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Q14687 (GSE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Genetic suppressor element 1
Gene names
Name:GSE1
Synonyms:KIAA0182
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1217 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

Sequence caution

The sequence BAA11499.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction PubMed 16189514PubMed 19060904. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RCOR3Q9P2K33EBI-372619,EBI-743428

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14687-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14687-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
Isoform 3 (identifier: Q14687-3)

The sequence of this isoform differs from the canonical sequence as follows:
     3-75: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12171217Genetic suppressor element 1
PRO_0000050730

Regions

Coiled coil321 – 40383 Potential
Coiled coil1127 – 120175 Potential
Compositional bias532 – 722191Pro-rich
Compositional bias745 – 7484Poly-Arg
Compositional bias1102 – 11076Poly-Glu

Amino acid modifications

Modified residue841Phosphoserine Ref.5
Modified residue4961N6-acetyllysine Ref.6
Modified residue7391N6-acetyllysine Ref.6
Modified residue7661Phosphoserine Ref.5
Modified residue8261Phosphoserine Ref.4
Modified residue8571Phosphoserine Ref.5 Ref.7
Modified residue9071Phosphothreonine Ref.5
Modified residue9091Phosphoserine Ref.4 Ref.5 Ref.7
Modified residue11011Phosphoserine Ref.4

Natural variations

Alternative sequence1 – 104104Missing in isoform 2.
VSP_021820
Alternative sequence3 – 7573Missing in isoform 3.
VSP_021821
Natural variant6271R → W in a colorectal cancer sample; somatic mutation. Ref.10
VAR_035926
Natural variant9361V → A. Ref.3
Corresponds to variant rs17853763 [ dbSNP | Ensembl ].
VAR_029546
Natural variant11531R → Q.
Corresponds to variant rs2303203 [ dbSNP | Ensembl ].
VAR_029547

Experimental info

Sequence conflict4441G → S in BAA11499. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 3.
Checksum: 4291FBE301B70F36

FASTA1,217136,164
        10         20         30         40         50         60 
MKGMSHEPKS PSLGMLSTAT RTTATVNPLT PSPLNGALVP SGSPATSSAL SAQAAPSSSF 

        70         80         90        100        110        120 
AAALRKLAKQ AEEPRGSSLS SESSPVSSPA TNHSSPASTP KRVPMGPIIV PPGGHSVPST 

       130        140        150        160        170        180 
PPVVTIAPTK TVNGVWRSES RQDAGSRSSS GGRERLIVEP PLPQEKAGGP AIPSHLLSTP 

       190        200        210        220        230        240 
YPFGLSPSSV VQDSRFPPLN LQRPVHHVVP PSTVTEDYLR SFRPYHTTDD LRMSSLPPLG 

       250        260        270        280        290        300 
LDPATAAAYY HPSYLAPHPF PHPAFRMDDS YCLSALRSPF YPIPTPGSLP PLHPSAMHLH 

       310        320        330        340        350        360 
LSGVRYPPEL SHSSLAALHS ERMSGLSAER LQMDEELRRE RERERERERE READREREKE 

       370        380        390        400        410        420 
REREREKERE QEKEREREKE RERELERQRE QRAREKELLA AKALEPSFLP VAELHGLRGH 

       430        440        450        460        470        480 
ATEERGKPSE QLTPTRAEKL KDAGLQAPKP VQHPLHPVPT PHHTVPSLIS NHGIFSLPSS 

       490        500        510        520        530        540 
SAATALLIQR TNEEEKWLAR QRRLRQEKED RQSQVSEFRQ QVLEQHLDMG RPPVPAEAEH 

       550        560        570        580        590        600 
RPESTTRPGP NRHEPGGRDP PQHFGGPPPL ISPKPQLHAA PTALWNPVSL MDNTLETRRA 

       610        620        630        640        650        660 
ESHSLHSHPA AFEPSRQAAV PLVKVERVFC PEKAEEGPRK REPAPLDKYQ PPPPPPREGG 

       670        680        690        700        710        720 
SLEHQPFLPG PGPFLAELEK STQTILGQQR ASLPQAATFG ELSGPLKPGS PYRPPVPRAP 

       730        740        750        760        770        780 
DPAYIYDEFL QQRRRLVSKL DLEERRRREA QEKGYYYDLD DSYDESDEEE VRAHLRCVAE 

       790        800        810        820        830        840 
QPPLKLDTSS EKLEFLQLFG LTTQQQKEEL VAQKRRKRRR MLRERSPSPP TIQSKRQTPS 

