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Q14687

- GSE1_HUMAN

UniProt

Q14687 - GSE1_HUMAN

Protein

Genetic suppressor element 1

Gene

GSE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 3 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Genetic suppressor element 1
    Gene namesi
    Name:GSE1
    Synonyms:KIAA0182
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:28979. GSE1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485512.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12171217Genetic suppressor element 1PRO_0000050730Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei84 – 841Phosphoserine1 Publication
    Modified residuei496 – 4961N6-acetyllysine1 Publication
    Modified residuei739 – 7391N6-acetyllysine1 Publication
    Modified residuei766 – 7661Phosphoserine1 Publication
    Modified residuei826 – 8261Phosphoserine1 Publication
    Modified residuei857 – 8571Phosphoserine2 Publications
    Modified residuei907 – 9071Phosphothreonine1 Publication
    Modified residuei909 – 9091Phosphoserine3 Publications
    Modified residuei1101 – 11011Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ14687.
    PaxDbiQ14687.
    PRIDEiQ14687.

    PTM databases

    PhosphoSiteiQ14687.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14687.
    BgeeiQ14687.
    CleanExiHS_KIAA0182.
    GenevestigatoriQ14687.

    Organism-specific databases

    HPAiHPA036365.

    Interactioni

    Subunit structurei

    May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RCOR3Q9P2K33EBI-372619,EBI-743428

    Protein-protein interaction databases

    BioGridi116808. 18 interactions.
    IntActiQ14687. 12 interactions.
    MINTiMINT-8304671.
    STRINGi9606.ENSP00000253458.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14687.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili321 – 40383Sequence AnalysisAdd
    BLAST
    Coiled coili1127 – 120175Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi532 – 722191Pro-richAdd
    BLAST
    Compositional biasi745 – 7484Poly-Arg
    Compositional biasi1102 – 11076Poly-Glu

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG46383.
    HOGENOMiHOG000112825.
    HOVERGENiHBG079773.
    InParanoidiQ14687.
    OMAiYDEFLQQ.
    OrthoDBiEOG7CCBQM.
    PhylomeDBiQ14687.
    TreeFamiTF332496.

    Family and domain databases

    InterProiIPR022207. GSE-like.
    [Graphical view]
    PfamiPF12540. DUF3736. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14687-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKGMSHEPKS PSLGMLSTAT RTTATVNPLT PSPLNGALVP SGSPATSSAL     50
    SAQAAPSSSF AAALRKLAKQ AEEPRGSSLS SESSPVSSPA TNHSSPASTP 100
    KRVPMGPIIV PPGGHSVPST PPVVTIAPTK TVNGVWRSES RQDAGSRSSS 150
    GGRERLIVEP PLPQEKAGGP AIPSHLLSTP YPFGLSPSSV VQDSRFPPLN 200
    LQRPVHHVVP PSTVTEDYLR SFRPYHTTDD LRMSSLPPLG LDPATAAAYY 250
    HPSYLAPHPF PHPAFRMDDS YCLSALRSPF YPIPTPGSLP PLHPSAMHLH 300
    LSGVRYPPEL SHSSLAALHS ERMSGLSAER LQMDEELRRE RERERERERE 350
    READREREKE REREREKERE QEKEREREKE RERELERQRE QRAREKELLA 400
    AKALEPSFLP VAELHGLRGH ATEERGKPSE QLTPTRAEKL KDAGLQAPKP 450
    VQHPLHPVPT PHHTVPSLIS NHGIFSLPSS SAATALLIQR TNEEEKWLAR 500
    QRRLRQEKED RQSQVSEFRQ QVLEQHLDMG RPPVPAEAEH RPESTTRPGP 550
    NRHEPGGRDP PQHFGGPPPL ISPKPQLHAA PTALWNPVSL MDNTLETRRA 600
    ESHSLHSHPA AFEPSRQAAV PLVKVERVFC PEKAEEGPRK REPAPLDKYQ 650
    PPPPPPREGG SLEHQPFLPG PGPFLAELEK STQTILGQQR ASLPQAATFG 700
    ELSGPLKPGS PYRPPVPRAP DPAYIYDEFL QQRRRLVSKL DLEERRRREA 750
    QEKGYYYDLD DSYDESDEEE VRAHLRCVAE QPPLKLDTSS EKLEFLQLFG 800
    LTTQQQKEEL VAQKRRKRRR MLRERSPSPP TIQSKRQTPS PRLALSTRYS 850
    PDEMNNSPNF EEKKKFLTIF NLTHISAEKR KDKERLVEML RAMKQKALSA 900
    AVADSLTNSP RDSPAVSLSE PATQQASLDV EKPVGVAASL SDIPKAAEPG 950
    KLEQVRPQEL SRVQELAPAS GEKARLSEAP GGKKSLSMLH YIRGAAPKDI 1000
    PVPLSHSTNG KSKPWEPFVA EEFAHQFHES VLQSTQKALQ KHKGSVAVLS 1050
    AEQNHKVDTS VHYNIPELQS SSRAPPPQHN GQQEPPTARK GPPTQELDRD 1100
    SEEEEEEDDE DGEDEEEVPK RKWQGIEAVF EAYQEHIEEQ NLERQVLQTQ 1150
    CRRLEARHYS LSLTAEQLSH SVAELRSQKQ KMVSERERLQ AELDHLRKCL 1200
    ALPAMHWPRG YLKGYPR 1217
    Length:1,217
    Mass (Da):136,164
    Last modified:February 20, 2007 - v3
    Checksum:i4291FBE301B70F36
    GO
    Isoform 2 (identifier: Q14687-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-104: Missing.

