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Protein

Major facilitator superfamily domain-containing protein 10

Gene

MFSD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.1 Publication

GO - Molecular functioni

  • organic anion transmembrane transporter activity Source: MGI
  • tetracycline transmembrane transporter activity Source: ProtInc

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • sodium-independent organic anion transport Source: MGI

Keywordsi

Biological processApoptosis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 10
Alternative name(s):
Tetracycline transporter-like protein
Gene namesi
Name:MFSD10
Synonyms:TETRAN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109736.14
HGNCiHGNC:16894 MFSD10
MIMi610977 gene
neXtProtiNX_Q14728

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei113 – 135HelicalSequence analysisAdd BLAST23
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Transmembranei310 – 327HelicalSequence analysisAdd BLAST18
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109736
PharmGKBiPA162395840

Polymorphism and mutation databases

BioMutaiMFSD10
DMDMi74735668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246581 – 455Major facilitator superfamily domain-containing protein 10Add BLAST455

Proteomic databases

EPDiQ14728
MaxQBiQ14728
PaxDbiQ14728
PeptideAtlasiQ14728
PRIDEiQ14728

PTM databases

iPTMnetiQ14728
PhosphoSitePlusiQ14728
SwissPalmiQ14728

Expressioni

Gene expression databases

BgeeiENSG00000109736
CleanExiHS_MFSD10
ExpressionAtlasiQ14728 baseline and differential
GenevisibleiQ14728 HS

Organism-specific databases

HPAiHPA043209

Interactioni

Protein-protein interaction databases

BioGridi1155215 interactors.
IntActiQ14728 4 interactors.
MINTiQ14728
STRINGi9606.ENSP00000332646

Structurei

3D structure databases

ProteinModelPortaliQ14728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2615 Eukaryota
ENOG410XSE0 LUCA
GeneTreeiENSGT00830000128422
HOGENOMiHOG000209369
HOVERGENiHBG053800
InParanoidiQ14728
PhylomeDBiQ14728
TreeFamiTF314512

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q14728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWGGGGGCT PRPPIHQQPP ERRVVTVVFL GLLLDLLAFT LLLPLLPGLL
60 70 80 90 100
ESHGRAHDPL YGSWQGGVDW FATAIGMPVE KRYNSVLFGG LIGSAFSVLQ
110 120 130 140 150
FLCAPLTGAT SDCLGRRPVM LLCLMGVATS YAVWATSRSF AAFLASRLIG
160 170 180 190 200
GISKGNVSLS TAIVADLGSP LARSQGMAVI GVAFSLGFTL GPMLGASLPL
210 220 230 240 250
EMAPWFALLF AASDLLFIFC FLPETLPLEK RAPSIALGFR DAADLLSPLA
260 270 280 290 300
LLRFSAVARG QDPPSGDRLS SLRRLGLVYF LYLFLFSGLE YTLSFLTHQR
310 320 330 340 350
FQFSSLQQGK MFFLIGLTMA TIQGAYARRI HPGGEVAAVK RALLLLVPAF
360 370 380 390 400
LLIGWGRSLP VLGLGLLLYS FAAAVVVPCL SSVVAGYGSP GQKGTVMGTL
410 420 430 440 450
RSLGALARAA GPLVAASVYW LAGAQACFTT WSGLFLLPFF LLQKLSYPAQ

TLKAE
Length:455
Mass (Da):48,339
Last modified:November 1, 1996 - v1
Checksum:iA449A8C479EAC889
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26T → I in AAA36729 (PubMed:8353488).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11669 mRNA Translation: AAA36729.1
AL390065 Genomic DNA Translation: CAM21300.1
CH471131 Genomic DNA Translation: EAW82496.1
BC001502 mRNA Translation: AAH01502.1
BC014979 mRNA Translation: AAH14979.1
CCDSiCCDS3365.1
PIRiI54353
RefSeqiNP_001111.3, NM_001120.4
NP_001139541.1, NM_001146069.1
UniGeneiHs.632581

Genome annotation databases

EnsembliENST00000329687; ENSP00000332646; ENSG00000109736
ENST00000355443; ENSP00000347619; ENSG00000109736
GeneIDi10227
KEGGihsa:10227
UCSCiuc003gfw.4 human

Similar proteinsi

Entry informationi

Entry nameiMFS10_HUMAN
AccessioniPrimary (citable) accession number: Q14728
Secondary accession number(s): Q07706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome