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Q14677

- EPN4_HUMAN

UniProt

Q14677 - EPN4_HUMAN

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Protein
Clathrin interactor 1
Gene
CLINT1, ENTH, EPN4, EPNR, KIAA0171
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291Phosphatidylinositol lipid headgroup By similarity
Binding sitei67 – 671Phosphatidylinositol lipid headgroup By similarity

GO - Molecular functioni

  1. clathrin binding Source: BHF-UCL
  2. lipid binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. clathrin coat assembly Source: Ensembl
  2. endocytosis Source: UniProtKB-KW
  3. membrane organization Source: Reactome
  4. post-Golgi vesicle-mediated transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin interactor 1
Alternative name(s):
Clathrin-interacting protein localized in the trans-Golgi region
Short name:
Clint
Enthoprotin
Epsin-4
Epsin-related protein
Short name:
EpsinR
Gene namesi
Name:CLINT1
Synonyms:ENTH, EPN4, EPNR, KIAA0171
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:23186. CLINT1.

Subcellular locationi

Cytoplasm. Cytoplasmperinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicleclathrin-coated vesicle
Note: Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.3 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. clathrin-coated vesicle Source: UniProtKB-SubCell
  3. cytosol Source: Reactome
  4. intracellular membrane-bounded organelle Source: HPA
  5. membrane Source: UniProtKB-SubCell
  6. nucleus Source: HPA
  7. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi29 – 291R → L: Reduces lipid binding. Abolishes lipid binding; when associated with G-34.
Mutagenesisi34 – 341D → G: Abolishes lipid binding; when associated with L-29. 1 Publication
Mutagenesisi349 – 3491D → R: Decreases AP-1 and AP-2 binding. 1 Publication
Mutagenesisi371 – 3711D → R: Slightly decreases AP-1 binding. 1 Publication
Mutagenesisi422 – 4221D → R: Strongly decreases clathrin binding. 1 Publication
Mutagenesisi423 – 4264LFDL → AFAA: Strongly reduces clathrin binding. 1 Publication

Organism-specific databases

Orphaneti3140. Schizophrenia.
PharmGKBiPA145149115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625Clathrin interactor 1
PRO_0000074521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei163 – 1631Phosphoserine By similarity
Modified residuei227 – 2271Phosphoserine2 Publications
Modified residuei245 – 2451Phosphoserine3 Publications
Modified residuei299 – 2991Phosphoserine5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14677.
PaxDbiQ14677.
PRIDEiQ14677.

PTM databases

PhosphoSiteiQ14677.

Expressioni

Tissue specificityi

Ubiquitously expressed at low to intermediate levels.2 Publications

Gene expression databases

BgeeiQ14677.
CleanExiHS_CLINT1.
GenevestigatoriQ14677.

Organism-specific databases

HPAiHPA043280.

Interactioni

Subunit structurei

Binds clathrin heavy chain, GGA2, AP-2 and AP1G1.

Binary interactionsi

WithEntry#Exp.IntActNotes
Ap1g1P2289210EBI-1171113,EBI-1040262From a different organism.
GABARAPL1Q9H0R82EBI-1171113,EBI-746969
MAP1LC3BQ9GZQ82EBI-1171113,EBI-373144

Protein-protein interaction databases

BioGridi115038. 35 interactions.
DIPiDIP-45604N.
IntActiQ14677. 20 interactions.
MINTiMINT-4999242.
STRINGi9606.ENSP00000388340.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 319
Beta strandi33 – 375
Helixi41 – 5010
Turni54 – 563
Helixi57 – 6913
Helixi76 – 9217
Helixi95 – 1039
Helixi105 – 1095
Helixi110 – 1134
Helixi125 – 13915
Helixi142 – 15110

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XGWX-ray1.90A1-165[»]
2QY7X-ray2.00A/B/C20-166[»]
2V8SX-ray2.22E20-166[»]
ProteinModelPortaliQ14677.
SMRiQ14677. Positions 17-152.

Miscellaneous databases

EvolutionaryTraceiQ14677.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 149134ENTH
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi549 – 60557Met-rich
Add
BLAST

Sequence similaritiesi

Belongs to the epsin family.

