Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q14678

- KANK1_HUMAN

UniProt

Q14678 - KANK1_HUMAN

Protein

KN motif and ankyrin repeat domain-containing protein 1

Gene

KANK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (30 Aug 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.4 Publications

    GO - Molecular functioni

    1. beta-catenin binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of actin filament polymerization Source: UniProtKB
    2. negative regulation of cell migration Source: UniProtKB
    3. negative regulation of insulin receptor signaling pathway Source: UniProtKB
    4. negative regulation of lamellipodium morphogenesis Source: UniProtKB
    5. negative regulation of neuron projection development Source: UniProtKB
    6. negative regulation of Rho protein signal transduction Source: UniProtKB
    7. negative regulation of ruffle assembly Source: UniProtKB
    8. negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
    9. positive regulation of catenin import into nucleus Source: UniProtKB
    10. positive regulation of Wnt signaling pathway Source: UniProtKB
    11. positive regulation of wound healing Source: UniProtKB
    12. regulation of establishment of cell polarity Source: UniProtKB
    13. regulation of transcription, DNA-templated Source: UniProtKB-KW
    14. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 1
    Alternative name(s):
    Ankyrin repeat domain-containing protein 15
    Kidney ankyrin repeat-containing protein
    Gene namesi
    Name:KANK1
    Synonyms:ANKRD15, KANK, KIAA0172
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:19309. KANK1.

    Subcellular locationi

    Cell projectionruffle membrane 2 Publications
    Note: Colocalizes with KIF21A in membrane ruffles.
    Isoform 1 : Cytoplasm. Nucleus
    Note: Shuttles between the cytoplasm and nucleus.
    Isoform 2 : Cytoplasm. Nucleus. Cell projectionruffle membrane
    Note: Shuttles between the cytoplasm and nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. ruffle membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Cerebral palsy, spastic quadriplegic 2 (CPSQ2) [MIM:612900]: A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi43 – 431L → A: Nuclear localization; when associated A-52; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication
    Mutagenesisi52 – 521I → A: Nuclear localization; when associated A-43; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication
    Mutagenesisi65 – 684KRRK → AAAA: Enhanced cytoplasmic localization; when associated with 979-A--A-981 and 991-A-A-992.
    Mutagenesisi125 – 1251L → A: Nuclear localization; when associated A-43; A-52; A-129; A-134; A-613; A-616; A-620 and A-622. 1 Publication
    Mutagenesisi129 – 1291L → A: Nuclear localization; when associated A-43; A-52; A-125; A-134; A-613; A-616; A-620 and A-622. 1 Publication
    Mutagenesisi134 – 1341I → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-613; A-616; A-620 and A-622. 1 Publication
    Mutagenesisi325 – 3251S → A: Abolishes phosphorylation by PKB. Abolishes interaction with YWHAB; YWHAG; YWHAE; YWHAH; YWHAQ; YWHAZ and SFN. 1 Publication
    Mutagenesisi613 – 6131L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-616; A-620 and A-622. 1 Publication
    Mutagenesisi616 – 6161L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-620 and A-622. 1 Publication
    Mutagenesisi620 – 6201L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-622. 1 Publication
    Mutagenesisi622 – 6221L → A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-620. 1 Publication
    Mutagenesisi979 – 9813KKK → AAA: Enhanced cytoplasmic localization; when associated with 65-A--A-68 and 991-A-A-992.
    Mutagenesisi991 – 9922KK → AA: Enhanced cytoplasmic localization; when associated with 65-A--68 and 979-A--A-981.

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    MIMi612900. phenotype.
    Orphaneti91498. Familial congenital palsy of trochlear nerve.
    210141. Inherited congenital spastic tetraplegia.
    PharmGKBiPA162392554.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13521352KN motif and ankyrin repeat domain-containing protein 1PRO_0000066911Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei325 – 3251Phosphoserine; by PKB3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14678.
    PaxDbiQ14678.
    PRIDEiQ14678.

