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Q14681

- KCTD2_HUMAN

UniProt

Q14681 - KCTD2_HUMAN

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Protein

BTB/POZ domain-containing protein KCTD2

Gene

KCTD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein complex binding Source: MGI

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD2
Alternative name(s):
Potassium channel tetramerization domain-containing protein 2
Gene namesi
Name:KCTD2
Synonyms:KIAA0176
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:21294. KCTD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134890451.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 263262BTB/POZ domain-containing protein KCTD2PRO_0000191287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ14681.
PaxDbiQ14681.
PRIDEiQ14681.

PTM databases

PhosphoSiteiQ14681.

Expressioni

Gene expression databases

BgeeiQ14681.
CleanExiHS_KCTD2.
ExpressionAtlasiQ14681. baseline and differential.
GenevestigatoriQ14681.

Interactioni

Protein-protein interaction databases

BioGridi117057. 9 interactions.
IntActiQ14681. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ14681.
SMRiQ14681. Positions 68-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 172101BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiNOG267996.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000231167.
HOVERGENiHBG053302.
InParanoidiQ14681.
OMAiTLCREPK.
PhylomeDBiQ14681.
TreeFamiTF313754.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14681-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA
60 70 80 90 100
VAQPLEPGPG PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR
110 120 130 140 150
LCCQEDPELD SDKDETGAYL IDRDPTYFGP ILNYLRHGKL IITKELAEEG
160 170 180 190 200
VLEEAEFYNI ASLVRLVKER IRDNENRTSQ GPVKHVYRVL QCQEEELTQM
210 220 230 240 250
VSTMSDGWKF EQLISIGSSY NYGNEDQAEF LCVVSRELNN STNGIVIEPS
260
EKAKILQERG SRM
Length:263
Mass (Da):28,527
Last modified:May 18, 2010 - v3
Checksum:iEF44819B2DC4AE49
GO

Sequence cautioni

The sequence BAA11493.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541P → R in BAA11493. (PubMed:8724849)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79998 mRNA. Translation: BAA11493.1. Different initiation.
AC087651 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
CCDSiCCDS32728.1.
RefSeqiNP_056168.1. NM_015353.2.
UniGeneiHs.514468.
Hs.733235.

Genome annotation databases

EnsembliENST00000322444; ENSP00000312814; ENSG00000180901.
GeneIDi23510.
KEGGihsa:23510.
UCSCiuc002jmp.3. human.

Polymorphism databases

DMDMi296439316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79998 mRNA. Translation: BAA11493.1 . Different initiation.
AC087651 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
CCDSi CCDS32728.1.
RefSeqi NP_056168.1. NM_015353.2.
UniGenei Hs.514468.
Hs.733235.

3D structure databases

ProteinModelPortali Q14681.
SMRi Q14681. Positions 68-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117057. 9 interactions.
IntActi Q14681. 1 interaction.

PTM databases

PhosphoSitei Q14681.

Polymorphism databases

DMDMi 296439316.

Proteomic databases

MaxQBi Q14681.
PaxDbi Q14681.
PRIDEi Q14681.

Protocols and materials databases

DNASUi 23510.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322444 ; ENSP00000312814 ; ENSG00000180901 .
GeneIDi 23510.
KEGGi hsa:23510.
UCSCi uc002jmp.3. human.

Organism-specific databases

CTDi 23510.
GeneCardsi GC17P073051.
H-InvDB HIX0014161.
HGNCi HGNC:21294. KCTD2.
MIMi 613422. gene.
neXtProti NX_Q14681.
PharmGKBi PA134890451.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267996.
GeneTreei ENSGT00530000062980.
HOGENOMi HOG000231167.
HOVERGENi HBG053302.
InParanoidi Q14681.
OMAi TLCREPK.
PhylomeDBi Q14681.
TreeFami TF313754.

Miscellaneous databases

ChiTaRSi KCTD2. human.
GenomeRNAii 23510.
NextBioi 45921.
PROi Q14681.
SOURCEi Search...

Gene expression databases

Bgeei Q14681.
CleanExi HS_KCTD2.
ExpressionAtlasi Q14681. baseline and differential.
Genevestigatori Q14681.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view ]
Pfami PF02214. BTB_2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-29; 76-87; 124-136; 145-165; 189-209 AND 237-252, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic kidney.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKCTD2_HUMAN
AccessioniPrimary (citable) accession number: Q14681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3