -.
DR   HOGENOM; CLU_1444125_0_0_1; -.
DR   InParanoid; Q14761; -.
DR   OMA; PGHWLQT; -.
DR   OrthoDB; 5474889at2759; -.
DR   PhylomeDB; Q14761; -.
DR   TreeFam; TF338317; -.
DR   PathwayCommons; Q14761; -.
DR   SignaLink; Q14761; -.
DR   SIGNOR; Q14761; -.
DR   BioGRID-ORCS; 5790; 22 hits in 1154 CRISPR screens.
DR   GeneWiki; PTPRCAP; -.
DR   GenomeRNAi; 5790; -.
DR   Pharos; Q14761; Tbio.
DR   PRO; PR:Q14761; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q14761; Protein.
DR   Bgee; ENSG00000213402; Expressed in granulocyte and 91 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0006952; P:defense response; TAS:ProtInc.
DR   InterPro; IPR016553; PTPRCAP.
DR   PANTHER; PTHR15312; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE C-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR15312:SF1; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE C-ASSOCIATED PROTEIN; 1.
DR   Pfam; PF15713; PTPRCAP; 1.
DR   PIRSF; PIRSF009325; PTPRC-associated_protein; 1.
DR   Genevisible; Q14761; HS.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..206
FT                   /note="Protein tyrosine phosphatase receptor type C-
FT                   associated protein"
FT                   /id="PRO_0000097087"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          98..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         99
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:24275569"
FT   MOD_RES         153
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:24275569"
FT   VARIANT         128
FT                   /note="G -> E (in dbSNP:rs60969594)"
FT                   /id="VAR_061698"
SQ   SEQUENCE   206 AA;  21196 MW;  26A9F96699BD34D5 CRC64;
     MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL ALAWRRLSRD
     SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST DNDLERQEDE QDTDYDHVAD
     GGLQADPGEG EQQCGEASSP EQVPVRAEEA RDSDTEGDLV LGSPGPASAG GSAEALLSDL
     HAFAGSAAWD DSARAAGGQG LHVTAL
//