Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein KCTD2

Gene

KCTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cullin family protein binding Source: GO_Central
  • protein-containing complex binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD2
Alternative name(s):
Potassium channel tetramerization domain-containing protein 2
Gene namesi
Name:KCTD2
Synonyms:KIAA0176
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000180901.10
HGNCiHGNC:21294 KCTD2
MIMi613422 gene
neXtProtiNX_Q14681

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi23510
OpenTargetsiENSG00000180901
PharmGKBiPA134890451

Polymorphism and mutation databases

BioMutaiKCTD2
DMDMi296439316

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001912872 – 263BTB/POZ domain-containing protein KCTD2Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei33PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14681
MaxQBiQ14681
PaxDbiQ14681
PeptideAtlasiQ14681
PRIDEiQ14681
ProteomicsDBi60116

PTM databases

iPTMnetiQ14681
PhosphoSitePlusiQ14681

Expressioni

Gene expression databases

BgeeiENSG00000180901
CleanExiHS_KCTD2
ExpressionAtlasiQ14681 baseline and differential
GenevisibleiQ14681 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117057, 29 interactors
IntActiQ14681, 7 interactors
STRINGi9606.ENSP00000312814

Structurei

3D structure databases

ProteinModelPortaliQ14681
SMRiQ14681
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 172BTBAdd BLAST101

Phylogenomic databases

eggNOGiKOG2715 Eukaryota
ENOG410XT4J LUCA
GeneTreeiENSGT00530000062980
HOGENOMiHOG000231167
HOVERGENiHBG053302
InParanoidiQ14681
KOiK21914
OMAiTLCREPK
OrthoDBiEOG091G0JJT
PhylomeDBiQ14681
TreeFamiTF313754

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA
60 70 80 90 100
VAQPLEPGPG PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR
110 120 130 140 150
LCCQEDPELD SDKDETGAYL IDRDPTYFGP ILNYLRHGKL IITKELAEEG
160 170 180 190 200
VLEEAEFYNI ASLVRLVKER IRDNENRTSQ GPVKHVYRVL QCQEEELTQM
210 220 230 240 250
VSTMSDGWKF EQLISIGSSY NYGNEDQAEF LCVVSRELNN STNGIVIEPS
260
EKAKILQERG SRM
Length:263
Mass (Da):28,527
Last modified:May 18, 2010 - v3
Checksum:iEF44819B2DC4AE49
GO

Sequence cautioni

The sequence BAA11493 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54P → R in BAA11493 (PubMed:8724849).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79998 mRNA Translation: BAA11493.1 Different initiation.
AC087651 Genomic DNA No translation available.
AC111186 Genomic DNA No translation available.
CCDSiCCDS32728.1
RefSeqiNP_056168.1, NM_015353.2
UniGeneiHs.514468
Hs.733235

Genome annotation databases

EnsembliENST00000322444; ENSP00000312814; ENSG00000180901
GeneIDi23510
KEGGihsa:23510
UCSCiuc002jmp.4 human

Similar proteinsi

Entry informationi

Entry nameiKCTD2_HUMAN
AccessioniPrimary (citable) accession number: Q14681
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health