Phylogenomic databases

eggNOGiNOG290795.
HOGENOMiHOG000082415.
HOVERGENiHBG048921.
InParanoidiQ14677.
OMAiPMSRSQP.
OrthoDBiEOG73V6K0.
PhylomeDBiQ14677.
TreeFamiTF313361.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR013809. Epsin-like_N.
IPR001026. Epsin_dom_N.
[Graphical view]
PfamiPF01417. ENTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14677-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLNMWKVREL VDKATNVVMN YSEIESKVRE ATNDDPWGPS GQLMGEIAKA    50
TFMYEQFPEL MNMLWSRMLK DNKKNWRRVY KSLLLLAYLI RNGSERVVTS 100
AREHIYDLRS LENYHFVDEH GKDQGINIRQ KVKELVEFAQ DDDRLREERK 150
KAKKNKDKYV GVSSDSVGGF RYSERYDPEP KSKWDEEWDK NKSAFPFSDK 200
LGELSDKIGS TIDDTISKFR RKDREDSPER CSDSDEEKKA RRGRSPKGEF 250
KDEEETVTTK HIHITQATET TTTRHKRTAN PSKTIDLGAA AHYTGDKASP 300
DQNASTHTPQ SSVKTSVPSS KSSGDLVDLF DGTSQSTGGS ADLFGGFADF 350
GSAAASGSFP SQVTATSGNG DFGDWSAFNQ APSGPVASSG EFFGSASQPA 400
VELVSGSQSA LGPPPAASNS SDLFDLMGSS QATMTSSQSM NFSMMSTNTV 450
GLGLPMSRSQ NTDMVQKSVS KTLPSTWSDP SVNISLDNLL PGMQPSKPQQ 500
PSLNTMIQQQ NMQQPMNVMT QSFGAVNLSS PSNMLPVRPQ TNALIGGPMP 550
MSMPNVMTGT MGMAPLGNTP MMNQSMMGMN MNIGMSAAGM GLTGTMGMGM 600
PNIAMTSGTV QPKQDAFANF ANFSK 625
Length:625
Mass (Da):68,259
Last modified:November 1, 1996 - v1
Checksum:i6C8C6689861E9F0D
GO
Isoform 2 (identifier: Q14677-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     460-460: Q → QPLQNVSTVLQKPNPLYNQ

Show »
Length:625
Mass (Da):68,166
Checksum:i5081B36E2F4F85F2
GO
Isoform 3 (identifier: Q14677-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SQPLQNVSTVLQKPNPLYN

Note: No experimental confirmation available.

Show »
Length:643
Mass (Da):70,295
Checksum:iFD6381C2E1957E9C
GO

Sequence cautioni

The sequence BAA11488.2 differs from that shown. Reason: Erroneous initiation.

Polymorphismi

Genetic variations in CLINT1 may contribute to susceptibility to schizophrenia and psychotic disorders in some populations.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818Missing in isoform 2.
VSP_009160Add
BLAST
Alternative sequencei459 – 4591S → SQPLQNVSTVLQKPNPLYN in isoform 3.
VSP_043302
Alternative sequencei460 – 4601Q → QPLQNVSTVLQKPNPLYNQ in isoform 2.
VSP_009161

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti476 – 4761T → A in BAC03971. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BK000414 Genomic DNA. Translation: DAA00062.1.
AF434813 mRNA. Translation: AAL30768.1.
D79993 mRNA. Translation: BAA11488.2. Different initiation.
AK092765 mRNA. Translation: BAC03971.1.
AK300257 mRNA. Translation: BAH13244.1.
AC011394 Genomic DNA. No translation available.
AC026407 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61585.1.
CH471062 Genomic DNA. Translation: EAW61588.1.
BC004467 mRNA. Translation: AAH04467.1.
BC013091 mRNA. Translation: AAH13091.1.
CCDSiCCDS47330.1. [Q14677-1]
CCDS56388.1. [Q14677-2]
CCDS56389.1. [Q14677-3]
RefSeqiNP_001182484.1. NM_001195555.1. [Q14677-3]
NP_001182485.1. NM_001195556.1. [Q14677-2]
NP_055481.1. NM_014666.3. [Q14677-1]
UniGeneiHs.644000.

Genome annotation databases

EnsembliENST00000296951; ENSP00000296951; ENSG00000113282. [Q14677-2]
ENST00000411809; ENSP00000388340; ENSG00000113282. [Q14677-1]
ENST00000523094; ENSP00000429345; ENSG00000113282. [Q14677-2]
ENST00000523908; ENSP00000429824; ENSG00000113282. [Q14677-3]
ENST00000530742; ENSP00000433419; ENSG00000113282. [Q14677-2]
GeneIDi9685.
KEGGihsa:9685.
UCSCiuc003lxi.2. human. [Q14677-2]
uc003lxj.2. human. [Q14677-1]
uc011ddv.2. human. [Q14677-3]

