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Q14677

- EPN4_HUMAN

UniProt

Q14677 - EPN4_HUMAN

Protein

Clathrin interactor 1

Gene

CLINT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291Phosphatidylinositol lipid headgroupBy similarity
    Binding sitei67 – 671Phosphatidylinositol lipid headgroupBy similarity

    GO - Molecular functioni

    1. clathrin binding Source: BHF-UCL
    2. lipid binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. clathrin coat assembly Source: Ensembl
    2. endocytosis Source: UniProtKB-KW
    3. membrane organization Source: Reactome
    4. post-Golgi vesicle-mediated transport Source: Reactome

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Clathrin interactor 1
    Alternative name(s):
    Clathrin-interacting protein localized in the trans-Golgi region
    Short name:
    Clint
    Enthoprotin
    Epsin-4
    Epsin-related protein
    Short name:
    EpsinR
    Gene namesi
    Name:CLINT1
    Synonyms:ENTH, EPN4, EPNR, KIAA0171
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:23186. CLINT1.

    Subcellular locationi

    Cytoplasm. Cytoplasmperinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicleclathrin-coated vesicle
    Note: Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.

    GO - Cellular componenti

    1. clathrin-coated vesicle Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. Golgi apparatus Source: UniProtKB
    4. intracellular membrane-bounded organelle Source: HPA
    5. membrane Source: UniProtKB
    6. nucleus Source: HPA
    7. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi29 – 291R → L: Reduces lipid binding. Abolishes lipid binding; when associated with G-34. 1 Publication
    Mutagenesisi34 – 341D → G: Abolishes lipid binding; when associated with L-29. 2 Publications
    Mutagenesisi349 – 3491D → R: Decreases AP-1 and AP-2 binding. 2 Publications
    Mutagenesisi371 – 3711D → R: Slightly decreases AP-1 binding. 2 Publications
    Mutagenesisi422 – 4221D → R: Strongly decreases clathrin binding. 2 Publications
    Mutagenesisi423 – 4264LFDL → AFAA: Strongly reduces clathrin binding. 1 Publication

    Organism-specific databases

    Orphaneti3140. Schizophrenia.
    PharmGKBiPA145149115.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 625625Clathrin interactor 1PRO_0000074521Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei163 – 1631PhosphoserineBy similarity
    Modified residuei227 – 2271Phosphoserine2 Publications
    Modified residuei245 – 2451Phosphoserine3 Publications
    Modified residuei299 – 2991Phosphoserine5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14677.
    PaxDbiQ14677.
    PRIDEiQ14677.

    PTM databases

    PhosphoSiteiQ14677.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed at low to intermediate levels.2 Publications

    Gene expression databases

    BgeeiQ14677.
    CleanExiHS_CLINT1.
    GenevestigatoriQ14677.

    Organism-specific databases

    HPAiHPA043280.

    Interactioni

    Subunit structurei

    Binds clathrin heavy chain, GGA2, AP-2 and AP1G1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ap1g1P2289210EBI-1171113,EBI-1040262From a different organism.
    GABARAPL1Q9H0R82EBI-1171113,EBI-746969
    MAP1LC3BQ9GZQ82EBI-1171113,EBI-373144

    Protein-protein interaction databases

    BioGridi115038. 35 interactions.
    DIPiDIP-45604N.
    IntActiQ14677. 20 interactions.
    MINTiMINT-4999242.
    STRINGi9606.ENSP00000388340.

