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Protein

Protein tyrosine phosphatase receptor type C-associated protein

Gene

PTPRCAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. defense response Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase receptor type C-associated protein
Short name:
PTPRC-associated protein
Alternative name(s):
CD45-associated protein
Short name:
CD45-AP
Lymphocyte phosphatase-associated phosphoprotein
Gene namesi
Name:PTPRCAP
Synonyms:LPAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9667. PTPRCAP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34012.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Protein tyrosine phosphatase receptor type C-associated proteinPRO_0000097087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991Phosphoserine1 Publication
Modified residuei153 – 1531Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14761.
PaxDbiQ14761.
PRIDEiQ14761.

PTM databases

PhosphoSiteiQ14761.

Expressioni

Gene expression databases

BgeeiQ14761.
CleanExiHS_PTPRCAP.
GenevestigatoriQ14761.

Organism-specific databases

HPAiHPA043734.

Interactioni

Subunit structurei

Interacts with CD45/PTPRC.1 Publication

Protein-protein interaction databases

BioGridi111754. 4 interactions.
IntActiQ14761. 2 interactions.
MINTiMINT-1389998.
STRINGi9606.ENSP00000325589.

Structurei

3D structure databases

ProteinModelPortaliQ14761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG87279.
GeneTreeiENSGT00390000017041.
HOGENOMiHOG000115756.
HOVERGENiHBG030697.
InParanoidiQ14761.
OMAiGYYHPAR.
OrthoDBiEOG70W3GN.
PhylomeDBiQ14761.
TreeFamiTF338317.

Family and domain databases

InterProiIPR016553. Tyr_Pase_rcpt_C-assoc_CD45-AP.
[Graphical view]
PANTHERiPTHR15312. PTHR15312. 1 hit.
PIRSFiPIRSF009325. PTPRC-associated_protein. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL
60 70 80 90 100
ALAWRRLSRD SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST
110 120 130 140 150
DNDLERQEDE QDTDYDHVAD GGLQADPGEG EQQCGEASSP EQVPVRAEEA
160 170 180 190 200
RDSDTEGDLV LGSPGPASAG GSAEALLSDL HAFAGSAAWD DSARAAGGQG

LHVTAL
Length:206
Mass (Da):21,196
Last modified:November 1, 1996 - v1
Checksum:i26A9F96699BD34D5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281G → E.
Corresponds to variant rs60969594 [ dbSNP | Ensembl ].
VAR_061698

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81422 mRNA. Translation: CAA57182.1.
X97267 Genomic DNA. Translation: CAA65922.1.
CR457429 mRNA. Translation: CAG33710.1.
AK312022 mRNA. Translation: BAG34959.1.
BC113859 mRNA. Translation: AAI13860.1.
BC114467 mRNA. Translation: AAI14468.1.
CCDSiCCDS8163.1.
PIRiA55412.
RefSeqiNP_005599.1. NM_005608.2.
UniGeneiHs.155975.

Genome annotation databases

EnsembliENST00000326294; ENSP00000325589; ENSG00000213402.
GeneIDi5790.
KEGGihsa:5790.
UCSCiuc001oli.1. human.

Polymorphism databases

DMDMi22001841.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81422 mRNA. Translation: CAA57182.1.
X97267 Genomic DNA. Translation: CAA65922.1.
CR457429 mRNA. Translation: CAG33710.1.
AK312022 mRNA. Translation: BAG34959.1.
BC113859 mRNA. Translation: AAI13860.1.
BC114467 mRNA. Translation: AAI14468.1.
CCDSiCCDS8163.1.
PIRiA55412.
RefSeqiNP_005599.1. NM_005608.2.
UniGeneiHs.155975.

3D structure databases

ProteinModelPortaliQ14761.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111754. 4 interactions.
IntActiQ14761. 2 interactions.
MINTiMINT-1389998.
STRINGi9606.ENSP00000325589.

Chemistry

BindingDBiQ14761.
ChEMBLiCHEMBL4806.

PTM databases

PhosphoSiteiQ14761.

Polymorphism databases

DMDMi22001841.

Proteomic databases

MaxQBiQ14761.
PaxDbiQ14761.
PRIDEiQ14761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326294; ENSP00000325589; ENSG00000213402.
GeneIDi5790.
KEGGihsa:5790.
UCSCiuc001oli.1. human.

Organism-specific databases

CTDi5790.
GeneCardsiGC11M067202.
H-InvDBHIX0079400.
HIX0201772.
HGNCiHGNC:9667. PTPRCAP.
HPAiHPA043734.
MIMi601577. gene.
neXtProtiNX_Q14761.
PharmGKBiPA34012.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87279.
GeneTreeiENSGT00390000017041.
HOGENOMiHOG000115756.
HOVERGENiHBG030697.
InParanoidiQ14761.
OMAiGYYHPAR.
OrthoDBiEOG70W3GN.
PhylomeDBiQ14761.
TreeFamiTF338317.

Miscellaneous databases

GeneWikiiPTPRCAP.
GenomeRNAii5790.
NextBioi22540.
PROiQ14761.
SOURCEiSearch...

Gene expression databases

BgeeiQ14761.
CleanExiHS_PTPRCAP.
GenevestigatoriQ14761.

Family and domain databases

InterProiIPR016553. Tyr_Pase_rcpt_C-assoc_CD45-AP.
[Graphical view]
PANTHERiPTHR15312. PTHR15312. 1 hit.
PIRSFiPIRSF009325. PTPRC-associated_protein. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes."
    Schraven B., Schoenhaut D., Bruyns E., Koretzky G., Eckerskorn C., Wallich R., Kirchgessner H., Sakorafas P., Labkovsky B., Ratnofsky S., Meuer S.
    J. Biol. Chem. 269:29102-29111(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes."
    Bruyns E., Mincheva A., Bruyns R.M., Kirchgessner H., Weitz S., Lichter P., Meuer S., Schraven B.
    Genomics 38:79-83(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45."
    Bruyns E., Hendricks-Taylor L.R., Meuer S., Koretzky G.A., Schraven B.
    J. Biol. Chem. 270:31372-31376(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD45.
  7. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPTCA_HUMAN
AccessioniPrimary (citable) accession number: Q14761
Secondary accession number(s): B2R512, O00643, Q6I9S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.