Q14761 (PTCA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein tyrosine phosphatase receptor type C-associated protein
Short name=PTPRC-associated protein

Alternative name(s):
CD45-associated protein
Short name=CD45-AP
Lymphocyte phosphatase-associated phosphoprotein

Gene names

Name:	PTPRCAP
Synonyms:	LPAP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CD45/PTPRC. Ref.6
Subcellular location	Membrane; Single-pass membrane protein Potential.
Post-translational modification	Phosphorylated on tyrosine residues.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 11390434. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Protein tyrosine phosphatase receptor type C-associated protein		PRO_0000097087
Regions
	Transmembrane	34 – 54	21	Helical; Potential
Natural variations
	Natural variant	128	1	G → E. Corresponds to variant rs60969594 [ dbSNP | Ensembl ].		VAR_061698

Sequences

	Sequence		Length	Mass (Da)
	Q14761 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 26A9F96699BD34D5	FASTA	206	21,196
	10 20 30 40 50 60 MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL ALAWRRLSRD 70 80 90 100 110 120 SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST DNDLERQEDE QDTDYDHVAD 130 140 150 160 170 180 GGLQADPGEG EQQCGEASSP EQVPVRAEEA RDSDTEGDLV LGSPGPASAG GSAEALLSDL 190 200 HAFAGSAAWD DSARAAGGQG LHVTAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes." Schraven B., Schoenhaut D., Bruyns E., Koretzky G., Eckerskorn C., Wallich R., Kirchgessner H., Sakorafas P., Labkovsky B., Ratnofsky S., Meuer S. J. Biol. Chem. 269:29102-29111(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes." Bruyns E., Mincheva A., Bruyns R.M., Kirchgessner H., Weitz S., Lichter P., Meuer S., Schraven B. Genomics 38:79-83(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45." Bruyns E., Hendricks-Taylor L.R., Meuer S., Koretzky G.A., Schraven B. J. Biol. Chem. 270:31372-31376(1995) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CD45.
[7]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: T-cell.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X81422 mRNA. Translation: CAA57182.1. X97267 Genomic DNA. Translation: CAA65922.1. CR457429 mRNA. Translation: CAG33710.1. AK312022 mRNA. Translation: BAG34959.1. BC113859 mRNA. Translation: AAI13860.1. BC114467 mRNA. Translation: AAI14468.1.
IPI	IPI00023786.
PIR	A55412.
RefSeq	NP_005599.1. NM_005608.2.
UniGene	Hs.155975.
3D structure databases
ProteinModelPortal	Q14761.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14761. 2 interactions.
MINT	MINT-1389998.
STRING	9606.ENSP00000325589.
PTM databases
PhosphoSite	Q14761.
Polymorphism databases
DMDM	22001841.
Proteomic databases
PaxDb	Q14761.
PRIDE	Q14761.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326294; ENSP00000325589; ENSG00000213402.
GeneID	5790.
KEGG	hsa:5790.
UCSC	uc001oli.1. human.
Organism-specific databases
CTD	5790.
GeneCards	GC11M067202.
H-InvDB	HIX0079400. HIX0201772.
HGNC	HGNC:9667. PTPRCAP.
HPA	HPA043734.
MIM	601577. gene.
neXtProt	NX_Q14761.
PharmGKB	PA34012.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG87279.
HOGENOM	HOG000115756.
HOVERGEN	HBG030697.
InParanoid	Q14761.
OMA	GYYHPAR.
OrthoDB	EOG4C87TQ.
PhylomeDB	Q14761.
Gene expression databases
Bgee	Q14761.
CleanEx	HS_PTPRCAP.
Genevestigator	Q14761.
GermOnline	ENSG00000172725. Homo sapiens.
Family and domain databases
InterPro	IPR016553. Tyr_Pase_rcpt_C-assoc_CD45-AP. [Graphical view]
PANTHER	PTHR15312. PTHR15312. 1 hit.
PIRSF	PIRSF009325. PTPRC-associated_protein. 1 hit.
ProtoNet	Search...
Other
BindingDB	Q14761.
ChEMBL	CHEMBL4806.
GenomeRNAi	5790.
NextBio	22540.
SOURCE	Search...

Entry information

Entry name

PTCA_HUMAN

Accession

Primary (citable) accession number: Q14761
Secondary accession number(s): B2R512, O00643, Q6I9S6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.