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Q14761

- PTCA_HUMAN

UniProt

Q14761 - PTCA_HUMAN

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Protein

Protein tyrosine phosphatase receptor type C-associated protein

Gene
PTPRCAP, LPAP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. defense response Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase receptor type C-associated protein
Short name:
PTPRC-associated protein
Alternative name(s):
CD45-associated protein
Short name:
CD45-AP
Lymphocyte phosphatase-associated phosphoprotein
Gene namesi
Name:PTPRCAP
Synonyms:LPAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9667. PTPRCAP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34012.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Protein tyrosine phosphatase receptor type C-associated proteinPRO_0000097087Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14761.
PaxDbiQ14761.
PRIDEiQ14761.

PTM databases

PhosphoSiteiQ14761.

Expressioni

Gene expression databases

BgeeiQ14761.
CleanExiHS_PTPRCAP.
GenevestigatoriQ14761.

Organism-specific databases

HPAiHPA043734.

Interactioni

Subunit structurei

Interacts with CD45/PTPRC.1 Publication

Protein-protein interaction databases

BioGridi111754. 4 interactions.
IntActiQ14761. 2 interactions.
MINTiMINT-1389998.
STRINGi9606.ENSP00000325589.

Structurei

3D structure databases

ProteinModelPortaliQ14761.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG87279.
HOGENOMiHOG000115756.
HOVERGENiHBG030697.
InParanoidiQ14761.
OMAiDSGGYYH.
OrthoDBiEOG70W3GN.
PhylomeDBiQ14761.
TreeFamiTF338317.

Family and domain databases

InterProiIPR016553. Tyr_Pase_rcpt_C-assoc_CD45-AP.
[Graphical view]
PANTHERiPTHR15312. PTHR15312. 1 hit.
PIRSFiPIRSF009325. PTPRC-associated_protein. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14761-1 [UniParc]FASTAAdd to Basket

« Hide

MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL    50
ALAWRRLSRD SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST 100
DNDLERQEDE QDTDYDHVAD GGLQADPGEG EQQCGEASSP EQVPVRAEEA 150
RDSDTEGDLV LGSPGPASAG GSAEALLSDL HAFAGSAAWD DSARAAGGQG 200
LHVTAL 206
Length:206
Mass (Da):21,196
Last modified:November 1, 1996 - v1
Checksum:i26A9F96699BD34D5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281G → E.
Corresponds to variant rs60969594 [ dbSNP | Ensembl ].
VAR_061698

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81422 mRNA. Translation: CAA57182.1.
X97267 Genomic DNA. Translation: CAA65922.1.
CR457429 mRNA. Translation: CAG33710.1.
AK312022 mRNA. Translation: BAG34959.1.
BC113859 mRNA. Translation: AAI13860.1.
BC114467 mRNA. Translation: AAI14468.1.
CCDSiCCDS8163.1.
PIRiA55412.
RefSeqiNP_005599.1. NM_005608.2.
UniGeneiHs.155975.

Genome annotation databases

EnsembliENST00000326294; ENSP00000325589; ENSG00000213402.
GeneIDi5790.
KEGGihsa:5790.
UCSCiuc001oli.1. human.

Polymorphism databases

DMDMi22001841.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81422 mRNA. Translation: CAA57182.1 .
X97267 Genomic DNA. Translation: CAA65922.1 .
CR457429 mRNA. Translation: CAG33710.1 .
AK312022 mRNA. Translation: BAG34959.1 .
BC113859 mRNA. Translation: AAI13860.1 .
BC114467 mRNA. Translation: AAI14468.1 .
CCDSi CCDS8163.1.
PIRi A55412.
RefSeqi NP_005599.1. NM_005608.2.
UniGenei Hs.155975.

3D structure databases

ProteinModelPortali Q14761.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111754. 4 interactions.
IntActi Q14761. 2 interactions.
MINTi MINT-1389998.
STRINGi 9606.ENSP00000325589.

Chemistry

BindingDBi Q14761.
ChEMBLi CHEMBL4806.

PTM databases

PhosphoSitei Q14761.

Polymorphism databases

DMDMi 22001841.

Proteomic databases

MaxQBi Q14761.
PaxDbi Q14761.
PRIDEi Q14761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326294 ; ENSP00000325589 ; ENSG00000213402 .
GeneIDi 5790.
KEGGi hsa:5790.
UCSCi uc001oli.1. human.

Organism-specific databases

CTDi 5790.
GeneCardsi GC11M067202.
H-InvDB HIX0079400.
HIX0201772.
HGNCi HGNC:9667. PTPRCAP.
HPAi HPA043734.
MIMi 601577. gene.
neXtProti NX_Q14761.
PharmGKBi PA34012.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87279.
HOGENOMi HOG000115756.
HOVERGENi HBG030697.
InParanoidi Q14761.
OMAi DSGGYYH.
OrthoDBi EOG70W3GN.
PhylomeDBi Q14761.
TreeFami TF338317.

Miscellaneous databases

GeneWikii PTPRCAP.
GenomeRNAii 5790.
NextBioi 22540.
PROi Q14761.
SOURCEi Search...

Gene expression databases

Bgeei Q14761.
CleanExi HS_PTPRCAP.
Genevestigatori Q14761.

Family and domain databases

InterProi IPR016553. Tyr_Pase_rcpt_C-assoc_CD45-AP.
[Graphical view ]
PANTHERi PTHR15312. PTHR15312. 1 hit.
PIRSFi PIRSF009325. PTPRC-associated_protein. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes."
    Schraven B., Schoenhaut D., Bruyns E., Koretzky G., Eckerskorn C., Wallich R., Kirchgessner H., Sakorafas P., Labkovsky B., Ratnofsky S., Meuer S.
    J. Biol. Chem. 269:29102-29111(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes."
    Bruyns E., Mincheva A., Bruyns R.M., Kirchgessner H., Weitz S., Lichter P., Meuer S., Schraven B.
    Genomics 38:79-83(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45."
    Bruyns E., Hendricks-Taylor L.R., Meuer S., Koretzky G.A., Schraven B.
    J. Biol. Chem. 270:31372-31376(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD45.
  7. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiPTCA_HUMAN
AccessioniPrimary (citable) accession number: Q14761
Secondary accession number(s): B2R512, O00643, Q6I9S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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