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Q14728

- MFS10_HUMAN

UniProt

Q14728 - MFS10_HUMAN

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Protein

Major facilitator superfamily domain-containing protein 10

Gene

MFSD10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.1 Publication

GO - Molecular functioni

  1. tetracycline transporter activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. tetracycline transport Source: GOC
  3. transmembrane transport Source: InterPro
  4. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 10
Alternative name(s):
Tetracycline transporter-like protein
Gene namesi
Name:MFSD10
Synonyms:TETRAN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:16894. MFSD10.

Subcellular locationi

Membrane Sequence Analysis; Multi-pass membrane protein Sequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13523HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei275 – 29521HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 32718HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence AnalysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Major facilitator superfamily domain-containing protein 10PRO_0000324658Add
BLAST

Proteomic databases

MaxQBiQ14728.
PaxDbiQ14728.
PRIDEiQ14728.

PTM databases

PhosphoSiteiQ14728.

Expressioni

Gene expression databases

BgeeiQ14728.
CleanExiHS_MFSD10.
ExpressionAtlasiQ14728. baseline and differential.
GenevestigatoriQ14728.

Organism-specific databases

HPAiHPA037398.
HPA043209.

Interactioni

Protein-protein interaction databases

BioGridi115521. 1 interaction.
STRINGi9606.ENSP00000332646.

Structurei

3D structure databases

ProteinModelPortaliQ14728.
SMRiQ14728. Positions 358-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00770000120670.
HOGENOMiHOG000209369.
HOVERGENiHBG053800.
InParanoidiQ14728.
PhylomeDBiQ14728.
TreeFamiTF314512.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14728-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGWGGGGGCT PRPPIHQQPP ERRVVTVVFL GLLLDLLAFT LLLPLLPGLL
60 70 80 90 100
ESHGRAHDPL YGSWQGGVDW FATAIGMPVE KRYNSVLFGG LIGSAFSVLQ
110 120 130 140 150
FLCAPLTGAT SDCLGRRPVM LLCLMGVATS YAVWATSRSF AAFLASRLIG
160 170 180 190 200
GISKGNVSLS TAIVADLGSP LARSQGMAVI GVAFSLGFTL GPMLGASLPL
210 220 230 240 250
EMAPWFALLF AASDLLFIFC FLPETLPLEK RAPSIALGFR DAADLLSPLA
260 270 280 290 300
LLRFSAVARG QDPPSGDRLS SLRRLGLVYF LYLFLFSGLE YTLSFLTHQR
310 320 330 340 350
FQFSSLQQGK MFFLIGLTMA TIQGAYARRI HPGGEVAAVK RALLLLVPAF
360 370 380 390 400
LLIGWGRSLP VLGLGLLLYS FAAAVVVPCL SSVVAGYGSP GQKGTVMGTL
410 420 430 440 450
RSLGALARAA GPLVAASVYW LAGAQACFTT WSGLFLLPFF LLQKLSYPAQ

TLKAE
Length:455
Mass (Da):48,339
Last modified:November 1, 1996 - v1
Checksum:iA449A8C479EAC889
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → I in AAA36729. (PubMed:8353488)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11669 mRNA. Translation: AAA36729.1.
AL390065 Genomic DNA. Translation: CAM21300.1.
CH471131 Genomic DNA. Translation: EAW82496.1.
BC001502 mRNA. Translation: AAH01502.1.
BC014979 mRNA. Translation: AAH14979.1.
CCDSiCCDS3365.1.
PIRiI54353.
RefSeqiNP_001111.3. NM_001120.4.
NP_001139541.1. NM_001146069.1.
UniGeneiHs.632581.

Genome annotation databases

EnsembliENST00000329687; ENSP00000332646; ENSG00000109736.
ENST00000355443; ENSP00000347619; ENSG00000109736.
GeneIDi10227.
KEGGihsa:10227.
UCSCiuc003gfw.3. human.

Polymorphism databases

DMDMi74735668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11669 mRNA. Translation: AAA36729.1 .
AL390065 Genomic DNA. Translation: CAM21300.1 .
CH471131 Genomic DNA. Translation: EAW82496.1 .
BC001502 mRNA. Translation: AAH01502.1 .
BC014979 mRNA. Translation: AAH14979.1 .
CCDSi CCDS3365.1.
PIRi I54353.
RefSeqi NP_001111.3. NM_001120.4.
NP_001139541.1. NM_001146069.1.
UniGenei Hs.632581.

3D structure databases

ProteinModelPortali Q14728.
SMRi Q14728. Positions 358-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115521. 1 interaction.
STRINGi 9606.ENSP00000332646.

PTM databases

PhosphoSitei Q14728.

Polymorphism databases

DMDMi 74735668.

Proteomic databases

MaxQBi Q14728.
PaxDbi Q14728.
PRIDEi Q14728.

Protocols and materials databases

DNASUi 10227.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329687 ; ENSP00000332646 ; ENSG00000109736 .
ENST00000355443 ; ENSP00000347619 ; ENSG00000109736 .
GeneIDi 10227.
KEGGi hsa:10227.
UCSCi uc003gfw.3. human.

Organism-specific databases

CTDi 10227.
GeneCardsi GC04M002903.
HGNCi HGNC:16894. MFSD10.
HPAi HPA037398.
HPA043209.
MIMi 610977. gene.
neXtProti NX_Q14728.
PharmGKBi PA162395840.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00770000120670.
HOGENOMi HOG000209369.
HOVERGENi HBG053800.
InParanoidi Q14728.
PhylomeDBi Q14728.
TreeFami TF314512.

Miscellaneous databases

ChiTaRSi MFSD10. human.
GenomeRNAii 10227.
NextBioi 38726.
PROi Q14728.
SOURCEi Search...

Gene expression databases

Bgeei Q14728.
CleanExi HS_MFSD10.
ExpressionAtlasi Q14728. baseline and differential.
Genevestigatori Q14728.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Frontal cortexImported.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cellImported and ColonImported.
  5. "Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs."
    Mima S., Ushijima H., Hwang H.-J., Tsutsumi S., Makise M., Yamaguchi Y., Tsuchiya T., Mizushima H., Mizushima T.
    FEBS Lett. 581:1457-1463(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMFS10_HUMAN
AccessioniPrimary (citable) accession number: Q14728
Secondary accession number(s): Q07706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3