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Q14738

- 2A5D_HUMAN

UniProt

Q14738 - 2A5D_HUMAN

Protein

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

Gene

PPP2R5D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein phosphatase type 2A regulator activity Source: ProtInc
    3. protein serine/threonine phosphatase activity Source: Reactome

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. dephosphorylation Source: GOC
    3. energy reserve metabolic process Source: Reactome
    4. glucose metabolic process Source: Reactome
    5. glycolytic process Source: Reactome
    6. innate immune response Source: Reactome
    7. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    8. MyD88-independent toll-like receptor signaling pathway Source: Reactome
    9. nervous system development Source: ProtInc
    10. neurotrophin TRK receptor signaling pathway Source: Reactome
    11. regulation of catalytic activity Source: GOC
    12. small molecule metabolic process Source: Reactome
    13. stress-activated MAPK cascade Source: Reactome
    14. toll-like receptor 10 signaling pathway Source: Reactome
    15. toll-like receptor 2 signaling pathway Source: Reactome
    16. toll-like receptor 3 signaling pathway Source: Reactome
    17. toll-like receptor 4 signaling pathway Source: Reactome
    18. toll-like receptor 5 signaling pathway Source: Reactome
    19. toll-like receptor 9 signaling pathway Source: Reactome
    20. toll-like receptor signaling pathway Source: Reactome
    21. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
    22. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
    23. TRIF-dependent toll-like receptor signaling pathway Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_11063. Degradation of beta-catenin by the destruction complex.
    REACT_11065. Beta-catenin phosphorylation cascade.
    REACT_12436. ERKs are inactivated.
    REACT_12599. ERK/MAPK targets.
    REACT_1383. Glycolysis.
    REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_1505. Integration of energy metabolism.
    REACT_15334. DARPP-32 events.
    REACT_19405. CTLA4 inhibitory signaling.
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_23879. Platelet sensitization by LDL.
    REACT_682. Mitotic Prometaphase.
    REACT_705. PP2A-mediated dephosphorylation of key metabolic factors.
    SignaLinkiQ14738.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
    Alternative name(s):
    PP2A B subunit isoform B'-delta
    PP2A B subunit isoform B56-delta
    PP2A B subunit isoform PR61-delta
    PP2A B subunit isoform R5-delta
    Gene namesi
    Name:PPP2R5D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:9312. PPP2R5D.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Nuclear in interphase, nuclear during mitosis.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleoplasm Source: Reactome
    3. nucleus Source: ProtInc
    4. protein phosphatase type 2A complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33676.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoformPRO_0000071452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei573 – 5731Phosphoserine2 Publications
    Modified residuei598 – 5981Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14738.
    PaxDbiQ14738.
    PRIDEiQ14738.

    PTM databases

    PhosphoSiteiQ14738.

    Expressioni

    Tissue specificityi

    Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.

    Inductioni

    By retinoic acid; in neuroblastoma cell lines.

    Gene expression databases

    ArrayExpressiQ14738.
    BgeeiQ14738.
    CleanExiHS_PPP2R5D.
    GenevestigatoriQ14738.

    Organism-specific databases

    HPAiHPA029045.
    HPA029046.

    Interactioni

    Subunit structurei

    PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ClockO087852EBI-396563,EBI-79859From a different organism.
    PPFIA1Q131362EBI-396563,EBI-745426
    PPP2R1AP301534EBI-396563,EBI-302388
    PPP2R1BP301542EBI-396563,EBI-357094

    Protein-protein interaction databases

    BioGridi111520. 32 interactions.
    DIPiDIP-29961N.
    IntActiQ14738. 26 interactions.
    MINTiMINT-5006095.
    STRINGi9606.ENSP00000417963.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14738.
    SMRiQ14738. Positions 110-512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati37 – 3821
    Repeati39 – 4022
    Repeati41 – 4223
    Repeati43 – 4424
    Repeati45 – 4625
    Repeati47 – 4826; approximate
    Repeati49 – 5027; approximate
    Repeati51 – 5228

