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Protein

Plastin-1

Gene

PLS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-bundling protein in the absence of calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi64 – 752PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • calcium ion binding Source: InterPro
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-1
Alternative name(s):
Intestine-specific plastin
Short name:
I-plastin
Gene namesi
Name:PLS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000120756.12
HGNCiHGNC:9090 PLS1
MIMi602734 gene
neXtProtiNX_Q14651

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5357
OpenTargetsiENSG00000120756
PharmGKBiPA33417

Polymorphism and mutation databases

BioMutaiPLS1
DMDMi224471848

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737501 – 629Plastin-1Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei9PhosphoserineBy similarity1
Modified residuei30PhosphotyrosineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei90N6-acetyllysineBy similarity1
Modified residuei267PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei296N6-acetyllysineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei362N6-acetyllysineBy similarity1
Modified residuei407PhosphoserineBy similarity1
Modified residuei473N6-acetyllysineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei543N6-acetyllysineBy similarity1
Modified residuei580N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14651
MaxQBiQ14651
PaxDbiQ14651
PeptideAtlasiQ14651
PRIDEiQ14651

PTM databases

iPTMnetiQ14651
PhosphoSitePlusiQ14651

Expressioni

Tissue specificityi

In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach.1 Publication

Gene expression databases

BgeeiENSG00000120756
CleanExiHS_PLS1
ExpressionAtlasiQ14651 baseline and differential
GenevisibleiQ14651 HS

Organism-specific databases

HPAiHPA055744

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111371, 59 interactors
IntActiQ14651, 7 interactors
MINTiQ14651
STRINGi9606.ENSP00000336831

Structurei

3D structure databases

ProteinModelPortaliQ14651
SMRiQ14651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini122 – 238Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST117
Domaini266 – 376Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST111
Domaini395 – 504Calponin-homology (CH) 3PROSITE-ProRule annotationAdd BLAST110
Domaini516 – 625Calponin-homology (CH) 4PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 380Actin-binding 1Add BLAST273
Regioni381 – 625Actin-binding 2Add BLAST245

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00390000005691
HOGENOMiHOG000213447
HOVERGENiHBG003082
InParanoidiQ14651
KOiK17275
OMAiKPDNNDI
OrthoDBiEOG091G03YP
PhylomeDBiQ14651
TreeFamiTF300680

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR030235 PLS1
PANTHERiPTHR19961:SF27 PTHR19961:SF27, 1 hit
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q14651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSTTTISR EELEELQEAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY
60 70 80 90 100
KVREIVEKIL SVADSNKDGK ISFEEFVSLM QELKSKDISK TFRKIINKRE
110 120 130 140 150
GITAIGGTST ISSEGTQHSY SEEEKVAFVN WINKALENDP DCKHLIPMNP
160 170 180 190 200
NDDSLFKSLA DGILLCKMIN LSEPDTIDER AINKKKLTPF TISENLNLAL
210 220 230 240 250
NSASAIGCTV VNIGASDLKE GKPHLVLGLL WQIIKVGLFA DIEISRNEAL
260 270 280 290 300
IALLNEGEEL EELMKLSPEE LLLRWVNYHL TNAGWHTISN FSQDIKDSRA
310 320 330 340 350
YFHLLNQIAP KGGEDGPAIA IDLSGINETN DLKRAGLMLQ EADKLGCKQF
360 370 380 390 400
VTPADVVSGN PKLNLAFVAN LFNTYPCLHK PNNNDIDMNL LEGESKEERT
410 420 430 440 450
FRNWMNSLGV NPYINHLYSD LADALVIFQL YEMIRVPVNW SHVNKPPYPA
460 470 480 490 500
LGGNMKKIEN CNYAVELGKN KAKFSLVGIA GQDLNEGNST LTLALVWQLM
510 520 530 540 550
RRYTLNVLSD LGEGEKVNDE IIIKWVNQTL KSANKKTSIS SFKDKSISTS
560 570 580 590 600
LPVLDLIDAI APNAVRQEMI RRENLSDEDK LNNAKYAISV ARKIGARIYA
610 620
LPDDLVEVKP KMVMTVFACL MGKGLNRIK
Length:629
Mass (Da):70,253
Last modified:March 3, 2009 - v2
Checksum:iF904031933C2C323
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317P → L in BAF83005 (PubMed:14702039).Curated1
Sequence conflicti441S → R in AAH31083 (PubMed:15489334).Curated1
Sequence conflicti487G → R in AAA19869 (PubMed:8139549).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048660146I → M. Corresponds to variant dbSNP:rs35710125Ensembl.1
Natural variantiVAR_048661216S → L. Corresponds to variant dbSNP:rs35435507Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20826 mRNA Translation: AAA19869.1
AK290316 mRNA Translation: BAF83005.1
CH471052 Genomic DNA Translation: EAW78965.1
CH471052 Genomic DNA Translation: EAW78967.1
BC031083 mRNA Translation: AAH31083.1
CCDSiCCDS3125.1
PIRiA56536
RefSeqiNP_001138791.1, NM_001145319.1
NP_001165783.1, NM_001172312.1
NP_002661.2, NM_002670.2
XP_006713723.1, XM_006713660.3
XP_011511202.1, XM_011512900.2
XP_011511203.1, XM_011512901.1
XP_011511205.1, XM_011512903.2
XP_016862115.1, XM_017006626.1
XP_016862116.1, XM_017006627.1
UniGeneiHs.203637

Genome annotation databases

EnsembliENST00000337777; ENSP00000336831; ENSG00000120756
ENST00000457734; ENSP00000387890; ENSG00000120756
ENST00000497002; ENSP00000418700; ENSG00000120756
GeneIDi5357
KEGGihsa:5357
UCSCiuc003euz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPLSI_HUMAN
AccessioniPrimary (citable) accession number: Q14651
Secondary accession number(s): A8K2Q1, D3DNG3, Q8NEG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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