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Protein

Ribosomal RNA processing protein 1 homolog B

Gene

RRP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015).By similarity3 Publications
(Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • RNA polymerase II transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • cellular response to virus Source: UniProtKB
  • negative regulation of GTPase activity Source: UniProtKB
  • negative regulation of phosphatase activity Source: UniProtKB
  • positive regulation by host of viral transcription Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of RNA splicing Source: UniProtKB
  • rRNA processing Source: GO_Central

Keywordsi

Molecular functionActivator
Biological processApoptosis, mRNA processing, mRNA splicing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA processing protein 1 homolog B
Alternative name(s):
RRP1-like protein B
Gene namesi
Name:RRP1B
Synonyms:KIAA0179
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160208.12.
HGNCiHGNC:23818. RRP1B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi684V → A: Abolishes interaction with protein phosphatase PP1 subunits PPP1CB and PPP1CC; when associated with A-686. 1 Publication1
Mutagenesisi686F → A: Abolishes interaction with protein phosphatase PP1 subunits PPP1CB and PPP1CC; when associated with A-684. 1 Publication1

Organism-specific databases

DisGeNETi23076.
OpenTargetsiENSG00000160208.
PharmGKBiPA162402138.

Polymorphism and mutation databases

BioMutaiRRP1B.
DMDMi296452976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507291 – 758Ribosomal RNA processing protein 1 homolog BAdd BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei652N6-acetyllysineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei706PhosphoserineCombined sources1
Modified residuei712CitrullineBy similarity1
Modified residuei728PhosphothreonineCombined sources1
Modified residuei732PhosphoserineCombined sources1
Modified residuei735PhosphoserineCombined sources1
Modified residuei736PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiQ14684.
MaxQBiQ14684.
PaxDbiQ14684.
PeptideAtlasiQ14684.
PRIDEiQ14684.

2D gel databases

SWISS-2DPAGEiQ14684.

PTM databases

iPTMnetiQ14684.
PhosphoSitePlusiQ14684.
SwissPalmiQ14684.

Expressioni

Developmental stagei

During the cell cycle, expression peaks at the G1/S transition.1 Publication

Inductioni

By DNA damage.1 Publication

Gene expression databases

BgeeiENSG00000160208.
CleanExiHS_RRP1B.
GenevisibleiQ14684. HS.

Organism-specific databases

HPAiHPA017893.
HPA020324.

Interactioni

Subunit structurei

Interacts with the transcriptional activator E2F1 (PubMed:20040599). Interacts with serine/threonine-protein phosphatase PP1 subunits PPP1CB and PPP1CC but not with PPP1CA (PubMed:20926688). Interacts with 60S ribosomal proteins RPL5 and RPL27, ribosomal processing protein RRP1/NNP1 and other nucleolar proteins including NOP2/NOL1 and FBL (PubMed:20926688). Also interacts with nucleolar protein NPM1/B23 (PubMed:20926688, PubMed:19710015). Interacts with splicing factor SRSF1 and with LUC7L3/CROP (PubMed:23604122). Interacts with GTPase activator SIPA1 (By similarity). Interacts with CBX5/HP1alpha, H1FX, NCL, PARP1, TRIM28 and YBX3 (PubMed:19710015).By similarity4 Publications
(Microbial infection) Interacts with influenza A virus nucleoprotein NP and with RNA-directed RNA polymerase subunits PB1 and PB2.1 Publication

Protein-protein interaction databases

BioGridi116708. 87 interactors.
IntActiQ14684. 23 interactors.
MINTiMINT-3029999.
STRINGi9606.ENSP00000339145.

Structurei

3D structure databases

ProteinModelPortaliQ14684.
SMRiQ14684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi402 – 406Poly-Lys5

Sequence similaritiesi

Belongs to the RRP1 family.Curated

Phylogenomic databases

eggNOGiKOG3911. Eukaryota.
ENOG4111GJ6. LUCA.
GeneTreeiENSGT00390000011821.
HOGENOMiHOG000070179.
HOVERGENiHBG098014.
InParanoidiQ14684.
KOiK14849.
OMAiQKPLHGV.
OrthoDBiEOG091G0AX5.
PhylomeDBiQ14684.
TreeFamiTF315294.

