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Q14696

- MESD_HUMAN

UniProt

Q14696 - MESD_HUMAN

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Protein

LDLR chaperone MESD

Gene
MESDC2, KIAA0081, MESD, UNQ1911/PRO4369
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.2 Publications

GO - Biological processi

  1. mesoderm development Source: UniProtKB
  2. protein folding Source: UniProtKB
  3. protein localization to cell surface Source: Ensembl
  4. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Renal carcinoma antigen NY-REN-61
Gene namesi
Name:MESDC2
Synonyms:KIAA0081, MESD
ORF Names:UNQ1911/PRO4369
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:13520. MESDC2.

Subcellular locationi

Endoplasmic reticulum 2 Publications

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 234201LDLR chaperone MESDPRO_0000096443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ14696.
PaxDbiQ14696.
PeptideAtlasiQ14696.
PRIDEiQ14696.

2D gel databases

OGPiQ14696.

PTM databases

PhosphoSiteiQ14696.

Expressioni

Gene expression databases

ArrayExpressiQ14696.
BgeeiQ14696.
CleanExiHS_MESDC2.
GenevestigatoriQ14696.

Organism-specific databases

HPAiHPA039414.
HPA041721.

Interactioni

Subunit structurei

Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane.1 Publication

Protein-protein interaction databases

BioGridi116794. 12 interactions.
IntActiQ14696. 8 interactions.
MINTiMINT-7006206.
STRINGi9606.ENSP00000261758.

Structurei

3D structure databases

ProteinModelPortaliQ14696.
SMRiQ14696. Positions 40-234.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 164164Chaperone domain By similarityAdd
BLAST
Regioni165 – 20440Escort domain By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi231 – 2344Prevents secretion from ER

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6 By similarity.
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding By similarity.

Sequence similaritiesi

Belongs to the MESD family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286690.
HOGENOMiHOG000230558.
InParanoidiQ14696.
OMAiFATIGHR.
OrthoDBiEOG7XPZ76.
PhylomeDBiQ14696.
TreeFamiTF315614.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14696-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASRWARKA VVLLCASDLL LLLLLLPPPG SCAAEGSPGT PDESTPPPRK    50
KKKDIRDYND ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK 100
PESILKMTKK GKTLMMFVTV SGSPTEKETE EITSLWQGSL FNANYDVQRF 150
IVGSDRAIFM LRDGSYAWEI KDFLVGQDRC ADVTLEGQVY PGKGGGSKEK 200
NKTKQDKGKK KKEGDLKSRS SKEENRAGNK REDL 234
Length:234
Mass (Da):26,077
Last modified:October 25, 2002 - v2
Checksum:i7F0D796A3CC4E339
GO
Isoform 2 (identifier: Q14696-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-138: KDDDIEEGDL...TEEITSLWQG → TPEPLPVLPE...WLPHRGGELK
     139-234: Missing.

Note: No experimental confirmation available.

Show »
Length:138
Mass (Da):14,895
Checksum:iC4035DB3367BEA7F
GO

Sequence cautioni

The sequence BAA07640.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 13867KDDDI…SLWQG → TPEPLPVLPEVPSTCACLSS ASLIWTCFSHLSPHALVKRV WPPAKQGLGGKESPASAWLP HRGGELK in isoform 2. VSP_055492Add
BLAST
Alternative sequencei139 – 23496Missing in isoform 2. VSP_055493Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42039 mRNA. Translation: BAA07640.2. Different initiation.
AY359110 mRNA. Translation: AAQ89468.1.
AK301416 mRNA. Translation: BAG62946.1.
AC027808 Genomic DNA. No translation available.
AC068870 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99109.1.
CH471136 Genomic DNA. Translation: EAW99110.1.
BC009210 mRNA. Translation: AAH09210.1.
BC012746 mRNA. Translation: AAH12746.1.
CCDSiCCDS32308.1.
RefSeqiNP_055969.1. NM_015154.1.
UniGeneiHs.578450.
Hs.732380.

Genome annotation databases

EnsembliENST00000261758; ENSP00000261758; ENSG00000117899.
ENST00000422879; ENSP00000403839; ENSG00000117899.
ENST00000561312; ENSP00000453430; ENSG00000117899.
GeneIDi23184.
KEGGihsa:23184.
UCSCiuc002bfy.1. human.

Polymorphism databases

DMDMi24418861.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42039 mRNA. Translation: BAA07640.2 . Different initiation.
AY359110 mRNA. Translation: AAQ89468.1 .
AK301416 mRNA. Translation: BAG62946.1 .
AC027808 Genomic DNA. No translation available.
AC068870 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99109.1 .
CH471136 Genomic DNA. Translation: EAW99110.1 .
BC009210 mRNA. Translation: AAH09210.1 .
BC012746 mRNA. Translation: AAH12746.1 .
CCDSi CCDS32308.1.
RefSeqi NP_055969.1. NM_015154.1.
UniGenei Hs.578450.
Hs.732380.

3D structure databases

ProteinModelPortali Q14696.
SMRi Q14696. Positions 40-234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116794. 12 interactions.
IntActi Q14696. 8 interactions.
MINTi MINT-7006206.
STRINGi 9606.ENSP00000261758.

PTM databases

PhosphoSitei Q14696.

Polymorphism databases

DMDMi 24418861.

2D gel databases

OGPi Q14696.

Proteomic databases

MaxQBi Q14696.
PaxDbi Q14696.
PeptideAtlasi Q14696.
PRIDEi Q14696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261758 ; ENSP00000261758 ; ENSG00000117899 .
ENST00000422879 ; ENSP00000403839 ; ENSG00000117899 .
ENST00000561312 ; ENSP00000453430 ; ENSG00000117899 .
GeneIDi 23184.
KEGGi hsa:23184.
UCSCi uc002bfy.1. human.

Organism-specific databases

CTDi 23184.
GeneCardsi GC15M081244.
HGNCi HGNC:13520. MESDC2.
HPAi HPA039414.
HPA041721.
MIMi 607783. gene.
neXtProti NX_Q14696.
PharmGKBi PA30761.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286690.
HOGENOMi HOG000230558.
InParanoidi Q14696.
OMAi FATIGHR.
OrthoDBi EOG7XPZ76.
PhylomeDBi Q14696.
TreeFami TF315614.

Miscellaneous databases

GeneWikii MESDC2.
GenomeRNAii 23184.
NextBioi 44647.
PROi Q14696.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14696.
Bgeei Q14696.
CleanExi HS_MESDC2.
Genevestigatori Q14696.

Family and domain databases

InterProi IPR019330. Mesoderm_development_cand-2.
[Graphical view ]
Pfami PF10185. Mesd. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Synovium.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Skin.
  8. Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN.
    Tissue: Renal cell carcinoma.
  9. "Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins."
    Culi J., Springer T.A., Mann R.S.
    EMBO J. 23:1372-1380(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. "Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation."
    Koduri V., Blacklow S.C.
    Biochemistry 46:6570-6577(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LRP5 AND LRP6, SUBCELLULAR LOCATION.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMESD_HUMAN
AccessioniPrimary (citable) accession number: Q14696
Secondary accession number(s): B4DW84, D3DW96, Q969U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 25, 2002
Last modified: September 3, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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