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Protein

Genetic suppressor element 1

Gene

GSE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Genetic suppressor element 1
Gene namesi
Name:GSE1
Synonyms:KIAA0182
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28979. GSE1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485512.

Polymorphism and mutation databases

BioMutaiGSE1.
DMDMi126302550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12171217Genetic suppressor element 1PRO_0000050730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841Phosphoserine1 Publication
Modified residuei496 – 4961N6-acetyllysine1 Publication
Modified residuei739 – 7391N6-acetyllysine1 Publication
Modified residuei766 – 7661Phosphoserine1 Publication
Modified residuei826 – 8261Phosphoserine1 Publication
Modified residuei857 – 8571Phosphoserine2 Publications
Modified residuei907 – 9071Phosphothreonine1 Publication
Modified residuei909 – 9091Phosphoserine4 Publications
Modified residuei1101 – 11011Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ14687.
PaxDbiQ14687.
PRIDEiQ14687.

PTM databases

PhosphoSiteiQ14687.

Expressioni

Gene expression databases

BgeeiQ14687.
CleanExiHS_KIAA0182.
ExpressionAtlasiQ14687. baseline and differential.
GenevisibleiQ14687. HS.

Organism-specific databases

HPAiHPA036365.

Interactioni

Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf94Q6P1W53EBI-372619,EBI-946029
C6orf165Q8IYR03EBI-372619,EBI-749051
GOLGA2Q083793EBI-372619,EBI-618309
RCOR3Q9P2K36EBI-372619,EBI-743428
RUNX1T1Q06455-43EBI-372619,EBI-10224192
TEKT4Q8WW243EBI-372619,EBI-750487
TRIP6Q156543EBI-372619,EBI-742327

Protein-protein interaction databases

BioGridi116808. 32 interactions.
IntActiQ14687. 19 interactions.
MINTiMINT-8304671.
STRINGi9606.ENSP00000253458.

Structurei

3D structure databases

ProteinModelPortaliQ14687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili321 – 40383Sequence AnalysisAdd
BLAST
Coiled coili1127 – 120175Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi532 – 722191Pro-richAdd
BLAST
Compositional biasi745 – 7484Poly-Arg
Compositional biasi1102 – 11076Poly-Glu

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG46383.
GeneTreeiENSGT00700000104539.
HOGENOMiHOG000112825.
HOVERGENiHBG079773.
InParanoidiQ14687.
OMAiPAYIYDE.
OrthoDBiEOG7CCBQM.
PhylomeDBiQ14687.
TreeFamiTF332496.

