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Q14728

- MFS10_HUMAN

UniProt

Q14728 - MFS10_HUMAN

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Protein
Major facilitator superfamily domain-containing protein 10
Gene
MFSD10, TETRAN
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.1 Publication

GO - Molecular functioni

  1. tetracycline transporter activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. tetracycline transport Source: GOC
  3. transmembrane transport Source: InterPro
  4. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 10
Alternative name(s):
Tetracycline transporter-like protein
Gene namesi
Name:MFSD10
Synonyms:TETRAN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:16894. MFSD10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Transmembranei113 – 13523Helical; Reviewed prediction
Add
BLAST
Transmembranei148 – 16821Helical; Reviewed prediction
Add
BLAST
Transmembranei176 – 19621Helical; Reviewed prediction
Add
BLAST
Transmembranei202 – 22221Helical; Reviewed prediction
Add
BLAST
Transmembranei275 – 29521Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 32718Helical; Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Reviewed prediction
Add
BLAST
Transmembranei359 – 37921Helical; Reviewed prediction
Add
BLAST
Transmembranei421 – 44121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Major facilitator superfamily domain-containing protein 10
PRO_0000324658Add
BLAST

Proteomic databases

MaxQBiQ14728.
PaxDbiQ14728.
PRIDEiQ14728.

PTM databases

PhosphoSiteiQ14728.

Expressioni

Gene expression databases

ArrayExpressiQ14728.
BgeeiQ14728.
CleanExiHS_MFSD10.
GenevestigatoriQ14728.

Organism-specific databases

HPAiHPA037398.
HPA043209.

Interactioni

Protein-protein interaction databases

BioGridi115521. 1 interaction.
STRINGi9606.ENSP00000332646.

Structurei

3D structure databases

ProteinModelPortaliQ14728.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000209369.
HOVERGENiHBG053800.
InParanoidiQ14728.
PhylomeDBiQ14728.
TreeFamiTF314512.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14728-1 [UniParc]FASTAAdd to Basket

« Hide

MGWGGGGGCT PRPPIHQQPP ERRVVTVVFL GLLLDLLAFT LLLPLLPGLL    50
ESHGRAHDPL YGSWQGGVDW FATAIGMPVE KRYNSVLFGG LIGSAFSVLQ 100
FLCAPLTGAT SDCLGRRPVM LLCLMGVATS YAVWATSRSF AAFLASRLIG 150
GISKGNVSLS TAIVADLGSP LARSQGMAVI GVAFSLGFTL GPMLGASLPL 200
EMAPWFALLF AASDLLFIFC FLPETLPLEK RAPSIALGFR DAADLLSPLA 250
LLRFSAVARG QDPPSGDRLS SLRRLGLVYF LYLFLFSGLE YTLSFLTHQR 300
FQFSSLQQGK MFFLIGLTMA TIQGAYARRI HPGGEVAAVK RALLLLVPAF 350
LLIGWGRSLP VLGLGLLLYS FAAAVVVPCL SSVVAGYGSP GQKGTVMGTL 400
RSLGALARAA GPLVAASVYW LAGAQACFTT WSGLFLLPFF LLQKLSYPAQ 450
TLKAE 455
Length:455
Mass (Da):48,339
Last modified:November 1, 1996 - v1
Checksum:iA449A8C479EAC889
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → I in AAA36729. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11669 mRNA. Translation: AAA36729.1.
AL390065 Genomic DNA. Translation: CAM21300.1.
CH471131 Genomic DNA. Translation: EAW82496.1.
BC001502 mRNA. Translation: AAH01502.1.
BC014979 mRNA. Translation: AAH14979.1.
CCDSiCCDS3365.1.
PIRiI54353.
RefSeqiNP_001111.3. NM_001120.4.
NP_001139541.1. NM_001146069.1.
UniGeneiHs.632581.

Genome annotation databases

EnsembliENST00000329687; ENSP00000332646; ENSG00000109736.
ENST00000355443; ENSP00000347619; ENSG00000109736.
GeneIDi10227.
KEGGihsa:10227.
UCSCiuc003gfw.3. human.

Polymorphism databases

DMDMi74735668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11669 mRNA. Translation: AAA36729.1 .
AL390065 Genomic DNA. Translation: CAM21300.1 .
CH471131 Genomic DNA. Translation: EAW82496.1 .
BC001502 mRNA. Translation: AAH01502.1 .
BC014979 mRNA. Translation: AAH14979.1 .
CCDSi CCDS3365.1.
PIRi I54353.
RefSeqi NP_001111.3. NM_001120.4.
NP_001139541.1. NM_001146069.1.
UniGenei Hs.632581.

3D structure databases

ProteinModelPortali Q14728.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115521. 1 interaction.
STRINGi 9606.ENSP00000332646.

PTM databases

PhosphoSitei Q14728.

Polymorphism databases

DMDMi 74735668.

Proteomic databases

MaxQBi Q14728.
PaxDbi Q14728.
PRIDEi Q14728.

Protocols and materials databases

DNASUi 10227.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329687 ; ENSP00000332646 ; ENSG00000109736 .
ENST00000355443 ; ENSP00000347619 ; ENSG00000109736 .
GeneIDi 10227.
KEGGi hsa:10227.
UCSCi uc003gfw.3. human.

Organism-specific databases

CTDi 10227.
GeneCardsi GC04M002903.
HGNCi HGNC:16894. MFSD10.
HPAi HPA037398.
HPA043209.
MIMi 610977. gene.
neXtProti NX_Q14728.
PharmGKBi PA162395840.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000209369.
HOVERGENi HBG053800.
InParanoidi Q14728.
PhylomeDBi Q14728.
TreeFami TF314512.

Miscellaneous databases

GenomeRNAii 10227.
NextBioi 38726.
PROi Q14728.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14728.
Bgeei Q14728.
CleanExi HS_MFSD10.
Genevestigatori Q14728.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Frontal cortex.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell and Colon.
  5. "Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs."
    Mima S., Ushijima H., Hwang H.-J., Tsutsumi S., Makise M., Yamaguchi Y., Tsuchiya T., Mizushima H., Mizushima T.
    FEBS Lett. 581:1457-1463(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMFS10_HUMAN
AccessioniPrimary (citable) accession number: Q14728
Secondary accession number(s): Q07706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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