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Protein

DNA replication complex GINS protein PSF1

Gene

GINS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-HSA-176974. Unwinding of DNA.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF1
Alternative name(s):
GINS complex subunit 1
Gene namesi
Name:GINS1
Synonyms:KIAA0186, PSF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101003.9.
HGNCiHGNC:28980. GINS1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9837.
OpenTargetsiENSG00000101003.
PharmGKBiPA145008291.

Polymorphism and mutation databases

BioMutaiGINS1.
DMDMi6226339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190351 – 196DNA replication complex GINS protein PSF1Add BLAST196

Proteomic databases

EPDiQ14691.
MaxQBiQ14691.
PaxDbiQ14691.
PeptideAtlasiQ14691.
PRIDEiQ14691.

PTM databases

iPTMnetiQ14691.
PhosphoSitePlusiQ14691.

Expressioni

Inductioni

Significantly up-regulated in aggressive melanomas.1 Publication

Gene expression databases

BgeeiENSG00000101003.
CleanExiHS_GINS1.
GenevisibleiQ14691. HS.

Organism-specific databases

HPAiHPA051185.

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro.4 Publications

Protein-protein interaction databases

BioGridi115174. 15 interactors.
CORUMiQ14691.
DIPiDIP-29331N.
IntActiQ14691. 3 interactors.
STRINGi9606.ENSP00000262460.

Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 15Combined sources12
Beta strandi16 – 19Combined sources4
Helixi26 – 49Combined sources24
Helixi56 – 58Combined sources3
Helixi59 – 94Combined sources36
Helixi100 – 104Combined sources5
Helixi108 – 127Combined sources20
Beta strandi128 – 132Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9XX-ray2.30A/E1-149[»]
2EHOX-ray3.00B/F/J1-151[»]
2Q9QX-ray2.36C/G1-196[»]
ProteinModelPortaliQ14691.
SMRiQ14691.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14691.

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS1/PSF1 family.Curated

Phylogenomic databases

eggNOGiKOG3303. Eukaryota.
COG5230. LUCA.
GeneTreeiENSGT00390000013968.
HOGENOMiHOG000192102.
HOVERGENiHBG053743.
InParanoidiQ14691.
KOiK10732.
OMAiNSQFYVR.
OrthoDBiEOG091G0M3U.
PhylomeDBiQ14691.
TreeFamiTF312848.

Family and domain databases

CDDicd11710. GINS_A_psf1. 1 hit.
InterProiView protein in InterPro
IPR036224. GINS_bundle-like_dom.
IPR005339. GINS_Psf1.
PANTHERiPTHR12914. PTHR12914. 1 hit.
SUPFAMiSSF158573. SSF158573. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14691-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCEKAMELI RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA
60 70 80 90 100
KSGGRSDLIP TIKFRHCSLL RNRRCTVAYL YDRLLRIRAL RWEYGSVLPN
110 120 130 140 150
ALRFHMAAEE MEWFNNYKRS LATYMRSLGG DEGLDITQDM KPPKSLYIEV
160 170 180 190
RCLKDYGEFE VDDGTSVLLK KNSQHFLPRW KCEQLIRQGV LEHILS
Length:196
Mass (Da):22,988
Last modified:November 1, 1996 - v1
Checksum:i2270B5CE6C43BFE5
GO

Sequence cautioni

Q14691: The sequence BAA11503 differs from that shown. Reason: Erroneous initiation.Curated

Mass spectrometryi

Q14691: Molecular mass is 98373±13 Da from positions 1 - 196. Determined by ESI. This is the measured mass for the GINS complex.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05160697V → I1 PublicationCorresponds to variant dbSNP:rs6076347Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D80008 mRNA. Translation: BAA11503.2. Different initiation.
AL353812, AL031672 Genomic DNA. Translation: CAI13764.1.
AL031672, AL353812 Genomic DNA. Translation: CAI43019.1.
BC012542 mRNA. Translation: AAH12542.1.
CCDSiCCDS33451.1.
RefSeqiNP_066545.3. NM_021067.4.
UniGeneiHs.658464.

Genome annotation databases

EnsembliENST00000262460; ENSP00000262460; ENSG00000101003.
GeneIDi9837.
KEGGihsa:9837.
UCSCiuc002wuv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPSF1_HUMAN
AccessioniPrimary (citable) accession number: Q14691
Secondary accession number(s): Q9NQE2, Q9NQI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families