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Reviewed, UniProtKB/Swiss-Prot Q14692 (BMS1_HUMAN)

Last modified November 3, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ribosome biogenesis protein BMS1 homolog
Alternative name(s):
    Ribosome assembly protein BMS1 homolog
Gene names
Name: BMS1
Synonyms: BMS1L, KIAA0187
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1282 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the BMS1/TSR1 family. BMS1 subfamily.

Ontologies

Keywords
   Biological processRibosome biogenesis
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandATP-binding
Nucleotide-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processribosome assembly

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular componentnucleolus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12821282Ribosome biogenesis protein BMS1 homolog
PRO_0000195004

Regions

Nucleotide binding89 – 968ATP Potential

Amino acid modifications

Modified residue5041Phosphoserine Ref.3
Modified residue5521Phosphoserine Ref.3 Ref.4
Modified residue6241Phosphoserine Ref.3
Modified residue6251Phosphoserine Ref.3 Ref.4
Modified residue6391Phosphoserine Ref.3
Modified residue7081Phosphothreonine Ref.4
Modified residue8201Phosphoserine Ref.3

Natural variations

Natural variant2371R → H: dbSNP rs2272881.
VAR_057503
Natural variant5521S → P: dbSNP rs3814621.
VAR_057504
Natural variant6521K → R: dbSNP rs787795.
VAR_057505
Natural variant8841M → V: dbSNP rs2419109.
VAR_057506
Natural variant11411V → I: dbSNP rs12764004. Ref.2
VAR_057507

Sequences

Sequence LengthMass (Da)Tools
Q14692-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 54A736ED250A5138

FASTA1,282145,807
        10         20         30         40         50         60 
MEAKDQKKHR KKNSGPKAAK KKKRLLQDLQ LGDEEDARKR NPKAFAVQSA VRMARSFHRT 

        70         80         90        100        110        120 
QDLKTKKHHI PVVDRTPLEP PPIVVVVMGP PKVGKSTLIQ CLIRNFTRQK LTEIRGPVTI 

       130        140        150        160        170        180 
VSGKKRRLTI IECGCDINMM IDLAKVADLV LMLIDASFGF EMETFEFLNI CQVHGFPKIM 

       190        200        210        220        230        240 
GVLTHLDSFK HNKQLKKTKK RLKHRFWTEV YPGAKLFYLS GMVHGEYQNQ EIHNLGRFIT 

       250        260        270        280        290        300 
VMKFRPLTWQ TSHPYILADR MEDLTNPEDI RTNIKCDRKV SLYGYLRGAH LKNKSQIHMP 

       310        320        330        340        350        360 
GVGDFAVSDI SFLPDPCALP EQQKKRCLNE KEKLVYAPLS GVGGVLYDKD AVYVDLGGSH 

       370        380        390        400        410        420 
VFQDEVGPTH ELVQSLISTH STIDAKMASS RVTLFSDSKP LGSEDIDNQG LMMPKEEKQM 

       430        440        450        460        470        480 
DLNTGRMRRK AIFGDEDESG DSDDEEDDEM SEDDGLENGS SDEEAEEEEN AEMTDQYMAV 

       490        500        510        520        530        540 
KGIKRRKLEL EEDSEMDLPA FADSDDDLER SSAEEGEAEE ADESSEEEDC TAGEKGISGS 

       550        560        570        580        590        600 
KAAGEGSKAG LSPANCQSDR VNLEKSLLMK KAALPTFDSG HCTAEEVFAS EDESEESSSL 

       610        620        630        640        650        660 
SAEEEDSENE EAIRKKLSKP SQVSSGQKLG PQNFIDETSD IENLLKEEED YKEENNDSKE 

       670        680        690        700        710        720 
TSGALKWKED LSRKAAEAFL RQQQAAPNLR KLIYGTVTED NEEEDDDTLE ELGGLFRVNQ 

       730        740        750        760        770        780 
PDRECKHKAD SLDCSRFLVE APHDWDLEEV MNSIRDCFVT GKWEDDKDAA KVLAEDEELY 

       790        800        810        820        830        840 
GDFEDLETGD VHKGKSGPNT QNEDIEKEVK EEIDPDEEES AKKKHLDKKR KLKEMFDAEY 

       850        860        870        880        890        900 
DEGESTYFDD LKGEMQKQAQ LNRAEFEDQD DEARVQYEGF RPGMYVRIEI ENVPCEFVQN 

       910        920        930        940        950        960 
FDPHYPIILG GLGNSEGNVG YVQMRLKKHR WYKKILKSRD PIIFSVGWRR FQTIPLYYIE 

       970        980        990       1000       1010       1020 
DHNGRQRLLK YTPQHMHCGA AFWGPITPQG TGFLAIQSVS GIMPDFRIAA TGVVLDLDKS 

      1030       1040       1050       1060       1070       1080 
IKIVKKLKLT GFPYKIFKNT SFIKGMFNSA LEVAKFEGAV IRTVSGIRGQ IKKALRAPEG 

      1090       1100       1110       1120       1130       1140 
AFRASFEDKL LMSDIVFMRT WYPVSIPAFY NPVTSLLKPV GEKDTWSGMR TTGQLRLAHG 

      1150       1160       1170       1180       1190       1200 
VRLKANKDSL YKPILRQKKH FNSLHIPKAL QKALPFKNKP KTQAKAGKVP KDRRRPAVIR 

      1210       1220       1230       1240       1250       1260 
EPHERKILAL LDALSTVHSQ KMKKAKEQRH LHNKEHFRAK QKEEEEKLKR QKDLRKKLFR 

      1270       1280 
IQGQKERRNQ KSSLKGAEGQ LQ 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
DNA Res. 3:17-24(1996) [PubMed: 8724849] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-1141.
Tissue: Skin.
[3]"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis."
Wang B., Malik R., Nigg E.A., Korner R.
Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504; SER-552; SER-624; SER-625; SER-639 AND SER-820, MASS SPECTROMETRY.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552; SER-625 AND THR-708, MASS SPECTROMETRY.
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

D80009 mRNA. Translation: BAA11504.2. Different initiation.
BC043345 mRNA. Translation: AAH43345.1.
IPIIPI00006099.
RefSeqNP_055568.3.
UniGeneHs.10848

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ14692.

PTM databases

PhosphoSiteQ14692.

Proteomic databases

PeptideAtlasQ14692.
PRIDEQ14692.

Genome annotation databases

EnsemblENST00000374518; ENSP00000363642; ENSG00000165733; Homo sapiens. [Genome view]
GeneID9790.
KEGGhsa:9790.

Organism-specific databases

CTD9790.
GeneCardsGC09M067017.
GC10P042599.
GC16M033398.
GC16M033404.
H-InvDBHIX0008773.
HIX0008796.
HIX0035374.
HGNCHGNC:23505. BMS1.
MIM611448. gene.
PharmGKBPA142672551.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ14692.
HOVERGENQ14692.
OMATRVQYEG.

Gene expression databases

ArrayExpressQ14692.
BgeeQ14692.
CleanExHS_BMS1.
GenevestigatorQ14692.
GermOnlineENSG00000165733. Homo sapiens.

Family and domain databases

InterProIPR012948. AARP2CN.
IPR007034. DUF663.
[Graphical view]
PfamPF08142. AARP2CN. 1 hit.
PF04950. DUF663. 1 hit.
[Graphical view]
SMARTSM00785. AARP2CN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio36866.
SOURCESearch...

Entry information

Entry nameBMS1_HUMAN
AccessionPrimary (citable) accession number: Q14692
Secondary accession number(s): Q86XJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: November 1, 1996
Last modified: November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents