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Q14722 (KCAB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-gated potassium channel subunit beta-1
Alternative name(s):
K(+) channel subunit beta-1
Kv-beta-1
Gene names
Name:KCNAB1
Synonyms:KCNA1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB12 has no effect on Kv1.1, Kv1.2 or Kv2.1.

Subunit structure

Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 By similarity. Part of a complex containing KCNA1, KCNA4 and LGI1 By similarity.

Subcellular location

Cytoplasm Potential.

Tissue specificity

In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. Ref.3 Ref.5

Domain

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit Probable.

Sequence similarities

Belongs to the shaker potassium channel beta subunit family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform KvB1.3 (identifier: Q14722-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform KvB1.1 (identifier: Q14722-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MQVSIACTEH...STAKQTGMKY
Isoform KvB1.2 (identifier: Q14722-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MHLYKPACAD...TTRAETGMAY

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Voltage-gated potassium channel subunit beta-1
PRO_0000148739

Natural variations

Alternative sequence1 – 9191MLAAR…TGMPH → MQVSIACTEHNLKSRNGEDR LLSKQSSTAPNVVNAARAKF RTVAIIARSLGTFTPQHHIS LKESTAKQTGMKY in isoform KvB1.1.
VSP_001051
Alternative sequence1 – 9191MLAAR…TGMPH → MHLYKPACADIPSPKLGLPK SSESALKCRWHLAVTKTQPQ AACKPVRPSGAAEQKYVEKF LRVHGISLQETTRAETGMAY in isoform KvB1.2.
VSP_001050

Experimental info

Sequence conflict2901V → L in CAA58208. Ref.5
Isoform KvB1.2:
Sequence conflict161L → S in AAC50113. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Isoform KvB1.3 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: EFFDA78568007A7A

FASTA41946,563
        10         20         30         40         50         60 
MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS GESQLRARQL 

        70         80         90        100        110        120 
ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR VSCLGLGTWV TFGGQISDEV 

       130        140        150        160        170        180 
AERLMTIAYE SGVNLFDTAE VYAAGKAEVI LGSIIKKKGW RRSSLVITTK LYWGGKAETE 

       190        200        210        220        230        240 
RGLSRKHIIE GLKGSLQRLQ LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS 

       250        260        270        280        290        300 
RWSAMEIMEA YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC 

       310        320        330        340        350        360 
GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER LGCTLPQLAV 

       370        380        390        400        410 
AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV NEIDNILRNK PYSKKDYRS 

« Hide

Isoform KvB1.1 [UniParc].

Checksum: F9F17404DF35FDA1
Show »

FASTA40144,710
Isoform KvB1.2 [UniParc].

Checksum: 0C7CD8C23411F8E0
Show »

