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Q146I4 (SYR_BURXL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Bxeno_A0217
ORF Names:Bxe_A4245
OrganismBurkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]
Taxonomic identifier266265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018006

Regions

Motif139 – 14911"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q146I4 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 350CAADC2EC5445C

FASTA59665,090
        10         20         30         40         50         60 
MLPAHKHTLE TLLADTVKQV ALASQGASEA AFVSPTITLE RPKVAAHGDV ACNVAMQLAK 

        70         80         90        100        110        120 
PLRANPRQLA QQIVDALLAQ PGARDLVEAA EVAGPGFINL RLTAAAKQAV IAAVFAEKER 

       130        140        150        160        170        180 
FGRSQRDAGK HVLIEFVSAN PTGPLHVGHG RQAALGDALS NVLASQGWDV HREFYYNDAG 

       190        200        210        220        230        240 
VQIQTLALST QARARGLAPG DEGWPASAYN GEYIADIAKD YLNGATVAAS DGEPVTGARD 

       250        260        270        280        290        300 
VEDLEAIRRF AVAYLRREQD MDLQAFGVKF DQYYLESSLY KEGRVEKTVA ALIAAGKTYE 

       310        320        330        340        350        360 
QEGALWLRTT DDGDDKDRVM RKTDGTYTYF VPDVAYHVAK WERGFTKVIN IQGSDHHGTI 

       370        380        390        400        410        420 
ARVRAGLQGL GIGIPKGYPD YILHKMVTVM RNGEEVKISK RAGSYVTVRD LIEWSGGATP 

       430        440        450        460        470        480 
GSEVDVDLID EETIRRGRDA VRFFLISRKA DTEFVFDIDL ALKQNDENPV HYVQYAHARI 

       490        500        510        520        530        540 
CSVIAECKAR YNMDESTLAD VDVTPLTSER AMALLNKLAE FPDMLQHAAD ELAPHAVAFY 

       550        560        570        580        590 
LRDLAGEFHS FYNDKAERVL VDDAAERNAR VALLAATRQV LANGLATIGV SAPVKM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000270 Genomic DNA. Translation: ABE28755.1.
RefSeqYP_556807.1. NC_007951.1.

3D structure databases

ProteinModelPortalQ146I4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266265.Bxe_A4245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE28755; ABE28755; Bxe_A4245.
GeneID4004021.
KEGGbxe:Bxe_A4245.
PATRIC19325771. VBIBurXen52548_0227.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycBXEN266265:GJII-222-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_BURXL
AccessionPrimary (citable) accession number: Q146I4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries