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Q14687

- GSE1_HUMAN

UniProt

Q14687 - GSE1_HUMAN

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Protein

Genetic suppressor element 1

Gene
GSE1, KIAA0182
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Genetic suppressor element 1
Gene namesi
Name:GSE1
Synonyms:KIAA0182
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28979. GSE1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12171217Genetic suppressor element 1PRO_0000050730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841Phosphoserine1 Publication
Modified residuei496 – 4961N6-acetyllysine1 Publication
Modified residuei739 – 7391N6-acetyllysine1 Publication
Modified residuei766 – 7661Phosphoserine1 Publication
Modified residuei826 – 8261Phosphoserine1 Publication
Modified residuei857 – 8571Phosphoserine2 Publications
Modified residuei907 – 9071Phosphothreonine1 Publication
Modified residuei909 – 9091Phosphoserine3 Publications
Modified residuei1101 – 11011Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ14687.
PaxDbiQ14687.
PRIDEiQ14687.

PTM databases

PhosphoSiteiQ14687.

Expressioni

Gene expression databases

ArrayExpressiQ14687.
BgeeiQ14687.
CleanExiHS_KIAA0182.
GenevestigatoriQ14687.

Organism-specific databases

HPAiHPA036365.

Interactioni

Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

Binary interactionsi

WithEntry#Exp.IntActNotes
RCOR3Q9P2K33EBI-372619,EBI-743428

Protein-protein interaction databases

BioGridi116808. 18 interactions.
IntActiQ14687. 12 interactions.
MINTiMINT-8304671.
STRINGi9606.ENSP00000253458.

Structurei

3D structure databases

ProteinModelPortaliQ14687.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili321 – 40383 Reviewed predictionAdd
BLAST
Coiled coili1127 – 120175 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi532 – 722191Pro-richAdd
BLAST
Compositional biasi745 – 7484Poly-Arg
Compositional biasi1102 – 11076Poly-Glu

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG46383.
HOGENOMiHOG000112825.
HOVERGENiHBG079773.
InParanoidiQ14687.
OMAiYDEFLQQ.
OrthoDBiEOG7CCBQM.
PhylomeDBiQ14687.
TreeFamiTF332496.

Family and domain databases

InterProiIPR022207. GSE-like.
[Graphical view]
PfamiPF12540. DUF3736. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14687-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKGMSHEPKS PSLGMLSTAT RTTATVNPLT PSPLNGALVP SGSPATSSAL     50
SAQAAPSSSF AAALRKLAKQ AEEPRGSSLS SESSPVSSPA TNHSSPASTP 100
KRVPMGPIIV PPGGHSVPST PPVVTIAPTK TVNGVWRSES RQDAGSRSSS 150
GGRERLIVEP PLPQEKAGGP AIPSHLLSTP YPFGLSPSSV VQDSRFPPLN 200
LQRPVHHVVP PSTVTEDYLR SFRPYHTTDD LRMSSLPPLG LDPATAAAYY 250
HPSYLAPHPF PHPAFRMDDS YCLSALRSPF YPIPTPGSLP PLHPSAMHLH 300
LSGVRYPPEL SHSSLAALHS ERMSGLSAER LQMDEELRRE RERERERERE 350
READREREKE REREREKERE QEKEREREKE RERELERQRE QRAREKELLA 400
AKALEPSFLP VAELHGLRGH ATEERGKPSE QLTPTRAEKL KDAGLQAPKP 450
VQHPLHPVPT PHHTVPSLIS NHGIFSLPSS SAATALLIQR TNEEEKWLAR 500
QRRLRQEKED RQSQVSEFRQ QVLEQHLDMG RPPVPAEAEH RPESTTRPGP 550
NRHEPGGRDP PQHFGGPPPL ISPKPQLHAA PTALWNPVSL MDNTLETRRA 600
ESHSLHSHPA AFEPSRQAAV PLVKVERVFC PEKAEEGPRK REPAPLDKYQ 650
PPPPPPREGG SLEHQPFLPG PGPFLAELEK STQTILGQQR ASLPQAATFG 700
ELSGPLKPGS PYRPPVPRAP DPAYIYDEFL QQRRRLVSKL DLEERRRREA 750
QEKGYYYDLD DSYDESDEEE VRAHLRCVAE QPPLKLDTSS EKLEFLQLFG 800
LTTQQQKEEL VAQKRRKRRR MLRERSPSPP TIQSKRQTPS PRLALSTRYS 850
PDEMNNSPNF EEKKKFLTIF NLTHISAEKR KDKERLVEML RAMKQKALSA 900
AVADSLTNSP RDSPAVSLSE PATQQASLDV EKPVGVAASL SDIPKAAEPG 950
KLEQVRPQEL SRVQELAPAS GEKARLSEAP GGKKSLSMLH YIRGAAPKDI 1000
PVPLSHSTNG KSKPWEPFVA EEFAHQFHES VLQSTQKALQ KHKGSVAVLS 1050
AEQNHKVDTS VHYNIPELQS SSRAPPPQHN GQQEPPTARK GPPTQELDRD 1100
SEEEEEEDDE DGEDEEEVPK RKWQGIEAVF EAYQEHIEEQ NLERQVLQTQ 1150
CRRLEARHYS LSLTAEQLSH SVAELRSQKQ KMVSERERLQ AELDHLRKCL 1200
ALPAMHWPRG YLKGYPR 1217
Length:1,217
Mass (Da):136,164
Last modified:February 20, 2007 - v3
Checksum:i4291FBE301B70F36
GO
Isoform 2 (identifier: Q14687-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Show »
Length:1,113
Mass (Da):125,842
Checksum:i5AB78CBD09B3216F
GO
Isoform 3 (identifier: Q14687-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-75: Missing.

