Separin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the ‘Names and taxonomy’ section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• catalytic activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12672959
• cysteine-type endopeptidase activity Source: GO_Central
• cysteine-type peptidase activity Source: Reactome

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• apoptotic process Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 11875078
• cytokinesis Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 11509732
• establishment of mitotic spindle localization Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12672959
• homologous chromosome segregation Source: Ensembl
• meiotic chromosome separation Source: GO_Central
• meiotic spindle organization Source: Ensembl
• mitotic sister chromatid segregation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 12672959
• negative regulation of sister chromatid cohesion Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12194817
• positive regulation of mitotic metaphase/anaphase transition Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12672959

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• centrosome Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12672959
• cytoplasm Source: GO_Central
• cytosol Source: Reactome
• mitotic spindle Source: GO_Central
• nucleus Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section"><span class="caps">PTM</span>/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MRSFKRVNFG TLLSSQKEAE ELLPALKEFL SNPPAGFPSS RSDAERRQAC 
        60         70         80         90        100
DAILRACNQQ LTAKLACPRH LGSLLELAEL ACDGYLVSTP QRPPLYLERI 
       110        120        130        140        150
LFVLLRNAAA QGSPEATLRL AQPLHACLVQ CSREAAPQDY EAVARGSFSL 
       160        170        180        190        200
LWKGAEALLE RRAAFAARLK ALSFLVLLED ESTPCEVPHF ASPTACRAVA 
       210        220        230        240        250
AHQLFDASGH GLNEADADFL DDLLSRHVIR ALVGERGSSS GLLSPQRALC 
       260        270        280        290        300
LLELTLEHCR RFCWSRHHDK AISAVEKAHS YLRNTNLAPS LQLCQLGVKL 
       310        320        330        340        350
LQVGEEGPQA VAKLLIKASA VLSKSMEAPS PPLRALYESC QFFLSGLERG 
       360        370        380        390        400
TKRRYRLDAI LSLFAFLGGY CSLLQQLRDD GVYGGSSKQQ QSFLQMYFQG 
       410        420        430        440        450
LHLYTVVVYD FAQGCQIVDL ADLTQLVDSC KSTVVWMLEA LEGLSGQELT 
       460        470        480        490        500
DHMGMTASYT SNLAYSFYSH KLYAEACAIS EPLCQHLGLV KPGTYPEVPP 
       510        520        530        540        550
EKLHRCFRLQ VESLKKLGKQ AQGCKMVILW LAALQPCSPE HMAEPVTFWV 
       560        570        580        590        600
RVKMDAARAG DKELQLKTLR DSLSGWDPET LALLLREELQ AYKAVRADTG 
       610        620        630        640        650
QERFNIICDL LELSPEETPA GAWARATHLV ELAQVLCYHD FTQQTNCSAL 
       660        670        680        690        700
DAIREALQLL DSVRPEAQAR DQLLDDKAQA LLWLYICTLE AKMQEGIERD 
       710        720        730        740        750
RRAQAPGNLE EFEVNDLNYE DKLQEDRFLY SNIAFNLAAD AAQSKCLDQA 
       760        770        780        790        800
LALWKELLTK GQAPAVRCLQ QTAASLQILA ALYQLVAKPM QALEVLLLLR 
       810        820        830        840        850
IVSERLKDHS KAAGSSCHIT QLLLTLGCPS YAQLHLEEAA SSLKHLDQTT 
       860        870        880        890        900
DTYLLLSLTC DLLRSQLYWT HQKVTKGVSL LLSVLRDPAL QKSSKAWYLL 