       850        860        870        880        890        900 
PRLALSTRYS PDEMNNSPNF EEKKKFLTIF NLTHISAEKR KDKERLVEML RAMKQKALSA 

       910        920        930        940        950        960 
AVADSLTNSP RDSPAVSLSE PATQQASLDV EKPVGVAASL SDIPKAAEPG KLEQVRPQEL 

       970        980        990       1000       1010       1020 
SRVQELAPAS GEKARLSEAP GGKKSLSMLH YIRGAAPKDI PVPLSHSTNG KSKPWEPFVA 

      1030       1040       1050       1060       1070       1080 
EEFAHQFHES VLQSTQKALQ KHKGSVAVLS AEQNHKVDTS VHYNIPELQS SSRAPPPQHN 

      1090       1100       1110       1120       1130       1140 
GQQEPPTARK GPPTQELDRD SEEEEEEDDE DGEDEEEVPK RKWQGIEAVF EAYQEHIEEQ 

      1150       1160       1170       1180       1190       1200 
NLERQVLQTQ CRRLEARHYS LSLTAEQLSH SVAELRSQKQ KMVSERERLQ AELDHLRKCL 

      1210 
ALPAMHWPRG YLKGYPR 

« Hide

Isoform 2 [UniParc].

Checksum: 5AB78CBD09B3216F
Show »

FASTA1,113125,842
Isoform 3 [UniParc].

Checksum: EFEA707A543C49D2
Show »

FASTA1,144128,923

References

[1]"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Bone marrow.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-936.
Tissue: Lung and Placenta.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826; SER-909 AND SER-1101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-766; SER-857; THR-907 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[6]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-496 AND LYS-739, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-627.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D80004 mRNA. Translation: BAA11499.2. Different initiation.
CH471114 Genomic DNA. Translation: EAW95445.1.
CH471114 Genomic DNA. Translation: EAW95447.1.
BC000753 mRNA. Translation: AAH00753.2.
BC009854 mRNA. Translation: AAH09854.2.
BC037556 mRNA. Translation: AAH37556.1.
BQ214916 mRNA. No translation available.
CCDSCCDS10952.1. [Q14687-1]
CCDS45539.1. [Q14687-2]
CCDS62007.1. [Q14687-3]
RefSeqNP_001127945.1. NM_001134473.2. [Q14687-2]
NP_001265113.1. NM_001278184.1. [Q14687-3]
NP_055430.1. NM_014615.3. [Q14687-1]
UniGeneHs.461647.

3D structure databases

ProteinModelPortalQ14687.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116808. 18 interactions.
IntActQ14687. 12 interactions.
MINTMINT-8304671.
STRING9606.ENSP00000253458.

PTM databases

PhosphoSiteQ14687.

Polymorphism databases

DMDM126302550.

Proteomic databases

MaxQBQ14687.
PaxDbQ14687.
PRIDEQ14687.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253458; ENSP00000253458; ENSG00000131149. [Q14687-1]
ENST00000393243; ENSP00000376934; ENSG00000131149. [Q14687-3]
ENST00000405402; ENSP00000384839; ENSG00000131149. [Q14687-2]
GeneID23199.
KEGGhsa:23199.
UCSCuc002fiw.3. human. [Q14687-1]
uc002fiy.4. human. [Q14687-3]

Organism-specific databases

CTD23199.
GeneCardsGC16P085646.
HGNCHGNC:28979. GSE1.
HPAHPA036365.
neXtProtNX_Q14687.
PharmGKBPA143485512.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46383.
HOGENOMHOG000112825.
HOVERGENHBG079773.
InParanoidQ14687.
OMAYDEFLQQ.
OrthoDBEOG7CCBQM.
PhylomeDBQ14687.
TreeFamTF332496.

Gene expression databases

ArrayExpressQ14687.
BgeeQ14687.
CleanExHS_KIAA0182.
GenevestigatorQ14687.

Family and domain databases

InterProIPR022207. GSE-like.
[Graphical view]
PfamPF12540. DUF3736. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKIAA0182.
GenomeRNAi23199.
NextBio44711.
PROQ14687.

Entry information

Entry nameGSE1_HUMAN
AccessionPrimary (citable) accession number: Q14687
Secondary accession number(s): D3DUM4 expand/collapse secondary AC list , Q8IY61, Q96GA4, Q9BW09
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM