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Q14761 (PTCA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein tyrosine phosphatase receptor type C-associated protein

Short name=PTPRC-associated protein
Alternative name(s):
CD45-associated protein
Short name=CD45-AP
Lymphocyte phosphatase-associated phosphoprotein
Gene names
Name:PTPRCAP
Synonyms:LPAP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with CD45/PTPRC. Ref.6

Subcellular location

Membrane; Single-pass membrane protein Potential.

Post-translational modification

Phosphorylated on tyrosine residues.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 11390434. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Protein tyrosine phosphatase receptor type C-associated protein
PRO_0000097087

Regions

Transmembrane34 – 5421Helical; Potential

Natural variations

Natural variant1281G → E.
Corresponds to variant rs60969594 [ dbSNP | Ensembl ].
VAR_061698

Sequences

Sequence LengthMass (Da)Tools
Q14761 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 26A9F96699BD34D5

FASTA20621,196
        10         20         30         40         50         60 
MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL ALAWRRLSRD 

        70         80         90        100        110        120 
SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST DNDLERQEDE QDTDYDHVAD 

       130        140        150        160        170        180 
GGLQADPGEG EQQCGEASSP EQVPVRAEEA RDSDTEGDLV LGSPGPASAG GSAEALLSDL 

       190        200 
HAFAGSAAWD DSARAAGGQG LHVTAL 

« Hide

References

« Hide 'large scale' references
[1]"LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes."
Schraven B., Schoenhaut D., Bruyns E., Koretzky G., Eckerskorn C., Wallich R., Kirchgessner H., Sakorafas P., Labkovsky B., Ratnofsky S., Meuer S.
J. Biol. Chem. 269:29102-29111(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes."
Bruyns E., Mincheva A., Bruyns R.M., Kirchgessner H., Weitz S., Lichter P., Meuer S., Schraven B.
Genomics 38:79-83(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45."
Bruyns E., Hendricks-Taylor L.R., Meuer S., Koretzky G.A., Schraven B.
J. Biol. Chem. 270:31372-31376(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CD45.
[7]"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: T-cell.
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X81422 mRNA. Translation: CAA57182.1.
X97267 Genomic DNA. Translation: CAA65922.1.
CR457429 mRNA. Translation: CAG33710.1.
AK312022 mRNA. Translation: BAG34959.1.
BC113859 mRNA. Translation: AAI13860.1.
BC114467 mRNA. Translation: AAI14468.1.
CCDSCCDS8163.1.
PIRA55412.
RefSeqNP_005599.1. NM_005608.2.
UniGeneHs.155975.

3D structure databases

ProteinModelPortalQ14761.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111754. 4 interactions.
IntActQ14761. 2 interactions.
MINTMINT-1389998.
STRING9606.ENSP00000325589.

Chemistry

BindingDBQ14761.
ChEMBLCHEMBL4806.

PTM databases

PhosphoSiteQ14761.

Polymorphism databases

DMDM22001841.

Proteomic databases

MaxQBQ14761.
PaxDbQ14761.
PRIDEQ14761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326294; ENSP00000325589; ENSG00000213402.
GeneID5790.
KEGGhsa:5790.
UCSCuc001oli.1. human.

Organism-specific databases

CTD5790.
GeneCardsGC11M067202.
H-InvDBHIX0079400.
HIX0201772.
HGNCHGNC:9667. PTPRCAP.
HPAHPA043734.
MIM601577. gene.
neXtProtNX_Q14761.
PharmGKBPA34012.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87279.
HOGENOMHOG000115756.
HOVERGENHBG030697.
InParanoidQ14761.
OMADSGGYYH.
OrthoDBEOG70W3GN.
PhylomeDBQ14761.
TreeFamTF338317.

Gene expression databases

BgeeQ14761.
CleanExHS_PTPRCAP.
GenevestigatorQ14761.

Family and domain databases

InterProIPR016553. Tyr_Pase_rcpt_C-assoc_CD45-AP.
[Graphical view]
PANTHERPTHR15312. PTHR15312. 1 hit.
PIRSFPIRSF009325. PTPRC-associated_protein. 1 hit.
ProtoNetSearch...

Other

GeneWikiPTPRCAP.
GenomeRNAi5790.
NextBio22540.
PROQ14761.
SOURCESearch...

Entry information

Entry namePTCA_HUMAN
AccessionPrimary (citable) accession number: Q14761
Secondary accession number(s): B2R512, O00643, Q6I9S6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM