Reviewed,
UniProtKB/Swiss-Prot Q14678 (KANK1_HUMAN)
Last modified
November 25, 2008.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: KN motif and ankyrin repeat domain-containing protein 1 Alternative name(s): Ankyrin repeat domain-containing protein 15 Kidney ankyrin repeat-containing protein | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1352 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Potential tumor suppressor for renal cell carcinoma. |
| Subcellular location | |
| Sequence similarities | Contains 5 ANK repeats. |
Ontologies
Keywords | |
|---|---|
| Biological process | Cell cycle |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Domain | ANK repeat Coiled coil Repeat |
| Molecular function | Anti-oncogene |
Gene Ontology (GO) | |
| Biological process | negative regulation of cell cycle Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1352 | 1352 | KN motif and ankyrin repeat domain-containing protein 1 | PRO_0000066911 | |||||
Regions | |||||||||
| Repeat | 1161 – 1191 | 31 | ANK 1 | ||||||
| Repeat | 1195 – 1228 | 34 | ANK 2 | ||||||
| Repeat | 1233 – 1262 | 30 | ANK 3 | ||||||
| Repeat | 1266 – 1298 | 33 | ANK 4 | ||||||
| Repeat | 1300 – 1329 | 30 | ANK 5 | ||||||
| Coiled coil | 258 – 316 | 59 | Potential | ||||||
| Coiled coil | 361 – 395 | 35 | Potential | ||||||
| Coiled coil | 446 – 500 | 55 | Potential | ||||||
Natural variations | |||||||||
| Natural variant | 206 | 1 | N → K: dbSNP rs17857145. | VAR_026212 | |||||
| Natural variant | 432 | 1 | E → Q: dbSNP rs4465020. | VAR_026213 | |||||
| Natural variant | 464 | 1 | S → A: dbSNP rs912174. | VAR_016697 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed: 8724849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-464. Tissue: Bone marrow. |
| [2] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-206 AND GLN-432. Tissue: Testis. |
| [4] | "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma." Sarkar S., Roy B.C., Hatano N., Aoyagi T., Gohji K., Kiyama R. J. Biol. Chem. 277:36585-36591(2002) [PubMed: 12133830] [Abstract] Cited for: PUTATIVE FUNCTION, SUBCELLULAR LOCATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D79994 mRNA. Translation: BAA11489.2. Different initiation. AL136979 Genomic DNA. Translation: CAH70388.1. BC037495 mRNA. Translation: AAH37495.1. | |
| RefSeq | NP_055973.2. |
| UniGene | Hs.306764 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q14678. |
Genome annotation databases | |
| Ensembl | ENSG00000107104. Homo sapiens. [Contig view] |
| GeneID | 23189. |
| KEGG | hsa:23189. |
Organism-specific databases | |
| HGNC | HGNC:19309. KANK1. |
| HPA | HPA005539. |
| MIM | 607704. gene. |
| Orphanet | 91498. Congenital palsy of trochlear nerve, familial form. |
| PharmGKB | PA128394610. |
| HUGE | Search... |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q14678. |
| HOVERGEN | Q14678. |
Gene expression databases | |
| ArrayExpress | Q14678. |
| CleanEx | HS_KANK1. |
| GermOnline | ENSG00000107104. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002110. ANK. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. |
| Pfam | PF00023. Ank. 5 hits. [Graphical view] |
| PRINTS | PR01415. ANKYRIN. |
| SMART | SM00248. ANK. 6 hits. [Graphical view] |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 44663. |
| SOURCE | Search... |
Entry information
| Entry name | KANK1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q14678 Secondary accession number(s): Q5W0W0, Q8IY65, Q8WX74 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