Polymorphism databases

DMDMi41016993.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BK000414 Genomic DNA. Translation: DAA00062.1 .
AF434813 mRNA. Translation: AAL30768.1 .
D79993 mRNA. Translation: BAA11488.2 . Different initiation.
AK092765 mRNA. Translation: BAC03971.1 .
AK300257 mRNA. Translation: BAH13244.1 .
AC011394 Genomic DNA. No translation available.
AC026407 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61585.1 .
CH471062 Genomic DNA. Translation: EAW61588.1 .
BC004467 mRNA. Translation: AAH04467.1 .
BC013091 mRNA. Translation: AAH13091.1 .
CCDSi CCDS47330.1. [Q14677-1 ]
CCDS56388.1. [Q14677-2 ]
CCDS56389.1. [Q14677-3 ]
RefSeqi NP_001182484.1. NM_001195555.1. [Q14677-3 ]
NP_001182485.1. NM_001195556.1. [Q14677-2 ]
NP_055481.1. NM_014666.3. [Q14677-1 ]
UniGenei Hs.644000.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XGW X-ray 1.90 A 1-165 [» ]
2QY7 X-ray 2.00 A/B/C 20-166 [» ]
2V8S X-ray 2.22 E 20-166 [» ]
ProteinModelPortali Q14677.
SMRi Q14677. Positions 17-152.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115038. 35 interactions.
DIPi DIP-45604N.
IntActi Q14677. 20 interactions.
MINTi MINT-4999242.
STRINGi 9606.ENSP00000388340.

PTM databases

PhosphoSitei Q14677.

Polymorphism databases

DMDMi 41016993.

Proteomic databases

MaxQBi Q14677.
PaxDbi Q14677.
PRIDEi Q14677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296951 ; ENSP00000296951 ; ENSG00000113282 . [Q14677-2 ]
ENST00000411809 ; ENSP00000388340 ; ENSG00000113282 . [Q14677-1 ]
ENST00000523094 ; ENSP00000429345 ; ENSG00000113282 . [Q14677-2 ]
ENST00000523908 ; ENSP00000429824 ; ENSG00000113282 . [Q14677-3 ]
ENST00000530742 ; ENSP00000433419 ; ENSG00000113282 . [Q14677-2 ]
GeneIDi 9685.
KEGGi hsa:9685.
UCSCi uc003lxi.2. human. [Q14677-2 ]
uc003lxj.2. human. [Q14677-1 ]
uc011ddv.2. human. [Q14677-3 ]

Organism-specific databases

CTDi 9685.
GeneCardsi GC05M157212.
HGNCi HGNC:23186. CLINT1.
HPAi HPA043280.
MIMi 607265. gene.
neXtProti NX_Q14677.
Orphaneti 3140. Schizophrenia.
PharmGKBi PA145149115.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290795.
HOGENOMi HOG000082415.
HOVERGENi HBG048921.
InParanoidi Q14677.
OMAi PMSRSQP.
OrthoDBi EOG73V6K0.
PhylomeDBi Q14677.
TreeFami TF313361.

Enzyme and pathway databases

Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSi CLINT1. human.
EvolutionaryTracei Q14677.
GeneWikii CLINT1.
GenomeRNAii 9685.
NextBioi 36372.
PROi Q14677.
SOURCEi Search...

Gene expression databases

Bgeei Q14677.
CleanExi HS_CLINT1.
Genevestigatori Q14677.

Family and domain databases

Gene3Di 1.25.40.90. 1 hit.
InterProi IPR008942. ENTH_VHS.
IPR013809. Epsin-like_N.
IPR001026. Epsin_dom_N.
[Graphical view ]
Pfami PF01417. ENTH. 1 hit.
[Graphical view ]
SMARTi SM00273. ENTH. 1 hit.
[Graphical view ]
SUPFAMi SSF48464. SSF48464. 1 hit.
PROSITEi PS50942. ENTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics."
    Wasiak S., Legendre-Guillemin V., Puertollano R., Blondeau F., Girard M., de Heuvel E., Boismenu D., Bell A.W., Bonifacino J.S., McPherson P.S.
    J. Cell Biol. 158:855-862(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 14-27; 30-49; 110-129; 134-146; 157-171; 201-218; 248-274 AND 284-297 (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CLATHRIN; AP1G1 AND GGA2, SUBCELLULAR LOCATION.
  2. "KIAA0171 as a new member (epsin 4) of the epsin family."
    Hong W.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Placenta and Small intestine.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Skin.
  8. "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi."
    Kalthoff C., Groos S., Kohl R., Mahrhold S., Ungewickell E.J.
    Mol. Biol. Cell 13:4060-4073(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 423-LEU--LEU-426, INTERACTION WITH CLATHRIN; AP1G1 AND AP-2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-34; ASP-349; ASP-371 AND ASP-422, INTERACTION WITH AP1G1; AP-2 AND CLATHRIN.
  10. "The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia."
    Pimm J., McQuillin A., Thirumalai S., Lawrence J., Quested D., Bass N., Lamb G., Moorey H., Datta S.R., Kalsi G., Badacsonyi A., Kelly K., Morgan J., Punukollu B., Curtis D., Gurling H.
    Am. J. Hum. Genet. 76:902-907(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SCZD1.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEPN4_HUMAN
AccessioniPrimary (citable) accession number: Q14677
Secondary accession number(s): B7Z6F8
, D3DQJ6, Q8NAF1, Q96E05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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