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Protein

Conserved oligomeric Golgi complex subunit 2

Gene

COG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi morphology and function.

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: Reactome
  • Golgi organization Source: UniProtKB
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 2
Short name:
COG complex subunit 2
Alternative name(s):
Component of oligomeric Golgi complex 2
Low density lipoprotein receptor defect C-complementing protein
Gene namesi
Name:COG2
Synonyms:LDLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6546. COG2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • Golgi membrane Source: Reactome
  • Golgi stack Source: UniProtKB
  • Golgi transport complex Source: UniProtKB
  • trans-Golgi network membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26697.

Polymorphism and mutation databases

BioMutaiCOG2.
DMDMi2498512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Conserved oligomeric Golgi complex subunit 2PRO_0000213495Add
BLAST

Proteomic databases

EPDiQ14746.
MaxQBiQ14746.
PaxDbiQ14746.
PeptideAtlasiQ14746.
PRIDEiQ14746.
TopDownProteomicsiQ14746-1. [Q14746-1]

PTM databases

iPTMnetiQ14746.
PhosphoSiteiQ14746.

Expressioni

Gene expression databases

BgeeiQ14746.
CleanExiHS_COG2.
ExpressionAtlasiQ14746. baseline and differential.
GenevisibleiQ14746. HS.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

Binary interactionsi

WithEntry#Exp.IntActNotes
COG4Q9H9E32EBI-389449,EBI-368382
MTUS2Q5JR593EBI-10233912,EBI-742948

Protein-protein interaction databases

BioGridi116477. 29 interactions.
IntActiQ14746. 12 interactions.
STRINGi9606.ENSP00000355629.

Structurei

3D structure databases

ProteinModelPortaliQ14746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG2 family.Curated

Phylogenomic databases

eggNOGiKOG2307. Eukaryota.
ENOG410XU2D. LUCA.
GeneTreeiENSGT00390000012040.
HOGENOMiHOG000046032.
HOVERGENiHBG030902.
InParanoidiQ14746.
OMAiVESHPNG.
OrthoDBiEOG7CZK59.
PhylomeDBiQ14746.
TreeFamiTF105824.

Family and domain databases

InterProiIPR009316. COG2.
IPR024603. COG_complex_COG2_C.
IPR024602. COG_su2_N.
[Graphical view]
PANTHERiPTHR12961. PTHR12961. 2 hits.
PfamiPF06148. COG2. 1 hit.
PF12022. DUF3510. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKSRMNLPK GPDTLCFDKD EFMKEDFDVD HFVSDCRKRV QLEELRDDLE
60 70 80 90 100
LYYKLLKTAM VELINKDYAD FVNLSTNLVG MDKALNQLSV PLGQLREEVL
110 120 130 140 150
SLRSSVSEGI RAVDERMSKQ EDIRKKKMCV LRLIQVIRSV EKIEKILNSQ
160 170 180 190 200
SSKETSALEA SSPLLTGQIL ERIATEFNQL QFHAVQSKGM PLLDKVRPRI
210 220 230 240 250
AGITAMLQQS LEGLLLEGLQ TSDVDIIRHC LRTYATIDKT RDAEALVGQV
260 270 280 290 300
LVKPYIDEVI IEQFVESHPN GLQVMYNKLL EFVPHHCRLL REVTGGAISS
310 320 330 340 350
EKGNTVPGYD FLVNSVWPQI VQGLEEKLPS LFNPGNPDAF HEKYTISMDF
360 370 380 390 400
VRRLERQCGS QASVKRLRAH PAYHSFNKKW NLPVYFQIRF REIAGSLEAA
410 420 430 440 450
LTDVLEDAPA ESPYCLLASH RTWSSLRRCW SDEMFLPLLV HRLWRLTLQI
460 470 480 490 500
LARYSVFVNE LSLRPISNES PKEIKKPLVT GSKEPSITQG NTEDQGSGPS
510 520 530 540 550
ETKPVVSISR TQLVYVVADL DKLQEQLPEL LEIIKPKLEM IGFKNFSSIS
560 570 580 590 600
AALEDSQSSF SACVPSLSSK IIQDLSDSCF GFLKSALEVP RLYRRTNKEV
610 620 630 640 650
PTTASSYVDS ALKPLFQLQS GHKDKLKQAI IQQWLEGTLS ESTHKYYETV
660 670 680 690 700
SDVLNSVKKM EESLKRLKQA RKTTPANPVG PSGGMSDDDK IRLQLALDVE
710 720 730
YLGEQIQKLG LQASDIKSFS ALAELVAAAK DQATAEQP
Length:738
Mass (Da):83,208
Last modified:November 1, 1997 - v1
Checksum:i8E393CBE1114DB28
GO
Isoform 2 (identifier: Q14746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-551: Missing.

