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Q14722

- KCAB1_HUMAN

UniProt

Q14722 - KCAB1_HUMAN

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Protein

Voltage-gated potassium channel subunit beta-1

Gene

KCNAB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.

GO - Molecular functioni

  1. potassium channel regulator activity Source: ProtInc
  2. voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

  1. learning or memory Source: Ensembl
  2. potassium ion transport Source: ProtInc
  3. regulation of potassium ion transmembrane transporter activity Source: Ensembl
  4. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Protein family/group databases

TCDBi8.A.5.1.1. the voltage-gated k(+) channel -subunit (kv) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-1
Alternative name(s):
K(+) channel subunit beta-1
Kv-beta-1
Gene namesi
Name:KCNAB1
Synonyms:KCNA1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:6228. KCNAB1.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: InterPro
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Voltage-gated potassium channel subunit beta-1PRO_0000148739Add
BLAST

Proteomic databases

MaxQBiQ14722.
PaxDbiQ14722.
PRIDEiQ14722.

PTM databases

PhosphoSiteiQ14722.

Expressioni

Tissue specificityi

In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.2 Publications

Gene expression databases

BgeeiQ14722.
CleanExiHS_KCNAB1.
ExpressionAtlasiQ14722. baseline and differential.
GenevestigatoriQ14722.

Organism-specific databases

HPAiHPA044550.

Interactioni

Subunit structurei

Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi113626. 11 interactions.
IntActiQ14722. 2 interactions.
STRINGi9606.ENSP00000419952.

Structurei

3D structure databases

DisProtiDP00090.
ProteinModelPortaliQ14722.
SMRiQ14722. Positions 91-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0667.
GeneTreeiENSGT00550000074567.
HOVERGENiHBG052216.
InParanoidiQ14722.
KOiK04882.
OMAiNASWRTE.
PhylomeDBiQ14722.
TreeFamiTF324563.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005400. K_chnl_volt-dep_bsu_KCNAB1.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR01578. KCNAB1CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMiSSF51430. SSF51430. 1 hit.
TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform KvB1.3 (identifier: Q14722-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS
60 70 80 90 100
GESQLRARQL ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR
110 120 130 140 150
VSCLGLGTWV TFGGQISDEV AERLMTIAYE SGVNLFDTAE VYAAGKAEVI
160 170 180 190 200
LGSIIKKKGW RRSSLVITTK LYWGGKAETE RGLSRKHIIE GLKGSLQRLQ
210 220 230 240 250
LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS RWSAMEIMEA
260 270 280 290 300
YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC
310 320 330 340 350
GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER
360 370 380 390 400
LGCTLPQLAV AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV
410
NEIDNILRNK PYSKKDYRS
Length:419
Mass (Da):46,563
Last modified:November 1, 1996 - v1
Checksum:iEFFDA78568007A7A
GO
Isoform KvB1.1 (identifier: Q14722-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MQVSIACTEH...STAKQTGMKY

Show »
Length:401
Mass (Da):44,710
Checksum:iF9F17404DF35FDA1
GO
Isoform KvB1.2 (identifier: Q14722-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MLAARTGAAG...TTVCTTGMPH → MHLYKPACAD...TTRAETGMAY

