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Q14728 (MFS10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major facilitator superfamily domain-containing protein 10
Alternative name(s):
Tetracycline transporter-like protein
Gene names
Name:MFSD10
Synonyms:TETRAN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump. Ref.5

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Major facilitator superfamily domain-containing protein 10
PRO_0000324658

Regions

Transmembrane27 – 4721Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane113 – 13523Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane275 – 29521Helical; Potential
Transmembrane310 – 32718Helical; Potential
Transmembrane336 – 35621Helical; Potential
Transmembrane359 – 37921Helical; Potential
Transmembrane421 – 44121Helical; Potential

Experimental info

Sequence conflict261T → I in AAA36729. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q14728 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A449A8C479EAC889

FASTA45548,339
        10         20         30         40         50         60 
MGWGGGGGCT PRPPIHQQPP ERRVVTVVFL GLLLDLLAFT LLLPLLPGLL ESHGRAHDPL 

        70         80         90        100        110        120 
YGSWQGGVDW FATAIGMPVE KRYNSVLFGG LIGSAFSVLQ FLCAPLTGAT SDCLGRRPVM 

       130        140        150        160        170        180 
LLCLMGVATS YAVWATSRSF AAFLASRLIG GISKGNVSLS TAIVADLGSP LARSQGMAVI 

       190        200        210        220        230        240 
GVAFSLGFTL GPMLGASLPL EMAPWFALLF AASDLLFIFC FLPETLPLEK RAPSIALGFR 

       250        260        270        280        290        300 
DAADLLSPLA LLRFSAVARG QDPPSGDRLS SLRRLGLVYF LYLFLFSGLE YTLSFLTHQR 

       310        320        330        340        350        360 
FQFSSLQQGK MFFLIGLTMA TIQGAYARRI HPGGEVAAVK RALLLLVPAF LLIGWGRSLP 

       370        380        390        400        410        420 
VLGLGLLLYS FAAAVVVPCL SSVVAGYGSP GQKGTVMGTL RSLGALARAA GPLVAASVYW 

       430        440        450 
LAGAQACFTT WSGLFLLPFF LLQKLSYPAQ TLKAE 

« Hide

References

« Hide 'large scale' references
[1]"A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins."
Duyao M.P., Taylor S.A.M., Buckler A.J., Ambrose C.M., Lin C., Groot N., Church D., Barnes G., Wasmuth J.J., Housman D.E., MacDonald M.E., Gusella J.F.
Hum. Mol. Genet. 2:673-676(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Frontal cortex.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell and Colon.
[5]"Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs."
Mima S., Ushijima H., Hwang H.-J., Tsutsumi S., Makise M., Yamaguchi Y., Tsuchiya T., Mizushima H., Mizushima T.
FEBS Lett. 581:1457-1463(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L11669 mRNA. Translation: AAA36729.1.
AL390065 Genomic DNA. Translation: CAM21300.1.
CH471131 Genomic DNA. Translation: EAW82496.1.
BC001502 mRNA. Translation: AAH01502.1.
BC014979 mRNA. Translation: AAH14979.1.
PIRI54353.
RefSeqNP_001111.3. NM_001120.4.
NP_001139541.1. NM_001146069.1.
UniGeneHs.632581.

3D structure databases

ProteinModelPortalQ14728.
SMRQ14728. Positions 7-39, 385-428.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115521. 1 interaction.
STRING9606.ENSP00000332646.

PTM databases

PhosphoSiteQ14728.

Polymorphism databases

DMDM74735668.

Proteomic databases

PaxDbQ14728.
PRIDEQ14728.

Protocols and materials databases

DNASU10227.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329687; ENSP00000332646; ENSG00000109736.
ENST00000355443; ENSP00000347619; ENSG00000109736.
GeneID10227.
KEGGhsa:10227.
UCSCuc003gfw.3. human.

Organism-specific databases

CTD10227.
GeneCardsGC04M002903.
HGNCHGNC:16894. MFSD10.
HPAHPA037398.
HPA043209.
MIM610977. gene.
neXtProtNX_Q14728.
PharmGKBPA162395840.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000209369.
HOVERGENHBG053800.
InParanoidQ14728.
PhylomeDBQ14728.
TreeFamTF314512.

Gene expression databases

ArrayExpressQ14728.
BgeeQ14728.
CleanExHS_MFSD10.
GenevestigatorQ14728.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10227.
NextBio38726.
PROQ14728.
SOURCESearch...

Entry information

Entry nameMFS10_HUMAN
AccessionPrimary (citable) accession number: Q14728
Secondary accession number(s): Q07706
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM