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Protein

Transmembrane protein 187

Gene

TMEM187

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 187
Alternative name(s):
Protein ITBA1
Gene namesi
Name:TMEM187
Synonyms:CXorf12, DXS9878E, ITBA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000177854.7
HGNCiHGNC:13705 TMEM187
MIMi300059 gene
neXtProtiNX_Q14656

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei140 – 162HelicalSequence analysisAdd BLAST23
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8269
OpenTargetsiENSG00000177854
PharmGKBiPA162406199

Polymorphism and mutation databases

BioMutaiTMEM187
DMDMi2498474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842621 – 261Transmembrane protein 187Add BLAST261

Proteomic databases

PaxDbiQ14656
PRIDEiQ14656

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000177854
CleanExiHS_TMEM187
ExpressionAtlasiQ14656 baseline and differential
GenevisibleiQ14656 HS

Organism-specific databases

HPAiHPA038134

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SPAG4Q9NPE64EBI-13046724,EBI-10819434

Protein-protein interaction databases

IntActiQ14656, 1 interactor
STRINGi9606.ENSP00000358999

Structurei

3D structure databases

ProteinModelPortaliQ14656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II78 Eukaryota
ENOG4111FSS LUCA
GeneTreeiENSGT00390000011272
HOGENOMiHOG000037946
HOVERGENiHBG107382
InParanoidiQ14656
OMAiCDVLQFH
OrthoDBiEOG091G0G6I
PhylomeDBiQ14656
TreeFamiTF353833

Family and domain databases

InterProiView protein in InterPro
IPR028066 TMEM187
PANTHERiPTHR15066 PTHR15066, 1 hit
PfamiView protein in Pfam
PF15100 TMEM187, 1 hit

Sequencei

Sequence statusi: Complete.

Q14656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPEWGQAFV HVAVAGGLCA VAVFTGIFDS VSVQVGYEHY AEAPVAGLPA
60 70 80 90 100
FLAMPFNSLV NMAYTLLGLS WLHRGGAMGL GPRYLKDVFA AMALLYGPVQ
110 120 130 140 150
WLRLWTQWRR AAVLDQWLTL PIFAWPVAWC LYLDRGWRPW LFLSLECVSL
160 170 180 190 200
ASYGLALLHP QGFEVALGAH VVAAVGQALR THRHYGSTTS ATYLALGVLS
210 220 230 240 250
CLGFVVLKLC DHQLARWRLF QCLTGHFWSK VCDVLQFHFA FLFLTHFNTH
260
PRFHPSGGKT R
Length:261
Mass (Da):29,148
Last modified:November 1, 1997 - v1
Checksum:i736265D26A32C380
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Y → C in CAG33328 (Ref. 2) Curated1
Sequence conflicti131L → F in CAG33328 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05143170S → L. Corresponds to variant dbSNP:rs2266890Ensembl.1
Natural variantiVAR_05143278M → V. Corresponds to variant dbSNP:rs7350355Ensembl.1
Natural variantiVAR_051433138R → Q. Corresponds to variant dbSNP:rs36085378Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92475 mRNA Translation: CAA63213.1
AK314938 mRNA Translation: BAG37444.1
CH471172 Genomic DNA Translation: EAW72766.1
BC008203 mRNA Translation: AAH08203.1
BC017026 mRNA Translation: AAH17026.1
CR457047 mRNA Translation: CAG33328.1
CCDSiCCDS14739.1
RefSeqiNP_003483.1, NM_003492.2
XP_011529501.1, XM_011531199.2
UniGeneiHs.23119

Genome annotation databases

EnsembliENST00000369982; ENSP00000358999; ENSG00000177854
GeneIDi8269
KEGGihsa:8269
UCSCiuc004fjq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM187_HUMAN
AccessioniPrimary (citable) accession number: Q14656
Secondary accession number(s): B2RC47, Q6IAV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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