    Show »
    Length:1,113
    Mass (Da):125,842
    Checksum:i5AB78CBD09B3216F
    GO
    Isoform 3 (identifier: Q14687-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3-75: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,144
    Mass (Da):128,923
    Checksum:iEFEA707A543C49D2
    GO

    Sequence cautioni

    The sequence BAA11499.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti444 – 4441G → S in BAA11499. (PubMed:8724849)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti627 – 6271R → W in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035926
    Natural varianti936 – 9361V → A.1 Publication
    Corresponds to variant rs17853763 [ dbSNP | Ensembl ].
    VAR_029546
    Natural varianti1153 – 11531R → Q.
    Corresponds to variant rs2303203 [ dbSNP | Ensembl ].
    VAR_029547

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 104104Missing in isoform 2. 1 PublicationVSP_021820Add
    BLAST
    Alternative sequencei3 – 7573Missing in isoform 3. 1 PublicationVSP_021821Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D80004 mRNA. Translation: BAA11499.2. Different initiation.
    CH471114 Genomic DNA. Translation: EAW95445.1.
    CH471114 Genomic DNA. Translation: EAW95447.1.
    BC000753 mRNA. Translation: AAH00753.2.
    BC009854 mRNA. Translation: AAH09854.2.
    BC037556 mRNA. Translation: AAH37556.1.
    BQ214916 mRNA. No translation available.
    CCDSiCCDS10952.1. [Q14687-1]
    CCDS45539.1. [Q14687-2]
    CCDS62007.1. [Q14687-3]
    RefSeqiNP_001127945.1. NM_001134473.2. [Q14687-2]
    NP_001265113.1. NM_001278184.1. [Q14687-3]
    NP_055430.1. NM_014615.3. [Q14687-1]
    UniGeneiHs.461647.

    Genome annotation databases

    EnsembliENST00000253458; ENSP00000253458; ENSG00000131149. [Q14687-1]
    ENST00000393243; ENSP00000376934; ENSG00000131149. [Q14687-3]
    ENST00000405402; ENSP00000384839; ENSG00000131149. [Q14687-2]
    GeneIDi23199.
    KEGGihsa:23199.
    UCSCiuc002fiw.3. human. [Q14687-1]
    uc002fiy.4. human. [Q14687-3]

    Polymorphism databases

    DMDMi126302550.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D80004 mRNA. Translation: BAA11499.2 . Different initiation.
    CH471114 Genomic DNA. Translation: EAW95445.1 .
    CH471114 Genomic DNA. Translation: EAW95447.1 .
    BC000753 mRNA. Translation: AAH00753.2 .
    BC009854 mRNA. Translation: AAH09854.2 .
    BC037556 mRNA. Translation: AAH37556.1 .
    BQ214916 mRNA. No translation available.
    CCDSi CCDS10952.1. [Q14687-1 ]
    CCDS45539.1. [Q14687-2 ]
    CCDS62007.1. [Q14687-3 ]
    RefSeqi NP_001127945.1. NM_001134473.2. [Q14687-2 ]
    NP_001265113.1. NM_001278184.1. [Q14687-3 ]
    NP_055430.1. NM_014615.3. [Q14687-1 ]
    UniGenei Hs.461647.

    3D structure databases

    ProteinModelPortali Q14687.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116808. 18 interactions.
    IntActi Q14687. 12 interactions.
    MINTi MINT-8304671.
    STRINGi 9606.ENSP00000253458.

    PTM databases

    PhosphoSitei Q14687.

    Polymorphism databases

    DMDMi 126302550.

    Proteomic databases

    MaxQBi Q14687.
    PaxDbi Q14687.
    PRIDEi Q14687.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253458 ; ENSP00000253458 ; ENSG00000131149 . [Q14687-1 ]
    ENST00000393243 ; ENSP00000376934 ; ENSG00000131149 . [Q14687-3 ]
    ENST00000405402 ; ENSP00000384839 ; ENSG00000131149 . [Q14687-2 ]
    GeneIDi 23199.
    KEGGi hsa:23199.
    UCSCi uc002fiw.3. human. [Q14687-1 ]
    uc002fiy.4. human. [Q14687-3 ]

    Organism-specific databases

    CTDi 23199.
    GeneCardsi GC16P085646.
    HGNCi HGNC:28979. GSE1.
    HPAi HPA036365.
    neXtProti NX_Q14687.
    PharmGKBi PA143485512.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46383.
    HOGENOMi HOG000112825.
    HOVERGENi HBG079773.
    InParanoidi Q14687.
    OMAi YDEFLQQ.
    OrthoDBi EOG7CCBQM.
    PhylomeDBi Q14687.
    TreeFami TF332496.

    Miscellaneous databases

    GeneWikii KIAA0182.
    GenomeRNAii 23199.
    NextBioi 44711.
    PROi Q14687.

    Gene expression databases

    ArrayExpressi Q14687.
    Bgeei Q14687.
    CleanExi HS_KIAA0182.
    Genevestigatori Q14687.

    Family and domain databases

    InterProi IPR022207. GSE-like.
    [Graphical view ]
    Pfami PF12540. DUF3736. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
      DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Bone marrow.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-936.
      Tissue: Lung and Placenta.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826; SER-909 AND SER-1101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-766; SER-857; THR-907 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-496 AND LYS-739, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-627.

    Entry informationi

    Entry nameiGSE1_HUMAN
    AccessioniPrimary (citable) accession number: Q14687
    Secondary accession number(s): D3DUM4
    , Q8IY61, Q96GA4, Q9BW09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3