Q14722 (KCAB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-gated potassium channel subunit beta-1

Alternative name(s):
K(+) channel subunit beta-1
Kv-beta-1

Gene names

Name:	KCNAB1
Synonyms:	KCNA1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.
Subunit structure	Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 By similarity. Part of a complex containing KCNA1, KCNA4 and LGI1 By similarity.
Subcellular location	Cytoplasm Potential.
Tissue specificity	In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. Ref.3 Ref.5
Domain	Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit Probable.
Sequence similarities	Belongs to the shaker potassium channel beta subunit family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Ligand	Potassium
Molecular function	Ion channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	potassium ion transport Traceable author statement Ref.1. Source: ProtInc synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome
Molecular_function	potassium channel regulator activity Traceable author statement Ref.1. Source: ProtInc voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform KvB1.3 (identifier: Q14722-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform KvB1.1 (identifier: Q14722-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MQVSIACTEH...STAKQTGMKY

Isoform KvB1.2 (identifier: Q14722-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MHLYKPACAD...TTRAETGMAY

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Voltage-gated potassium channel subunit beta-1		PRO_0000148739
Natural variations
	Alternative sequence	1 – 91	91	MLAAR…TGMPH → MQVSIACTEHNLKSRNGEDR LLSKQSSTAPNVVNAARAKF RTVAIIARSLGTFTPQHHIS LKESTAKQTGMKY in isoform KvB1.1.		VSP_001051
	Alternative sequence	1 – 91	91	MLAAR…TGMPH → MHLYKPACADIPSPKLGLPK SSESALKCRWHLAVTKTQPQ AACKPVRPSGAAEQKYVEKF LRVHGISLQETTRAETGMAY in isoform KvB1.2.		VSP_001050
Experimental info
	Sequence conflict	290	1	V → L in CAA58208. Ref.5
Isoform KvB1.2:
	Sequence conflict	16	1	L → S in AAC50113. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform KvB1.3 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EFFDA78568007A7A	FASTA	419	46,563
	10 20 30 40 50 60 MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS GESQLRARQL 70 80 90 100 110 120 ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR VSCLGLGTWV TFGGQISDEV 130 140 150 160 170 180 AERLMTIAYE SGVNLFDTAE VYAAGKAEVI LGSIIKKKGW RRSSLVITTK LYWGGKAETE 190 200 210 220 230 240 RGLSRKHIIE GLKGSLQRLQ LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS 250 260 270 280 290 300 RWSAMEIMEA YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC 310 320 330 340 350 360 GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER LGCTLPQLAV 370 380 390 400 410 AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV NEIDNILRNK PYSKKDYRS
	Isoform KvB1.1 [UniParc]. Checksum: F9F17404DF35FDA1	FASTA	401	44,710
	10 20 30 40 50 60 MQVSIACTEH NLKSRNGEDR LLSKQSSTAP NVVNAARAKF RTVAIIARSL GTFTPQHHIS 70 80 90 100 110 120 LKESTAKQTG MKYRNLGKSG LRVSCLGLGT WVTFGGQISD EVAERLMTIA YESGVNLFDT 130 140 150 160 170 180 AEVYAAGKAE VILGSIIKKK GWRRSSLVIT TKLYWGGKAE TERGLSRKHI IEGLKGSLQR 190 200 210 220 230 240 LQLEYVDVVF ANRPDSNTPM EEIVRAMTHV INQGMAMYWG TSRWSAMEIM EAYSVARQFN 250 260 270 280 290 300 MIPPVCEQAE YHLFQREKVE VQLPELYHKI GVGAMTWSPL ACGIISGKYG NGVPESSRAS 310 320 330 340 350 360 LKCYQWLKER IVSEEGRKQQ NKLKDLSPIA ERLGCTLPQL AVAWCLRNEG VSSVLLGSST 370 380 390 400 PEQLIENLGA IQVLPKMTSH VVNEIDNILR NKPYSKKDYR S
	Isoform KvB1.2 [UniParc]. Checksum: 0C7CD8C23411F8E0	FASTA	408	45,492
	10 20 30 40 50 60 MHLYKPACAD IPSPKLGLPK SSESALKCRW HLAVTKTQPQ AACKPVRPSG AAEQKYVEKF 70 80 90 100 110 120 LRVHGISLQE TTRAETGMAY RNLGKSGLRV SCLGLGTWVT FGGQISDEVA ERLMTIAYES 130 140 150 160 170 180 GVNLFDTAEV YAAGKAEVIL GSIIKKKGWR RSSLVITTKL YWGGKAETER GLSRKHIIEG 190 200 210 220 230 240 LKGSLQRLQL EYVDVVFANR PDSNTPMEEI VRAMTHVINQ GMAMYWGTSR WSAMEIMEAY 250 260 270 280 290 300 SVARQFNMIP PVCEQAEYHL FQREKVEVQL PELYHKIGVG AMTWSPLACG IISGKYGNGV 310 320 330 340 350 360 PESSRASLKC YQWLKERIVS EEGRKQQNKL KDLSPIAERL GCTLPQLAVA WCLRNEGVSS 370 380 390 400 VLLGSSTPEQ LIENLGAIQV LPKMTSHVVN EIDNILRNKP YSKKDYRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing." England S.K., Uebele V.N., Kodali J., Bennett P.B., Tamkun M.M. J. Biol. Chem. 270:28531-28534(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.3). Tissue: Heart left ventricle.
