Q14671 (PUM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pumilio homolog 1
Short name=HsPUM
Short name=Pumilio-1

Gene names

Name:	PUM1
Synonyms:	KIAA0099, PUMH1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1186 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells By similarity.
Subunit structure	Binds in a sequence-specific manner to the 3'-UTR of some mRNAs.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. Ref.1
Induction	Strongly down-regulated in keratinocytes upon UVB irradiation. Ref.8
Domain	The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs.
Sequence similarities	Contains 1 PUM-HD domain. Contains 8 pumilio repeats.
Sequence caution	The sequence BAA07895.3 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Translation regulation
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular membrane organization Traceable author statement. Source: Reactome post-Golgi vesicle-mediated transport Traceable author statement. Source: Reactome regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Traceable author statement. Source: Reactome
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14671-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14671-2)

The sequence of this isoform differs from the canonical sequence as follows:
     417-417: I → IA
     597-623: Missing.
     950-950: Q → QVI

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1186

1186

Pumilio homolog 1

PRO_0000075917

Regions

Domain

828 – 1168

341

PUM-HD

Repeat

848 – 883

36

Pumilio 1

Repeat

884 – 919

36

Pumilio 2

Repeat

920 – 955

36

Pumilio 3

Repeat

956 – 991

36

Pumilio 4

Repeat

992 – 1027

36

Pumilio 5

Repeat

1028 – 1063

36

Pumilio 6

Repeat

1064 – 1099

36

Pumilio 7

Repeat

1103 – 1142

40

Pumilio 8

Compositional bias

393 – 613

221

Ala-rich

Compositional bias

475 – 523

49

Gln-rich

Compositional bias

642 – 815

174

Ser-rich

Amino acid modifications

Modified residue

19

1

Phosphoserine Ref.12

Modified residue

75

1

Phosphoserine Ref.12 Ref.13

Modified residue

124

1

Phosphoserine By similarity

Modified residue

209

1

Phosphoserine Ref.9 Ref.12 Ref.13

Modified residue

709

1

Phosphoserine Ref.11 Ref.12 Ref.13

Modified residue

714

1

Phosphoserine Ref.10

Modified residue

806

1

Phosphoserine Ref.13

Natural variations

Alternative sequence

417

1

I → IA in isoform 2.

VSP_017059

Alternative sequence

597 – 623

27

Missing in isoform 2.

VSP_017060

Alternative sequence

950

1

Q → QVI in isoform 2.

VSP_017061

Experimental info

Mutagenesis

1043 – 1044

2

NY → SN: Changes the specificity for RNA; when associated with E-1047.

Mutagenesis

1047

1

Q → E: Changes the specificity for RNA; when associated with 1043-SN-1044. Ref.16

Sequence conflict

893

1

M → N in BAA07895. Ref.2

Secondary structure

1

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1186

Helix Strand Turn

Details...

