Q14692 (BMS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosome biogenesis protein BMS1 homolog

Alternative name(s):
Ribosome assembly protein BMS1 homolog

Gene names

Name:	BMS1
Synonyms:	BMS1L, KIAA0187

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1282 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the BMS1/TSR1 family. BMS1 subfamily.
Sequence caution	The sequence BAA11504.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC ribosome assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1282	1282	Ribosome biogenesis protein BMS1 homolog		PRO_0000195004
Regions
	Nucleotide binding	89 – 96	8	ATP Potential
Amino acid modifications
	Modified residue	552	1	Phosphoserine Ref.6 Ref.7
	Modified residue	625	1	Phosphoserine Ref.6
	Modified residue	639	1	Phosphoserine Ref.9
	Modified residue	708	1	Phosphothreonine Ref.6 Ref.7
Natural variations
	Natural variant	237	1	R → H. Corresponds to variant rs2272881 [ dbSNP | Ensembl ].		VAR_057503
	Natural variant	552	1	S → P. Corresponds to variant rs3814621 [ dbSNP | Ensembl ].		VAR_057504
	Natural variant	652	1	K → R. Corresponds to variant rs787795 [ dbSNP | Ensembl ].		VAR_057505
	Natural variant	884	1	M → V. Corresponds to variant rs2419109 [ dbSNP | Ensembl ].		VAR_057506
	Natural variant	1141	1	V → I. Ref.4 Corresponds to variant rs12764004 [ dbSNP | Ensembl ].		VAR_057507

Sequences

	Sequence		Length	Mass (Da)
	Q14692 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 54A736ED250A5138	FASTA	1,282	145,807
	10 20 30 40 50 60 MEAKDQKKHR KKNSGPKAAK KKKRLLQDLQ LGDEEDARKR NPKAFAVQSA VRMARSFHRT 70 80 90 100 110 120 QDLKTKKHHI PVVDRTPLEP PPIVVVVMGP PKVGKSTLIQ CLIRNFTRQK LTEIRGPVTI 130 140 150 160 170 180 VSGKKRRLTI IECGCDINMM IDLAKVADLV LMLIDASFGF EMETFEFLNI CQVHGFPKIM 190 200 210 220 230 240 GVLTHLDSFK HNKQLKKTKK RLKHRFWTEV YPGAKLFYLS GMVHGEYQNQ EIHNLGRFIT 250 260 270 280 290 300 VMKFRPLTWQ TSHPYILADR MEDLTNPEDI RTNIKCDRKV SLYGYLRGAH LKNKSQIHMP 310 320 330 340 350 360 GVGDFAVSDI SFLPDPCALP EQQKKRCLNE KEKLVYAPLS GVGGVLYDKD AVYVDLGGSH 370 380 390 400 410 420 VFQDEVGPTH ELVQSLISTH STIDAKMASS RVTLFSDSKP LGSEDIDNQG LMMPKEEKQM 430 440 450 460 470 480 DLNTGRMRRK AIFGDEDESG DSDDEEDDEM SEDDGLENGS SDEEAEEEEN AEMTDQYMAV 490 500 510 520 530 540 KGIKRRKLEL EEDSEMDLPA FADSDDDLER SSAEEGEAEE ADESSEEEDC TAGEKGISGS 550 560 570 580 590 600 KAAGEGSKAG LSPANCQSDR VNLEKSLLMK KAALPTFDSG HCTAEEVFAS EDESEESSSL 610 620 630 640 650 660 SAEEEDSENE EAIRKKLSKP SQVSSGQKLG PQNFIDETSD IENLLKEEED YKEENNDSKE 670 680 690 700 710 720 TSGALKWKED LSRKAAEAFL RQQQAAPNLR KLIYGTVTED NEEEDDDTLE ELGGLFRVNQ 730 740 750 760 770 780 PDRECKHKAD SLDCSRFLVE APHDWDLEEV MNSIRDCFVT GKWEDDKDAA KVLAEDEELY 790 800 810 820 830 840 GDFEDLETGD VHKGKSGPNT QNEDIEKEVK EEIDPDEEES AKKKHLDKKR KLKEMFDAEY 850 860 870 880 890 900 DEGESTYFDD LKGEMQKQAQ LNRAEFEDQD DEARVQYEGF RPGMYVRIEI ENVPCEFVQN 910 920 930 940 950 960 FDPHYPIILG GLGNSEGNVG YVQMRLKKHR WYKKILKSRD PIIFSVGWRR FQTIPLYYIE 970 980 990 1000 1010 1020 DHNGRQRLLK YTPQHMHCGA AFWGPITPQG TGFLAIQSVS GIMPDFRIAA TGVVLDLDKS 1030 1040 1050 1060 1070 1080 IKIVKKLKLT GFPYKIFKNT SFIKGMFNSA LEVAKFEGAV IRTVSGIRGQ IKKALRAPEG 1090 1100 1110 1120 1130 1140 AFRASFEDKL LMSDIVFMRT WYPVSIPAFY NPVTSLLKPV GEKDTWSGMR TTGQLRLAHG 1150 1160 1170 1180 1190 1200 VRLKANKDSL YKPILRQKKH FNSLHIPKAL QKALPFKNKP KTQAKAGKVP KDRRRPAVIR 1210 1220 1230 1240 1250 1260 EPHERKILAL LDALSTVHSQ KMKKAKEQRH LHNKEHFRAK QKEEEEKLKR QKDLRKKLFR 1270 1280 IQGQKERRNQ KSSLKGAEGQ LQ