    PTM databases

    PhosphoSiteiQ14678.

    Expressioni

    Tissue specificityi

    Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.1 Publication

    Gene expression databases

    ArrayExpressiQ14678.
    BgeeiQ14678.
    CleanExiHS_KANK1.
    GenevestigatoriQ14678.

    Organism-specific databases

    HPAiHPA005539.

    Interactioni

    Subunit structurei

    Interacts with YWHAQ; the interaction requires KANK1 phosphorylation at Ser-325 and is enhanced by growth factor stimulation. Interacts with YWHAB, YWHAG, YWHAE, YWHAH, YWHAZ and SFN; the interaction requires KANK1 phosphorylation at Ser-325. Interacts with ARFGEF1; however, colocalization cannot be experimentally confirmed. Interacts with BAIAP2. Interacts (via ANK repeats 1-5) with KIF21A (via coiled coil region); KIF21A enhances translocation of KANK1 to the plasma membrane. Interacts with CTNNB1.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BAIAP2Q9UQB86EBI-2556221,EBI-525456
    BAIAP2Q9UQB8-44EBI-6173812,EBI-6174091
    CTNNB1P352222EBI-2556221,EBI-491549
    KIF21AQ7Z4S63EBI-6173812,EBI-2691397
    YWHAEP622583EBI-6173812,EBI-356498
    YWHAGP619813EBI-6173812,EBI-359832
    YWHAHQ049173EBI-6173812,EBI-306940
    YWHAQP273483EBI-6173812,EBI-359854

    Protein-protein interaction databases

    BioGridi116798. 3 interactions.
    DIPiDIP-56491N.
    IntActiQ14678. 14 interactions.
    MINTiMINT-7997401.
    STRINGi9606.ENSP00000371734.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14678.
    SMRiQ14678. Positions 1084-1325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1161 – 119131ANK 1Add
    BLAST
    Repeati1195 – 122834ANK 2Add
    BLAST
    Repeati1233 – 126230ANK 3Add
    BLAST
    Repeati1266 – 129833ANK 4Add
    BLAST
    Repeati1300 – 132930ANK 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni43 – 5210Nuclear export signal 1 (NES 1)
    Regioni65 – 684Nuclear localization signal 1 (NLS 1)
    Regioni125 – 13410Nuclear export signal 2 (NES 2)
    Regioni291 – 467177Interaction with KIF21AAdd
    BLAST
    Regioni613 – 62210Nuclear export signal 3 (NES 3)
    Regioni979 – 99214Nuclear localization signal 2 (NLS 2)Add
    BLAST
    Regioni1156 – 1308153Interaction with KIF21AAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili258 – 31659Sequence AnalysisAdd
    BLAST
    Coiled coili361 – 39535Sequence AnalysisAdd
    BLAST
    Coiled coili446 – 50055Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000230897.
    HOVERGENiHBG050511.
    InParanoidiQ14678.
    OMAiMTGLDHY.
    OrthoDBiEOG7NW687.
    PhylomeDBiQ14678.
    TreeFamiTF324499.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR021939. KN_motif.
    [Graphical view]
    PfamiPF00023. Ank. 3 hits.
    PF12075. KN_motif. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 6 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform 1 (identifier: Q14678-1) [UniParc]FASTAAdd to Basket

