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Q14721

- KCNB1_HUMAN

UniProt

Q14721 - KCNB1_HUMAN

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Protein
Potassium voltage-gated channel subfamily B member 1
Gene
KCNB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. outward rectifier potassium channel activity Source: Ensembl
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. energy reserve metabolic process Source: Reactome
  2. protein homooligomerization Source: InterPro
  3. regulation of insulin secretion Source: Reactome
  4. small molecule metabolic process Source: Reactome
  5. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.11. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily B member 1
Alternative name(s):
Delayed rectifier potassium channel 1
Short name:
DRK1
Short name:
h-DRK1
Voltage-gated potassium channel subunit Kv2.1
Gene namesi
Name:KCNB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:6231. KCNB1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 186186Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei187 – 20822Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei229 – 25022Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini251 – 26010Cytoplasmic Reviewed prediction
Transmembranei261 – 28222Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei295 – 31622Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini317 – 33014Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei331 – 35222Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Intramembranei365 – 38521Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Transmembranei393 – 41422Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini415 – 858444Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. dendrite membrane Source: Ensembl
  3. neuronal cell body membrane Source: Ensembl
  4. plasma membrane Source: Reactome
  5. postsynaptic membrane Source: Ensembl
  6. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Potassium voltage-gated channel subfamily B member 1
PRO_0000054042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine By similarity
Modified residuei128 – 1281Phosphotyrosine; by Src By similarity
Modified residuei457 – 4571Phosphoserine By similarity
Modified residuei484 – 4841Phosphoserine By similarity
Modified residuei496 – 4961Phosphoserine By similarity
Modified residuei503 – 5031Phosphoserine By similarity
Modified residuei520 – 5201Phosphoserine By similarity
Modified residuei541 – 5411Phosphoserine By similarity
Modified residuei567 – 5671Phosphoserine By similarity
Modified residuei590 – 5901Phosphoserine By similarity
Modified residuei607 – 6071Phosphoserine By similarity
Modified residuei656 – 6561Phosphoserine By similarity
Modified residuei720 – 7201Phosphoserine By similarity
Modified residuei772 – 7721Phosphoserine By similarity
Modified residuei800 – 8001Phosphoserine By similarity
Modified residuei805 – 8051Phosphoserine By similarity

Post-translational modificationi

Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/ dephosphorylation activities. Tyr-128 can be dephosphorylated by PTPalpha and cyt-PTPepsilon. Phosphorylation levels on Ser-607 are supersensitive to neuronal activity. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5. Levels then increase to reach adult levels by P14. Phosphorylation levels on Ser-564 and Ser-607 are greatly reduced during seizures, by 40% and 85% respectively By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ14721.
PRIDEiQ14721.

2D gel databases

OGPiQ14721.

PTM databases

PhosphoSiteiQ14721.

Expressioni

Gene expression databases

BgeeiQ14721.
CleanExiHS_KCNB1.
GenevestigatoriQ14721.

Organism-specific databases

HPAiCAB001979.

Interactioni

Subunit structurei

Heteromultimer with KCNG2, KCNG3, KCNG4, KCNS1, KCNS2, KCNS3 and KCNV2 By similarity.

Protein-protein interaction databases

BioGridi109947. 16 interactions.
IntActiQ14721. 1 interaction.
STRINGi9606.ENSP00000360806.

Structurei

3D structure databases

ProteinModelPortaliQ14721.
SMRiQ14721. Positions 30-462.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi377 – 3826Selectivity filter By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi517 – 5204Poly-Ser
Compositional biasi701 – 7066Poly-Ala

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000113206.
HOVERGENiHBG052225.
InParanoidiQ14721.
KOiK04885.
OMAiCATDFPE.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ14721.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003973. K_chnl_volt-dep_Kv2.
IPR004350. K_chnl_volt-dep_Kv2.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF03521. Kv2channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01514. KV21CHANNEL.
PR01491. KVCHANNEL.
PR01495. SHABCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14721-1 [UniParc]FASTAAdd to Basket

« Hide

MPAGMTKHGS RSTSSLPPEP MEIVRSKACS RRVRLNVGGL AHEVLWRTLD    50
RLPRTRLGKL RDCNTHDSLL EVCDDYSLDD NEYFFDRHPG AFTSILNFYR 100
TGRLHMMEEM CALSFSQELD YWGIDEIYLE SCCQARYHQK KEQMNEELKR 150
EAETLREREG EEFDNTCCAE KRKKLWDLLE KPNSSVAAKI LAIISIMFIV 200
LSTIALSLNT LPELQSLDEF GQSTDNPQLA HVEAVCIAWF TMEYLLRFLS 250
SPKKWKFFKG PLNAIDLLAI LPYYVTIFLT ESNKSVLQFQ NVRRVVQIFR 300
IMRILRILKL ARHSTGLQSL GFTLRRSYNE LGLLILFLAM GIMIFSSLVF 350
FAEKDEDDTK FKSIPASFWW ATITMTTVGY GDIYPKTLLG KIVGGLCCIA 400
GVLVIALPIP IIVNNFSEFY KEQKRQEKAI KRREALERAK RNGSIVSMNM 450
KDAFARSIEM MDIVVEKNGE NMGKKDKVQD NHLSPNKWKW TKRTLSETSS 500
SKSFETKEQG SPEKARSSSS PQHLNVQQLE DMYNKMAKTQ SQPILNTKES 550
AAQSKPKEEL EMESIPSPVA PLPTRTEGVI DMRSMSSIDS FISCATDFPE 600
ATRFSHSPLT SLPSKTGGST APEVGWRGAL GASGGRFVEA NPSPDASQHS 650
SFFIESPKSS MKTNNPLKLR ALKVNFMEGD PSPLLPVLGM YHDPLRNRGS 700
AAAAVAGLEC ATLLDKAVLS PESSIYTTAS AKTPPRSPEK HTAIAFNFEA 750
GVHQYIDADT DDEGQLLYSV DSSPPKSLPG STSPKFSTGT RSEKNHFESS 800
PLPTSPKFLR QNCIYSTEAL TGKGPSGQEK CKLENHISPD VRVLPGGGAH 850
GSTRDQSI 858
Length:858
Mass (Da):95,878
Last modified:October 25, 2002 - v2
Checksum:iC4B426174ED0DEE4
GO

