Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein tyrosine phosphatase receptor type C-associated protein

Gene

PTPRCAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • defense response Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase receptor type C-associated protein
Short name:
PTPRC-associated protein
Alternative name(s):
CD45-associated protein
Short name:
CD45-AP
Lymphocyte phosphatase-associated phosphoprotein
Gene namesi
Name:PTPRCAP
Synonyms:LPAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000213402.2
HGNCiHGNC:9667 PTPRCAP
MIMi601577 gene
neXtProtiNX_Q14761

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5790
OpenTargetsiENSG00000213402
PharmGKBiPA34012

Chemistry databases

ChEMBLiCHEMBL4806

Polymorphism and mutation databases

BioMutaiPTPRCAP
DMDMi22001841

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000970871 – 206Protein tyrosine phosphatase receptor type C-associated proteinAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14761
MaxQBiQ14761
PaxDbiQ14761
PeptideAtlasiQ14761
PRIDEiQ14761
ProteomicsDBi60156

PTM databases

iPTMnetiQ14761
PhosphoSitePlusiQ14761

Expressioni

Gene expression databases

BgeeiENSG00000213402
CleanExiHS_PTPRCAP
GenevisibleiQ14761 HS

Organism-specific databases

HPAiHPA043734

Interactioni

Subunit structurei

Interacts with CD45/PTPRC.1 Publication

Protein-protein interaction databases

BioGridi111754, 3 interactors
IntActiQ14761, 5 interactors
STRINGi9606.ENSP00000325589

Chemistry databases

BindingDBiQ14761

Structurei

3D structure databases

ProteinModelPortaliQ14761
SMRiQ14761
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3TA Eukaryota
ENOG4111AXC LUCA
GeneTreeiENSGT00390000017041
HOGENOMiHOG000115756
HOVERGENiHBG030697
InParanoidiQ14761
OMAiGYYHPAR
OrthoDBiEOG091G0Y47
PhylomeDBiQ14761
TreeFamiTF338317

Family and domain databases

InterProiView protein in InterPro
IPR016553 PTPRCAP
PANTHERiPTHR15312 PTHR15312, 1 hit
PfamiView protein in Pfam
PF15713 PTPRCAP, 1 hit
PIRSFiPIRSF009325 PTPRC-associated_protein, 1 hit

Sequencei

Sequence statusi: Complete.

Q14761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPCTLGLG MLLALPGALG SGGSAEDSVG SSSVTVVLLL LLLLLLATGL
60 70 80 90 100
ALAWRRLSRD SGGYYHPARL GAALWGRTRR LLWASPPGRW LQARAELGST
110 120 130 140 150
DNDLERQEDE QDTDYDHVAD GGLQADPGEG EQQCGEASSP EQVPVRAEEA
160 170 180 190 200
RDSDTEGDLV LGSPGPASAG GSAEALLSDL HAFAGSAAWD DSARAAGGQG

LHVTAL
Length:206
Mass (Da):21,196
Last modified:November 1, 1996 - v1
Checksum:i26A9F96699BD34D5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061698128G → E. Corresponds to variant dbSNP:rs60969594Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81422 mRNA Translation: CAA57182.1
X97267 Genomic DNA Translation: CAA65922.1
CR457429 mRNA Translation: CAG33710.1
AK312022 mRNA Translation: BAG34959.1
BC113859 mRNA Translation: AAI13860.1
BC114467 mRNA Translation: AAI14468.1
CCDSiCCDS8163.1
PIRiA55412
RefSeqiNP_005599.1, NM_005608.2
UniGeneiHs.155975

Genome annotation databases

EnsembliENST00000326294; ENSP00000325589; ENSG00000213402
GeneIDi5790
KEGGihsa:5790
UCSCiuc001oli.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPTCA_HUMAN
AccessioniPrimary (citable) accession number: Q14761
Secondary accession number(s): B2R512, O00643, Q6I9S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health