Show »
Length:408
Mass (Da):45,492
Checksum:i0C7CD8C23411F8E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901V → L in CAA58208. (PubMed:8938711)Curated
Isoform KvB1.2 (identifier: Q14722-3)
Sequence conflicti16 – 161L → S in AAC50113. (PubMed:7890764)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9191MLAAR…TGMPH → MQVSIACTEHNLKSRNGEDR LLSKQSSTAPNVVNAARAKF RTVAIIARSLGTFTPQHHIS LKESTAKQTGMKY in isoform KvB1.1. 4 PublicationsVSP_001051Add
BLAST
Alternative sequencei1 – 9191MLAAR…TGMPH → MHLYKPACADIPSPKLGLPK SSESALKCRWHLAVTKTQPQ AACKPVRPSGAAEQKYVEKF LRVHGISLQETTRAETGMAY in isoform KvB1.2. 4 PublicationsVSP_001050Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47665 mRNA. Translation: AAC41926.1.
U16953 mRNA. Translation: AAC50122.1.
L39833 mRNA. Translation: AAC37573.1.
U33428 mRNA. Translation: AAC50953.1.
X83127 mRNA. Translation: CAA58208.1.
AK057059 mRNA. Translation: BAG51856.1.
AK127240 mRNA. Translation: BAG54461.1.
AK292693 mRNA. Translation: BAF85382.1.
AK292999 mRNA. Translation: BAF85688.1.
CH471052 Genomic DNA. Translation: EAW78732.1.
CH471052 Genomic DNA. Translation: EAW78733.1.
CH471052 Genomic DNA. Translation: EAW78734.1.
BC043166 mRNA. Translation: AAH43166.1.
U17968 mRNA. Translation: AAC50113.1.
CCDSiCCDS3174.1. [Q14722-1]
CCDS3175.1. [Q14722-3]
CCDS33882.1. [Q14722-2]
PIRiI55463.
I59393.
RefSeqiNP_003462.2. NM_003471.3. [Q14722-3]
NP_751891.1. NM_172159.3. [Q14722-2]
NP_751892.1. NM_172160.2. [Q14722-1]
UniGeneiHs.654519.
Hs.703187.

Genome annotation databases

EnsembliENST00000302490; ENSP00000305858; ENSG00000169282. [Q14722-2]
ENST00000471742; ENSP00000418956; ENSG00000169282. [Q14722-3]
ENST00000490337; ENSP00000419952; ENSG00000169282. [Q14722-1]
GeneIDi7881.
KEGGihsa:7881.
UCSCiuc003far.2. human. [Q14722-1]
uc003fas.2. human. [Q14722-3]
uc003fat.2. human. [Q14722-2]

Polymorphism databases

DMDMi18202500.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47665 mRNA. Translation: AAC41926.1 .
U16953 mRNA. Translation: AAC50122.1 .
L39833 mRNA. Translation: AAC37573.1 .
U33428 mRNA. Translation: AAC50953.1 .
X83127 mRNA. Translation: CAA58208.1 .
AK057059 mRNA. Translation: BAG51856.1 .
AK127240 mRNA. Translation: BAG54461.1 .
AK292693 mRNA. Translation: BAF85382.1 .
AK292999 mRNA. Translation: BAF85688.1 .
CH471052 Genomic DNA. Translation: EAW78732.1 .
CH471052 Genomic DNA. Translation: EAW78733.1 .
CH471052 Genomic DNA. Translation: EAW78734.1 .
BC043166 mRNA. Translation: AAH43166.1 .
U17968 mRNA. Translation: AAC50113.1 .
CCDSi CCDS3174.1. [Q14722-1 ]
CCDS3175.1. [Q14722-3 ]
CCDS33882.1. [Q14722-2 ]
PIRi I55463.
I59393.
RefSeqi NP_003462.2. NM_003471.3. [Q14722-3 ]
NP_751891.1. NM_172159.3. [Q14722-2 ]
NP_751892.1. NM_172160.2. [Q14722-1 ]
UniGenei Hs.654519.
Hs.703187.

3D structure databases

DisProti DP00090.
ProteinModelPortali Q14722.
SMRi Q14722. Positions 91-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113626. 11 interactions.
IntActi Q14722. 2 interactions.
STRINGi 9606.ENSP00000419952.

Chemistry

ChEMBLi CHEMBL5884.

Protein family/group databases

TCDBi 8.A.5.1.1. the voltage-gated k(+) channel -subunit (kv) family.

PTM databases

PhosphoSitei Q14722.

Polymorphism databases

DMDMi 18202500.

