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Q14696 (MESD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Renal carcinoma antigen NY-REN-61
Gene names
Name:MESDC2
Synonyms:KIAA0081, MESD
ORF Names:UNQ1911/PRO4369
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Ref.7 Ref.8

Subunit structure

Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Ref.8

Subcellular location

Endoplasmic reticulum Ref.7 Ref.8.

Domain

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6 By similarity.

The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding By similarity.

Sequence similarities

Belongs to the MESD family.

Sequence caution

The sequence BAA07640.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 234201LDLR chaperone MESD
PRO_0000096443

Regions

Region1 – 164164Chaperone domain By similarity
Region165 – 20440Escort domain By similarity
Motif231 – 2344Prevents secretion from ER

Amino acid modifications

Glycosylation2011N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q14696 [UniParc].

Last modified October 25, 2002. Version 2.
Checksum: 7F0D796A3CC4E339

FASTA23426,077
        10         20         30         40         50         60 
MAASRWARKA VVLLCASDLL LLLLLLPPPG SCAAEGSPGT PDESTPPPRK KKKDIRDYND 

        70         80         90        100        110        120 
ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK PESILKMTKK GKTLMMFVTV 

       130        140        150        160        170        180 
SGSPTEKETE EITSLWQGSL FNANYDVQRF IVGSDRAIFM LRDGSYAWEI KDFLVGQDRC 

       190        200        210        220        230 
ADVTLEGQVY PGKGGGSKEK NKTKQDKGKK KKEGDLKSRS SKEENRAGNK REDL 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Skin.
[6]"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J.
Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN.
Tissue: Renal cell carcinoma.
[7]"Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins."
Culi J., Springer T.A., Mann R.S.
EMBO J. 23:1372-1380(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]"Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation."
Koduri V., Blacklow S.C.
Biochemistry 46:6570-6577(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH LRP5 AND LRP6, SUBCELLULAR LOCATION.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D42039 mRNA. Translation: BAA07640.2. Different initiation.
AY359110 mRNA. Translation: AAQ89468.1.
CH471136 Genomic DNA. Translation: EAW99109.1.
CH471136 Genomic DNA. Translation: EAW99110.1.
BC009210 mRNA. Translation: AAH09210.1.
BC012746 mRNA. Translation: AAH12746.1.
RefSeqNP_055969.1. NM_015154.1.
UniGeneHs.578450.
Hs.732380.

3D structure databases

ProteinModelPortalQ14696.
SMRQ14696. Positions 40-234.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116794. 12 interactions.
IntActQ14696. 8 interactions.
MINTMINT-7006206.
STRING9606.ENSP00000261758.

PTM databases

PhosphoSiteQ14696.

Polymorphism databases

DMDM24418861.

2D gel databases

OGPQ14696.

Proteomic databases

PaxDbQ14696.
PeptideAtlasQ14696.
PRIDEQ14696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261758; ENSP00000261758; ENSG00000117899.
ENST00000561312; ENSP00000453430; ENSG00000117899.
GeneID23184.
KEGGhsa:23184.
UCSCuc002bfy.1. human.

Organism-specific databases

CTD23184.
GeneCardsGC15M081244.
HGNCHGNC:13520. MESDC2.
HPAHPA039414.
HPA041721.
MIM607783. gene.
neXtProtNX_Q14696.
PharmGKBPA30761.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286690.
HOGENOMHOG000230558.
InParanoidQ14696.
OMAIVGSNRA.
OrthoDBEOG7XPZ76.
PhylomeDBQ14696.
TreeFamTF315614.

Gene expression databases

ArrayExpressQ14696.
BgeeQ14696.
CleanExHS_MESDC2.
GenevestigatorQ14696.

Family and domain databases

InterProIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamPF10185. Mesd. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMESDC2.
GenomeRNAi23184.
NextBio44647.
PROQ14696.
SOURCESearch...

Entry information

Entry nameMESD_HUMAN
AccessionPrimary (citable) accession number: Q14696
Secondary accession number(s): D3DW96, Q969U1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 25, 2002
Last modified: February 19, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM