Q14696 (MESD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LDLR chaperone MESD

Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Renal carcinoma antigen NY-REN-61

Gene names

Name:	MESDC2
Synonyms:	KIAA0081, MESD
ORF Names:	UNQ1911/PRO4369

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Ref.7 Ref.8
Subunit structure	Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Ref.8
Subcellular location	Endoplasmic reticulum Ref.7 Ref.8.
Domain	The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6 By similarity. The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding By similarity.
Sequence similarities	Belongs to the MESD family.
Sequence caution	The sequence BAA07640.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Chaperone
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW mesoderm development Non-traceable author statement PubMed 11247670. Source: UniProtKB protein folding Inferred from sequence or structural similarity. Source: UniProtKB protein localization to cell surface Inferred from electronic annotation. Source: Compara
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 234	201	LDLR chaperone MESD		PRO_0000096443
Regions
	Region	1 – 164	164	Chaperone domain By similarity
	Region	165 – 204	40	Escort domain By similarity
	Motif	231 – 234	4	Prevents secretion from ER
Amino acid modifications
	Glycosylation	201	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q14696 [UniParc]. Last modified October 25, 2002. Version 2. Checksum: 7F0D796A3CC4E339	FASTA	234	26,077
	10 20 30 40 50 60 MAASRWARKA VVLLCASDLL LLLLLLPPPG SCAAEGSPGT PDESTPPPRK KKKDIRDYND 70 80 90 100 110 120 ADMARLLEQW EKDDDIEEGD LPEHKRPSAP VDFSKIDPSK PESILKMTKK GKTLMMFVTV 130 140 150 160 170 180 SGSPTEKETE EITSLWQGSL FNANYDVQRF IVGSDRAIFM LRDGSYAWEI KDFLVGQDRC 190 200 210 220 230 ADVTLEGQVY PGKGGGSKEK NKTKQDKGKK KKEGDLKSRS SKEENRAGNK REDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Skin.
[6]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN. Tissue: Renal cell carcinoma.
[7]	"Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins." Culi J., Springer T.A., Mann R.S. EMBO J. 23:1372-1380(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]	"Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation." Koduri V., Blacklow S.C. Biochemistry 46:6570-6577(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH LRP5 AND LRP6, SUBCELLULAR LOCATION.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D42039 mRNA. Translation: BAA07640.2. Different initiation. AY359110 mRNA. Translation: AAQ89468.1. CH471136 Genomic DNA. Translation: EAW99109.1. CH471136 Genomic DNA. Translation: EAW99110.1. BC009210 mRNA. Translation: AAH09210.1. BC012746 mRNA. Translation: AAH12746.1.
IPI	IPI00399089.
RefSeq	NP_055969.1. NM_015154.1.
UniGene	Hs.578450. Hs.732380.
3D structure databases
ProteinModelPortal	Q14696.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14696. 1 interaction.
MINT	MINT-7006206.
STRING	9606.ENSP00000261758.
PTM databases
PhosphoSite	Q14696.
Polymorphism databases
DMDM	24418861.
2D gel databases
OGP	Q14696.
Proteomic databases
PaxDb	Q14696.
PeptideAtlas	Q14696.
PRIDE	Q14696.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261758; ENSP00000261758; ENSG00000117899. ENST00000561312; ENSP00000453430; ENSG00000117899.
GeneID	23184.
KEGG	hsa:23184.
UCSC	uc002bfy.1. human.
Organism-specific databases
CTD	23184.
GeneCards	GC15M081244.
HGNC	HGNC:13520. MESDC2.
HPA	HPA039414.
MIM	607783. gene.
neXtProt	NX_Q14696.
PharmGKB	PA30761.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG286690.
HOGENOM	HOG000230558.
InParanoid	Q14696.
OMA	IVGSNRA.
OrthoDB	EOG4QRH59.
PhylomeDB	Q14696.
Gene expression databases
ArrayExpress	Q14696.
Bgee	Q14696.
CleanEx	HS_MESDC2.
Genevestigator	Q14696.
GermOnline	ENSG00000117899. Homo sapiens.
Family and domain databases
InterPro	IPR019330. Mesoderm_development_cand-2. [Graphical view]
Pfam	PF10185. Mesd. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23184.
NextBio	44647.
SOURCE	Search...

Entry information

Entry name

MESD_HUMAN

Accession

Primary (citable) accession number: Q14696
Secondary accession number(s): D3DW96, Q969U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 25, 2002
Last modified:	May 29, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.