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Q14722

- KCAB1_HUMAN

UniProt

Q14722 - KCAB1_HUMAN

Protein

Voltage-gated potassium channel subunit beta-1

Gene

KCNAB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.

    GO - Molecular functioni

    1. potassium channel regulator activity Source: ProtInc
    2. voltage-gated potassium channel activity Source: InterPro

    GO - Biological processi

    1. learning or memory Source: Ensembl
    2. potassium ion transport Source: ProtInc
    3. regulation of potassium ion transmembrane transporter activity Source: Ensembl
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Protein family/group databases

    TCDBi8.A.5.1.1. the voltage-gated k(+) channel -subunit (kv) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-gated potassium channel subunit beta-1
    Alternative name(s):
    K(+) channel subunit beta-1
    Kv-beta-1
    Gene namesi
    Name:KCNAB1
    Synonyms:KCNA1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:6228. KCNAB1.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: InterPro
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA370.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Voltage-gated potassium channel subunit beta-1PRO_0000148739Add
    BLAST

    Proteomic databases

    MaxQBiQ14722.
    PaxDbiQ14722.
    PRIDEiQ14722.

    PTM databases

    PhosphoSiteiQ14722.

    Expressioni

    Tissue specificityi

    In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.2 Publications

    Gene expression databases

    ArrayExpressiQ14722.
    BgeeiQ14722.
    CleanExiHS_KCNAB1.
    GenevestigatoriQ14722.

    Organism-specific databases

    HPAiHPA044550.

    Interactioni

    Subunit structurei

    Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 By similarity. Part of a complex containing KCNA1, KCNA4 and LGI1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi113626. 10 interactions.
    IntActiQ14722. 2 interactions.
    STRINGi9606.ENSP00000419952.

    Structurei

    3D structure databases

    DisProtiDP00090.
    ProteinModelPortaliQ14722.
    SMRiQ14722. Positions 91-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0667.
    HOVERGENiHBG052216.
    KOiK04882.
    OMAiNASWRTE.
    PhylomeDBiQ14722.
    TreeFamiTF324563.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005400. K_chnl_volt-dep_bsu_KCNAB1.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PRINTSiPR01578. KCNAB1CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform KvB1.3 (identifier: Q14722-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS    50
    GESQLRARQL ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR 100
    VSCLGLGTWV TFGGQISDEV AERLMTIAYE SGVNLFDTAE VYAAGKAEVI 150
    LGSIIKKKGW RRSSLVITTK LYWGGKAETE RGLSRKHIIE GLKGSLQRLQ 200
    LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS RWSAMEIMEA 250
    YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC 300
    GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER 350
    LGCTLPQLAV AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV 400
    NEIDNILRNK PYSKKDYRS 419
    Length:419
    Mass (Da):46,563
    Last modified:November 1, 1996 - v1
    Checksum:iEFFDA78568007A7A
    GO
    Isoform KvB1.1 (identifier: Q14722-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-91: MLAARTGAAG...TTVCTTGMPH → MQVSIACTEH...STAKQTGMKY

    Show »
    Length:401
    Mass (Da):44,710
    Checksum:iF9F17404DF35FDA1
    GO
    Isoform KvB1.2 (identifier: Q14722-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-91: MLAARTGAAG...TTVCTTGMPH → MHLYKPACAD...TTRAETGMAY

    Show »
    Length:408
    Mass (Da):45,492
    Checksum:i0C7CD8C23411F8E0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti290 – 2901V → L in CAA58208. (PubMed:8938711)Curated
    Isoform KvB1.2 (identifier: Q14722-3)
    Sequence conflicti16 – 161L → S in AAC50113. (PubMed:7890764)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9191MLAAR…TGMPH → MQVSIACTEHNLKSRNGEDR LLSKQSSTAPNVVNAARAKF RTVAIIARSLGTFTPQHHIS LKESTAKQTGMKY in isoform KvB1.1. 4 PublicationsVSP_001051Add
    BLAST
    Alternative sequencei1 – 9191MLAAR…TGMPH → MHLYKPACADIPSPKLGLPK SSESALKCRWHLAVTKTQPQ AACKPVRPSGAAEQKYVEKF LRVHGISLQETTRAETGMAY in isoform KvB1.2. 4 PublicationsVSP_001050Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47665 mRNA. Translation: AAC41926.1.
    U16953 mRNA. Translation: AAC50122.1.
    L39833 mRNA. Translation: AAC37573.1.
    U33428 mRNA. Translation: AAC50953.1.
    X83127 mRNA. Translation: CAA58208.1.
    AK057059 mRNA. Translation: BAG51856.1.
    AK127240 mRNA. Translation: BAG54461.1.
    AK292693 mRNA. Translation: BAF85382.1.
    AK292999 mRNA. Translation: BAF85688.1.
    CH471052 Genomic DNA. Translation: EAW78732.1.
    CH471052 Genomic DNA. Translation: EAW78733.1.
    CH471052 Genomic DNA. Translation: EAW78734.1.
    BC043166 mRNA. Translation: AAH43166.1.
    U17968 mRNA. Translation: AAC50113.1.
    CCDSiCCDS3174.1. [Q14722-1]
    CCDS3175.1. [Q14722-3]
    CCDS33882.1. [Q14722-2]
    PIRiI55463.
    I59393.
    RefSeqiNP_003462.2. NM_003471.3. [Q14722-3]
    NP_751891.1. NM_172159.3. [Q14722-2]
    NP_751892.1. NM_172160.2. [Q14722-1]
    UniGeneiHs.654519.
    Hs.703187.

