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Protein

BTB/POZ domain-containing protein KCTD2

Gene

KCTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cullin family protein binding Source: GO_Central
  • protein complex binding Source: MGI

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180901-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD2
Alternative name(s):
Potassium channel tetramerization domain-containing protein 2
Gene namesi
Name:KCTD2
Synonyms:KIAA0176
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:21294. KCTD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi23510.
OpenTargetsiENSG00000180901.
PharmGKBiPA134890451.

Polymorphism and mutation databases

BioMutaiKCTD2.
DMDMi296439316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001912872 – 263BTB/POZ domain-containing protein KCTD2Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei33PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14681.
MaxQBiQ14681.
PaxDbiQ14681.
PeptideAtlasiQ14681.
PRIDEiQ14681.

PTM databases

iPTMnetiQ14681.
PhosphoSitePlusiQ14681.

Expressioni

Gene expression databases

BgeeiENSG00000180901.
CleanExiHS_KCTD2.
ExpressionAtlasiQ14681. baseline and differential.
GenevisibleiQ14681. HS.

Interactioni

GO - Molecular functioni

  • cullin family protein binding Source: GO_Central
  • protein complex binding Source: MGI

Protein-protein interaction databases

BioGridi117057. 22 interactors.
IntActiQ14681. 6 interactors.
STRINGi9606.ENSP00000312814.

Structurei

3D structure databases

ProteinModelPortaliQ14681.
SMRiQ14681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 172BTBAdd BLAST101

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000231167.
HOVERGENiHBG053302.
InParanoidiQ14681.
OMAiTLCREPK.
OrthoDBiEOG091G0JJT.
PhylomeDBiQ14681.
TreeFamiTF313754.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA
60 70 80 90 100
VAQPLEPGPG PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR
110 120 130 140 150
LCCQEDPELD SDKDETGAYL IDRDPTYFGP ILNYLRHGKL IITKELAEEG
160 170 180 190 200
VLEEAEFYNI ASLVRLVKER IRDNENRTSQ GPVKHVYRVL QCQEEELTQM
210 220 230 240 250
VSTMSDGWKF EQLISIGSSY NYGNEDQAEF LCVVSRELNN STNGIVIEPS
260
EKAKILQERG SRM
Length:263
Mass (Da):28,527
Last modified:May 18, 2010 - v3
Checksum:iEF44819B2DC4AE49
GO

Sequence cautioni

The sequence BAA11493 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54P → R in BAA11493 (PubMed:8724849).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79998 mRNA. Translation: BAA11493.1. Different initiation.
AC087651 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
CCDSiCCDS32728.1.
RefSeqiNP_056168.1. NM_015353.2.
UniGeneiHs.514468.
Hs.733235.

Genome annotation databases

EnsembliENST00000322444; ENSP00000312814; ENSG00000180901.
GeneIDi23510.
KEGGihsa:23510.
UCSCiuc002jmp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79998 mRNA. Translation: BAA11493.1. Different initiation.
AC087651 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
CCDSiCCDS32728.1.
RefSeqiNP_056168.1. NM_015353.2.
UniGeneiHs.514468.
Hs.733235.

3D structure databases

ProteinModelPortaliQ14681.
SMRiQ14681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117057. 22 interactors.
IntActiQ14681. 6 interactors.
STRINGi9606.ENSP00000312814.

PTM databases

iPTMnetiQ14681.
PhosphoSitePlusiQ14681.

Polymorphism and mutation databases

BioMutaiKCTD2.
DMDMi296439316.

Proteomic databases

EPDiQ14681.
MaxQBiQ14681.
PaxDbiQ14681.
PeptideAtlasiQ14681.
PRIDEiQ14681.

Protocols and materials databases

DNASUi23510.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322444; ENSP00000312814; ENSG00000180901.
GeneIDi23510.
KEGGihsa:23510.
UCSCiuc002jmp.4. human.

Organism-specific databases

CTDi23510.
DisGeNETi23510.
GeneCardsiKCTD2.
H-InvDBHIX0014161.
HGNCiHGNC:21294. KCTD2.
MIMi613422. gene.
neXtProtiNX_Q14681.
OpenTargetsiENSG00000180901.
PharmGKBiPA134890451.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000231167.
HOVERGENiHBG053302.
InParanoidiQ14681.
OMAiTLCREPK.
OrthoDBiEOG091G0JJT.
PhylomeDBiQ14681.
TreeFamiTF313754.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180901-MONOMER.

Miscellaneous databases

ChiTaRSiKCTD2. human.
GenomeRNAii23510.
PROiQ14681.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180901.
CleanExiHS_KCTD2.
ExpressionAtlasiQ14681. baseline and differential.
GenevisibleiQ14681. HS.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD2_HUMAN
AccessioniPrimary (citable) accession number: Q14681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.