Reviewed, UniProtKB/Swiss-Prot Q14692 (BMS1_HUMAN)

Names and origin

Protein names

Recommended name:
    Ribosome biogenesis protein BMS1 homolog
Alternative name(s):
    Ribosome assembly protein BMS1 homolog

Gene names

Name:	BMS1
Synonyms:	BMS1L, KIAA0187

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1282 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the BMS1/TSR1 family. BMS1 subfamily.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ribosome assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1282	1282	Ribosome biogenesis protein BMS1 homolog		PRO_0000195004
Regions
	Nucleotide binding	89 – 96	8	ATP Potential
Amino acid modifications
	Modified residue	504	1	Phosphoserine Ref.3
	Modified residue	552	1	Phosphoserine Ref.3 Ref.4
	Modified residue	624	1	Phosphoserine Ref.3
	Modified residue	625	1	Phosphoserine Ref.3 Ref.4
	Modified residue	639	1	Phosphoserine Ref.3
	Modified residue	708	1	Phosphothreonine Ref.4
	Modified residue	820	1	Phosphoserine Ref.3
Natural variations
	Natural variant	237	1	R → H: dbSNP rs2272881.		VAR_057503
	Natural variant	552	1	S → P: dbSNP rs3814621.		VAR_057504
	Natural variant	652	1	K → R: dbSNP rs787795.		VAR_057505
	Natural variant	884	1	M → V: dbSNP rs2419109.		VAR_057506
	Natural variant	1141	1	V → I: dbSNP rs12764004. Ref.2		VAR_057507

Sequences

	Sequence		Length	Mass (Da)
	Q14692-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 54A736ED250A5138	FASTA	1,282	145,807
	10 20 30 40 50 60 MEAKDQKKHR KKNSGPKAAK KKKRLLQDLQ LGDEEDARKR NPKAFAVQSA VRMARSFHRT 70 80 90 100 110 120 QDLKTKKHHI PVVDRTPLEP PPIVVVVMGP PKVGKSTLIQ CLIRNFTRQK LTEIRGPVTI 130 140 150 160 170 180 VSGKKRRLTI IECGCDINMM IDLAKVADLV LMLIDASFGF EMETFEFLNI CQVHGFPKIM 190 200 210 220 230 240 GVLTHLDSFK HNKQLKKTKK RLKHRFWTEV YPGAKLFYLS GMVHGEYQNQ EIHNLGRFIT 250 260 270 280 290 300 VMKFRPLTWQ TSHPYILADR MEDLTNPEDI RTNIKCDRKV SLYGYLRGAH LKNKSQIHMP 310 320 330 340 350 360 GVGDFAVSDI SFLPDPCALP EQQKKRCLNE KEKLVYAPLS GVGGVLYDKD AVYVDLGGSH 370 380 390 400 410 420 VFQDEVGPTH ELVQSLISTH STIDAKMASS RVTLFSDSKP LGSEDIDNQG LMMPKEEKQM 430 440 450 460 470 480 DLNTGRMRRK AIFGDEDESG DSDDEEDDEM SEDDGLENGS SDEEAEEEEN AEMTDQYMAV 490 500 510 520 530 540 KGIKRRKLEL EEDSEMDLPA FADSDDDLER SSAEEGEAEE ADESSEEEDC TAGEKGISGS 550 560 570 580 590 600 KAAGEGSKAG LSPANCQSDR VNLEKSLLMK KAALPTFDSG HCTAEEVFAS EDESEESSSL 610 620 630 640 650 660 SAEEEDSENE EAIRKKLSKP SQVSSGQKLG PQNFIDETSD IENLLKEEED YKEENNDSKE 670 680 690 700 710 720 TSGALKWKED LSRKAAEAFL RQQQAAPNLR KLIYGTVTED NEEEDDDTLE ELGGLFRVNQ 730 740 750 760 770 780 PDRECKHKAD SLDCSRFLVE APHDWDLEEV MNSIRDCFVT GKWEDDKDAA KVLAEDEELY 790 800 810 820 830 840 GDFEDLETGD VHKGKSGPNT QNEDIEKEVK EEIDPDEEES AKKKHLDKKR KLKEMFDAEY 850 860 870 880 890 900 DEGESTYFDD LKGEMQKQAQ LNRAEFEDQD DEARVQYEGF RPGMYVRIEI ENVPCEFVQN 910 920 930 940 950 960 FDPHYPIILG GLGNSEGNVG YVQMRLKKHR WYKKILKSRD PIIFSVGWRR FQTIPLYYIE 970 980 990 1000 1010 1020 DHNGRQRLLK YTPQHMHCGA AFWGPITPQG TGFLAIQSVS GIMPDFRIAA TGVVLDLDKS 1030 1040 1050 1060 1070 1080 IKIVKKLKLT GFPYKIFKNT SFIKGMFNSA LEVAKFEGAV IRTVSGIRGQ IKKALRAPEG 1090 1100 1110 1120 1130 1140 AFRASFEDKL LMSDIVFMRT WYPVSIPAFY NPVTSLLKPV GEKDTWSGMR TTGQLRLAHG 1150 1160 1170 1180 1190 1200 VRLKANKDSL YKPILRQKKH FNSLHIPKAL QKALPFKNKP KTQAKAGKVP KDRRRPAVIR 1210 1220 1230 1240 1250 1260 EPHERKILAL LDALSTVHSQ KMKKAKEQRH LHNKEHFRAK QKEEEEKLKR QKDLRKKLFR 1270 1280 IQGQKERRNQ KSSLKGAEGQ LQ

References

[1]	"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed: 8724849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-1141. Tissue: Skin.
[3]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504; SER-552; SER-624; SER-625; SER-639 AND SER-820, MASS SPECTROMETRY.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552; SER-625 AND THR-708, MASS SPECTROMETRY.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D80009 mRNA. Translation: BAA11504.2. Different initiation. BC043345 mRNA. Translation: AAH43345.1.
IPI	IPI00006099.
RefSeq	NP_055568.3.
UniGene	Hs.10848
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q14692.
PTM databases
PhosphoSite	Q14692.
Proteomic databases
PeptideAtlas	Q14692.
PRIDE	Q14692.
Genome annotation databases
Ensembl	ENST00000374518; ENSP00000363642; ENSG00000165733; Homo sapiens. [Genome view]
GeneID	9790.
KEGG	hsa:9790.
Organism-specific databases
CTD	9790.
GeneCards	GC09M067017. GC10P042599. GC16M033398. GC16M033404.
H-InvDB	HIX0008773. HIX0008796. HIX0035374.
HGNC	HGNC:23505. BMS1.
MIM	611448. gene.
PharmGKB	PA142672551.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q14692.
HOVERGEN	Q14692.
OMA	TRVQYEG.
Gene expression databases
ArrayExpress	Q14692.
Bgee	Q14692.
CleanEx	HS_BMS1.
Genevestigator	Q14692.
GermOnline	ENSG00000165733. Homo sapiens.
Family and domain databases
InterPro	IPR012948. AARP2CN. IPR007034. DUF663. [Graphical view]
Pfam	PF08142. AARP2CN. 1 hit. PF04950. DUF663. 1 hit. [Graphical view]
SMART	SM00785. AARP2CN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	36866.
SOURCE	Search...

Entry information

Entry name

BMS1_HUMAN

Accession

Primary (citable) accession number: Q14692
Secondary accession number(s): Q86XJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.