References

[1]	"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-1141. Tissue: Skin.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552; SER-625 AND THR-708, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552 AND THR-708, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D80009 mRNA. Translation: BAA11504.2. Different initiation. AL022344 Genomic DNA. Translation: CAI23617.1. CH471160 Genomic DNA. Translation: EAW86571.1. BC043345 mRNA. Translation: AAH43345.1. BC150252 mRNA. Translation: AAI50253.1.
IPI	IPI00006099.
RefSeq	NP_055568.3. NM_014753.3.
UniGene	Hs.10848.
3D structure databases
ProteinModelPortal	Q14692.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14692. 5 interactions.
STRING	9606.ENSP00000363642.
PTM databases
PhosphoSite	Q14692.
Polymorphism databases
DMDM	27151474.
Proteomic databases
PaxDb	Q14692.
PeptideAtlas	Q14692.
PRIDE	Q14692.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374518; ENSP00000363642; ENSG00000165733.
GeneID	9790.
KEGG	hsa:9790.
UCSC	uc001jaj.3. human.
Organism-specific databases
CTD	9790.
GeneCards	GC10P043277.
H-InvDB	HIX0059462. HIX0172328. HIX0172329.
HGNC	HGNC:23505. BMS1.
HPA	HPA036589.
MIM	611448. gene.
neXtProt	NX_Q14692.
PharmGKB	PA162377556.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5192.
HOGENOM	HOG000166882.
HOVERGEN	HBG023890.
InParanoid	Q14692.
KO	K14569.
OMA	ASYGFEM.
OrthoDB	EOG4KWJS4.
PhylomeDB	Q14692.
Gene expression databases
Bgee	Q14692.
CleanEx	HS_BMS1.
Genevestigator	Q14692.
GermOnline	ENSG00000165733. Homo sapiens.
Family and domain databases
InterPro	IPR012948. AARP2CN. IPR007034. BMS1_TSR1_C. IPR000795. EF_GTP-bd_dom. [Graphical view]
Pfam	PF08142. AARP2CN. 1 hit. PF04950. DUF663. 1 hit. PF00009. GTP_EFTU. 1 hit. [Graphical view]
SMART	SM00785. AARP2CN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BMS1. human.
GenomeRNAi	9790.
NextBio	36866.
SOURCE	Search...

Entry information

Entry name

BMS1_HUMAN

Accession

Primary (citable) accession number: Q14692
Secondary accession number(s): Q5QPT5, Q86XJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.