    Also known as: Kank-L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAHTTKVNGS ASGKAGDILS GDQDKEQKDP YFVETPYGYQ LDLDFLKYVD     50
    DIQKGNTIKR LNIQKRRKPS VPCPEPRTTS GQQGIWTSTE SLSSSNSDDN 100
    KQCPNFLIAR SQVTSTPISK PPPPLETSLP FLTIPENRQL PPPSPQLPKH 150
    NLHVTKTLME TRRRLEQERA TMQMTPGEFR RPRLASFGGM GTTSSLPSFV 200
    GSGNHNPAKH QLQNGYQGNG DYGSYAPAAP TTSSMGSSIR HSPLSSGIST 250
    PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ 300
    LVSQLKNQRA ASQINVCGVR KRSYSAGNAS QLEQLSRARR SGGELYIDYE 350
    EEEMETVEQS TQRIKEFRQL TADMQALEQK IQDSSCEASS ELRENGECRS 400
    VAVGAEENMN DIVVYHRGSR SCKDAAVGTL VEMRNCGVSV TEAMLGVMTE 450
    ADKEIELQQQ TIESLKEKIY RLEVQLRETT HDREMTKLKQ ELQAAGSRKK 500
    VDKATMAQPL VFSKVVEAVV QTRDQMVGSH MDLVDTCVGT SVETNSVGIS 550
    CQPECKNKVV GPELPMNWWI VKERVEMHDR CAGRSVEMCD KSVSVEVSVC 600
    ETGSNTEESV NDLTLLKTNL NLKEVRSIGC GDCSVDVTVC SPKECASRGV 650
    NTEAVSQVEA AVMAVPRTAD QDTSTDLEQV HQFTNTETAT LIESCTNTCL 700
    STLDKQTSTQ TVETRTVAVG EGRVKDINSS TKTRSIGVGT LLSGHSGFDR 750
    PSAVKTKESG VGQININDNY LVGLKMRTIA CGPPQLTVGL TASRRSVGVG 800
    DDPVGESLEN PQPQAPLGMM TGLDHYIERI QKLLAEQQTL LAENYSELAE 850
    AFGEPHSQMG SLNSQLISTL SSINSVMKSA STEELRNPDF QKTSLGKITG 900
    NYLGYTCKCG GLQSGSPLSS QTSQPEQEVG TSEGKPISSL DAFPTQEGTL 950
    SPVNLTDDQI AAGLYACTNN ESTLKSIMKK KDGNKDSNGA KKNLQFVGIN 1000
    GGYETTSSDD SSSDESSSSE SDDECDVIEY PLEEEEEEED EDTRGMAEGH 1050
    HAVNIEGLKS ARVEDEMQVQ ECEPEKVEIR ERYELSEKML SACNLLKNTI 1100
    NDPKALTSKD MRFCLNTLQH EWFRVSSQKS AIPAMVGDYI AAFEAISPDV 1150
    LRYVINLADG NGNTALHYSV SHSNFEIVKL LLDADVCNVD HQNKAGYTPI 1200
    MLAALAAVEA EKDMRIVEEL FGCGDVNAKA SQAGQTALML AVSHGRIDMV 1250
    KGLLACGADV NIQDDEGSTA LMCASEHGHV EIVKLLLAQP GCNGHLEDND 1300
    GSTALSIALE AGHKDIAVLL YAHVNFAKAQ SPGTPRLGRK TSPGPTHRGS 1350
    FD 1352
    Length:1,352
    Mass (Da):147,289
    Last modified:August 30, 2005 - v3
    Checksum:i0C3993143391363B
    GO
    Isoform 2 (identifier: Q14678-2) [UniParc]FASTAAdd to Basket

    Also known as: Kank-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-158: Missing.

    Show »
    Length:1,194
    Mass (Da):129,782
    Checksum:iF7CB58D947CCCE4C
    GO