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 52168 X 2 AA approximate tandem repeats of Q-PAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi523 – 5308SH3-binding; class ISequence Analysis
    Motifi548 – 56518Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG264925.
    HOVERGENiHBG000009.
    InParanoidiQ14738.
    KOiK11584.
    OMAiGSGRAEM.
    OrthoDBiEOG7C2R2S.
    PhylomeDBiQ14738.
    TreeFamiTF105556.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR002554. PP2A_B56.
    [Graphical view]
    PANTHERiPTHR10257. PTHR10257. 1 hit.
    PfamiPF01603. B56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028043. PP2A_B56. 1 hit.
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Delta-1 (identifier: Q14738-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPYKLKKEKE PPKVAKCTAK PSSSGKDGGG ENTEEAQPQP QPQPQPQAQS    50
    QPPSSNKRPS NSTPPPTQLS KIKYSGGPQI VKKERRQSSS RFNLSKNREL 100
    QKLPALKDSP TQEREELFIQ KLRQCCVLFD FVSDPLSDLK FKEVKRAGLN 150
    EMVEYITHSR DVVTEAIYPE AVTMFSVNLF RTLPPSSNPT GAEFDPEEDE 200
    PTLEAAWPHL QLVYEFFLRF LESPDFQPNI AKKYIDQKFV LALLDLFDSE 250
    DPRERDFLKT ILHRIYGKFL GLRAYIRRQI NHIFYRFIYE TEHHNGIAEL 300
    LEILGSIING FALPLKEEHK MFLIRVLLPL HKVKSLSVYH PQLAYCVVQF 350
    LEKESSLTEP VIVGLLKFWP KTHSPKEVMF LNELEEILDV IEPSEFSKVM 400
    EPLFRQLAKC VSSPHFQVAE RALYYWNNEY IMSLISDNAA RVLPIMFPAL 450
    YRNSKSHWNK TIHGLIYNAL KLFMEMNQKL FDDCTQQYKA EKQKGRFRMK 500
    EREEMWQKIE ELARLNPQYP MFRAPPPLPP VYSMETETPT AEDIQLLKRT 550
    VETEAVQMLK DIKKEKVLLR RKSELPQDVY TIKALEAHKR AEEFLTASQE 600
    AL 602
    Length:602
    Mass (Da):69,992
    Last modified:November 1, 1996 - v1
    Checksum:iF15F71AF4E565387
    GO
    Isoform Delta-2 (identifier: Q14738-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         85-116: Missing.

    Show »
    Length:570
    Mass (Da):66,181
    Checksum:i978213A7CD1B21A5
    GO
    Isoform Delta-3 (identifier: Q14738-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         11-116: Missing.

    Show »
    Length:496
    Mass (Da):58,453
    Checksum:iA57661F8B20731CB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531P → S Found in a patient with delayed psychomotor development, no speech and cataracts. 1 Publication
    VAR_069414

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei11 – 116106Missing in isoform Delta-3. 1 PublicationVSP_005110Add
    BLAST
    Alternative sequencei85 – 11632Missing in isoform Delta-2. 3 PublicationsVSP_005111Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L76702 mRNA. Translation: AAB69751.1.
    AB000634 mRNA. Translation: BAA20381.1.
    AB000635 mRNA. Translation: BAA20382.1.
    D78360 mRNA. Translation: BAA11372.1.
    AK290604 mRNA. Translation: BAF83293.1.
    AB451342 mRNA. Translation: BAG70156.1.
    AB451357 mRNA. Translation: BAG70171.1.
    AL136304 Genomic DNA. Translation: CAI19791.1.
    CH471081 Genomic DNA. Translation: EAX04133.1.
    BC010692 mRNA. Translation: AAH10692.1.
    BC001095 mRNA. Translation: AAH01095.1.
    BC001175 mRNA. Translation: AAH01175.1.
    CCDSiCCDS43464.1. [Q14738-3]
    CCDS4878.1. [Q14738-1]
    CCDS55002.1. [Q14738-2]
    PIRiS68686.
    RefSeqiNP_001257405.1. NM_001270476.1.
    NP_006236.1. NM_006245.3. [Q14738-1]
    NP_851307.1. NM_180976.2. [Q14738-2]
    NP_851308.1. NM_180977.2. [Q14738-3]
    UniGeneiHs.533308.

    Genome annotation databases

    EnsembliENST00000394110; ENSP00000377669; ENSG00000112640. [Q14738-2]
    ENST00000461010; ENSP00000420674; ENSG00000112640. [Q14738-3]
    ENST00000485511; ENSP00000417963; ENSG00000112640. [Q14738-1]
    GeneIDi5528.
    KEGGihsa:5528.
    UCSCiuc003oth.4. human. [Q14738-1]
    uc010jyd.4. human. [Q14738-3]
    uc021yzq.2. human. [Q14738-2]

    Polymorphism databases

    DMDMi7387495.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L76702 mRNA. Translation: AAB69751.1 .
    AB000634 mRNA. Translation: BAA20381.1 .
    AB000635 mRNA. Translation: BAA20382.1 .
    D78360 mRNA. Translation: BAA11372.1 .
    AK290604 mRNA. Translation: BAF83293.1 .
    AB451342 mRNA. Translation: BAG70156.1 .
    AB451357 mRNA. Translation: BAG70171.1 .
    AL136304 Genomic DNA. Translation: CAI19791.1 .
    CH471081 Genomic DNA. Translation: EAX04133.1 .
    BC010692 mRNA. Translation: AAH10692.1 .
    BC001095 mRNA. Translation: AAH01095.1 .
    BC001175 mRNA. Translation: AAH01175.1 .
    CCDSi CCDS43464.1. [Q14738-3 ]
    CCDS4878.1. [Q14738-1 ]
    CCDS55002.1. [Q14738-2 ]
    PIRi S68686.
    RefSeqi NP_001257405.1. NM_001270476.1.
    NP_006236.1. NM_006245.3. [Q14738-1 ]
    NP_851307.1. NM_180976.2. [Q14738-2 ]
    NP_851308.1. NM_180977.2. [Q14738-3 ]
    UniGenei Hs.533308.

