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Protein

LRP chaperone MESD

Gene

MESD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LRP chaperone MESDCurated
Alternative name(s):
LDLR chaperone MESD
Mesoderm development LRP chaperone MESDImported
Mesoderm development candidate 2
Mesoderm development protein
Renal carcinoma antigen NY-REN-61
Gene namesi
Name:MESDImported
Synonyms:KIAA0081, MESDC2, MESDM
ORF Names:UNQ1911/PRO4369
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000117899.10
HGNCiHGNC:13520 MESD
MIMi607783 gene
neXtProtiNX_Q14696

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi23184
OpenTargetsiENSG00000117899
PharmGKBiPA30761

Polymorphism and mutation databases

BioMutaiMESDC2
DMDMi24418861

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000009644334 – 234LRP chaperone MESDAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ14696
MaxQBiQ14696
PaxDbiQ14696
PeptideAtlasiQ14696
PRIDEiQ14696
ProteomicsDBi60136
TopDownProteomicsiQ14696-1 [Q14696-1]

2D gel databases

OGPiQ14696

PTM databases

iPTMnetiQ14696
PhosphoSitePlusiQ14696

Expressioni

Gene expression databases

BgeeiENSG00000117899
CleanExiHS_MESDC2
ExpressionAtlasiQ14696 baseline and differential
GenevisibleiQ14696 HS

Organism-specific databases

HPAiHPA039414
HPA041721

Interactioni

Subunit structurei

Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane (PubMed:17488095). Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane (PubMed:17488095). Interacts with LRP4; the interaction promotes glycosylation of LRP4 and its cell-surface expression (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116794, 30 interactors
IntActiQ14696, 12 interactors
MINTiQ14696
STRINGi9606.ENSP00000261758

Structurei

3D structure databases

ProteinModelPortaliQ14696
SMRiQ14696
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 164Chaperone domainBy similarityAdd BLAST164
Regioni165 – 204Escort domainBy similarityAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi231 – 234Prevents secretion from ER4

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4357 Eukaryota
ENOG4111SG4 LUCA
GeneTreeiENSGT00390000000993
HOGENOMiHOG000230558
InParanoidiQ14696
OMAiIVGSNRA
OrthoDBiEOG091G0TTK
PhylomeDBiQ14696
TreeFamiTF315614

Family and domain databases

InterProiView protein in InterPro
IPR019330 MESD
PANTHERiPTHR17600 PTHR17600, 1 hit
PfamiView protein in Pfam
PF10185 Mesd, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14696-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRWARKA VVLLCASDLL LLLLLLPPPG SCAAEGSPGT PDESTPPPRK
60 70 80 90 100
KKKDIRDYND ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK
110 120 130 140 150
PESILKMTKK GKTLMMFVTV SGSPTEKETE EITSLWQGSL FNANYDVQRF
160 170 180 190 200
IVGSDRAIFM LRDGSYAWEI KDFLVGQDRC ADVTLEGQVY PGKGGGSKEK
210 220 230
NKTKQDKGKK KKEGDLKSRS SKEENRAGNK REDL
Length:234
Mass (Da):26,077
Last modified:October 25, 2002 - v2
Checksum:i7F0D796A3CC4E339
GO
Isoform 2 (identifier: Q14696-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-138: KDDDIEEGDL...TEEITSLWQG → TPEPLPVLPE...WLPHRGGELK
     139-234: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):14,895
Checksum:iC4035DB3367BEA7F
GO

Sequence cautioni

The sequence BAA07640 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05549272 – 138KDDDI…SLWQG → TPEPLPVLPEVPSTCACLSS ASLIWTCFSHLSPHALVKRV WPPAKQGLGGKESPASAWLP HRGGELK in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_055493139 – 234Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42039 mRNA Translation: BAA07640.2 Different initiation.
AY359110 mRNA Translation: AAQ89468.1
AK301416 mRNA Translation: BAG62946.1
AC027808 Genomic DNA No translation available.
AC068870 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99109.1
CH471136 Genomic DNA Translation: EAW99110.1
BC009210 mRNA Translation: AAH09210.1
BC012746 mRNA Translation: AAH12746.1
CCDSiCCDS32308.1 [Q14696-1]
RefSeqiNP_055969.1, NM_015154.2 [Q14696-1]
UniGeneiHs.578450
Hs.732380

Genome annotation databases

EnsembliENST00000261758; ENSP00000261758; ENSG00000117899 [Q14696-1]
ENST00000422879; ENSP00000403839; ENSG00000117899 [Q14696-2]
ENST00000561312; ENSP00000453430; ENSG00000117899 [Q14696-1]
ENST00000619987; ENSP00000482455; ENSG00000117899 [Q14696-1]
GeneIDi23184
KEGGihsa:23184
UCSCiuc002bfy.2 human [Q14696-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMESD_HUMAN
AccessioniPrimary (citable) accession number: Q14696
Secondary accession number(s): B4DW84, D3DW96, Q969U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 25, 2002
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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