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Q14681

- KCTD2_HUMAN

UniProt

Q14681 - KCTD2_HUMAN

Protein

BTB/POZ domain-containing protein KCTD2

Gene

KCTD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein complex binding Source: MGI

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing protein KCTD2
    Alternative name(s):
    Potassium channel tetramerization domain-containing protein 2
    Gene namesi
    Name:KCTD2
    Synonyms:KIAA0176
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:21294. KCTD2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134890451.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 263262BTB/POZ domain-containing protein KCTD2PRO_0000191287Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ14681.
    PaxDbiQ14681.
    PRIDEiQ14681.

    PTM databases

    PhosphoSiteiQ14681.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14681.
    BgeeiQ14681.
    CleanExiHS_KCTD2.
    GenevestigatoriQ14681.

    Interactioni

    Protein-protein interaction databases

    BioGridi117057. 6 interactions.
    IntActiQ14681. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14681.
    SMRiQ14681. Positions 68-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini72 – 172101BTBAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.Curated

    Phylogenomic databases

    eggNOGiNOG267996.
    HOGENOMiHOG000231167.
    HOVERGENiHBG053302.
    InParanoidiQ14681.
    OMAiTLCREPK.
    PhylomeDBiQ14681.
    TreeFamiTF313754.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view]
    PfamiPF02214. BTB_2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14681-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA    50
    VAQPLEPGPG PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR 100
    LCCQEDPELD SDKDETGAYL IDRDPTYFGP ILNYLRHGKL IITKELAEEG 150
    VLEEAEFYNI ASLVRLVKER IRDNENRTSQ GPVKHVYRVL QCQEEELTQM 200
    VSTMSDGWKF EQLISIGSSY NYGNEDQAEF LCVVSRELNN STNGIVIEPS 250
    EKAKILQERG SRM 263
    Length:263
    Mass (Da):28,527
    Last modified:May 18, 2010 - v3
    Checksum:iEF44819B2DC4AE49
    GO

    Sequence cautioni

    The sequence BAA11493.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541P → R in BAA11493. (PubMed:8724849)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D79998 mRNA. Translation: BAA11493.1. Different initiation.
    AC087651 Genomic DNA. No translation available.
    AC111186 Genomic DNA. No translation available.
    CCDSiCCDS32728.1.
    RefSeqiNP_056168.1. NM_015353.2.
    UniGeneiHs.514468.
    Hs.733235.

    Genome annotation databases

    EnsembliENST00000322444; ENSP00000312814; ENSG00000180901.
    GeneIDi23510.
    KEGGihsa:23510.
    UCSCiuc002jmp.3. human.

    Polymorphism databases

    DMDMi296439316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D79998 mRNA. Translation: BAA11493.1 . Different initiation.
    AC087651 Genomic DNA. No translation available.
    AC111186 Genomic DNA. No translation available.
    CCDSi CCDS32728.1.
    RefSeqi NP_056168.1. NM_015353.2.
    UniGenei Hs.514468.
    Hs.733235.

    3D structure databases

    ProteinModelPortali Q14681.
    SMRi Q14681. Positions 68-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117057. 6 interactions.
    IntActi Q14681. 1 interaction.

    PTM databases

    PhosphoSitei Q14681.

    Polymorphism databases

    DMDMi 296439316.

    Proteomic databases

    MaxQBi Q14681.
    PaxDbi Q14681.
    PRIDEi Q14681.

    Protocols and materials databases

    DNASUi 23510.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322444 ; ENSP00000312814 ; ENSG00000180901 .
    GeneIDi 23510.
    KEGGi hsa:23510.
    UCSCi uc002jmp.3. human.

    Organism-specific databases

    CTDi 23510.
    GeneCardsi GC17P073034.
    H-InvDB HIX0014161.
    HGNCi HGNC:21294. KCTD2.
    MIMi 613422. gene.
    neXtProti NX_Q14681.
    PharmGKBi PA134890451.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267996.
    HOGENOMi HOG000231167.
    HOVERGENi HBG053302.
    InParanoidi Q14681.
    OMAi TLCREPK.
    PhylomeDBi Q14681.
    TreeFami TF313754.

    Miscellaneous databases

    ChiTaRSi KCTD2. human.
    GenomeRNAii 23510.
    NextBioi 45921.
    PROi Q14681.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14681.
    Bgeei Q14681.
    CleanExi HS_KCTD2.
    Genevestigatori Q14681.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view ]
    Pfami PF02214. BTB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
      DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-29; 76-87; 124-136; 145-165; 189-209 AND 237-252, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryonic kidney.
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKCTD2_HUMAN
    AccessioniPrimary (citable) accession number: Q14681
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3