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Protein

EKC/KEOPS complex subunit LAGE3

Gene

LAGE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
EKC/KEOPS complex subunit LAGE3
Alternative name(s):
L antigen family member 3
Protein ESO-3
Protein ITBA2
Gene namesi
Name:LAGE3
Synonyms:DXS9879E, ESO3, ITBA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000196976.6.
HGNCiHGNC:26058. LAGE3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196976.
PharmGKBiPA128394540.

Polymorphism and mutation databases

DMDMi54041570.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189241 – 143EKC/KEOPS complex subunit LAGE3Add BLAST143

Proteomic databases

EPDiQ14657.
MaxQBiQ14657.
PaxDbiQ14657.
PeptideAtlasiQ14657.
PRIDEiQ14657.

PTM databases

iPTMnetiQ14657.
PhosphoSitePlusiQ14657.

Miscellaneous databases

PMAP-CutDBiQ14657.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiENSG00000196976.
CleanExiHS_LAGE3.
GenevisibleiQ14657. HS.

Organism-specific databases

HPAiHPA036122.
HPA036123.

Interactioni

Subunit structurei

Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113888. 68 interactors.
IntActiQ14657. 25 interactors.
MINTiMINT-4719865.
STRINGi9606.ENSP00000349923.

Structurei

3D structure databases

ProteinModelPortaliQ14657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTAG/PCC1 family.Curated

Phylogenomic databases

eggNOGiENOG410J4BY. Eukaryota.
ENOG410Y0JU. LUCA.
GeneTreeiENSGT00410000025802.
HOGENOMiHOG000040003.
HOVERGENiHBG052154.
InParanoidiQ14657.
KOiK15902.
OMAiRPHIFTL.
OrthoDBiEOG091G0LGL.
PhylomeDBiQ14657.
TreeFamiTF337064.

Family and domain databases

InterProiView protein in InterPro
IPR015419. CTAG/Pcc1.
PfamiView protein in Pfam
PF09341. Pcc1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDADADAGG GADGGDGRGG HSCRGGVDTA AAPAGGAPPA HAPGPGRDAA
60 70 80 90 100
SAARGSRMRP HIFTLSVPFP TPLEAEIAHG SLAPDAEPHQ RVVGKDLTVS
110 120 130 140
GRILVVRWKA EDCRLLRISV INFLDQLSLV VRTMQRFGPP VSR
Length:143
Mass (Da):14,804
Last modified:October 11, 2004 - v2
Checksum:iAD164559371449F8
GO

Sequence cautioni

The sequence CAA63489 differs from that shown. Reason: Frameshift at position 54.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936365 Genomic DNA. No translation available.
BC015744 mRNA. Translation: AAH15744.2.
BC062330 mRNA. Translation: AAH62330.1.
X92896 mRNA. Translation: CAA63489.1. Frameshift.
CCDSiCCDS14753.1.
RefSeqiNP_006005.2. NM_006014.4.
UniGeneiHs.444619.

Genome annotation databases

EnsembliENST00000357360; ENSP00000349923; ENSG00000196976.
GeneIDi8270.
KEGGihsa:8270.
UCSCiuc033fbs.1. human.

Similar proteinsi

Entry informationi

Entry nameiLAGE3_HUMAN
AccessioniPrimary (citable) accession number: Q14657
Secondary accession number(s): Q5HY39, Q8IZ78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2004
Last modified: October 25, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families