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Q14657

- LAGE3_HUMAN

UniProt

Q14657 - LAGE3_HUMAN

Protein

EKC/KEOPS complex subunit LAGE3

Gene

LAGE3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex By similarity.By similarity

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EKC/KEOPS complex subunit LAGE3
    Alternative name(s):
    L antigen family member 3
    Protein ESO-3
    Protein ITBA2
    Gene namesi
    Name:LAGE3
    Synonyms:DXS9879E, ESO3, ITBA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:26058. LAGE3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394540.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 143143EKC/KEOPS complex subunit LAGE3PRO_0000218924Add
    BLAST

    Proteomic databases

    MaxQBiQ14657.
    PaxDbiQ14657.
    PeptideAtlasiQ14657.
    PRIDEiQ14657.

    PTM databases

    PhosphoSiteiQ14657.

    Miscellaneous databases

    PMAP-CutDBQ14657.

    Expressioni

    Tissue specificityi

    Ubiquitous.2 Publications

    Gene expression databases

    ArrayExpressiQ14657.
    BgeeiQ14657.
    CleanExiHS_LAGE3.
    GenevestigatoriQ14657.

    Organism-specific databases

    HPAiHPA036122.
    HPA036123.

    Interactioni

    Subunit structurei

    Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.1 Publication

    Protein-protein interaction databases

    BioGridi113888. 34 interactions.
    IntActiQ14657. 4 interactions.
    MINTiMINT-4719865.
    STRINGi9606.ENSP00000349923.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14657.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CTAG/PCC1 family.Curated

    Phylogenomic databases

    eggNOGiNOG40896.
    HOGENOMiHOG000040003.
    HOVERGENiHBG052154.
    InParanoidiQ14657.
    KOiK15902.
    OMAiWTAKDPR.
    PhylomeDBiQ14657.
    TreeFamiTF337064.

    Family and domain databases

    InterProiIPR015419. EKC/KEOPS_Pcc1.
    [Graphical view]
    PfamiPF09341. Pcc1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14657-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDADADAGG GADGGDGRGG HSCRGGVDTA AAPAGGAPPA HAPGPGRDAA    50
    SAARGSRMRP HIFTLSVPFP TPLEAEIAHG SLAPDAEPHQ RVVGKDLTVS 100
    GRILVVRWKA EDCRLLRISV INFLDQLSLV VRTMQRFGPP VSR 143
    Length:143
    Mass (Da):14,804
    Last modified:October 11, 2004 - v2
    Checksum:iAD164559371449F8
    GO

    Sequence cautioni

    The sequence CAA63489.1 differs from that shown. Reason: Frameshift at position 54.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936365 Genomic DNA. Translation: CAI43195.1.
    BC015744 mRNA. Translation: AAH15744.2.
    BC062330 mRNA. Translation: AAH62330.1.
    X92896 mRNA. Translation: CAA63489.1. Frameshift.
    CCDSiCCDS14753.1.
    RefSeqiNP_006005.2. NM_006014.4.
    UniGeneiHs.444619.

    Genome annotation databases

    EnsembliENST00000357360; ENSP00000349923; ENSG00000196976.
    GeneIDi8270.
    KEGGihsa:8270.
    UCSCiuc004fln.1. human.

    Polymorphism databases

    DMDMi54041570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936365 Genomic DNA. Translation: CAI43195.1 .
    BC015744 mRNA. Translation: AAH15744.2 .
    BC062330 mRNA. Translation: AAH62330.1 .
    X92896 mRNA. Translation: CAA63489.1 . Frameshift.
    CCDSi CCDS14753.1.
    RefSeqi NP_006005.2. NM_006014.4.
    UniGenei Hs.444619.

    3D structure databases

    ProteinModelPortali Q14657.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113888. 34 interactions.
    IntActi Q14657. 4 interactions.
    MINTi MINT-4719865.
    STRINGi 9606.ENSP00000349923.

    PTM databases

    PhosphoSitei Q14657.

    Polymorphism databases

    DMDMi 54041570.

    Proteomic databases

    MaxQBi Q14657.
    PaxDbi Q14657.
    PeptideAtlasi Q14657.
    PRIDEi Q14657.

    Protocols and materials databases

    DNASUi 8270.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357360 ; ENSP00000349923 ; ENSG00000196976 .
    GeneIDi 8270.
    KEGGi hsa:8270.
    UCSCi uc004fln.1. human.

    Organism-specific databases

    CTDi 8270.
    GeneCardsi GC0XM153707.
    HGNCi HGNC:26058. LAGE3.
    HPAi HPA036122.
    HPA036123.
    MIMi 300060. gene.
    neXtProti NX_Q14657.
    PharmGKBi PA128394540.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40896.
    HOGENOMi HOG000040003.
    HOVERGENi HBG052154.
    InParanoidi Q14657.
    KOi K15902.
    OMAi WTAKDPR.
    PhylomeDBi Q14657.
    TreeFami TF337064.

    Miscellaneous databases

    GenomeRNAii 8270.
    NextBioi 31037.
    PMAP-CutDB Q14657.
    PROi Q14657.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14657.
    Bgeei Q14657.
    CleanExi HS_LAGE3.
    Genevestigatori Q14657.

    Family and domain databases

    InterProi IPR015419. EKC/KEOPS_Pcc1.
    [Graphical view ]
    Pfami PF09341. Pcc1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood and Pancreas.
    3. "Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach."
      Faranda S., Frattini A., Zucchi I., Patrosso C., Milanesi L., Montagna C., Vezzoni P.
      Genomics 34:323-327(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-143, TISSUE SPECIFICITY.
      Tissue: Liver.
    4. "A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved."
      Alpen B., Guere A.O., Scanlan M.J., Old L.J., Chen Y.-T.
      Gene 297:141-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME."
      Costessi A., Mahrour N., Sharma V., Stunnenberg R., Stoel M.A., Tijchon E., Conaway J.W., Conaway R.C., Stunnenberg H.G.
      PLoS ONE 7:E42822-E42822(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE EKC/KEOPS COMPLEX, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiLAGE3_HUMAN
    AccessioniPrimary (citable) accession number: Q14657
    Secondary accession number(s): Q5HY39, Q8IZ78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3