Family and domain databases

InterProiIPR022207. GSE-like.
[Graphical view]
PfamiPF12540. DUF3736. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14687-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGMSHEPKS PSLGMLSTAT RTTATVNPLT PSPLNGALVP SGSPATSSAL
60 70 80 90 100
SAQAAPSSSF AAALRKLAKQ AEEPRGSSLS SESSPVSSPA TNHSSPASTP
110 120 130 140 150
KRVPMGPIIV PPGGHSVPST PPVVTIAPTK TVNGVWRSES RQDAGSRSSS
160 170 180 190 200
GGRERLIVEP PLPQEKAGGP AIPSHLLSTP YPFGLSPSSV VQDSRFPPLN
210 220 230 240 250
LQRPVHHVVP PSTVTEDYLR SFRPYHTTDD LRMSSLPPLG LDPATAAAYY
260 270 280 290 300
HPSYLAPHPF PHPAFRMDDS YCLSALRSPF YPIPTPGSLP PLHPSAMHLH
310 320 330 340 350
LSGVRYPPEL SHSSLAALHS ERMSGLSAER LQMDEELRRE RERERERERE
360 370 380 390 400
READREREKE REREREKERE QEKEREREKE RERELERQRE QRAREKELLA
410 420 430 440 450
AKALEPSFLP VAELHGLRGH ATEERGKPSE QLTPTRAEKL KDAGLQAPKP
460 470 480 490 500
VQHPLHPVPT PHHTVPSLIS NHGIFSLPSS SAATALLIQR TNEEEKWLAR
510 520 530 540 550
QRRLRQEKED RQSQVSEFRQ QVLEQHLDMG RPPVPAEAEH RPESTTRPGP
560 570 580 590 600
NRHEPGGRDP PQHFGGPPPL ISPKPQLHAA PTALWNPVSL MDNTLETRRA
610 620 630 640 650
ESHSLHSHPA AFEPSRQAAV PLVKVERVFC PEKAEEGPRK REPAPLDKYQ
660 670 680 690 700
PPPPPPREGG SLEHQPFLPG PGPFLAELEK STQTILGQQR ASLPQAATFG
710 720 730 740 750
ELSGPLKPGS PYRPPVPRAP DPAYIYDEFL QQRRRLVSKL DLEERRRREA
760 770 780 790 800
QEKGYYYDLD DSYDESDEEE VRAHLRCVAE QPPLKLDTSS EKLEFLQLFG
810 820 830 840 850
LTTQQQKEEL VAQKRRKRRR MLRERSPSPP TIQSKRQTPS PRLALSTRYS
860 870 880 890 900
PDEMNNSPNF EEKKKFLTIF NLTHISAEKR KDKERLVEML RAMKQKALSA
910 920 930 940 950
AVADSLTNSP RDSPAVSLSE PATQQASLDV EKPVGVAASL SDIPKAAEPG
960 970 980 990 1000
KLEQVRPQEL SRVQELAPAS GEKARLSEAP GGKKSLSMLH YIRGAAPKDI
1010 1020 1030 1040 1050
PVPLSHSTNG KSKPWEPFVA EEFAHQFHES VLQSTQKALQ KHKGSVAVLS
1060 1070 1080 1090 1100
AEQNHKVDTS VHYNIPELQS SSRAPPPQHN GQQEPPTARK GPPTQELDRD
1110 1120 1130 1140 1150
SEEEEEEDDE DGEDEEEVPK RKWQGIEAVF EAYQEHIEEQ NLERQVLQTQ
1160 1170 1180 1190 1200
CRRLEARHYS LSLTAEQLSH SVAELRSQKQ KMVSERERLQ AELDHLRKCL
1210
ALPAMHWPRG YLKGYPR
Length:1,217
Mass (Da):136,164
Last modified:February 20, 2007 - v3
Checksum:i4291FBE301B70F36
GO
Isoform 2 (identifier: Q14687-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Show »
Length:1,113
Mass (Da):125,842
Checksum:i5AB78CBD09B3216F
GO
Isoform 3 (identifier: Q14687-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-75: Missing.

Note: No experimental confirmation available.
Show »
Length:1,144
Mass (Da):128,923
Checksum:iEFEA707A543C49D2
GO

Sequence cautioni

The sequence BAA11499.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti444 – 4441G → S in BAA11499 (PubMed:8724849).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti627 – 6271R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035926
Natural varianti936 – 9361V → A.1 Publication
Corresponds to variant rs17853763 [ dbSNP | Ensembl ].
VAR_029546
Natural varianti1153 – 11531R → Q.
Corresponds to variant rs2303203 [ dbSNP | Ensembl ].
VAR_029547

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 104104Missing in isoform 2. 1 PublicationVSP_021820Add
BLAST
Alternative sequencei3 – 7573Missing in isoform 3. 1 PublicationVSP_021821Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D80004 mRNA. Translation: BAA11499.2. Different initiation.
CH471114 Genomic DNA. Translation: EAW95445.1.
CH471114 Genomic DNA. Translation: EAW95447.1.
BC000753 mRNA. Translation: AAH00753.2.
BC009854 mRNA. Translation: AAH09854.2.
BC037556 mRNA. Translation: AAH37556.1.
BQ214916 mRNA. No translation available.
CCDSiCCDS10952.1. [Q14687-1]
CCDS45539.1. [Q14687-2]
CCDS62007.1. [Q14687-3]
RefSeqiNP_001127945.1. NM_001134473.2. [Q14687-2]
NP_001265113.1. NM_001278184.1. [Q14687-3]
NP_055430.1. NM_014615.3. [Q14687-1]
UniGeneiHs.461647.