FASTA40845,492

References

« Hide 'large scale' references
[1]"A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing."
England S.K., Uebele V.N., Kodali J., Bennett P.B., Tamkun M.M.
J. Biol. Chem. 270:28531-28534(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.3).
Tissue: Heart left ventricle.
[2]"Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium."
Majumder K., De Biasi M., Wang Z., Wible B.A.
FEBS Lett. 361:13-16(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.2).
Tissue: Heart atrium.
[3]"Characterization of a voltage-gated K+ channel beta subunit expressed in human heart."
England S.K., Uebele V.N., Shear H., Kodali J., Bennett P.B., Tamkun M.M.
Proc. Natl. Acad. Sci. U.S.A. 92:6309-6313(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.2), TISSUE SPECIFICITY.
Tissue: Heart left ventricle.
[4]"Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product."
Mccormack K., McCormack T., Tanouye M.A., Rudy B., Stuehmer W.
FEBS Lett. 370:32-36(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.1).
Tissue: Hippocampus.
[5]"Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B)."
Leicher T., Roeper J., Weber K., Wang X., Pongs O.
Neuropharmacology 35:787-795(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.1), TISSUE SPECIFICITY.
Tissue: Brain cortex.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS KVB1.1; KVB1.2 AND KVB1.3).
Tissue: Hippocampus, Thymus and Trachea.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM KVB1.1).
Tissue: Brain.
[9]"A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits."
Morales M.J., Castellino R.C., Crews A.L., Rasmusson R.L., Strauss H.C.
J. Biol. Chem. 270:6272-6277(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-147 (ISOFORM KVB1.2).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L47665 mRNA. Translation: AAC41926.1.
U16953 mRNA. Translation: AAC50122.1.
L39833 mRNA. Translation: AAC37573.1.
U33428 mRNA. Translation: AAC50953.1.
X83127 mRNA. Translation: CAA58208.1.
AK057059 mRNA. Translation: BAG51856.1.
AK127240 mRNA. Translation: BAG54461.1.
AK292693 mRNA. Translation: BAF85382.1.
AK292999 mRNA. Translation: BAF85688.1.
CH471052 Genomic DNA. Translation: EAW78732.1.
CH471052 Genomic DNA. Translation: EAW78733.1.
CH471052 Genomic DNA. Translation: EAW78734.1.
BC043166 mRNA. Translation: AAH43166.1.
U17968 mRNA. Translation: AAC50113.1.
CCDSCCDS3174.1. [Q14722-1]
CCDS3175.1. [Q14722-3]
CCDS33882.1. [Q14722-2]
PIRI55463.
I59393.
RefSeqNP_003462.2. NM_003471.3. [Q14722-3]
NP_751891.1. NM_172159.3. [Q14722-2]
NP_751892.1. NM_172160.2. [Q14722-1]
UniGeneHs.654519.
Hs.703187.

3D structure databases

DisProtDP00090.
ProteinModelPortalQ14722.
SMRQ14722. Positions 91-413.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113626. 10 interactions.
IntActQ14722. 2 interactions.
STRING9606.ENSP00000419952.

Chemistry

ChEMBLCHEMBL5884.

Protein family/group databases

TCDB8.A.5.1.1. the voltage-gated k(+) channel -subunit (kv) family.

PTM databases

PhosphoSiteQ14722.

Polymorphism databases

DMDM18202500.

Proteomic databases

MaxQBQ14722.
PaxDbQ14722.
PRIDEQ14722.

Protocols and materials databases

DNASU7881.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302490; ENSP00000305858; ENSG00000169282. [Q14722-2]
ENST00000471742; ENSP00000418956; ENSG00000169282. [Q14722-3]
ENST00000490337; ENSP00000419952; ENSG00000169282. [Q14722-1]
GeneID7881.
KEGGhsa:7881.
UCSCuc003far.2. human. [Q14722-1]
uc003fas.2. human. [Q14722-3]
uc003fat.2. human. [Q14722-2]

Organism-specific databases

CTD7881.
GeneCardsGC03P155755.
HGNCHGNC:6228. KCNAB1.
HPAHPA044550.
MIM601141. gene.
neXtProtNX_Q14722.
PharmGKBPA370.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0667.
HOVERGENHBG052216.
KOK04882.
OMANASWRTE.
PhylomeDBQ14722.
TreeFamTF324563.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ14722.
BgeeQ14722.
CleanExHS_KCNAB1.
GenevestigatorQ14722.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005400. K_chnl_volt-dep_bsu_KCNAB1.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSPR01578. KCNAB1CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMSSF51430. SSF51430. 1 hit.
TIGRFAMsTIGR01293. Kv_beta. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNAB1.
GenomeRNAi7881.
NextBio30342.
PROQ14722.
SOURCESearch...

Entry information

Entry nameKCAB1_HUMAN
AccessionPrimary (citable) accession number: Q14722
Secondary accession number(s): A8K9H8 expand/collapse secondary AC list , A8KAD4, B3KPZ4, Q13031, Q13302, Q16547, Q6PI60, Q99869
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM