Q14681 (KCTD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BTB/POZ domain-containing protein KCTD2

Alternative name(s):
Potassium channel tetramerization domain-containing protein 2

Gene names

Name:	KCTD2
Synonyms:	KIAA0176

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 BTB (POZ) domain.
Sequence caution	The sequence BAA11493.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 263	262	BTB/POZ domain-containing protein KCTD2		PRO_0000191287
Regions
	Domain	72 – 172	101	BTB
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.3
Experimental info
	Sequence conflict	54	1	P → R in BAA11493. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q14681 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: EF44819B2DC4AE49	FASTA	263	28,527
	10 20 30 40 50 60 MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA VAQPLEPGPG 70 80 90 100 110 120 PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR LCCQEDPELD SDKDETGAYL 130 140 150 160 170 180 IDRDPTYFGP ILNYLRHGKL IITKELAEEG VLEEAEFYNI ASLVRLVKER IRDNENRTSQ 190 200 210 220 230 240 GPVKHVYRVL QCQEEELTQM VSTMSDGWKF EQLISIGSSY NYGNEDQAEF LCVVSRELNN 250 260 STNGIVIEPS EKAKILQERG SRM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-29; 76-87; 124-136; 145-165; 189-209 AND 237-252, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D79998 mRNA. Translation: BAA11493.1. Different initiation. AC087651 Genomic DNA. No translation available. AC111186 Genomic DNA. No translation available.
IPI	IPI00455348.
RefSeq	NP_056168.1. NM_015353.1.
UniGene	Hs.514468.
3D structure databases
ProteinModelPortal	Q14681.
SMR	Q14681. Positions 68-240.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14681. 1 interaction.
PTM databases
PhosphoSite	Q14681.
Polymorphism databases
DMDM	296439316.
Proteomic databases
PaxDb	Q14681.
PRIDE	Q14681.
Protocols and materials databases
DNASU	23510.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322444; ENSP00000312814; ENSG00000180901.
GeneID	23510.
KEGG	hsa:23510.
UCSC	uc002jmp.3. human.
Organism-specific databases
CTD	23510.
GeneCards	GC17P073043.
H-InvDB	HIX0014161.
HGNC	HGNC:21294. KCTD2.
MIM	613422. gene.
neXtProt	NX_Q14681.
PharmGKB	PA134890451.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267996.
HOGENOM	HOG000231167.
HOVERGEN	HBG053302.
InParanoid	Q14681.
OMA	EDPDLDS.
OrthoDB	EOG4WQ13F.
Gene expression databases
Bgee	Q14681.
CleanEx	HS_KCTD2.
Genevestigator	Q14681.
GermOnline	ENSG00000180901. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR003131. T1-type_BTB. [Graphical view]
Pfam	PF02214. K_tetra. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KCTD2. human.
GenomeRNAi	23510.
NextBio	45921.
SOURCE	Search...

Entry information

Entry name

KCTD2_HUMAN

Accession

Primary (citable) accession number: Q14681

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.