Genome annotation databases

EnsembliENST00000253458; ENSP00000253458; ENSG00000131149.
ENST00000393243; ENSP00000376934; ENSG00000131149. [Q14687-3]
ENST00000405402; ENSP00000384839; ENSG00000131149. [Q14687-2]
GeneIDi23199.
KEGGihsa:23199.
UCSCiuc002fiw.3. human. [Q14687-1]
uc002fiy.4. human. [Q14687-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D80004 mRNA. Translation: BAA11499.2. Different initiation.
CH471114 Genomic DNA. Translation: EAW95445.1.
CH471114 Genomic DNA. Translation: EAW95447.1.
BC000753 mRNA. Translation: AAH00753.2.
BC009854 mRNA. Translation: AAH09854.2.
BC037556 mRNA. Translation: AAH37556.1.
BQ214916 mRNA. No translation available.
CCDSiCCDS10952.1. [Q14687-1]
CCDS45539.1. [Q14687-2]
CCDS62007.1. [Q14687-3]
RefSeqiNP_001127945.1. NM_001134473.2. [Q14687-2]
NP_001265113.1. NM_001278184.1. [Q14687-3]
NP_055430.1. NM_014615.3. [Q14687-1]
UniGeneiHs.461647.

3D structure databases

ProteinModelPortaliQ14687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116808. 32 interactions.
IntActiQ14687. 19 interactions.
MINTiMINT-8304671.
STRINGi9606.ENSP00000253458.

PTM databases

PhosphoSiteiQ14687.

Polymorphism and mutation databases

BioMutaiGSE1.
DMDMi126302550.

Proteomic databases

MaxQBiQ14687.
PaxDbiQ14687.
PRIDEiQ14687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253458; ENSP00000253458; ENSG00000131149.
ENST00000393243; ENSP00000376934; ENSG00000131149. [Q14687-3]
ENST00000405402; ENSP00000384839; ENSG00000131149. [Q14687-2]
GeneIDi23199.
KEGGihsa:23199.
UCSCiuc002fiw.3. human. [Q14687-1]
uc002fiy.4. human. [Q14687-3]

Organism-specific databases

CTDi23199.
GeneCardsiGC16P085646.
HGNCiHGNC:28979. GSE1.
HPAiHPA036365.
neXtProtiNX_Q14687.
PharmGKBiPA143485512.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46383.
GeneTreeiENSGT00700000104539.
HOGENOMiHOG000112825.
HOVERGENiHBG079773.
InParanoidiQ14687.
OMAiPAYIYDE.
OrthoDBiEOG7CCBQM.
PhylomeDBiQ14687.
TreeFamiTF332496.

Miscellaneous databases

GeneWikiiKIAA0182.
GenomeRNAii23199.
NextBioi44711.
PROiQ14687.

Gene expression databases

BgeeiQ14687.
CleanExiHS_KIAA0182.
ExpressionAtlasiQ14687. baseline and differential.
GenevisibleiQ14687. HS.

Family and domain databases

InterProiIPR022207. GSE-like.
[Graphical view]
PfamiPF12540. DUF3736. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-936.
    Tissue: Lung and Placenta.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826; SER-909 AND SER-1101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-766; SER-857; THR-907 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-496 AND LYS-739, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857 AND SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-627.

Entry informationi

Entry nameiGSE1_HUMAN
AccessioniPrimary (citable) accession number: Q14687
Secondary accession number(s): D3DUM4
, Q8IY61, Q96GA4, Q9BW09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 20, 2007
Last modified: July 22, 2015
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.