Family and domain databases

InterProiView protein in InterPro
IPR010301. Nop52.
PANTHERiPTHR13026. PTHR13026. 1 hit.
PfamiView protein in Pfam
PF05997. Nop52. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14684-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAMQPAEI QFAQRLASSE KGIRDRAVKK LRQYISVKTQ RETGGFSQEE
60 70 80 90 100
LLKIWKGLFY CMWVQDEPLL QEELANTIAQ LVHAVNNSAA QHLFIQTFWQ
110 120 130 140 150
TMNREWKGID RLRLDKYYML IRLVLRQSFE VLKRNGWEES RIKVFLDVLM
160 170 180 190 200
KEVLCPESQS PNGVRFHFID IYLDELSKVG GKELLADQNL KFIDPFCKIA
210 220 230 240 250
AKTKDHTLVQ TIARGVFEAI VDQSPFVPEE TMEEQKTKVG DGDLSAEEIP
260 270 280 290 300
ENEVSLRRAV SKKKTALGKN HSRKDGLSDE RGRDDCGTFE DTGPLLQFDY
310 320 330 340 350
KAVADRLLEM TSRKNTPHFN RKRLSKLIKK FQDLSEGSSI SQLSFAEDIS
360 370 380 390 400
ADEDDQILSQ GKHKKKGNKL LEKTNLEKEK GSRVFCVEEE DSESSLQKRR
410 420 430 440 450
RKKKKKHHLQ PENPGPGGAA PSLEQNRGRE PEASGLKALK ARVAEPGAEA
460 470 480 490 500
TSSTGEESGS EHPPAVPMHN KRKRPRKKSP RAHREMLESA VLPPEDMSQS
510 520 530 540 550
GPSGSHPQGP RGSPTGGAQL LKRKRKLGVV PVNGSGLSTP AWPPLQQEGP
560 570 580 590 600
PTGPAEGANS HTTLPQRRRL QKKKAGPGSL ELCGLPSQKT ASLKKRKKMR
610 620 630 640 650
VMSNLVEHNG VLESEAGQPQ ALGSSGTCSS LKKQKLRAES DFVKFDTPFL
660 670 680 690 700
PKPLFFRRAK SSTATHPPGP AVQLNKTPSS SKKVTFGLNR NMTAEFKKTD
710 720 730 740 750
KSILVSPTGP SRVAFDPEQK PLHGVLKTPT SSPASSPLVA KKPLTTTPRR

RPRAMDFF
Length:758
Mass (Da):84,428
Last modified:May 18, 2010 - v3
Checksum:i738117A7062054F2
GO
Isoform 2 (identifier: Q14684-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-68: Missing.

Note: No experimental confirmation available.
Show »
Length:740
Mass (Da):82,176
Checksum:i7D39CB77AA4BE255
GO

Sequence cautioni

The sequence BAA11496 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079135436L → P3 PublicationsCorresponds to variant dbSNP:rs9306160Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00780151 – 68Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D80001 mRNA. Translation: BAA11496.1. Different initiation.
AP001052 Genomic DNA. No translation available.
BC028386 mRNA. Translation: AAH28386.1.
CCDSiCCDS33577.1. [Q14684-1]
RefSeqiNP_055871.1. NM_015056.2. [Q14684-1]
UniGeneiHs.565725.

Genome annotation databases

EnsembliENST00000340648; ENSP00000339145; ENSG00000160208. [Q14684-1]
GeneIDi23076.
KEGGihsa:23076.
UCSCiuc002zdk.4. human. [Q14684-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRRP1B_HUMAN
AccessioniPrimary (citable) accession number: Q14684
Secondary accession number(s): Q8TBZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: November 22, 2017
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families