Q14657 (LAGE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L antigen family member 3

Alternative name(s):
Protein ESO-3
Protein ITBA2

Gene names

Name:	LAGE3
Synonyms:	DXS9879E, ESO3, ITBA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Ubiquitous. Ref.3 Ref.4
Sequence similarities	Belongs to the CTAG family.
Sequence caution	The sequence CAA63489.1 differs from that shown. Reason: Frameshift at position 54.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	L antigen family member 3		PRO_0000218924

Sequences

	Sequence		Length	Mass (Da)
	Q14657 [UniParc]. Last modified October 11, 2004. Version 2. Checksum: AD164559371449F8	FASTA	143	14,804
	10 20 30 40 50 60 MRDADADAGG GADGGDGRGG HSCRGGVDTA AAPAGGAPPA HAPGPGRDAA SAARGSRMRP 70 80 90 100 110 120 HIFTLSVPFP TPLEAEIAHG SLAPDAEPHQ RVVGKDLTVS GRILVVRWKA EDCRLLRISV 130 140 INFLDQLSLV VRTMQRFGPP VSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood and Pancreas.
[3]	"Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach." Faranda S., Frattini A., Zucchi I., Patrosso C., Milanesi L., Montagna C., Vezzoni P. Genomics 34:323-327(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-143, TISSUE SPECIFICITY. Tissue: Liver.
[4]	"A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved." Alpen B., Guere A.O., Scanlan M.J., Old L.J., Chen Y.-T. Gene 297:141-149(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX936365 Genomic DNA. Translation: CAI43195.1. BC015744 mRNA. Translation: AAH15744.2. BC062330 mRNA. Translation: AAH62330.1. X92896 mRNA. Translation: CAA63489.1. Frameshift.
IPI	IPI00032314.
RefSeq	NP_006005.2. NM_006014.3.
UniGene	Hs.444619.
3D structure databases
ProteinModelPortal	Q14657.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14657. 3 interactions.
MINT	MINT-4719865.
STRING	9606.ENSP00000349923.
PTM databases
PhosphoSite	Q14657.
Polymorphism databases
DMDM	54041570.
Proteomic databases
PaxDb	Q14657.
PeptideAtlas	Q14657.
PRIDE	Q14657.
Protocols and materials databases
DNASU	8270.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357360; ENSP00000349923; ENSG00000196976.
GeneID	8270.
KEGG	hsa:8270.
UCSC	uc004fln.1. human.
Organism-specific databases
CTD	8270.
GeneCards	GC0XM153707.
HGNC	HGNC:26058. LAGE3.
HPA	HPA036123.
MIM	300060. gene.
neXtProt	NX_Q14657.
PharmGKB	PA128394540.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40896.
HOGENOM	HOG000040003.
HOVERGEN	HBG052154.
InParanoid	Q14657.
KO	K15902.
OMA	GMRPHIF.
Gene expression databases
ArrayExpress	Q14657.
Bgee	Q14657.
CleanEx	HS_LAGE3.
Genevestigator	Q14657.
GermOnline	ENSG00000196976. Homo sapiens.
Family and domain databases
InterPro	IPR015419. EKC/KEOPS_Pcc1. [Graphical view]
Pfam	PF09341. Pcc1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8270.
NextBio	31037.
PMAP-CutDB	Q14657.
SOURCE	Search...

Entry information

Entry name

LAGE3_HUMAN

Accession

Primary (citable) accession number: Q14657
Secondary accession number(s): Q5HY39, Q8IZ78

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 11, 2004
Last modified:	May 29, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.