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Protein

Raftlin

Gene

RFTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.1 Publication

GO - Molecular functioni

  • double-stranded RNA binding Source: MGI

GO - Biological processi

  • B cell receptor signaling pathway Source: UniProtKB
  • dsRNA transport Source: MGI
  • growth Source: UniProtKB
  • interleukin-17 production Source: UniProtKB
  • membrane raft assembly Source: UniProtKB
  • protein localization to membrane raft Source: UniProtKB
  • protein transport into membrane raft Source: UniProtKB
  • response to exogenous dsRNA Source: MGI
  • T cell antigen processing and presentation Source: UniProtKB
  • T cell receptor signaling pathway Source: UniProtKB
  • toll-like receptor 3 signaling pathway Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Raftlin
Alternative name(s):
Cell migration-inducing gene 2 protein
Raft-linking protein
Gene namesi
Name:RFTN1
Synonyms:KIAA0084
ORF Names:MIG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000131378.13.
HGNCiHGNC:30278. RFTN1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Loss of association with membranes. Same effect; when associated with S-3. 1 Publication1
Mutagenesisi3C → S: Partially affects association with membranes. Loss of association with membranes; when associated with A-2. 1 Publication1

Organism-specific databases

DisGeNETi23180.
OpenTargetsiENSG00000131378.
PharmGKBiPA162401206.

Polymorphism and mutation databases

BioMutaiRFTN1.
DMDMi115502444.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000507182 – 578RaftlinAdd BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1
Lipidationi3S-palmitoyl cysteine1 Publication1
Modified residuei183PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei505PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ14699.
MaxQBiQ14699.
PaxDbiQ14699.
PeptideAtlasiQ14699.
PRIDEiQ14699.

PTM databases

iPTMnetiQ14699.
PhosphoSitePlusiQ14699.
SwissPalmiQ14699.

Expressioni

Tissue specificityi

Specifically expressed by B-cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000131378.
CleanExiHS_RFTN1.
ExpressionAtlasiQ14699. baseline and differential.
GenevisibleiQ14699. HS.

Organism-specific databases

HPAiHPA048725.

Interactioni

Protein-protein interaction databases

BioGridi116792. 10 interactors.
ELMiQ14699.
IntActiQ14699. 15 interactors.
MINTiMINT-4657377.
STRINGi9606.ENSP00000334153.

Structurei

3D structure databases

ProteinModelPortaliQ14699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the raftlin family.Curated

Phylogenomic databases

eggNOGiENOG410IETJ. Eukaryota.
ENOG410ZCAE. LUCA.
GeneTreeiENSGT00530000063609.
HOVERGENiHBG093894.
InParanoidiQ14699.
OMAiVEQWTVL.
OrthoDBiEOG091G07W6.
PhylomeDBiQ14699.
TreeFamiTF333285.

Family and domain databases

InterProiView protein in InterPro
IPR028169. Raftlin.
PANTHERiPTHR17601. PTHR17601. 1 hit.
PfamiView protein in Pfam
PF15250. Raftlin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGLNKLEK RDEKRPGNIY STLKRPQVET KIDVSYEYRF LEFTTLSAAE
60 70 80 90 100
LPGSSAVRLA SLRDLPAQLL ELYQQGFSLA ALHPFVQPTH EREKTPLEHI
110 120 130 140 150
FRAILIKKTD RSQKTDLHNE GYILELDCCS SLDHPTDQKL IPEFIKKIQE
160 170 180 190 200
AASQGLKFVG VIPQYHSSVN SAGSSAPVST ANSTEDARDA KNARGDHASL
210 220 230 240 250
ENEKPGTGDV CSAPAGRNQS PEPSSGPRGE VPLAKQPSSP SGEGDGGELS
260 270 280 290 300
PQGVSKTLDG PESNPLEVHE EPLSGKMEIF TLFNKPKSHQ KCRQYYPVTI
310 320 330 340 350
PLHVSKNGQT VSGLDANWLE HMSDHFRKGG MLVNAVFYLG IVNDSLHGLT
360 370 380 390 400
DGVFIFEAVS TEDSKTIQGY DAIVVEQWTV LEGVEVQTDY VPLLNSLAAY
410 420 430 440 450
GWQLTCVLPT PVVKTTSEGS VSTKQIVFLQ RPCLPQKIKK KESKFQWRFS
460 470 480 490 500
REEMHNRQMR KSKGKLSARD KQQAEENEKN LEDQSSKAGD MGNCVSGQQQ
510 520 530 540 550
EGGVSEEMKG PVQEDKGEQL SPGGLLCGVG VEGEAVQNGP ASHSRALVGI
560 570
CTGHSNPGED ARDGDAEEVR ELGTVEEN
Length:578
Mass (Da):63,146
Last modified:January 23, 2007 - v4
Checksum:i889928D62A62F189
GO

Sequence cautioni

The sequence AAH51336 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH69209 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA07644 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86V → A in AAH98270 (PubMed:15489334).Curated1
Sequence conflicti211C → S in AAH51336 (PubMed:15489334).Curated1
Sequence conflicti211C → S in AAH69209 (PubMed:15489334).Curated1
Sequence conflicti358A → V in AAH51336 (PubMed:15489334).Curated1
Sequence conflicti358A → V in AAH69209 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051317248E → K. Corresponds to variant dbSNP:rs34276015Ensembl.1
Natural variantiVAR_061699421V → I1 PublicationCorresponds to variant dbSNP:rs11554130Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237654 mRNA. Translation: AAO91814.1.
D42043 mRNA. Translation: BAA07644.1. Different initiation.
BC051336 mRNA. Translation: AAH51336.1. Different initiation.
BC069209 mRNA. Translation: AAH69209.1. Different initiation.
BC098270 mRNA. Translation: AAH98270.2.
BC100667 mRNA. Translation: AAI00668.2.
BC100669 mRNA. Translation: AAI00670.2.
BC121795 mRNA. Translation: AAI21796.1.
CCDSiCCDS33712.1.
RefSeqiNP_055965.1. NM_015150.1.
XP_005265042.1. XM_005264985.1.
XP_005265043.1. XM_005264986.2.
XP_006713132.1. XM_006713069.1.
XP_011531832.1. XM_011533530.1.
UniGeneiHs.98910.

Genome annotation databases

EnsembliENST00000334133; ENSP00000334153; ENSG00000131378.
GeneIDi23180.
KEGGihsa:23180.
UCSCiuc003cay.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRFTN1_HUMAN
AccessioniPrimary (citable) accession number: Q14699
Secondary accession number(s): Q0D2G0
, Q496Y2, Q4QQI7, Q5JB48, Q7Z7P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 129 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families