[2]	"Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium." Majumder K., De Biasi M., Wang Z., Wible B.A. FEBS Lett. 361:13-16(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.2). Tissue: Heart atrium.
[3]	"Characterization of a voltage-gated K+ channel beta subunit expressed in human heart." England S.K., Uebele V.N., Shear H., Kodali J., Bennett P.B., Tamkun M.M. Proc. Natl. Acad. Sci. U.S.A. 92:6309-6313(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.2), TISSUE SPECIFICITY. Tissue: Heart left ventricle.
[4]	"Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product." Mccormack K., McCormack T., Tanouye M.A., Rudy B., Stuehmer W. FEBS Lett. 370:32-36(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.1). Tissue: Hippocampus.
[5]	"Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B)." Leicher T., Roeper J., Weber K., Wang X., Pongs O. Neuropharmacology 35:787-795(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.1), TISSUE SPECIFICITY. Tissue: Brain cortex.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS KVB1.1; KVB1.2 AND KVB1.3). Tissue: Hippocampus, Thymus and Trachea.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM KVB1.1). Tissue: Brain.
[9]	"A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits." Morales M.J., Castellino R.C., Crews A.L., Rasmusson R.L., Strauss H.C. J. Biol. Chem. 270:6272-6277(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-147 (ISOFORM KVB1.2). Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L47665 mRNA. Translation: AAC41926.1. U16953 mRNA. Translation: AAC50122.1. L39833 mRNA. Translation: AAC37573.1. U33428 mRNA. Translation: AAC50953.1. X83127 mRNA. Translation: CAA58208.1. AK057059 mRNA. Translation: BAG51856.1. AK127240 mRNA. Translation: BAG54461.1. AK292693 mRNA. Translation: BAF85382.1. AK292999 mRNA. Translation: BAF85688.1. CH471052 Genomic DNA. Translation: EAW78732.1. CH471052 Genomic DNA. Translation: EAW78733.1. CH471052 Genomic DNA. Translation: EAW78734.1. BC043166 mRNA. Translation: AAH43166.1. U17968 mRNA. Translation: AAC50113.1.
IPI	IPI00221124. IPI00783784. IPI00783814.
PIR	I55463. I59393.
RefSeq	NP_003462.2. NM_003471.3. NP_751891.1. NM_172159.3. NP_751892.1. NM_172160.2.
UniGene	Hs.654519. Hs.703187.
3D structure databases
ProteinModelPortal	Q14722.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14722. 1 interaction.
STRING	9606.ENSP00000419952.
Protein family/group databases
TCDB	8.A.5.1.1. voltage-gated K+ channel beta-subunit (Kvbeta) family.
PTM databases
PhosphoSite	Q14722.
Polymorphism databases
DMDM	18202500.
Proteomic databases
PaxDb	Q14722.
PRIDE	Q14722.
Protocols and materials databases
DNASU	7881.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302490; ENSP00000305858; ENSG00000169282. ENST00000471742; ENSP00000418956; ENSG00000169282. ENST00000490337; ENSP00000419952; ENSG00000169282.
GeneID	7881.
KEGG	hsa:7881.
UCSC	uc003far.2. human. uc003fas.2. human.
Organism-specific databases
CTD	7881.
GeneCards	GC03P155755.
HGNC	HGNC:6228. KCNAB1.
HPA	HPA044550.
MIM	601141. gene.
neXtProt	NX_Q14722.
PharmGKB	PA370.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0667.
HOVERGEN	HBG052216.
KO	K04882.
OMA	NGDHSKQ.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q14722.
Bgee	Q14722.
CleanEx	HS_KCNAB1.
Genevestigator	Q14722.
GermOnline	ENSG00000169282. Homo sapiens.
Family and domain databases
Gene3D	3.20.20.100. 1 hit.
InterPro	IPR001395. Aldo/ket_red. IPR005983. K_chnl_volt-dep_bsu_KCNAB. IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel. IPR005400. K_chnl_volt-dep_bsu_KCNAB1. IPR023210. NADP_OxRdtase_dom. [Graphical view]
PANTHER	PTHR11732. PTHR11732. 1 hit. PTHR11732:SF14. PTHR11732:SF14. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PRINTS	PR01578. KCNAB1CHANEL. PR01577. KCNABCHANNEL.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
TIGRFAMs	TIGR01293. Kv_beta. 1 hit.
ProtoNet	Search...
Other
ChEMBL	CHEMBL5884.
GenomeRNAi	7881.
NextBio	30342.
SOURCE	Search...

Entry information

Entry name

KCAB1_HUMAN

Accession

Primary (citable) accession number: Q14722
Secondary accession number(s): A8K9H8 , A8KAD4, B3KPZ4, Q13031, Q13302, Q16547, Q6PI60, Q99869

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 124 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.