Sequence cautioni

The sequence AAA36156.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti616 – 6161T → N.
Corresponds to variant rs2229006 [ dbSNP | Ensembl ].
VAR_062182
Natural varianti616 – 6161T → S.
Corresponds to variant rs2229006 [ dbSNP | Ensembl ].
VAR_062183
Natural varianti825 – 8251P → S.
Corresponds to variant rs34467662 [ dbSNP | Ensembl ].
VAR_034049
Natural varianti857 – 8571S → N.
Corresponds to variant rs34280195 [ dbSNP | Ensembl ].
VAR_062184

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68302 Genomic DNA. Translation: CAA48374.1.
L02840 mRNA. Translation: AAA36156.1. Different initiation.
AF026005 mRNA. Translation: AAB88808.1.
AL035685 Genomic DNA. Translation: CAB89417.1.
CCDSiCCDS13418.1.
PIRiS31761.
RefSeqiNP_004966.1. NM_004975.2.
XP_006723847.1. XM_006723784.1.
UniGeneiHs.84244.

Genome annotation databases

EnsembliENST00000371741; ENSP00000360806; ENSG00000158445.
GeneIDi3745.
KEGGihsa:3745.
UCSCiuc002xur.1. human.

Polymorphism databases

DMDMi24418854.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68302 Genomic DNA. Translation: CAA48374.1 .
L02840 mRNA. Translation: AAA36156.1 . Different initiation.
AF026005 mRNA. Translation: AAB88808.1 .
AL035685 Genomic DNA. Translation: CAB89417.1 .
CCDSi CCDS13418.1.
PIRi S31761.
RefSeqi NP_004966.1. NM_004975.2.
XP_006723847.1. XM_006723784.1.
UniGenei Hs.84244.

3D structure databases

ProteinModelPortali Q14721.
SMRi Q14721. Positions 30-462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109947. 16 interactions.
IntActi Q14721. 1 interaction.
STRINGi 9606.ENSP00000360806.

Chemistry

ChEMBLi CHEMBL2362996.
GuidetoPHARMACOLOGYi 546.

Protein family/group databases

TCDBi 1.A.1.2.11. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q14721.

Polymorphism databases

DMDMi 24418854.

2D gel databases

OGPi Q14721.

Proteomic databases

PaxDbi Q14721.
PRIDEi Q14721.

Protocols and materials databases

DNASUi 3745.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371741 ; ENSP00000360806 ; ENSG00000158445 .
GeneIDi 3745.
KEGGi hsa:3745.
UCSCi uc002xur.1. human.

Organism-specific databases

CTDi 3745.
GeneCardsi GC20M047984.
HGNCi HGNC:6231. KCNB1.
HPAi CAB001979.
MIMi 600397. gene.
neXtProti NX_Q14721.
PharmGKBi PA209.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000113206.
HOVERGENi HBG052225.
InParanoidi Q14721.
KOi K04885.
OMAi CATDFPE.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q14721.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNB1.
GenomeRNAii 3745.
NextBioi 14655.
PROi Q14721.
SOURCEi Search...

Gene expression databases

Bgeei Q14721.
CleanExi HS_KCNB1.
Genevestigatori Q14721.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003973. K_chnl_volt-dep_Kv2.
IPR004350. K_chnl_volt-dep_Kv2.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF03521. Kv2channel. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01514. KV21CHANNEL.
PR01491. KVCHANNEL.
PR01495. SHABCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a human delayed rectifier potassium channel gene."
    Albrecht B., Lorra C., Stocker K., Pongs O.
    Recept. Channels 1:99-110(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Heterologous expression of the human potassium channel Kv2.1 in clonal mammalian cells by direct cytoplasmic microinjection of cRNA."
    Ikeda S.R., Soler F., Zuhlke R.D., Joho R.H., Lewis D.L.
    Pflugers Arch. 422:201-203(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.
  3. "Identification of potassium channels in human lens epithelium."
    Rae J.L., Shepard A.R.
    (In) Civan M.M. (eds.); The eye's aqueous humor-from secretion to glaucoma, pp.69-104, Academic Press, San Diego (1998)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lens epithelium.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKCNB1_HUMAN
AccessioniPrimary (citable) accession number: Q14721
Secondary accession number(s): Q14193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 25, 2002
Last modified: September 3, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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