Note: No experimental confirmation available.
Show »
Length:737
Mass (Da):83,136
Checksum:i9B2BF9F84F702F31
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti288 – 2881R → H.
Corresponds to variant rs34796217 [ dbSNP | Ensembl ].
VAR_048757
Natural varianti304 – 3041N → K.
Corresponds to variant rs6681346 [ dbSNP | Ensembl ].
VAR_029274
Natural varianti589 – 5891V → I.
Corresponds to variant rs34109129 [ dbSNP | Ensembl ].
VAR_048758

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei551 – 5511Missing in isoform 2. 1 PublicationVSP_042942

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34975 mRNA. Translation: CAA84427.1.
AL158214 Genomic DNA. Translation: CAI15359.1.
CH471098 Genomic DNA. Translation: EAW69916.1.
BC014960 mRNA. Translation: AAH14960.1.
BC051906 mRNA. Translation: AAH51906.1.
CCDSiCCDS1584.1. [Q14746-1]
CCDS44329.1. [Q14746-2]
PIRiA53542.
RefSeqiNP_001138508.1. NM_001145036.1. [Q14746-2]
NP_031383.1. NM_007357.2. [Q14746-1]
UniGeneiHs.211800.

Genome annotation databases

EnsembliENST00000366668; ENSP00000355628; ENSG00000135775. [Q14746-2]
ENST00000366669; ENSP00000355629; ENSG00000135775. [Q14746-1]
GeneIDi22796.
KEGGihsa:22796.
UCSCiuc001htw.4. human. [Q14746-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34975 mRNA. Translation: CAA84427.1.
AL158214 Genomic DNA. Translation: CAI15359.1.
CH471098 Genomic DNA. Translation: EAW69916.1.
BC014960 mRNA. Translation: AAH14960.1.
BC051906 mRNA. Translation: AAH51906.1.
CCDSiCCDS1584.1. [Q14746-1]
CCDS44329.1. [Q14746-2]
PIRiA53542.
RefSeqiNP_001138508.1. NM_001145036.1. [Q14746-2]
NP_031383.1. NM_007357.2. [Q14746-1]
UniGeneiHs.211800.

3D structure databases

ProteinModelPortaliQ14746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116477. 29 interactions.
IntActiQ14746. 12 interactions.
STRINGi9606.ENSP00000355629.

PTM databases

iPTMnetiQ14746.
PhosphoSiteiQ14746.

Polymorphism and mutation databases

BioMutaiCOG2.
DMDMi2498512.

Proteomic databases

EPDiQ14746.
MaxQBiQ14746.
PaxDbiQ14746.
PeptideAtlasiQ14746.
PRIDEiQ14746.
TopDownProteomicsiQ14746-1. [Q14746-1]

Protocols and materials databases

DNASUi22796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366668; ENSP00000355628; ENSG00000135775. [Q14746-2]
ENST00000366669; ENSP00000355629; ENSG00000135775. [Q14746-1]
GeneIDi22796.
KEGGihsa:22796.
UCSCiuc001htw.4. human. [Q14746-1]

Organism-specific databases

CTDi22796.
GeneCardsiCOG2.
HGNCiHGNC:6546. COG2.
MIMi606974. gene.
neXtProtiNX_Q14746.
PharmGKBiPA26697.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2307. Eukaryota.
ENOG410XU2D. LUCA.
GeneTreeiENSGT00390000012040.
HOGENOMiHOG000046032.
HOVERGENiHBG030902.
InParanoidiQ14746.
OMAiVESHPNG.
OrthoDBiEOG7CZK59.
PhylomeDBiQ14746.
TreeFamiTF105824.

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

GeneWikiiCOG2.
GenomeRNAii22796.
PROiQ14746.
SOURCEiSearch...

Gene expression databases

BgeeiQ14746.
CleanExiHS_COG2.
ExpressionAtlasiQ14746. baseline and differential.
GenevisibleiQ14746. HS.

Family and domain databases

InterProiIPR009316. COG2.
IPR024603. COG_complex_COG2_C.
IPR024602. COG_su2_N.
[Graphical view]
PANTHERiPTHR12961. PTHR12961. 2 hits.
PfamiPF06148. COG2. 1 hit.
PF12022. DUF3510. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function."
    Podos S.D., Reddy P., Ashkenas J., Krieger M.
    J. Cell Biol. 127:679-691(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Retinal pigment epithelium and Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOG2_HUMAN
AccessioniPrimary (citable) accession number: Q14746
Secondary accession number(s): Q86U99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.