    Structurei

    Secondary structure

    1
    625
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi23 – 319
    Beta strandi33 – 375
    Helixi41 – 5010
    Turni54 – 563
    Helixi57 – 6913
    Helixi76 – 9217
    Helixi95 – 1039
    Helixi105 – 1095
    Helixi110 – 1134
    Helixi125 – 13915
    Helixi142 – 15110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XGWX-ray1.90A1-165[»]
    2QY7X-ray2.00A/B/C20-166[»]
    2V8SX-ray2.22E20-166[»]
    ProteinModelPortaliQ14677.
    SMRiQ14677. Positions 17-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14677.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 149134ENTHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi549 – 60557Met-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the epsin family.Curated
    Contains 1 ENTH (epsin N-terminal homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG290795.
    HOGENOMiHOG000082415.
    HOVERGENiHBG048921.
    InParanoidiQ14677.
    OMAiPMSRSQP.
    OrthoDBiEOG73V6K0.
    PhylomeDBiQ14677.
    TreeFamiTF313361.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    InterProiIPR008942. ENTH_VHS.
    IPR013809. Epsin-like_N.
    IPR001026. Epsin_dom_N.
    [Graphical view]
    PfamiPF01417. ENTH. 1 hit.
    [Graphical view]
    SMARTiSM00273. ENTH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    PROSITEiPS50942. ENTH. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14677-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLNMWKVREL VDKATNVVMN YSEIESKVRE ATNDDPWGPS GQLMGEIAKA    50
    TFMYEQFPEL MNMLWSRMLK DNKKNWRRVY KSLLLLAYLI RNGSERVVTS 100
    AREHIYDLRS LENYHFVDEH GKDQGINIRQ KVKELVEFAQ DDDRLREERK 150
    KAKKNKDKYV GVSSDSVGGF RYSERYDPEP KSKWDEEWDK NKSAFPFSDK 200
    LGELSDKIGS TIDDTISKFR RKDREDSPER CSDSDEEKKA RRGRSPKGEF 250
    KDEEETVTTK HIHITQATET TTTRHKRTAN PSKTIDLGAA AHYTGDKASP 300
    DQNASTHTPQ SSVKTSVPSS KSSGDLVDLF DGTSQSTGGS ADLFGGFADF 350
    GSAAASGSFP SQVTATSGNG DFGDWSAFNQ APSGPVASSG EFFGSASQPA 400
    VELVSGSQSA LGPPPAASNS SDLFDLMGSS QATMTSSQSM NFSMMSTNTV 450
    GLGLPMSRSQ NTDMVQKSVS KTLPSTWSDP SVNISLDNLL PGMQPSKPQQ 500
    PSLNTMIQQQ NMQQPMNVMT QSFGAVNLSS PSNMLPVRPQ TNALIGGPMP 550
    MSMPNVMTGT MGMAPLGNTP MMNQSMMGMN MNIGMSAAGM GLTGTMGMGM 600
    PNIAMTSGTV QPKQDAFANF ANFSK 625
    Length:625
    Mass (Da):68,259
    Last modified:November 1, 1996 - v1
    Checksum:i6C8C6689861E9F0D
    GO
    Isoform 2 (identifier: Q14677-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: Missing.
         460-460: Q → QPLQNVSTVLQKPNPLYNQ

    Show »
    Length:625
    Mass (Da):68,166
    Checksum:i5081B36E2F4F85F2
    GO
    Isoform 3 (identifier: Q14677-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         459-459: S → SQPLQNVSTVLQKPNPLYN

    Note: No experimental confirmation available.

    Show »
    Length:643
    Mass (Da):70,295
    Checksum:iFD6381C2E1957E9C
    GO

    Sequence cautioni

    The sequence BAA11488.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti476 – 4761T → A in BAC03971. (PubMed:14702039)Curated

    Polymorphismi

    Genetic variations in CLINT1 may contribute to susceptibility to schizophrenia and psychotic disorders in some populations.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818Missing in isoform 2. 2 PublicationsVSP_009160Add
    BLAST
    Alternative sequencei459 – 4591S → SQPLQNVSTVLQKPNPLYN in isoform 3. 1 PublicationVSP_043302
    Alternative sequencei460 – 4601Q → QPLQNVSTVLQKPNPLYNQ in isoform 2. 2 PublicationsVSP_009161

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BK000414 Genomic DNA. Translation: DAA00062.1.
    AF434813 mRNA. Translation: AAL30768.1.
    D79993 mRNA. Translation: BAA11488.2. Different initiation.
    AK092765 mRNA. Translation: BAC03971.1.
    AK300257 mRNA. Translation: BAH13244.1.
    AC011394 Genomic DNA. No translation available.
    AC026407 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61585.1.
    CH471062 Genomic DNA. Translation: EAW61588.1.
    BC004467 mRNA. Translation: AAH04467.1.
    BC013091 mRNA. Translation: AAH13091.1.
    CCDSiCCDS47330.1. [Q14677-1]
    CCDS56388.1. [Q14677-2]
    CCDS56389.1. [Q14677-3]
    RefSeqiNP_001182484.1. NM_001195555.1. [Q14677-3]
    NP_001182485.1. NM_001195556.1. [Q14677-2]
    NP_055481.1. NM_014666.3. [Q14677-1]
    UniGeneiHs.644000.

    Genome annotation databases

    EnsembliENST00000411809; ENSP00000388340; ENSG00000113282. [Q14677-1]
    ENST00000523094; ENSP00000429345; ENSG00000113282. [Q14677-2]
    ENST00000523908; ENSP00000429824; ENSG00000113282. [Q14677-3]
    ENST00000530742; ENSP00000433419; ENSG00000113282. [Q14677-2]
    GeneIDi9685.
    KEGGihsa:9685.
    UCSCiuc003lxi.2. human. [Q14677-2]
    uc003lxj.2. human. [Q14677-1]
    uc011ddv.2. human. [Q14677-3]