    Sequence cautioni

    The sequence BAA11489.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti206 – 2061N → K.1 Publication
    Corresponds to variant rs17857145 [ dbSNP | Ensembl ].
    VAR_026212
    Natural varianti210 – 2101H → Q.
    Corresponds to variant rs28374506 [ dbSNP | Ensembl ].
    VAR_048298
    Natural varianti321 – 3211K → R.
    Corresponds to variant rs17857159 [ dbSNP | Ensembl ].
    VAR_048299
    Natural varianti432 – 4321E → Q.2 Publications
    Corresponds to variant rs4465020 [ dbSNP | Ensembl ].
    VAR_026213
    Natural varianti464 – 4641S → A.1 Publication
    Corresponds to variant rs912174 [ dbSNP | Ensembl ].
    VAR_016697
    Natural varianti664 – 6641A → V.
    Corresponds to variant rs3824421 [ dbSNP | Ensembl ].
    VAR_048300
    Natural varianti667 – 6671R → H.
    Corresponds to variant rs3824420 [ dbSNP | Ensembl ].
    VAR_048301
    Natural varianti901 – 9011N → S.
    Corresponds to variant rs12352313 [ dbSNP | Ensembl ].
    VAR_048302
    Natural varianti1055 – 10551I → T.
    Corresponds to variant rs34832656 [ dbSNP | Ensembl ].
    VAR_048303

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 158158Missing in isoform 2. CuratedVSP_043958Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D79994 mRNA. Translation: BAA11489.2. Different initiation.
    AL136979 Genomic DNA. Translation: CAH70388.1.
    AL136979 Genomic DNA. Translation: CAM13084.1.
    CH471071 Genomic DNA. Translation: EAW58821.1.
    CH471071 Genomic DNA. Translation: EAW58822.1.
    BC037495 mRNA. Translation: AAH37495.1.
    CCDSiCCDS34976.1. [Q14678-1]
    CCDS6441.1. [Q14678-2]
    RefSeqiNP_001243805.1. NM_001256876.1. [Q14678-1]
    NP_001243806.1. NM_001256877.1. [Q14678-1]
    NP_055973.2. NM_015158.3. [Q14678-1]
    XP_006716807.1. XM_006716744.1. [Q14678-1]
    UniGeneiHs.306764.

    Genome annotation databases

    EnsembliENST00000382293; ENSP00000371730; ENSG00000107104. [Q14678-2]
    ENST00000382297; ENSP00000371734; ENSG00000107104. [Q14678-1]
    ENST00000382303; ENSP00000371740; ENSG00000107104. [Q14678-1]
    GeneIDi23189.
    KEGGihsa:23189.
    UCSCiuc003zgl.2. human. [Q14678-1]

    Polymorphism databases

    DMDMi73920184.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D79994 mRNA. Translation: BAA11489.2 . Different initiation.
    AL136979 Genomic DNA. Translation: CAH70388.1 .
    AL136979 Genomic DNA. Translation: CAM13084.1 .
    CH471071 Genomic DNA. Translation: EAW58821.1 .
    CH471071 Genomic DNA. Translation: EAW58822.1 .
    BC037495 mRNA. Translation: AAH37495.1 .
    CCDSi CCDS34976.1. [Q14678-1 ]
    CCDS6441.1. [Q14678-2 ]
    RefSeqi NP_001243805.1. NM_001256876.1. [Q14678-1 ]
    NP_001243806.1. NM_001256877.1. [Q14678-1 ]
    NP_055973.2. NM_015158.3. [Q14678-1 ]
    XP_006716807.1. XM_006716744.1. [Q14678-1 ]
    UniGenei Hs.306764.

    3D structure databases

    ProteinModelPortali Q14678.
    SMRi Q14678. Positions 1084-1325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116798. 3 interactions.
    DIPi DIP-56491N.
    IntActi Q14678. 14 interactions.
    MINTi MINT-7997401.
    STRINGi 9606.ENSP00000371734.

    PTM databases

    PhosphoSitei Q14678.

    Polymorphism databases

    DMDMi 73920184.

