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Q14761

- PTCA_HUMAN

UniProt

Q14761 - PTCA_HUMAN

Protein

Protein tyrosine phosphatase receptor type C-associated protein

Gene

PTPRCAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. defense response Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein tyrosine phosphatase receptor type C-associated protein
    Short name:
    PTPRC-associated protein
    Alternative name(s):
    CD45-associated protein
    Short name:
    CD45-AP
    Lymphocyte phosphatase-associated phosphoprotein
    Gene namesi
    Name:PTPRCAP
    Synonyms:LPAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9667. PTPRCAP.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34012.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Protein tyrosine phosphatase receptor type C-associated proteinPRO_0000097087Add
    BLAST

    Post-translational modificationi

    Phosphorylated on tyrosine residues.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14761.
    PaxDbiQ14761.
    PRIDEiQ14761.

    PTM databases

    PhosphoSiteiQ14761.

    Expressioni

    Gene expression databases

    BgeeiQ14761.
    CleanExiHS_PTPRCAP.
    GenevestigatoriQ14761.

    Organism-specific databases

    HPAiHPA043734.

    Interactioni

    Subunit structurei

    Interacts with CD45/PTPRC.1 Publication

    Protein-protein interaction databases

    BioGridi111754. 4 interactions.
    IntActiQ14761. 2 interactions.
    MINTiMINT-1389998.
    STRINGi9606.ENSP00000325589.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14761.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG87279.
    HOGENOMiHOG000115756.
    HOVERGENiHBG030697.
    InParanoidiQ14761.
    OMAiDSGGYYH.
    OrthoDBiEOG70W3GN.
    PhylomeDBiQ14761.
    TreeFamiTF338317.

    Family and domain databases

    InterProiIPR016553. Tyr_Pase_rcpt_C-assoc_CD45-AP.
    [Graphical view]
    PANTHERiPTHR15312. PTHR15312. 1 hit.
    PIRSFiPIRSF009325. PTPRC-associated_protein. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q14761-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL    50
    ALAWRRLSRD SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST 100
    DNDLERQEDE QDTDYDHVAD GGLQADPGEG EQQCGEASSP EQVPVRAEEA 150
    RDSDTEGDLV LGSPGPASAG GSAEALLSDL HAFAGSAAWD DSARAAGGQG 200
    LHVTAL 206
    Length:206
    Mass (Da):21,196
    Last modified:November 1, 1996 - v1
    Checksum:i26A9F96699BD34D5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti128 – 1281G → E.
    Corresponds to variant rs60969594 [ dbSNP | Ensembl ].
    VAR_061698

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81422 mRNA. Translation: CAA57182.1.
    X97267 Genomic DNA. Translation: CAA65922.1.
    CR457429 mRNA. Translation: CAG33710.1.
    AK312022 mRNA. Translation: BAG34959.1.
    BC113859 mRNA. Translation: AAI13860.1.
    BC114467 mRNA. Translation: AAI14468.1.
    CCDSiCCDS8163.1.
    PIRiA55412.
    RefSeqiNP_005599.1. NM_005608.2.
    UniGeneiHs.155975.

    Genome annotation databases

    EnsembliENST00000326294; ENSP00000325589; ENSG00000213402.
    GeneIDi5790.
    KEGGihsa:5790.
    UCSCiuc001oli.1. human.

    Polymorphism databases

    DMDMi22001841.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81422 mRNA. Translation: CAA57182.1 .
    X97267 Genomic DNA. Translation: CAA65922.1 .
    CR457429 mRNA. Translation: CAG33710.1 .
    AK312022 mRNA. Translation: BAG34959.1 .
    BC113859 mRNA. Translation: AAI13860.1 .
    BC114467 mRNA. Translation: AAI14468.1 .
    CCDSi CCDS8163.1.
    PIRi A55412.
    RefSeqi NP_005599.1. NM_005608.2.
    UniGenei Hs.155975.

    3D structure databases

    ProteinModelPortali Q14761.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111754. 4 interactions.
    IntActi Q14761. 2 interactions.
    MINTi MINT-1389998.
    STRINGi 9606.ENSP00000325589.

    Chemistry

    BindingDBi Q14761.
    ChEMBLi CHEMBL4806.

    PTM databases

    PhosphoSitei Q14761.

    Polymorphism databases

    DMDMi 22001841.

    Proteomic databases

    MaxQBi Q14761.
    PaxDbi Q14761.
    PRIDEi Q14761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326294 ; ENSP00000325589 ; ENSG00000213402 .
    GeneIDi 5790.
    KEGGi hsa:5790.
    UCSCi uc001oli.1. human.

    Organism-specific databases

    CTDi 5790.
    GeneCardsi GC11M067202.
    H-InvDB HIX0079400.
    HIX0201772.
    HGNCi HGNC:9667. PTPRCAP.
    HPAi HPA043734.
    MIMi 601577. gene.
    neXtProti NX_Q14761.
    PharmGKBi PA34012.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87279.
    HOGENOMi HOG000115756.
    HOVERGENi HBG030697.
    InParanoidi Q14761.
    OMAi DSGGYYH.
    OrthoDBi EOG70W3GN.
    PhylomeDBi Q14761.
    TreeFami TF338317.

    Miscellaneous databases

    GeneWikii PTPRCAP.
    GenomeRNAii 5790.
    NextBioi 22540.
    PROi Q14761.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14761.
    CleanExi HS_PTPRCAP.
    Genevestigatori Q14761.

    Family and domain databases

    InterProi IPR016553. Tyr_Pase_rcpt_C-assoc_CD45-AP.
    [Graphical view ]
    PANTHERi PTHR15312. PTHR15312. 1 hit.
    PIRSFi PIRSF009325. PTPRC-associated_protein. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes."
      Schraven B., Schoenhaut D., Bruyns E., Koretzky G., Eckerskorn C., Wallich R., Kirchgessner H., Sakorafas P., Labkovsky B., Ratnofsky S., Meuer S.
      J. Biol. Chem. 269:29102-29111(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes."
      Bruyns E., Mincheva A., Bruyns R.M., Kirchgessner H., Weitz S., Lichter P., Meuer S., Schraven B.
      Genomics 38:79-83(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45."
      Bruyns E., Hendricks-Taylor L.R., Meuer S., Koretzky G.A., Schraven B.
      J. Biol. Chem. 270:31372-31376(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD45.
    7. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiPTCA_HUMAN
    AccessioniPrimary (citable) accession number: Q14761
    Secondary accession number(s): B2R512, O00643, Q6I9S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3