ID   Q14663_HUMAN            Unreviewed;       420 AA.
AC   Q14663;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   13-SEP-2023, entry version 110.
DE   SubName: Full=H-2K binding factor-2 {ECO:0000313|EMBL:AAA91836.1};
GN   Name=KBF2 {ECO:0000313|EMBL:AAA91836.1};
GN   Synonyms=pKBF-2 {ECO:0000313|EMBL:BAA21773.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA91836.1};
RN   [1] {ECO:0000313|EMBL:AAA91836.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Tang X., Gachelin G., Yokoyama K., Israel A.;
RT   "Nucleotide sequence and the chromosomal mapping of KBF-2 cDNA.";
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAA21773.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9290259; DOI=10.1007/BF02766956;
RA   Tang X., Saito-Ohara F., Song J., Koga C., Ugai H., Murakami H.,
RA   Ikeuchi T., Yokoyama K.K.;
RT   "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and
RT   9q13 by fluorescence in situ hybridization.";
RL   Jpn. J. Hum. Genet. 42:337-341(1997).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the Su(H) family.
CC       {ECO:0000256|ARBA:ARBA00009704}.
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DR   EMBL; L08904; AAA91836.1; -; Genomic_DNA.
DR   EMBL; D14041; BAA21773.1; -; mRNA.
DR   AlphaFoldDB; Q14663; -.
DR   MaxQB; Q14663; -.
DR   PeptideAtlas; Q14663; -.
DR   ChiTaRS; RBPJ; human.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 2.80.10.50; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.1450; LAG1, DNA binding domain; 1.
DR   InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR   InterPro; IPR036358; BTD_sf.
DR   InterPro; IPR040159; CLS_fam.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR   InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR   InterPro; IPR038007; RBP-Jkappa_IPT.
DR   PANTHER; PTHR10665:SF4; -; 1.
DR   PANTHER; PTHR10665; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS; 1.
DR   Pfam; PF09270; BTD; 1.
DR   Pfam; PF09271; LAG1-DNAbind; 1.
DR   Pfam; PF20144; TIG_SUH; 1.
DR   SMART; SM01268; BTD; 1.
DR   SMART; SM01267; LAG1_DNAbind; 1.
DR   SUPFAM; SSF110217; DNA-binding protein LAG-1 (CSL); 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          1..99
FT                   /note="RBP-J/Cbf11/Cbf12 DNA binding"
FT                   /evidence="ECO:0000259|SMART:SM01267"
FT   DOMAIN          100..248
FT                   /note="Beta-trefoil DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01268"
FT   REGION          386..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..420
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   420 AA;  46098 MW;  642D382ED07845A6 CRC64;
     MGSGWKKIKL QMKCDGCSEQ GSHPCAFIGI GNSDQEMQQL NLEGKNYCTA KTLYISDSDK
     QKHFMLSVKV FYGNGDDIGV FLSKSSKPSK KKQSLKNADL CIGSGTKVAL FNRLRSQTVS
     TRYLHVEGGN FHASSQQWGA FTLFLDDDGS EGEEFTVRDG YIHYGQTVKL VCSVTGMALP
     RLIIRKVDKQ TTLLDADDPV SQLHKCAFDL EDTERMYLCL SQERIIQFQA TPCPTEPNKE
     MINDGASWAI ISTHKAKYTF YERMGPVLAL VMPMPVVESL KLNGGGDEAM LELTGQNFTP
     NLRVWFGDVE AETMYRCGES MLRVVPDVLH SEKVGDSSQQ PVQVSVTLVR NDGIIYSTSL
     TFTYTPEAGP RPHCSVAGAI LKASSSHVPP NELNTNSDGS YTNASTNSTS VTSSTPTVVS
//