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Q14692

- BMS1_HUMAN

UniProt

Q14692 - BMS1_HUMAN

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Protein
Ribosome biogenesis protein BMS1 homolog
Gene
BMS1, BMS1L, KIAA0187
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 968ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. ribosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BMS1 homolog
Alternative name(s):
Ribosome assembly protein BMS1 homolog
Gene namesi
Name:BMS1
Synonyms:BMS1L, KIAA0187
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23505. BMS1.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti1114. Circumscribed cutaneous aplasia of the vertex.
PharmGKBiPA162377556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12821282Ribosome biogenesis protein BMS1 homolog
PRO_0000195004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei552 – 5521Phosphoserine2 Publications
Modified residuei625 – 6251Phosphoserine1 Publication
Modified residuei639 – 6391Phosphoserine1 Publication
Modified residuei708 – 7081Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14692.
PaxDbiQ14692.
PeptideAtlasiQ14692.
PRIDEiQ14692.

PTM databases

PhosphoSiteiQ14692.

Expressioni

Gene expression databases

BgeeiQ14692.
CleanExiHS_BMS1.
GenevestigatoriQ14692.

Organism-specific databases

HPAiHPA036589.
HPA043081.

Interactioni

Protein-protein interaction databases

BioGridi115134. 9 interactions.
IntActiQ14692. 6 interactions.
MINTiMINT-3030112.
STRINGi9606.ENSP00000363642.

Structurei

3D structure databases

ProteinModelPortaliQ14692.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 246167Bms1-type G
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5192.
HOGENOMiHOG000166882.
HOVERGENiHBG023890.
InParanoidiQ14692.
KOiK14569.
OMAiPMVDRTP.
OrthoDBiEOG7FNC7S.
PhylomeDBiQ14692.
TreeFamiTF105751.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR012948. AARP2CN.
IPR007034. BMS1_TSR1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08142. AARP2CN. 1 hit.
PF04950. DUF663. 1 hit.
[Graphical view]
SMARTiSM00785. AARP2CN. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51714. G_BMS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14692-1 [UniParc]FASTAAdd to Basket

« Hide

MEAKDQKKHR KKNSGPKAAK KKKRLLQDLQ LGDEEDARKR NPKAFAVQSA     50
VRMARSFHRT QDLKTKKHHI PVVDRTPLEP PPIVVVVMGP PKVGKSTLIQ 100
CLIRNFTRQK LTEIRGPVTI VSGKKRRLTI IECGCDINMM IDLAKVADLV 150
LMLIDASFGF EMETFEFLNI CQVHGFPKIM GVLTHLDSFK HNKQLKKTKK 200
RLKHRFWTEV YPGAKLFYLS GMVHGEYQNQ EIHNLGRFIT VMKFRPLTWQ 250
TSHPYILADR MEDLTNPEDI RTNIKCDRKV SLYGYLRGAH LKNKSQIHMP 300
GVGDFAVSDI SFLPDPCALP EQQKKRCLNE KEKLVYAPLS GVGGVLYDKD 350
AVYVDLGGSH VFQDEVGPTH ELVQSLISTH STIDAKMASS RVTLFSDSKP 400
LGSEDIDNQG LMMPKEEKQM DLNTGRMRRK AIFGDEDESG DSDDEEDDEM 450
SEDDGLENGS SDEEAEEEEN AEMTDQYMAV KGIKRRKLEL EEDSEMDLPA 500
FADSDDDLER SSAEEGEAEE ADESSEEEDC TAGEKGISGS KAAGEGSKAG 550
LSPANCQSDR VNLEKSLLMK KAALPTFDSG HCTAEEVFAS EDESEESSSL 600
SAEEEDSENE EAIRKKLSKP SQVSSGQKLG PQNFIDETSD IENLLKEEED 650
YKEENNDSKE TSGALKWKED LSRKAAEAFL RQQQAAPNLR KLIYGTVTED 700
NEEEDDDTLE ELGGLFRVNQ PDRECKHKAD SLDCSRFLVE APHDWDLEEV 750
MNSIRDCFVT GKWEDDKDAA KVLAEDEELY GDFEDLETGD VHKGKSGPNT 800
QNEDIEKEVK EEIDPDEEES AKKKHLDKKR KLKEMFDAEY DEGESTYFDD 850
LKGEMQKQAQ LNRAEFEDQD DEARVQYEGF RPGMYVRIEI ENVPCEFVQN 900
FDPHYPIILG GLGNSEGNVG YVQMRLKKHR WYKKILKSRD PIIFSVGWRR 950
FQTIPLYYIE DHNGRQRLLK YTPQHMHCGA AFWGPITPQG TGFLAIQSVS 1000
GIMPDFRIAA TGVVLDLDKS IKIVKKLKLT GFPYKIFKNT SFIKGMFNSA 1050
LEVAKFEGAV IRTVSGIRGQ IKKALRAPEG AFRASFEDKL LMSDIVFMRT 1100
WYPVSIPAFY NPVTSLLKPV GEKDTWSGMR TTGQLRLAHG VRLKANKDSL 1150
YKPILRQKKH FNSLHIPKAL QKALPFKNKP KTQAKAGKVP KDRRRPAVIR 1200
EPHERKILAL LDALSTVHSQ KMKKAKEQRH LHNKEHFRAK QKEEEEKLKR 1250
QKDLRKKLFR IQGQKERRNQ KSSLKGAEGQ LQ 1282
Length:1,282
Mass (Da):145,807
Last modified:November 1, 1996 - v1
Checksum:i54A736ED250A5138
GO