       910        920        930        940        950
RVQVLQLVAA YLSLPSNNLS HSLWEQLCAQ GWQTPEIALI DSHKLLRSII 
       960        970        980        990       1000
LLLMGSDILS TQKAAVETSF LDYGENLVQK WQVLSEVLSC SEKLVCHLGR 
      1010       1020       1030       1040       1050
LGSVSEAKAF CLEALKLTTK LQIPRQCALF LVLKGELELA RNDIDLCQSD 
      1060       1070       1080       1090       1100
LQQVLFLLES CTEFGGVTQH LDSVKKVHLQ KGKQQAQVPC PPQLPEEELF 
      1110       1120       1130       1140       1150
LRGPALELVA TVAKEPGPIA PSTNSSPVLK TKPQPIPNFL SHSPTCDCSL 
      1160       1170       1180       1190       1200
CASPVLTAVC LRWVLVTAGV RLAMGHQAQG LDLLQVVLKG CPEAAERLTQ 
      1210       1220       1230       1240       1250
ALQASLNHKT PPSLVPSLLD EILAQAYTLL ALEGLNQPSN ESLQKVLQSG 
      1260       1270       1280       1290       1300
LKFVAARIPH LEPWRASLLL IWALTKLGGL SCCTTQLFAS SWGWQPPLIK 
      1310       1320       1330       1340       1350
SVPGSEPSKT QGQKRSGRGR QKLASAPLRL NNTSQKGLEG RGLPCTPKPP 
      1360       1370       1380       1390       1400
DRIRQAGPHV PFTVFEEVCP TESKPEVPQA PRVQQRVQTR LKVNFSDDSD 
      1410       1420       1430       1440       1450
LEDPVSAEAW LAEEPKRRGT ASRGRGRARK GLSLKTDAVV APGSAPGNPG 
      1460       1470       1480       1490       1500
LNGRSRRAKK VASRHCEERR PQRASDQARP GPEIMRTIPE EELTDNWRKM 
      1510       1520       1530       1540       1550
SFEILRGSDG EDSASGGKTP APGPEAASGE WELLRLDSSK KKLPSPCPDK 
      1560       1570       1580       1590       1600
ESDKDLGPRL RLPSAPVATG LSTLDSICDS LSVAFRGISH CPPSGLYAHL 
      1610       1620       1630       1640       1650
CRFLALCLGH RDPYATAFLV TESVSITCRH QLLTHLHRQL SKAQKHRGSL 
      1660       1670       1680       1690       1700
EIADQLQGLS LQEMPGDVPL ARIQRLFSFR ALESGHFPQP EKESFQERLA 
      1710       1720       1730       1740       1750
LIPSGVTVCV LALATLQPGT VGNTLLLTRL EKDSPPVSVQ IPTGQNKLHL 
      1760       1770       1780       1790       1800
RSVLNEFDAI QKAQKENSSC TDKREWWTGR LALDHRMEVL IASLEKSVLG 
      1810       1820       1830       1840       1850
CWKGLLLPSS EEPGPAQEAS RLQELLQDCG WKYPDRTLLK IMLSGAGALT 
      1860       1870       1880       1890       1900
PQDIQALAYG LCPTQPERAQ ELLNEAVGRL QGLTVPSNSH LVLVLDKDLQ 
      1910       1920       1930       1940       1950
KLPWESMPSL QALPVTRLPS FRFLLSYSII KEYGASPVLS QGVDPRSTFY 
      1960       1970       1980       1990       2000
VLNPHNNLSS TEEQFRANFS SEAGWRGVVG EVPRPEQVQE ALTKHDLYIY 
      2010       2020       2030       2040       2050
AGHGAGARFL DGQAVLRLSC RAVALLFGCS SAALAVRGNL EGAGIVLKYI 
      2060       2070       2080       2090       2100
MAGCPLFLGN LWDVTDRDID RYTEALLQGW LGAGPGAPLL YYVNQARQAP 
      2110       2120
RLKYLIGAAP IAYGLPVSLR                                  

        10         20         30         40         50
MEAPSPPLRA LYESCQFFLS GLERGTKRRY RLDAILSLFA FLGGYCSLLQ 
        60         70         80         90        100
QLRDDGVYGG SSKQQQSFLQ MYFQGLHLYT VVVYDFAQGC QIVDLADLTQ 
       110        120        130        140        150
LVDSCKSTVV WMLEALEGLS GQELTDHMGM TASYTSNLAY SFYSHKLYAE 
       160        170        180        190        200
ACAISEPLCQ HLGLVKPGTY PEVPPEKLHR CFRLQVESLK KLGKQAQGCK 
       210        220        230        240        250
MVILWLAALQ PCSPEHMAEP VTFWVRVKMD AARAGDKELQ LKTLRDSLSG 
       260        270        280        290        300
WDPETLALLL REELQAYKAV RADTGQERFN IICDLLELSP EETPAGAWAR 
       310        320        330        340        350
