Reviewed, UniProtKB/Swiss-Prot Q14657 (LAGE3_HUMAN)

Names and origin

Protein names

Recommended name:
    L antigen family member 3
Alternative name(s):
    Protein ITBA2
    Protein ESO-3

Gene names

Name:	LAGE3
Synonyms:	DXS9879E, ESO3, ITBA2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Ubiquitous. Ref.3 Ref.4
Sequence similarities	Belongs to the CTAG family.
Sequence caution	The sequence CAA63489.1 differs from that shown. Reason: Frameshift at position 54.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
OSGEP	Q9NPF4	1	EBI-1052105,EBI-1056510

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	L antigen family member 3		PRO_0000218924

Sequences

	Sequence		Length	Mass (Da)
	Q14657-1 [UniParc]. Last modified October 11, 2004. Version 2. Checksum: AD164559371449F8	FASTA	143	14,804
	10 20 30 40 50 60 MRDADADAGG GADGGDGRGG HSCRGGVDTA AAPAGGAPPA HAPGPGRDAA SAARGSRMRP 70 80 90 100 110 120 HIFTLSVPFP TPLEAEIAHG SLAPDAEPHQ RVVGKDLTVS GRILVVRWKA EDCRLLRISV 130 140 INFLDQLSLV VRTMQRFGPP VSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood and Pancreas.
[3]	"Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach." Faranda S., Frattini A., Zucchi I., Patrosso C., Milanesi L., Montagna C., Vezzoni P. Genomics 34:323-327(1996) [PubMed: 8786131] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-143, TISSUE SPECIFICITY. Tissue: Liver.
[4]	"A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved." Alpen B., Guere A.O., Scanlan M.J., Old L.J., Chen Y.-T. Gene 297:141-149(2002) [PubMed: 12384295] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX936365 Genomic DNA. Translation: CAI43195.1. BC015744 mRNA. Translation: AAH15744.2. BC062330 mRNA. Translation: AAH62330.1. X92896 mRNA. Translation: CAA63489.1. Frameshift.
IPI	IPI00032314.
RefSeq	NP_006005.2.
UniGene	Hs.444619
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14657. 3 interactions.
STRING	Q14657.
Proteomic databases
PeptideAtlas	Q14657.
PRIDE	Q14657.
Genome annotation databases
Ensembl	ENST00000357360; ENSP00000349923; ENSG00000196976; Homo sapiens. [Genome view]
GeneID	8270.
KEGG	hsa:8270.
UCSC	uc004fln.1. human.
Organism-specific databases
CTD	8270.
GeneCards	GC0XM153359.
H-InvDB	HIX0028364.
HGNC	HGNC:26058. LAGE3.
MIM	300060. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q14657.
HOVERGEN	Q14657.
OMA	MRPHIFT
OrthoDB	EOG973S9V
Gene expression databases
ArrayExpress	Q14657.
Bgee	Q14657.
CleanEx	HS_LAGE3.
Genevestigator	Q14657.
GermOnline	ENSG00000196976. Homo sapiens.
Family and domain databases
InterPro	IPR015419. Pcc1. [Graphical view]
Pfam	PF09341. Pcc1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	31037.
PMAP-CutDB	Q14657.
SOURCE	Search...

Entry information

Entry name

LAGE3_HUMAN

Accession

Primary (citable) accession number: Q14657
Secondary accession number(s): Q5HY39, Q8IZ78

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 11, 2004
Last modified:	November 24, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.