Note: No experimental confirmation available.

Show »
Length:1,144
Mass (Da):128,923
Checksum:iEFEA707A543C49D2
GO

Sequence cautioni

The sequence BAA11499.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti627 – 6271R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035926
Natural varianti936 – 9361V → A.1 Publication
Corresponds to variant rs17853763 [ dbSNP | Ensembl ].
VAR_029546
Natural varianti1153 – 11531R → Q.
Corresponds to variant rs2303203 [ dbSNP | Ensembl ].
VAR_029547

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 104104Missing in isoform 2. VSP_021820Add
BLAST
Alternative sequencei3 – 7573Missing in isoform 3. VSP_021821Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti444 – 4441G → S in BAA11499. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D80004 mRNA. Translation: BAA11499.2. Different initiation.
CH471114 Genomic DNA. Translation: EAW95445.1.
CH471114 Genomic DNA. Translation: EAW95447.1.
BC000753 mRNA. Translation: AAH00753.2.
BC009854 mRNA. Translation: AAH09854.2.
BC037556 mRNA. Translation: AAH37556.1.
BQ214916 mRNA. No translation available.
CCDSiCCDS10952.1. [Q14687-1]
CCDS45539.1. [Q14687-2]
CCDS62007.1. [Q14687-3]
RefSeqiNP_001127945.1. NM_001134473.2. [Q14687-2]
NP_001265113.1. NM_001278184.1. [Q14687-3]
NP_055430.1. NM_014615.3. [Q14687-1]
UniGeneiHs.461647.

Genome annotation databases

EnsembliENST00000253458; ENSP00000253458; ENSG00000131149. [Q14687-1]
ENST00000393243; ENSP00000376934; ENSG00000131149. [Q14687-3]
ENST00000405402; ENSP00000384839; ENSG00000131149. [Q14687-2]
GeneIDi23199.
KEGGihsa:23199.
UCSCiuc002fiw.3. human. [Q14687-1]
uc002fiy.4. human. [Q14687-3]

Polymorphism databases

DMDMi126302550.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D80004 mRNA. Translation: BAA11499.2 . Different initiation.
CH471114 Genomic DNA. Translation: EAW95445.1 .
CH471114 Genomic DNA. Translation: EAW95447.1 .
BC000753 mRNA. Translation: AAH00753.2 .
BC009854 mRNA. Translation: AAH09854.2 .
BC037556 mRNA. Translation: AAH37556.1 .
BQ214916 mRNA. No translation available.
CCDSi CCDS10952.1. [Q14687-1 ]
CCDS45539.1. [Q14687-2 ]
CCDS62007.1. [Q14687-3 ]
RefSeqi NP_001127945.1. NM_001134473.2. [Q14687-2 ]
NP_001265113.1. NM_001278184.1. [Q14687-3 ]
NP_055430.1. NM_014615.3. [Q14687-1 ]
UniGenei Hs.461647.

3D structure databases

ProteinModelPortali Q14687.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116808. 18 interactions.
IntActi Q14687. 12 interactions.
MINTi MINT-8304671.
STRINGi 9606.ENSP00000253458.

PTM databases

PhosphoSitei Q14687.

Polymorphism databases

DMDMi 126302550.

Proteomic databases

MaxQBi Q14687.
PaxDbi Q14687.
PRIDEi Q14687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253458 ; ENSP00000253458 ; ENSG00000131149 . [Q14687-1 ]
ENST00000393243 ; ENSP00000376934 ; ENSG00000131149 . [Q14687-3 ]
ENST00000405402 ; ENSP00000384839 ; ENSG00000131149 . [Q14687-2 ]
GeneIDi 23199.
KEGGi hsa:23199.
UCSCi uc002fiw.3. human. [Q14687-1 ]
uc002fiy.4. human. [Q14687-3 ]

Organism-specific databases

CTDi 23199.
GeneCardsi GC16P085646.
HGNCi HGNC:28979. GSE1.
HPAi HPA036365.
neXtProti NX_Q14687.
PharmGKBi PA143485512.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46383.
HOGENOMi HOG000112825.
HOVERGENi HBG079773.
InParanoidi Q14687.
OMAi YDEFLQQ.
OrthoDBi EOG7CCBQM.
PhylomeDBi Q14687.
TreeFami TF332496.

Miscellaneous databases

GeneWikii KIAA0182.
GenomeRNAii 23199.
NextBioi 44711.
PROi Q14687.

Gene expression databases

ArrayExpressi Q14687.
Bgeei Q14687.
CleanExi HS_KIAA0182.
Genevestigatori Q14687.

Family and domain databases

InterProi IPR022207. GSE-like.
[Graphical view ]
Pfami PF12540. DUF3736. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-936.
    Tissue: Lung and Placenta.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826; SER-909 AND SER-1101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-766; SER-857; THR-907 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-496 AND LYS-739, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-627.

Entry informationi

Entry nameiGSE1_HUMAN
AccessioniPrimary (citable) accession number: Q14687
Secondary accession number(s): D3DUM4
, Q8IY61, Q96GA4, Q9BW09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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