Proteomic databases

MaxQBi Q14722.
PaxDbi Q14722.
PRIDEi Q14722.

Protocols and materials databases

DNASUi 7881.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302490 ; ENSP00000305858 ; ENSG00000169282 . [Q14722-2 ]
ENST00000471742 ; ENSP00000418956 ; ENSG00000169282 . [Q14722-3 ]
ENST00000490337 ; ENSP00000419952 ; ENSG00000169282 . [Q14722-1 ]
GeneIDi 7881.
KEGGi hsa:7881.
UCSCi uc003far.2. human. [Q14722-1 ]
uc003fas.2. human. [Q14722-3 ]
uc003fat.2. human. [Q14722-2 ]

Organism-specific databases

CTDi 7881.
GeneCardsi GC03P155755.
HGNCi HGNC:6228. KCNAB1.
HPAi HPA044550.
MIMi 601141. gene.
neXtProti NX_Q14722.
PharmGKBi PA370.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0667.
GeneTreei ENSGT00550000074567.
HOVERGENi HBG052216.
InParanoidi Q14722.
KOi K04882.
OMAi NASWRTE.
PhylomeDBi Q14722.
TreeFami TF324563.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSi KCNAB1. human.
GeneWikii KCNAB1.
GenomeRNAii 7881.
NextBioi 30342.
PROi Q14722.
SOURCEi Search...

Gene expression databases

Bgeei Q14722.
CleanExi HS_KCNAB1.
ExpressionAtlasi Q14722. baseline and differential.
Genevestigatori Q14722.

Family and domain databases

Gene3Di 3.20.20.100. 1 hit.
InterProi IPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005400. K_chnl_volt-dep_bsu_KCNAB1.
IPR023210. NADP_OxRdtase_dom.
[Graphical view ]
PANTHERi PTHR11732. PTHR11732. 1 hit.
Pfami PF00248. Aldo_ket_red. 1 hit.
[Graphical view ]
PRINTSi PR01578. KCNAB1CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMi SSF51430. SSF51430. 1 hit.
TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing."
    England S.K., Uebele V.N., Kodali J., Bennett P.B., Tamkun M.M.
    J. Biol. Chem. 270:28531-28534(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.3).
    Tissue: Heart left ventricle.
  2. "Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium."
    Majumder K., De Biasi M., Wang Z., Wible B.A.
    FEBS Lett. 361:13-16(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.2).
    Tissue: Heart atrium.
  3. "Characterization of a voltage-gated K+ channel beta subunit expressed in human heart."
    England S.K., Uebele V.N., Shear H., Kodali J., Bennett P.B., Tamkun M.M.
    Proc. Natl. Acad. Sci. U.S.A. 92:6309-6313(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.2), TISSUE SPECIFICITY.
    Tissue: Heart left ventricle.
  4. "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product."
    Mccormack K., McCormack T., Tanouye M.A., Rudy B., Stuehmer W.
    FEBS Lett. 370:32-36(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.1).
    Tissue: Hippocampus.
  5. "Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B)."
    Leicher T., Roeper J., Weber K., Wang X., Pongs O.
    Neuropharmacology 35:787-795(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KVB1.1), TISSUE SPECIFICITY.
    Tissue: Brain cortex.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS KVB1.1; KVB1.2 AND KVB1.3).
    Tissue: Hippocampus, Thymus and Trachea.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM KVB1.1).
    Tissue: Brain.
  9. "A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits."
    Morales M.J., Castellino R.C., Crews A.L., Rasmusson R.L., Strauss H.C.
    J. Biol. Chem. 270:6272-6277(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-147 (ISOFORM KVB1.2).
    Tissue: Heart.

Entry informationi

Entry nameiKCAB1_HUMAN
AccessioniPrimary (citable) accession number: Q14722
Secondary accession number(s): A8K9H8
, A8KAD4, B3KPZ4, Q13031, Q13302, Q16547, Q6PI60, Q99869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3