    Proteomic databases

    MaxQBi Q14678.
    PaxDbi Q14678.
    PRIDEi Q14678.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382293 ; ENSP00000371730 ; ENSG00000107104 . [Q14678-2 ]
    ENST00000382297 ; ENSP00000371734 ; ENSG00000107104 . [Q14678-1 ]
    ENST00000382303 ; ENSP00000371740 ; ENSG00000107104 . [Q14678-1 ]
    GeneIDi 23189.
    KEGGi hsa:23189.
    UCSCi uc003zgl.2. human. [Q14678-1 ]

    Organism-specific databases

    CTDi 23189.
    GeneCardsi GC09P000461.
    HGNCi HGNC:19309. KANK1.
    HPAi HPA005539.
    MIMi 607704. gene.
    612900. phenotype.
    neXtProti NX_Q14678.
    Orphaneti 91498. Familial congenital palsy of trochlear nerve.
    210141. Inherited congenital spastic tetraplegia.
    PharmGKBi PA162392554.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000230897.
    HOVERGENi HBG050511.
    InParanoidi Q14678.
    OMAi MTGLDHY.
    OrthoDBi EOG7NW687.
    PhylomeDBi Q14678.
    TreeFami TF324499.

    Miscellaneous databases

    ChiTaRSi KANK1. human.
    GeneWikii ANKRD15.
    GenomeRNAii 23189.
    NextBioi 44663.
    PROi Q14678.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14678.
    Bgeei Q14678.
    CleanExi HS_KANK1.
    Genevestigatori Q14678.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR021939. KN_motif.
    [Graphical view ]
    Pfami PF00023. Ank. 3 hits.
    PF12075. KN_motif. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
      DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-464.
      Tissue: Bone marrow.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-432.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LYS-206 AND GLN-432.
      Tissue: Testis.
    5. "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma."
      Sarkar S., Roy B.C., Hatano N., Aoyagi T., Gohji K., Kiyama R.
      J. Biol. Chem. 277:36585-36591(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PUTATIVE FUNCTION, SUBCELLULAR LOCATION.
    6. "Alternative splicing of the human Kank gene produces two types of Kank protein."
      Wang Y., Onishi Y., Kakinuma N., Roy B.C., Aoyagi T., Kiyama R.
      Biochem. Biophys. Res. Commun. 330:1247-1253(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE PROMOTER USAGE (ISOFORM 2), TISSUE SPECIFICITY.
    7. "Deletion of the ANKRD15 gene at 9p24.3 causes parent-of-origin-dependent inheritance of familial cerebral palsy."
      Lerer I., Sagi M., Meiner V., Cohen T., Zlotogora J., Abeliovich D.
      Hum. Mol. Genet. 14:3911-3920(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN CPSQ2.
    8. "Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin."
      Wang Y., Kakinuma N., Zhu Y., Kiyama R.
      J. Cell Sci. 119:4002-4010(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CTNNB1, MUTAGENESIS OF LEU-43; ILE-52; 65-LYS--LYS-68; LEU-125; LEU-129; ILE-134; LEU-613; LEU-616; LEU-620; LEU-622; 979-LYS--LYS-981 AND 991-LYS-LYS-992.
    9. "Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling."
      Kakinuma N., Roy B.C., Zhu Y., Wang Y., Kiyama R.
      J. Cell Biol. 181:537-549(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-325, INTERACTION WITH YWHAB; YWHAG; YWHAE; YWHAH; YWHAQ; YWHAZ AND SFN, MUTAGENESIS OF SER-325.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "A major mutation of KIF21A associated with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) enhances translocation of Kank1 to the membrane."
      Kakinuma N., Kiyama R.
      Biochem. Biophys. Res. Commun. 386:639-644(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIF21A.
    12. "Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1."
      Roy B.C., Kakinuma N., Kiyama R.
      J. Cell Biol. 184:253-267(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BAIAP2.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing."
      Li C.C., Kuo J.C., Waterman C.M., Kiyama R., Moss J., Vaughan M.
      Proc. Natl. Acad. Sci. U.S.A. 108:19228-19233(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ARFGEF1.
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKANK1_HUMAN
    AccessioniPrimary (citable) accession number: Q14678
    Secondary accession number(s): A2A2W8
    , D3DRH3, Q5W0W0, Q8IY65, Q8WX74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3