    Polymorphism databases

    DMDMi41016993.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BK000414 Genomic DNA. Translation: DAA00062.1 .
    AF434813 mRNA. Translation: AAL30768.1 .
    D79993 mRNA. Translation: BAA11488.2 . Different initiation.
    AK092765 mRNA. Translation: BAC03971.1 .
    AK300257 mRNA. Translation: BAH13244.1 .
    AC011394 Genomic DNA. No translation available.
    AC026407 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61585.1 .
    CH471062 Genomic DNA. Translation: EAW61588.1 .
    BC004467 mRNA. Translation: AAH04467.1 .
    BC013091 mRNA. Translation: AAH13091.1 .
    CCDSi CCDS47330.1. [Q14677-1 ]
    CCDS56388.1. [Q14677-2 ]
    CCDS56389.1. [Q14677-3 ]
    RefSeqi NP_001182484.1. NM_001195555.1. [Q14677-3 ]
    NP_001182485.1. NM_001195556.1. [Q14677-2 ]
    NP_055481.1. NM_014666.3. [Q14677-1 ]
    UniGenei Hs.644000.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XGW X-ray 1.90 A 1-165 [» ]
    2QY7 X-ray 2.00 A/B/C 20-166 [» ]
    2V8S X-ray 2.22 E 20-166 [» ]
    ProteinModelPortali Q14677.
    SMRi Q14677. Positions 17-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115038. 35 interactions.
    DIPi DIP-45604N.
    IntActi Q14677. 20 interactions.
    MINTi MINT-4999242.
    STRINGi 9606.ENSP00000388340.

    PTM databases

    PhosphoSitei Q14677.

    Polymorphism databases

    DMDMi 41016993.

    Proteomic databases

    MaxQBi Q14677.
    PaxDbi Q14677.
    PRIDEi Q14677.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000411809 ; ENSP00000388340 ; ENSG00000113282 . [Q14677-1 ]
    ENST00000523094 ; ENSP00000429345 ; ENSG00000113282 . [Q14677-2 ]
    ENST00000523908 ; ENSP00000429824 ; ENSG00000113282 . [Q14677-3 ]
    ENST00000530742 ; ENSP00000433419 ; ENSG00000113282 . [Q14677-2 ]
    GeneIDi 9685.
    KEGGi hsa:9685.
    UCSCi uc003lxi.2. human. [Q14677-2 ]
    uc003lxj.2. human. [Q14677-1 ]
    uc011ddv.2. human. [Q14677-3 ]

    Organism-specific databases

    CTDi 9685.
    GeneCardsi GC05M157212.
    HGNCi HGNC:23186. CLINT1.
    HPAi HPA043280.
    MIMi 607265. gene.
    neXtProti NX_Q14677.
    Orphaneti 3140. Schizophrenia.
    PharmGKBi PA145149115.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290795.
    HOGENOMi HOG000082415.
    HOVERGENi HBG048921.
    InParanoidi Q14677.
    OMAi PMSRSQP.
    OrthoDBi EOG73V6K0.
    PhylomeDBi Q14677.
    TreeFami TF313361.

    Enzyme and pathway databases

    Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

    Miscellaneous databases

    ChiTaRSi CLINT1. human.
    EvolutionaryTracei Q14677.
    GeneWikii CLINT1.
    GenomeRNAii 9685.
    NextBioi 36372.
    PROi Q14677.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14677.
    CleanExi HS_CLINT1.
    Genevestigatori Q14677.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    InterProi IPR008942. ENTH_VHS.
    IPR013809. Epsin-like_N.
    IPR001026. Epsin_dom_N.
    [Graphical view ]
    Pfami PF01417. ENTH. 1 hit.
    [Graphical view ]
    SMARTi SM00273. ENTH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    PROSITEi PS50942. ENTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics."
      Wasiak S., Legendre-Guillemin V., Puertollano R., Blondeau F., Girard M., de Heuvel E., Boismenu D., Bell A.W., Bonifacino J.S., McPherson P.S.
      J. Cell Biol. 158:855-862(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 14-27; 30-49; 110-129; 134-146; 157-171; 201-218; 248-274 AND 284-297 (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CLATHRIN; AP1G1 AND GGA2, SUBCELLULAR LOCATION.
    2. "KIAA0171 as a new member (epsin 4) of the epsin family."
      Hong W.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
      DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Placenta and Small intestine.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung and Skin.
    8. "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi."
      Kalthoff C., Groos S., Kohl R., Mahrhold S., Ungewickell E.J.
      Mol. Biol. Cell 13:4060-4073(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 423-LEU--LEU-426, INTERACTION WITH CLATHRIN; AP1G1 AND AP-2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    9. Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-34; ASP-349; ASP-371 AND ASP-422, INTERACTION WITH AP1G1; AP-2 AND CLATHRIN.
    10. "The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia."
      Pimm J., McQuillin A., Thirumalai S., Lawrence J., Quested D., Bass N., Lamb G., Moorey H., Datta S.R., Kalsi G., Badacsonyi A., Kelly K., Morgan J., Punukollu B., Curtis D., Gurling H.
      Am. J. Hum. Genet. 76:902-907(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN SCZD1.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEPN4_HUMAN
    AccessioniPrimary (citable) accession number: Q14677
    Secondary accession number(s): B7Z6F8
    , D3DQJ6, Q8NAF1, Q96E05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3