##gff-version 3 Q14686 UniProtKB Chain 1 2063 . . . ID=PRO_0000094413;Note=Nuclear receptor coactivator 6 Q14686 UniProtKB Region 1 1310 . . . Note=NCOA1-binding region Q14686 UniProtKB Region 1 1057 . . . Note=CREBBP-binding region Q14686 UniProtKB Region 1 928 . . . Note=TBP/GTF2A-binding region Q14686 UniProtKB Region 184 251 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Region 281 549 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Region 773 927 . . . Note=NCOA6IP-binding region Q14686 UniProtKB Region 789 811 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Region 899 1278 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Region 1310 1353 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Region 1448 1474 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Region 1641 2063 . . . Note=EP300/CRSP3-binding region Q14686 UniProtKB Region 1738 1820 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Region 1837 1908 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Region 1995 2063 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Motif 887 891 . . . Note=LXXLL motif 1 Q14686 UniProtKB Motif 1491 1495 . . . Note=LXXLL motif 2 Q14686 UniProtKB Compositional bias 184 198 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 281 307 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 325 341 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 380 456 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 465 502 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 523 549 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 991 1022 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 1023 1038 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 1065 1080 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 1101 1129 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 1170 1213 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 1215 1229 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 1767 1813 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 1862 1898 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 2004 2038 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Compositional bias 2039 2053 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14686 UniProtKB Modified residue 95 95 . . . Note=Asymmetric dimethylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q14686 UniProtKB Modified residue 884 884 . . . Note=Phosphoserine%3B by MAPK%3B in vitro;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11773444;Dbxref=PMID:11773444 Q14686 UniProtKB Modified residue 1047 1047 . . . Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19 Q14686 UniProtKB Modified residue 1058 1058 . . . Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19 Q14686 UniProtKB Modified residue 1096 1096 . . . Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19 Q14686 UniProtKB Modified residue 1819 1819 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19 Q14686 UniProtKB Modified residue 1822 1822 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JL19 Q14686 UniProtKB Modified residue 2018 2018 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q14686 UniProtKB Natural variant 512 512 . . . ID=VAR_027874;Note=P->L;Dbxref=dbSNP:rs6060031 Q14686 UniProtKB Natural variant 955 955 . . . ID=VAR_027875;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10567404,ECO:0000269|PubMed:10681503,ECO:0000269|PubMed:10823961,ECO:0000269|PubMed:10866662,ECO:0000269|PubMed:8724849;Dbxref=dbSNP:rs17092079,PMID:10567404,PMID:10681503,PMID:10823961,PMID:10866662,PMID:8724849 Q14686 UniProtKB Natural variant 1060 1060 . . . ID=VAR_036551;Note=In a breast cancer sample%3B somatic mutation. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Q14686 UniProtKB Natural variant 1191 1191 . . . ID=VAR_036552;Note=In a breast cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Q14686 UniProtKB Natural variant 1995 1995 . . . ID=VAR_027876;Note=I->V;Dbxref=dbSNP:rs6060022 Q14686 UniProtKB Mutagenesis 883 894 . . . Note=Reduced binding to THRB%2C RXRA%2C ESR2 and ESR1. TSPLLVNLLQSD->ENPLLVNLLQFI;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11773444;Dbxref=PMID:11773444 Q14686 UniProtKB Mutagenesis 883 894 . . . Note=Reduced binding to THRB%2C RXRA%2C ESR2 and ESR1. TSPLLVNLLQSD->NLPLLVNLLQHT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11773444;Dbxref=PMID:11773444 Q14686 UniProtKB Mutagenesis 883 894 . . . Note=Reduced binding to THRB%2C RXRA%2C ESR2 and ESR1. TSPLLVNLLQSD->VNPLLVNLLQFI;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11773444;Dbxref=PMID:11773444 Q14686 UniProtKB Mutagenesis 883 884 . . . Note=Strong increase in binding to THRB%2C RXRA and ESR2%2C but dramatic decrease in binding to ESR1. TS->SY Q14686 UniProtKB Mutagenesis 884 894 . . . Note=Reduced binding to THRB%2C RXRA%2C ESR2 and ESR1. SPLLVNLLQSD->NPLLVNLLQLL