    Genome annotation databases

    EnsembliENST00000302490; ENSP00000305858; ENSG00000169282. [Q14722-2]
    ENST00000471742; ENSP00000418956; ENSG00000169282. [Q14722-3]
    ENST00000490337; ENSP00000419952; ENSG00000169282. [Q14722-1]
    GeneIDi7881.
    KEGGihsa:7881.
    UCSCiuc003far.2. human. [Q14722-1]
    uc003fas.2. human. [Q14722-3]
    uc003fat.2. human. [Q14722-2]

    Polymorphism databases

    DMDMi18202500.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47665 mRNA. Translation: AAC41926.1 .
    U16953 mRNA. Translation: AAC50122.1 .
    L39833 mRNA. Translation: AAC37573.1 .
    U33428 mRNA. Translation: AAC50953.1 .
    X83127 mRNA. Translation: CAA58208.1 .
    AK057059 mRNA. Translation: BAG51856.1 .
    AK127240 mRNA. Translation: BAG54461.1 .
    AK292693 mRNA. Translation: BAF85382.1 .
    AK292999 mRNA. Translation: BAF85688.1 .
    CH471052 Genomic DNA. Translation: EAW78732.1 .
    CH471052 Genomic DNA. Translation: EAW78733.1 .
    CH471052 Genomic DNA. Translation: EAW78734.1 .
    BC043166 mRNA. Translation: AAH43166.1 .
    U17968 mRNA. Translation: AAC50113.1 .
    CCDSi CCDS3174.1. [Q14722-1 ]
    CCDS3175.1. [Q14722-3 ]
    CCDS33882.1. [Q14722-2 ]
    PIRi I55463.
    I59393.
    RefSeqi NP_003462.2. NM_003471.3. [Q14722-3 ]
    NP_751891.1. NM_172159.3. [Q14722-2 ]
    NP_751892.1. NM_172160.2. [Q14722-1 ]
    UniGenei Hs.654519.
    Hs.703187.

    3D structure databases

    DisProti DP00090.
    ProteinModelPortali Q14722.
    SMRi Q14722. Positions 91-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113626. 10 interactions.
    IntActi Q14722. 2 interactions.
    STRINGi 9606.ENSP00000419952.

    Chemistry

    ChEMBLi CHEMBL5884.

    Protein family/group databases

    TCDBi 8.A.5.1.1. the voltage-gated k(+) channel -subunit (kv) family.

    PTM databases

    PhosphoSitei Q14722.

    Polymorphism databases

    DMDMi 18202500.

    Proteomic databases

    MaxQBi Q14722.
    PaxDbi Q14722.
    PRIDEi Q14722.

    Protocols and materials databases

    DNASUi 7881.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302490 ; ENSP00000305858 ; ENSG00000169282 . [Q14722-2 ]
    ENST00000471742 ; ENSP00000418956 ; ENSG00000169282 . [Q14722-3 ]
    ENST00000490337 ; ENSP00000419952 ; ENSG00000169282 . [Q14722-1 ]
    GeneIDi 7881.
    KEGGi hsa:7881.
    UCSCi uc003far.2. human. [Q14722-1 ]
    uc003fas.2. human. [Q14722-3 ]
    uc003fat.2. human. [Q14722-2 ]

    Organism-specific databases

    CTDi 7881.
    GeneCardsi GC03P155755.
    HGNCi HGNC:6228. KCNAB1.
    HPAi HPA044550.
    MIMi 601141. gene.
    neXtProti NX_Q14722.
    PharmGKBi PA370.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0667.
    HOVERGENi HBG052216.
    KOi K04882.
    OMAi NASWRTE.
    PhylomeDBi Q14722.
    TreeFami TF324563.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNAB1.
    GenomeRNAii 7881.
    NextBioi 30342.
    PROi Q14722.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14722.
    Bgeei Q14722.
    CleanExi HS_KCNAB1.
    Genevestigatori Q14722.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005400. K_chnl_volt-dep_bsu_KCNAB1.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PRINTSi PR01578. KCNAB1CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing."
      England S.K., Uebele V.N., Kodali J., Bennett P.B., Tamkun M.M.
      J. Biol. Chem. 270:28531-28534(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.3).
      Tissue: Heart left ventricle.
    2. "Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium."
      Majumder K., De Biasi M., Wang Z., Wible B.A.
      FEBS Lett. 361:13-16(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.2).
      Tissue: Heart atrium.
    3. "Characterization of a voltage-gated K+ channel beta subunit expressed in human heart."
      England S.K., Uebele V.N., Shear H., Kodali J., Bennett P.B., Tamkun M.M.
      Proc. Natl. Acad. Sci. U.S.A. 92:6309-6313(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.2), TISSUE SPECIFICITY.
      Tissue: Heart left ventricle.
    4. "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product."
      Mccormack K., McCormack T., Tanouye M.A., Rudy B., Stuehmer W.
      FEBS Lett. 370:32-36(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.1).
      Tissue: Hippocampus.
    5. "Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B)."
      Leicher T., Roeper J., Weber K., Wang X., Pongs O.
      Neuropharmacology 35:787-795(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.1), TISSUE SPECIFICITY.
      Tissue: Brain cortex.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS KVB1.1; KVB1.2 AND KVB1.3).
      Tissue: Hippocampus, Thymus and Trachea.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM KVB1.1).
      Tissue: Brain.
    9. "A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits."
      Morales M.J., Castellino R.C., Crews A.L., Rasmusson R.L., Strauss H.C.
      J. Biol. Chem. 270:6272-6277(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-147 (ISOFORM KVB1.2).
      Tissue: Heart.

    Entry informationi

    Entry nameiKCAB1_HUMAN
    AccessioniPrimary (citable) accession number: Q14722
    Secondary accession number(s): A8K9H8
    , A8KAD4, B3KPZ4, Q13031, Q13302, Q16547, Q6PI60, Q99869
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3