Sequence cautioni

The sequence BAA11504.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371R → H.
Corresponds to variant rs2272881 [ dbSNP | Ensembl ].
VAR_057503
Natural varianti552 – 5521S → P.
Corresponds to variant rs3814621 [ dbSNP | Ensembl ].
VAR_057504
Natural varianti652 – 6521K → R.
Corresponds to variant rs787795 [ dbSNP | Ensembl ].
VAR_057505
Natural varianti884 – 8841M → V.
Corresponds to variant rs2419109 [ dbSNP | Ensembl ].
VAR_057506
Natural varianti1141 – 11411V → I.1 Publication
Corresponds to variant rs12764004 [ dbSNP | Ensembl ].
VAR_057507

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D80009 mRNA. Translation: BAA11504.2. Different initiation.
AL022344 Genomic DNA. Translation: CAI23617.1.
CH471160 Genomic DNA. Translation: EAW86571.1.
BC043345 mRNA. Translation: AAH43345.1.
BC150252 mRNA. Translation: AAI50253.1.
CCDSiCCDS7199.1.
RefSeqiNP_055568.3. NM_014753.3.
XP_005271903.1. XM_005271846.1.
UniGeneiHs.10848.

Genome annotation databases

EnsembliENST00000374518; ENSP00000363642; ENSG00000165733.
GeneIDi9790.
KEGGihsa:9790.
UCSCiuc001jaj.3. human.

Polymorphism databases

DMDMi27151474.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D80009 mRNA. Translation: BAA11504.2 . Different initiation.
AL022344 Genomic DNA. Translation: CAI23617.1 .
CH471160 Genomic DNA. Translation: EAW86571.1 .
BC043345 mRNA. Translation: AAH43345.1 .
BC150252 mRNA. Translation: AAI50253.1 .
CCDSi CCDS7199.1.
RefSeqi NP_055568.3. NM_014753.3.
XP_005271903.1. XM_005271846.1.
UniGenei Hs.10848.

3D structure databases

ProteinModelPortali Q14692.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115134. 9 interactions.
IntActi Q14692. 6 interactions.
MINTi MINT-3030112.
STRINGi 9606.ENSP00000363642.

PTM databases

PhosphoSitei Q14692.

Polymorphism databases

DMDMi 27151474.

Proteomic databases

MaxQBi Q14692.
PaxDbi Q14692.
PeptideAtlasi Q14692.
PRIDEi Q14692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374518 ; ENSP00000363642 ; ENSG00000165733 .
GeneIDi 9790.
KEGGi hsa:9790.
UCSCi uc001jaj.3. human.

Organism-specific databases

CTDi 9790.
GeneCardsi GC10P043277.
H-InvDB HIX0059462.
HIX0172328.
HIX0172329.
HGNCi HGNC:23505. BMS1.
HPAi HPA036589.
HPA043081.
MIMi 611448. gene.
neXtProti NX_Q14692.
Orphaneti 1114. Circumscribed cutaneous aplasia of the vertex.
PharmGKBi PA162377556.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5192.
HOGENOMi HOG000166882.
HOVERGENi HBG023890.
InParanoidi Q14692.
KOi K14569.
OMAi PMVDRTP.
OrthoDBi EOG7FNC7S.
PhylomeDBi Q14692.
TreeFami TF105751.

Miscellaneous databases

ChiTaRSi BMS1. human.
GenomeRNAii 9790.
NextBioi 36866.
PROi Q14692.
SOURCEi Search...

Gene expression databases

Bgeei Q14692.
CleanExi HS_BMS1.
Genevestigatori Q14692.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR012948. AARP2CN.
IPR007034. BMS1_TSR1_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF08142. AARP2CN. 1 hit.
PF04950. DUF663. 1 hit.
[Graphical view ]
SMARTi SM00785. AARP2CN. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51714. G_BMS1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-1141.
    Tissue: Skin.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552; SER-625 AND THR-708, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552 AND THR-708, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBMS1_HUMAN
AccessioniPrimary (citable) accession number: Q14692
Secondary accession number(s): Q5QPT5, Q86XJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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