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Protein

Transmembrane protein 187

Gene

TMEM187

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 187
Alternative name(s):
Protein ITBA1
Gene namesi
Name:TMEM187
Synonyms:CXorf12, DXS9878E, ITBA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13705. TMEM187.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16223HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406199.

Polymorphism and mutation databases

BioMutaiTMEM187.
DMDMi2498474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Transmembrane protein 187PRO_0000084262Add
BLAST

Proteomic databases

PaxDbiQ14656.
PRIDEiQ14656.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ14656.
CleanExiHS_TMEM187.
ExpressionAtlasiQ14656. baseline and differential.
GenevisibleiQ14656. HS.

Organism-specific databases

HPAiHPA038134.

Interactioni

Protein-protein interaction databases

MINTiMINT-4723905.
STRINGi9606.ENSP00000358999.

Structurei

3D structure databases

ProteinModelPortaliQ14656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II78. Eukaryota.
ENOG4111FSS. LUCA.
GeneTreeiENSGT00390000011272.
HOGENOMiHOG000037946.
HOVERGENiHBG107382.
InParanoidiQ14656.
OMAiCDVLQFH.
PhylomeDBiQ14656.
TreeFamiTF353833.

Family and domain databases

InterProiIPR028066. TMEM187.
[Graphical view]
PANTHERiPTHR15066. PTHR15066. 1 hit.
PfamiPF15100. TMEM187. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPEWGQAFV HVAVAGGLCA VAVFTGIFDS VSVQVGYEHY AEAPVAGLPA
60 70 80 90 100
FLAMPFNSLV NMAYTLLGLS WLHRGGAMGL GPRYLKDVFA AMALLYGPVQ
110 120 130 140 150
WLRLWTQWRR AAVLDQWLTL PIFAWPVAWC LYLDRGWRPW LFLSLECVSL
160 170 180 190 200
ASYGLALLHP QGFEVALGAH VVAAVGQALR THRHYGSTTS ATYLALGVLS
210 220 230 240 250
CLGFVVLKLC DHQLARWRLF QCLTGHFWSK VCDVLQFHFA FLFLTHFNTH
260
PRFHPSGGKT R
Length:261
Mass (Da):29,148
Last modified:November 1, 1997 - v1
Checksum:i736265D26A32C380
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371Y → C in CAG33328 (Ref. 2) Curated
Sequence conflicti131 – 1311L → F in CAG33328 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701S → L.
Corresponds to variant rs2266890 [ dbSNP | Ensembl ].
VAR_051431
Natural varianti78 – 781M → V.
Corresponds to variant rs7350355 [ dbSNP | Ensembl ].
VAR_051432
Natural varianti138 – 1381R → Q.
Corresponds to variant rs36085378 [ dbSNP | Ensembl ].
VAR_051433

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92475 mRNA. Translation: CAA63213.1.
AK314938 mRNA. Translation: BAG37444.1.
CH471172 Genomic DNA. Translation: EAW72766.1.
BC008203 mRNA. Translation: AAH08203.1.
BC017026 mRNA. Translation: AAH17026.1.
CR457047 mRNA. Translation: CAG33328.1.
CCDSiCCDS14739.1.
RefSeqiNP_003483.1. NM_003492.2.
XP_011529501.1. XM_011531199.1.
UniGeneiHs.23119.

Genome annotation databases

EnsembliENST00000369982; ENSP00000358999; ENSG00000177854.
GeneIDi8269.
KEGGihsa:8269.
UCSCiuc004fjq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92475 mRNA. Translation: CAA63213.1.
AK314938 mRNA. Translation: BAG37444.1.
CH471172 Genomic DNA. Translation: EAW72766.1.
BC008203 mRNA. Translation: AAH08203.1.
BC017026 mRNA. Translation: AAH17026.1.
CR457047 mRNA. Translation: CAG33328.1.
CCDSiCCDS14739.1.
RefSeqiNP_003483.1. NM_003492.2.
XP_011529501.1. XM_011531199.1.
UniGeneiHs.23119.

3D structure databases

ProteinModelPortaliQ14656.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4723905.
STRINGi9606.ENSP00000358999.

Polymorphism and mutation databases

BioMutaiTMEM187.
DMDMi2498474.

Proteomic databases

PaxDbiQ14656.
PRIDEiQ14656.

Protocols and materials databases

DNASUi8269.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369982; ENSP00000358999; ENSG00000177854.
GeneIDi8269.
KEGGihsa:8269.
UCSCiuc004fjq.3. human.

Organism-specific databases

CTDi8269.
GeneCardsiTMEM187.
HGNCiHGNC:13705. TMEM187.
HPAiHPA038134.
MIMi300059. gene.
neXtProtiNX_Q14656.
PharmGKBiPA162406199.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II78. Eukaryota.
ENOG4111FSS. LUCA.
GeneTreeiENSGT00390000011272.
HOGENOMiHOG000037946.
HOVERGENiHBG107382.
InParanoidiQ14656.
OMAiCDVLQFH.
PhylomeDBiQ14656.
TreeFamiTF353833.

Miscellaneous databases

GenomeRNAii8269.
PROiQ14656.
SOURCEiSearch...

Gene expression databases

BgeeiQ14656.
CleanExiHS_TMEM187.
ExpressionAtlasiQ14656. baseline and differential.
GenevisibleiQ14656. HS.

Family and domain databases

InterProiIPR028066. TMEM187.
[Graphical view]
PANTHERiPTHR15066. PTHR15066. 1 hit.
PfamiPF15100. TMEM187. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach."
    Faranda S., Frattini A., Zucchi I., Patrosso C., Milanesi L., Montagna C., Vezzoni P.
    Genomics 34:323-327(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Eye.

Entry informationi

Entry nameiTM187_HUMAN
AccessioniPrimary (citable) accession number: Q14656
Secondary accession number(s): B2RC47, Q6IAV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.