    3D structure databases

    ProteinModelPortali Q14738.
    SMRi Q14738. Positions 110-512.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111520. 32 interactions.
    DIPi DIP-29961N.
    IntActi Q14738. 26 interactions.
    MINTi MINT-5006095.
    STRINGi 9606.ENSP00000417963.

    PTM databases

    PhosphoSitei Q14738.

    Polymorphism databases

    DMDMi 7387495.

    Proteomic databases

    MaxQBi Q14738.
    PaxDbi Q14738.
    PRIDEi Q14738.

    Protocols and materials databases

    DNASUi 5528.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394110 ; ENSP00000377669 ; ENSG00000112640 . [Q14738-2 ]
    ENST00000461010 ; ENSP00000420674 ; ENSG00000112640 . [Q14738-3 ]
    ENST00000485511 ; ENSP00000417963 ; ENSG00000112640 . [Q14738-1 ]
    GeneIDi 5528.
    KEGGi hsa:5528.
    UCSCi uc003oth.4. human. [Q14738-1 ]
    uc010jyd.4. human. [Q14738-3 ]
    uc021yzq.2. human. [Q14738-2 ]

    Organism-specific databases

    CTDi 5528.
    GeneCardsi GC06P042952.
    HGNCi HGNC:9312. PPP2R5D.
    HPAi HPA029045.
    HPA029046.
    MIMi 601646. gene.
    neXtProti NX_Q14738.
    PharmGKBi PA33676.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264925.
    HOVERGENi HBG000009.
    InParanoidi Q14738.
    KOi K11584.
    OMAi GSGRAEM.
    OrthoDBi EOG7C2R2S.
    PhylomeDBi Q14738.
    TreeFami TF105556.

    Enzyme and pathway databases

    Reactomei REACT_11063. Degradation of beta-catenin by the destruction complex.
    REACT_11065. Beta-catenin phosphorylation cascade.
    REACT_12436. ERKs are inactivated.
    REACT_12599. ERK/MAPK targets.
    REACT_1383. Glycolysis.
    REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_1505. Integration of energy metabolism.
    REACT_15334. DARPP-32 events.
    REACT_19405. CTLA4 inhibitory signaling.
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_23879. Platelet sensitization by LDL.
    REACT_682. Mitotic Prometaphase.
    REACT_705. PP2A-mediated dephosphorylation of key metabolic factors.
    SignaLinki Q14738.

    Miscellaneous databases

    GeneWikii PPP2R5D.
    GenomeRNAii 5528.
    NextBioi 21410.
    PROi Q14738.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14738.
    Bgeei Q14738.
    CleanExi HS_PPP2R5D.
    Genevestigatori Q14738.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR002554. PP2A_B56.
    [Graphical view ]
    PANTHERi PTHR10257. PTHR10257. 1 hit.
    Pfami PF01603. B56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028043. PP2A_B56. 1 hit.
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm."
      McCright B., Rivers A.M., Audlin S., Virshup D.M.
      J. Biol. Chem. 271:22081-22089(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA-1).
      Tissue: Fetal brain.
    2. "Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A."
      Tanabe O., Gomez G.A., Nishito Y., Usui H., Takeda M.
      FEBS Lett. 408:52-56(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS DELTA-1 AND DELTA-3).
      Tissue: Brain cortex.
    3. "Molecular cloning of a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A."
      Tanabe O., Nagase T., Murakami T., Nozaki H., Usui H., Nishito Y., Hayashi H., Kagamiyama H., Takeda M.
      FEBS Lett. 379:107-111(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA-2), PROTEIN SEQUENCE OF 501-508; 550-559; 573-580 AND 584-601 (DELTA-1).
      Tissue: Bone marrow and Brain cortex.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA-2).
      Tissue: Heart.
    5. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA-1).
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS DELTA-1 AND DELTA-2).
      Tissue: Colon, Eye and Kidney.
    9. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."
      Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T., Kawashima S.A., Watanabe Y.
      Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SGOL1.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-598, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: VARIANT SER-53.

    Entry informationi

    Entry namei2A5D_HUMAN
    AccessioniPrimary (citable) accession number: Q14738
    Secondary accession number(s): A8K3I9
    , B5BUA6, O00494, O00696, Q15171, Q5TC39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 156 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3