ATHLVELAQV LCYHDFTQQT NCSALDAIRE ALQLLDSVRP EAQARDQLLD 
       360        370        380        390        400
DKAQALLWLY ICTLEAKMQE GIERDRRAQA PGNLEEFEVN DLNYEDKLQE 
       410        420        430        440        450
DRFLYSNIAF NLAADAAQSK CLDQALALWK ELLTKGQAPA VRCLQQTAAS 
       460        470        480        490        500
LQILAALYQL VAKPMQALEV LLLLRIVSER LKDHSKAAGS SCHITQLLLT 
       510        520        530        540        550
LGCPSYAQLH LEEAASSLKH LDQTTDTYLL LSLTCDLLRS QLYWTHQKVT 
       560        570        580        590        600
KGVSLLLSVL RDPALQKSSK AWYLLRVQVL QLVAAYLSLP SNNLSHSLWE 
       610        620        630        640        650
QLCAQGWQTP EIALIDSHKL LRSIILLLMG SDILSTQKAA VETSFLDYGE 
       660        670        680        690        700
NLVQKWQVLS EVLSCSEKLV CHLGRLGSVS EAKAFCLEAL KLTTKLQIPR 
       710        720        730        740        750
QCALFLVLKG ELELARNDID LCQSDLQQVL FLLESCTEFG GVTQHLDSVK 
       760        770        780        790        800
KVHLQKGKQQ AQVPCPPQLP EEELFLRGPA LELVATVAKE PGPIAPSTNS 
       810        820        830        840        850
SPVLKTKPQP IPNFLSHSPT CDCSLCASPV LTAVCLRWVL VTAGVRLAMG 
       860        870        880        890        900
HQAQGLDLLQ VVLKGCPEAA ERLTQALQAS LNHKTPPSLV PSLLDEILAQ 
       910        920        930        940        950
AYTLLALEGL NQPSNESLQK VLQSGLKFVA ARIPHLEPWR ASLLLIWALT 
       960        970        980        990       1000
KLGGLSCCTT QLFASSWGWQ PPLIKSVPGS EPSKTQGQKR SGRGRQKLAS 
      1010       1020       1030       1040       1050
APLRLNNTSQ KGLEGRGLPC TPKPPDRIRQ AGPHVPFTVF EEVCPTESKP 
      1060       1070       1080       1090       1100
EVPQAPRVQQ RVQTRLKVNF SDDSDLEDPV SAEAWLAEEP KRRGTASRGR 
      1110       1120       1130       1140       1150
GRARKGLSLK TDAVVAPGSA PGNPGLNGRS RRAKKVASRH CEERRPQRAS 
      1160       1170       1180       1190       1200
DQARPGPEIM RTIPEEELTD NWRKMSFEIL RGSDGEDSAS GGKTPAPGPE 
      1210       1220       1230       1240       1250
AASGEWELLR LDSSKKKLPS PCPDKESDKD LGPRLRLPSA PVATGLSTLD 
      1260       1270       1280       1290       1300
SICDSLSVAF RGISHCPPSG LYAHLCRFLA LCLGHRDPYA TAFLVTESVS 
      1310       1320       1330       1340       1350
ITCRHQLLTH LHRQLSKAQK HRGSLEIADQ LQGLSLQEMP GDVPLARIQR 
      1360       1370       1380       1390       1400
LFSFRALESG HFPQPEKESF QERLALIPSG VTVCVLALAT LQPGTVGNTL 
      1410       1420       1430       1440       1450
LLTRLEKDSP PVSVQIPTGQ NKLHLRSVLN EFDAIQKAQK ENSSCTDKRE 
      1460       1470       1480       1490       1500
WWTGRLALDH RMEVLIASLE KSVLGCWKGL LLPSSEEPGP AQEASRLQEL 
      1510       1520       1530       1540       1550
LQDCGWKYPD RTLLKIMLSG AGALTPQDIQ ALAYGLCPTQ PERAQELLNE 
      1560       1570       1580       1590       1600
AVGRLQGLTV PSNSHLVLVL DKDLQKLPWE SMPSLQALPV TRLPSFRFLL 
      1610       1620       1630       1640       1650
SYSIIKEYGA SPVLSQGVDP RSTFYVLNPH NNLSSTEEQF RANFSSEAGW 
      1660       1670       1680       1690       1700
RGVVGEVPRP EQVQEALTKH DLYIYAGHGA GARFLDGQAV LRLSCRAVAL 
      1710       1720       1730       1740       1750
LFGCSSAALA VRGNLEGAGI VLKYIMAGCP LFLGNLWDVT DRDIDRYTEA 
      1760       1770       1780       1790 
LLQGWLGAGP GAPLLYYVNQ ARQAPRLKYL IGAAPIAYGL PVSLR 

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to the UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 12
   Human chromosome 12: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot