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Q14728

- MFS10_HUMAN

UniProt

Q14728 - MFS10_HUMAN

Protein

Major facilitator superfamily domain-containing protein 10

Gene

MFSD10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.1 Publication

    GO - Molecular functioni

    1. tetracycline transporter activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. tetracycline transport Source: GOC
    3. transmembrane transport Source: InterPro
    4. transport Source: ProtInc

    Keywords - Biological processi

    Apoptosis, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major facilitator superfamily domain-containing protein 10
    Alternative name(s):
    Tetracycline transporter-like protein
    Gene namesi
    Name:MFSD10
    Synonyms:TETRAN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:16894. MFSD10.

    Subcellular locationi

    Membrane Sequence Analysis; Multi-pass membrane protein Sequence Analysis

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162395840.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Major facilitator superfamily domain-containing protein 10PRO_0000324658Add
    BLAST

    Proteomic databases

    MaxQBiQ14728.
    PaxDbiQ14728.
    PRIDEiQ14728.

    PTM databases

    PhosphoSiteiQ14728.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14728.
    BgeeiQ14728.
    CleanExiHS_MFSD10.
    GenevestigatoriQ14728.

    Organism-specific databases

    HPAiHPA037398.
    HPA043209.

    Interactioni

    Protein-protein interaction databases

    BioGridi115521. 1 interaction.
    STRINGi9606.ENSP00000332646.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14728.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 32718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the major facilitator superfamily.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000209369.
    HOVERGENiHBG053800.
    InParanoidiQ14728.
    PhylomeDBiQ14728.
    TreeFamiTF314512.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14728-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWGGGGGCT PRPPIHQQPP ERRVVTVVFL GLLLDLLAFT LLLPLLPGLL    50
    ESHGRAHDPL YGSWQGGVDW FATAIGMPVE KRYNSVLFGG LIGSAFSVLQ 100
    FLCAPLTGAT SDCLGRRPVM LLCLMGVATS YAVWATSRSF AAFLASRLIG 150
    GISKGNVSLS TAIVADLGSP LARSQGMAVI GVAFSLGFTL GPMLGASLPL 200
    EMAPWFALLF AASDLLFIFC FLPETLPLEK RAPSIALGFR DAADLLSPLA 250
    LLRFSAVARG QDPPSGDRLS SLRRLGLVYF LYLFLFSGLE YTLSFLTHQR 300
    FQFSSLQQGK MFFLIGLTMA TIQGAYARRI HPGGEVAAVK RALLLLVPAF 350
    LLIGWGRSLP VLGLGLLLYS FAAAVVVPCL SSVVAGYGSP GQKGTVMGTL 400
    RSLGALARAA GPLVAASVYW LAGAQACFTT WSGLFLLPFF LLQKLSYPAQ 450
    TLKAE 455
    Length:455
    Mass (Da):48,339
    Last modified:November 1, 1996 - v1
    Checksum:iA449A8C479EAC889
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261T → I in AAA36729. (PubMed:8353488)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11669 mRNA. Translation: AAA36729.1.
    AL390065 Genomic DNA. Translation: CAM21300.1.
    CH471131 Genomic DNA. Translation: EAW82496.1.
    BC001502 mRNA. Translation: AAH01502.1.
    BC014979 mRNA. Translation: AAH14979.1.
    CCDSiCCDS3365.1.
    PIRiI54353.
    RefSeqiNP_001111.3. NM_001120.4.
    NP_001139541.1. NM_001146069.1.
    UniGeneiHs.632581.

    Genome annotation databases

    EnsembliENST00000329687; ENSP00000332646; ENSG00000109736.
    ENST00000355443; ENSP00000347619; ENSG00000109736.
    GeneIDi10227.
    KEGGihsa:10227.
    UCSCiuc003gfw.3. human.

    Polymorphism databases

    DMDMi74735668.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11669 mRNA. Translation: AAA36729.1 .
    AL390065 Genomic DNA. Translation: CAM21300.1 .
    CH471131 Genomic DNA. Translation: EAW82496.1 .
    BC001502 mRNA. Translation: AAH01502.1 .
    BC014979 mRNA. Translation: AAH14979.1 .
    CCDSi CCDS3365.1.
    PIRi I54353.
    RefSeqi NP_001111.3. NM_001120.4.
    NP_001139541.1. NM_001146069.1.
    UniGenei Hs.632581.

    3D structure databases

    ProteinModelPortali Q14728.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115521. 1 interaction.
    STRINGi 9606.ENSP00000332646.

    PTM databases

    PhosphoSitei Q14728.

    Polymorphism databases

    DMDMi 74735668.

    Proteomic databases

    MaxQBi Q14728.
    PaxDbi Q14728.
    PRIDEi Q14728.

    Protocols and materials databases

    DNASUi 10227.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329687 ; ENSP00000332646 ; ENSG00000109736 .
    ENST00000355443 ; ENSP00000347619 ; ENSG00000109736 .
    GeneIDi 10227.
    KEGGi hsa:10227.
    UCSCi uc003gfw.3. human.

    Organism-specific databases

    CTDi 10227.
    GeneCardsi GC04M002903.
    HGNCi HGNC:16894. MFSD10.
    HPAi HPA037398.
    HPA043209.
    MIMi 610977. gene.
    neXtProti NX_Q14728.
    PharmGKBi PA162395840.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000209369.
    HOVERGENi HBG053800.
    InParanoidi Q14728.
    PhylomeDBi Q14728.
    TreeFami TF314512.

    Miscellaneous databases

    GenomeRNAii 10227.
    NextBioi 38726.
    PROi Q14728.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14728.
    Bgeei Q14728.
    CleanExi HS_MFSD10.
    Genevestigatori Q14728.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Frontal cortexImported.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cellImported and ColonImported.
    5. "Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs."
      Mima S., Ushijima H., Hwang H.-J., Tsutsumi S., Makise M., Yamaguchi Y., Tsuchiya T., Mizushima H., Mizushima T.
      FEBS Lett. 581:1457-1463(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiMFS10_HUMAN
    AccessioniPrimary (citable) accession number: Q14728
    Secondary accession number(s): Q07706
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3