Helix

831 – 837

7

Helix

846 – 849

4

Helix

853 – 857

5

Helix

860 – 872

13

Helix

875 – 885

11

Helix

886 – 888

3

Helix

889 – 893

5

Helix

898 – 908

11

Helix

911 – 921

11

Helix

925 – 929

5

Helix

934 – 944

11

Helix

947 – 954

8

Helix

955 – 957

3

Helix

961 – 966

6

Helix

970 – 980

11

Helix

983 – 986

4

Helix

987 – 992

6

Turn

993 – 996

4

Helix

997 – 1001

5

Helix

1006 – 1016

11

Helix

1019 – 1031

13

Helix

1033 – 1036

4

Helix

1042 – 1052

11

Helix

1055 – 1065

11

Helix

1069 – 1073

5

Helix

1078 – 1088

11

Helix

1091 – 1103

13

Helix

1111 – 1116

6

Helix

1121 – 1131

11

Helix

1134 – 1142

9

Helix

1157 – 1166

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 2, 2004. Version 3. Checksum: E1E0D8B3B0181308	FASTA	1,186	126,473
	10 20 30 40 50 60 MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT 70 80 90 100 110 120 HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH 130 140 150 160 170 180 QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS 190 200 210 220 230 240 DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP GDSCLRKGGF 250 260 270 280 290 300 GPRDADSDEN DKGEKKNKGT FDGDKLGDLK EEGDVMDKTN GLPVQNGIDA DVKDFSRTPG 310 320 330 340 350 360 NCQNSANEVD LLGPNQNGSE GLAQLTSTNG AKPVEDFSNM ESQSVPLDPM EHVGMEPLQF 370 380 390 400 410 420 DYSGTQVPVD SAAATVGLFD YNSQQQLFQR PNALAVQQLT AAQQQQYALA AAHQPHIGLA 430 440 450 460 470 480 PAAFVPNPYI ISAAPPGTDP YTAGLAAAAT LGPAVVPHQY YGVTPWGVYP ASLFQQQAAA 490 500 510 520 530 540 AAAATNSANQ QTTPQAQQGQ QQVLRGGASQ RPLTPNQNQQ GQQTDPLVAA AAVNSALAFG 550 560 570 580 590 600 QGLAAGMPGY PVLAPAAYYD QTGALVVNAG ARNGLGAPVR LVAPAPVIIS SSAAQAAVAA 610 620 630 640 650 660 AAASANGAAG GLAGTTNGPF RPLGTQQPQP QPQQQPNNNL ASSSFYGNNS LNSNSQSSSL 670 680 690 700 710 720 FSQGSAQPAN TSLGFGSSSS LGATLGSALG GFGTAVANSN TGSGSRRDSL TGSSDLYKRT 730 740 750 760 770 780 SSSLTPIGHS FYNGLSFSSS PGPVGMPLPS QGPGHSQTPP PSLSSHGSSS SLNLGGLTNG 790 800 810 820 830 840 SGRYISAAPG AEAKYRSASS ASSLFSPSST LFSSSRLRYG MSDVMPSGRS RLLEDFRNNR 850 860 870 880 890 900 YPNLQLREIA GHIMEFSQDQ HGSRFIQLKL ERATPAERQL VFNEILQAAY QLMVDVFGNY 910 920 930 940 950 960 VIQKFFEFGS LEQKLALAER IRGHVLSLAL QMYGCRVIQK ALEFIPSDQQ NEMVRELDGH 970 980 990 1000 1010 1020 VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFAL STHPYGCRVI QRILEHCLPD 1030 1040 1050 1060 1070 1080 QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVAEIRGNVL VLSQHKFASN 1090 1100 1110 1120 1130 1140 VVEKCVTHAS RTERAVLIDE VCTMNDGPHS ALYTMMKDQY ANYVVQKMID VAEPGQRKIV 1150 1160 1170 1180 MHKIRPHIAT LRKYTYGKHI LAKLEKYYMK NGVDLGPICG PPNGII
	Isoform 2 [UniParc]. Checksum: 84FF134AA644F074	FASTA	1,162	124,420
	10 20 30 40 50 60 MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT 70 80 90 100 110 120 HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH 130 140 150 160 170 180 QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS 190 200 210 220 230 240 DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP GDSCLRKGGF 250 260 270 280 290 300 GPRDADSDEN DKGEKKNKGT FDGDKLGDLK EEGDVMDKTN GLPVQNGIDA DVKDFSRTPG 310 320 330 340 350 360 NCQNSANEVD LLGPNQNGSE GLAQLTSTNG AKPVEDFSNM ESQSVPLDPM EHVGMEPLQF 370 380 390 400 410 420 DYSGTQVPVD SAAATVGLFD YNSQQQLFQR PNALAVQQLT AAQQQQYALA AAHQPHIAGL 430 440 450 460 470 480 APAAFVPNPY IISAAPPGTD PYTAGLAAAA TLGPAVVPHQ YYGVTPWGVY PASLFQQQAA 490 500 510 520 530 540 AAAAATNSAN QQTTPQAQQG QQQVLRGGAS QRPLTPNQNQ QGQQTDPLVA AAAVNSALAF 550 560 570 580 590 600 GQGLAAGMPG YPVLAPAAYY DQTGALVVNA GARNGLGAPV RLVAPAPVII SSSAAQAGTQ 610 620 630 640 650 660 QPQPQPQQQP NNNLASSSFY GNNSLNSNSQ SSSLFSQGSA QPANTSLGFG SSSSLGATLG 670 680 690 700 710 720 SALGGFGTAV ANSNTGSGSR RDSLTGSSDL YKRTSSSLTP IGHSFYNGLS FSSSPGPVGM 730 740 750 760 770 780 PLPSQGPGHS QTPPPSLSSH GSSSSLNLGG LTNGSGRYIS AAPGAEAKYR SASSASSLFS 790 800 810 820 830 840 PSSTLFSSSR LRYGMSDVMP SGRSRLLEDF RNNRYPNLQL REIAGHIMEF SQDQHGSRFI 850 860 870 880 890 900 QLKLERATPA ERQLVFNEIL QAAYQLMVDV FGNYVIQKFF EFGSLEQKLA LAERIRGHVL 910 920 930 940 950 960 SLALQMYGCR VIQKALEFIP SDQQVINEMV RELDGHVLKC VKDQNGNHVV QKCIECVQPQ 970 980 990 1000 1010 1020 SLQFIIDAFK GQVFALSTHP YGCRVIQRIL EHCLPDQTLP ILEELHQHTE QLVQDQYGNY 1030 1040 1050 1060 1070 1080 VIQHVLEHGR PEDKSKIVAE IRGNVLVLSQ HKFASNVVEK CVTHASRTER AVLIDEVCTM 1090 1100 1110 1120 1130 1140 NDGPHSALYT MMKDQYANYV VQKMIDVAEP GQRKIVMHKI RPHIATLRKY TYGKHILAKL 1150 1160 EKYYMKNGVD LGPICGPPNG II

