ID   ANR15_HUMAN    STANDARD;      PRT;  1194 AA.
AC   Q14678; Q8IY65; Q8WX74;
DT   10-OCT-2003 (Rel. 42, Created)
DT   10-OCT-2003 (Rel. 42, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Ankyrin repeat domain protein 15 (Kidney ankyrin repeat-containing
DE   protein).
GN   Name=ANKRD15; Synonyms=KANK, KIAA0172;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-306.
RC   TISSUE=Bone marrow;
RX   MEDLINE=96281124; PubMed=8724849;
RA   Nagase T., Seki N., Ishikawa K.-I., Tanaka A., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. V.
RT   The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by
RT   analysis of cDNA clones from human cell line KG-1.";
RL   DNA Res. 3:17-24(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [4]
RP   PUTATIVE FUNCTION, AND SUBCELLULAR LOCATION.
RX   MEDLINE=22229386; PubMed=12133830; DOI=10.1074/jbc.M204244200;
RA   Sarkar S., Roy B.C., Hatano N., Aoyagi T., Gohji K., Kiyama R.;
RT   "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a
RT   growth suppressor of renal cell carcinoma.";
RL   J. Biol. Chem. 277:36585-36591(2002).
CC   -!- FUNCTION: Potential tumor suppressor for renal cell carcinoma.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic.
CC   -!- SIMILARITY: Contains 5 ANK repeats.
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DR   EMBL; D79994; BAA11489.1; ALT_INIT.
DR   EMBL; AL136979; CAD13248.1; ALT_INIT.
DR   EMBL; BC037495; AAH37495.1; ALT_INIT.
DR   Ensembl; ENSG00000107104; Homo sapiens.
DR   Genew; HGNC:19309; ANKRD15.
DR   MIM; 607704; -.
DR   InterPro; IPR002110; ANK.
DR   InterPro; IPR003191; GBP.
DR   Pfam; PF00023; Ank; 5.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
KW   ANK repeat; Anti-oncogene; Cell cycle; Coiled coil; Polymorphism;
KW   Repeat.
FT   DOMAIN      100    156       Coiled coil (Potential).
FT   DOMAIN      197    239       Coiled coil (Potential).
FT   DOMAIN      284    338       Coiled coil (Potential).
FT   REPEAT     1003   1033       ANK 1.
FT   REPEAT     1037   1070       ANK 2.
FT   REPEAT     1075   1104       ANK 3.
FT   REPEAT     1108   1140       ANK 4.
FT   REPEAT     1142   1171       ANK 5.
FT   VARIANT     306    306       S -> A (in dbSNP:912174).
FT                                /FTId=VAR_016697.
FT   CONFLICT     48     48       N -> K (in Ref. 3).
FT   CONFLICT    274    274       E -> Q (in Ref. 3).
SQ   SEQUENCE   1194 AA;  129782 MW;  F7CB58D947CCCE4C CRC64;
     METRRRLEQE RATMQMTPGE FRRPRLASFG GMGTTSSLPS FVGSGNHNPA KHQLQNGYQG
     NGDYGSYAPA APTTSSMGSS IRHSPLSSGI STPVTNVSPM HLQHIREQMA IALKRLKELE
     EQVRTIPVLQ VKISVLQEEK RQLVSQLKNQ RAASQINVCG VRKRSYSAGN ASQLEQLSRA
     RRSGGELYID YEEEEMETVE QSTQRIKEFR QLTADMQALE QKIQDSSCEA SSELRENGEC
     RSVAVGAEEN MNDIVVYHRG SRSCKDAAVG TLVEMRNCGV SVTEAMLGVM TEADKEIELQ
     QQTIESLKEK IYRLEVQLRE TTHDREMTKL KQELQAAGSR KKVDKATMAQ PLVFSKVVEA
     VVQTRDQMVG SHMDLVDTCV GTSVETNSVG ISCQPECKNK VVGPELPMNW WIVKERVEMH
     DRCAGRSVEM CDKSVSVEVS VCETGSNTEE SVNDLTLLKT NLNLKEVRSI GCGDCSVDVT
     VCSPKECASR GVNTEAVSQV EAAVMAVPRT ADQDTSTDLE QVHQFTNTET ATLIESCTNT
     CLSTLDKQTS TQTVETRTVA VGEGRVKDIN SSTKTRSIGV GTLLSGHSGF DRPSAVKTKE
     SGVGQININD NYLVGLKMRT IACGPPQLTV GLTASRRSVG VGDDPVGESL ENPQPQAPLG
     MMTGLDHYIE RIQKLLAEQQ TLLAENYSEL AEAFGEPHSQ MGSLNSQLIS TLSSINSVMK
     SASTEELRNP DFQKTSLGKI TGNYLGYTCK CGGLQSGSPL SSQTSQPEQE VGTSEGKPIS
     SLDAFPTQEG TLSPVNLTDD QIAAGLYACT NNESTLKSIM KKKDGNKDSN GAKKNLQFVG
     INGGYETTSS DDSSSDESSS SESDDECDVI EYPLEEEEEE EDEDTRGMAE GHHAVNIEGL
     KSARVEDEMQ VQECEPEKVE IRERYELSEK MLSACNLLKN TINDPKALTS KDMRFCLNTL
     QHEWFRVSSQ KSAIPAMVGD YIAAFEAISP DVLRYVINLA DGNGNTALHY SVSHSNFEIV
     KLLLDADVCN VDHQNKAGYT PIMLAALAAV EAEKDMRIVE ELFGCGDVNA KASQAGQTAL
     MLAVSHGRID MVKGLLACGA DVNIQDDEGS TALMCASEHG HVEIVKLLLA QPGCNGHLED
     NDGSTALSIA LEAGHKDIAV LLYAHVNFAK AQSPGTPRLG RKTSPGPTHR GSFD
//