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Protein

LDLR chaperone MESD

Gene

MESDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.2 Publications

GO - Biological processi

  • mesoderm development Source: UniProtKB
  • protein folding Source: UniProtKB
  • protein localization to cell surface Source: Ensembl
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Renal carcinoma antigen NY-REN-61
Gene namesi
Name:MESDC2
Synonyms:KIAA0081, MESD
ORF Names:UNQ1911/PRO4369
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:13520. MESDC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30761.

Polymorphism and mutation databases

BioMutaiMESDC2.
DMDMi24418861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 234201LDLR chaperone MESDPRO_0000096443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ14696.
PaxDbiQ14696.
PeptideAtlasiQ14696.
PRIDEiQ14696.

2D gel databases

OGPiQ14696.

PTM databases

PhosphoSiteiQ14696.

Expressioni

Gene expression databases

BgeeiQ14696.
CleanExiHS_MESDC2.
ExpressionAtlasiQ14696. baseline and differential.
GenevisibleiQ14696. HS.

Organism-specific databases

HPAiHPA039414.
HPA041721.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane.By similarity1 Publication

Protein-protein interaction databases

BioGridi116794. 17 interactions.
IntActiQ14696. 8 interactions.
MINTiMINT-7006206.
STRINGi9606.ENSP00000261758.

Structurei

3D structure databases

ProteinModelPortaliQ14696.
SMRiQ14696. Positions 40-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 164164Chaperone domainBy similarityAdd
BLAST
Regioni165 – 20440Escort domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi231 – 2344Prevents secretion from ER

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ14696.
OMAiMAASGWA.
OrthoDBiEOG7XPZ76.
PhylomeDBiQ14696.
TreeFamiTF315614.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14696-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRWARKA VVLLCASDLL LLLLLLPPPG SCAAEGSPGT PDESTPPPRK
60 70 80 90 100
KKKDIRDYND ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK
110 120 130 140 150
PESILKMTKK GKTLMMFVTV SGSPTEKETE EITSLWQGSL FNANYDVQRF
160 170 180 190 200
IVGSDRAIFM LRDGSYAWEI KDFLVGQDRC ADVTLEGQVY PGKGGGSKEK
210 220 230
NKTKQDKGKK KKEGDLKSRS SKEENRAGNK REDL
Length:234
Mass (Da):26,077
Last modified:October 25, 2002 - v2
Checksum:i7F0D796A3CC4E339
GO
Isoform 2 (identifier: Q14696-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-138: KDDDIEEGDL...TEEITSLWQG → TPEPLPVLPE...WLPHRGGELK
     139-234: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):14,895
Checksum:iC4035DB3367BEA7F
GO

Sequence cautioni

The sequence BAA07640.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 13867KDDDI…SLWQG → TPEPLPVLPEVPSTCACLSS ASLIWTCFSHLSPHALVKRV WPPAKQGLGGKESPASAWLP HRGGELK in isoform 2. 1 PublicationVSP_055492Add
BLAST
Alternative sequencei139 – 23496Missing in isoform 2. 1 PublicationVSP_055493Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42039 mRNA. Translation: BAA07640.2. Different initiation.
AY359110 mRNA. Translation: AAQ89468.1.
AK301416 mRNA. Translation: BAG62946.1.
AC027808 Genomic DNA. No translation available.
AC068870 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99109.1.
CH471136 Genomic DNA. Translation: EAW99110.1.
BC009210 mRNA. Translation: AAH09210.1.
BC012746 mRNA. Translation: AAH12746.1.
CCDSiCCDS32308.1. [Q14696-1]
RefSeqiNP_055969.1. NM_015154.2. [Q14696-1]
UniGeneiHs.578450.
Hs.732380.

Genome annotation databases

EnsembliENST00000261758; ENSP00000261758; ENSG00000117899.
ENST00000422879; ENSP00000403839; ENSG00000117899. [Q14696-2]
ENST00000561312; ENSP00000453430; ENSG00000117899.
ENST00000619987; ENSP00000482455; ENSG00000117899.
GeneIDi23184.
KEGGihsa:23184.
UCSCiuc002bfy.1. human. [Q14696-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42039 mRNA. Translation: BAA07640.2. Different initiation.
AY359110 mRNA. Translation: AAQ89468.1.
AK301416 mRNA. Translation: BAG62946.1.
AC027808 Genomic DNA. No translation available.
AC068870 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99109.1.
CH471136 Genomic DNA. Translation: EAW99110.1.
BC009210 mRNA. Translation: AAH09210.1.
BC012746 mRNA. Translation: AAH12746.1.
CCDSiCCDS32308.1. [Q14696-1]
RefSeqiNP_055969.1. NM_015154.2. [Q14696-1]
UniGeneiHs.578450.
Hs.732380.

3D structure databases

ProteinModelPortaliQ14696.
SMRiQ14696. Positions 40-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116794. 17 interactions.
IntActiQ14696. 8 interactions.
MINTiMINT-7006206.
STRINGi9606.ENSP00000261758.

PTM databases

PhosphoSiteiQ14696.

Polymorphism and mutation databases

BioMutaiMESDC2.
DMDMi24418861.

2D gel databases

OGPiQ14696.

Proteomic databases

MaxQBiQ14696.
PaxDbiQ14696.
PeptideAtlasiQ14696.
PRIDEiQ14696.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261758; ENSP00000261758; ENSG00000117899.
ENST00000422879; ENSP00000403839; ENSG00000117899. [Q14696-2]
ENST00000561312; ENSP00000453430; ENSG00000117899.
ENST00000619987; ENSP00000482455; ENSG00000117899.
GeneIDi23184.
KEGGihsa:23184.
UCSCiuc002bfy.1. human. [Q14696-1]

Organism-specific databases

CTDi23184.
GeneCardsiGC15M081244.
HGNCiHGNC:13520. MESDC2.
HPAiHPA039414.
HPA041721.
MIMi607783. gene.
neXtProtiNX_Q14696.
PharmGKBiPA30761.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ14696.
OMAiMAASGWA.
OrthoDBiEOG7XPZ76.
PhylomeDBiQ14696.
TreeFamiTF315614.

Miscellaneous databases

ChiTaRSiMESDC2. human.
GeneWikiiMESDC2.
GenomeRNAii23184.
NextBioi35475655.
PROiQ14696.
SOURCEiSearch...

Gene expression databases

BgeeiQ14696.
CleanExiHS_MESDC2.
ExpressionAtlasiQ14696. baseline and differential.
GenevisibleiQ14696. HS.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Synovium.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Skin.
  8. Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN.
    Tissue: Renal cell carcinoma.
  9. "Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins."
    Culi J., Springer T.A., Mann R.S.
    EMBO J. 23:1372-1380(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. "Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation."
    Koduri V., Blacklow S.C.
    Biochemistry 46:6570-6577(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LRP5 AND LRP6, SUBCELLULAR LOCATION.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMESD_HUMAN
AccessioniPrimary (citable) accession number: Q14696
Secondary accession number(s): B4DW84, D3DW96, Q969U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 25, 2002
Last modified: July 22, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.