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins." Spassov D.S., Jurecic R. Gene 299:195-204(2002) [PubMed: 12459267] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed: 7788527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow.
[3]	Ohara O., Nagase T., Kikuno R., Nomura N. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[8]	"Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer." Dazard J.-E., Gal H., Amariglio N., Rechavi G., Domany E., Givol D. Oncogene 22:2993-3006(2003) [PubMed: 12771951] [Abstract] Cited for: INDUCTION.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line." Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S. Electrophoresis 28:2027-2034(2007) [PubMed: 17487921] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-714, MASS SPECTROMETRY. Tissue: Prostate cancer.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-709, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-75; SER-209 AND SER-709, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-209; SER-709 AND SER-806, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Crystal structure of a Pumilio homology domain." Wang X., Zamore P.D., Hall T.M.T. Mol. Cell 7:855-865(2001) [PubMed: 11336708] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 828-1166.
[16]	"Modular recognition of RNA by a human pumilio-homology domain." Wang X., McLachlan J., Zamore P.D., Hall T.M.T. Cell 110:501-512(2002) [PubMed: 12202039] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 828-1176 IN COMPLEX WITH RNA, MUTAGENESIS OF 1043-ASN-TYR-1044 AND GLN-1047.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF315592 mRNA. Translation: AAG31807.1.
D43951 mRNA. Translation: BAA07895.3. Different initiation.
AL356320, AL445235 Genomic DNA. Translation: CAH71203.1.
AK291779 mRNA. Translation: BAF84468.1.
AL445235, AL356320 Genomic DNA. Translation: CAI22246.1.
CH471059 Genomic DNA. Translation: EAX07633.1.
CH471059 Genomic DNA. Translation: EAX07634.1.
BC013398 mRNA. Translation: AAH13398.1.

IPI

IPI00551014.
IPI00941189.

RefSeq

NP_001018494.1. NM_001020658.1.
NP_055491.1. NM_014676.2.

UniGene

Hs.281707.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1IB2	X-ray	1.90	A	828-1176	[»]
1M8W	X-ray	2.20	A/B	828-1176	[»]
1M8X	X-ray	2.20	A/B	828-1176	[»]
1M8Y	X-ray	2.60	A/B	828-1176	[»]
1M8Z	X-ray	1.90	A	828-1176	[»]
2YJY	X-ray	2.60	A/B	828-1176	[»]
3BSB	X-ray	2.80	A/B	828-1170	[»]
3BSX	X-ray	2.32	A/B	828-1170	[»]
3Q0L	X-ray	2.50	A/B	828-1176	[»]
3Q0M	X-ray	2.70	A/B	828-1176	[»]
3Q0N	X-ray	2.40	A/B	828-1176	[»]
3Q0O	X-ray	2.80	A/B	828-1176	[»]
3Q0P	X-ray	2.60	A/B	828-1176	[»]

ProteinModelPortal

Q14671.

SMR

Q14671. Positions 828-1165.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29082N.

IntAct

Q14671. 3 interactions.

MINT

MINT-1199500.

STRING

Q14671.

PTM databases

PhosphoSite

Q14671.

Polymorphism databases

DMDM

41688619.

2D gel databases

UCD-2DPAGE

Q14671.

Proteomic databases

PRIDE

Q14671.

Protocols and materials databases

StructuralBiologyKnowledgebase

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Genome annotation databases

Ensembl

ENST00000257075; ENSP00000257075; ENSG00000134644.

GeneID

9698.

KEGG

hsa:9698.

UCSC

uc001bsi.1. human.
uc001bsj.1. human.

Organism-specific databases

CTD

9698.

GeneCards

GC01M031405.

H-InvDB

HIX0000349.

HGNC

HGNC:14957. PUM1.

HPA

HPA027424.

MIM

607204. gene.

neXtProt

NX_Q14671.

PharmGKB

PA34042.

HUGE

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GenAtlas

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Phylogenomic databases

eggNOG

prNOG15759.

GeneTree

ENSGT00390000017241.

HOVERGEN

HBG049462.

OrthoDB

EOG4P8FHP.

PhylomeDB

Q14671.

Enzyme and pathway databases

Reactome

REACT_11123. Membrane Trafficking.

Gene expression databases

ArrayExpress

Q14671.

Bgee

Q14671.

CleanEx

HS_PUM1.

Genevestigator

Q14671.

GermOnline

ENSG00000134644. Homo sapiens.

Family and domain databases

InterPro

IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]

Gene3D

G3DSA:1.25.10.10. ARM-like. 1 hit.

Pfam

PF00806. PUF. 8 hits.
[Graphical view]

SMART

SM00025. Pumilio. 8 hits.
[Graphical view]

SUPFAM

SSF48371. ARM-type_fold. 1 hit.

PROSITE

PS50302. PUM. 8 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view]

ProtoNet

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Other

NextBio

36439.

SOURCE

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Entry information

Entry name

PUM1_HUMAN

Accession

Primary (citable) accession number: Q14671
Secondary accession number(s): A8K6W4 , D3DPN3, Q5VXY7, Q9HAN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	February 2, 2004
Last modified:	January 25, 2012
This is version 106 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.