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Protein

Plastin-1

Gene

PLS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actin-bundling protein in the absence of calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi64 – 752PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin filament binding Source: ProtInc
  • calcium ion binding Source: InterPro
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120756-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-1
Alternative name(s):
Intestine-specific plastin
Short name:
I-plastin
Gene namesi
Name:PLS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9090. PLS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5357.
OpenTargetsiENSG00000120756.
PharmGKBiPA33417.

Polymorphism and mutation databases

BioMutaiPLS1.
DMDMi224471848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737501 – 629Plastin-1Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei9PhosphoserineBy similarity1
Modified residuei30PhosphotyrosineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei90N6-acetyllysineBy similarity1
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei267PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei296N6-acetyllysineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei362N6-acetyllysineBy similarity1
Modified residuei407PhosphoserineBy similarity1
Modified residuei473N6-acetyllysineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei543N6-acetyllysineBy similarity1
Modified residuei580N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ14651.
MaxQBiQ14651.
PaxDbiQ14651.
PeptideAtlasiQ14651.
PRIDEiQ14651.

PTM databases

iPTMnetiQ14651.
PhosphoSitePlusiQ14651.

Expressioni

Tissue specificityi

In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach.1 Publication

Gene expression databases

BgeeiENSG00000120756.
CleanExiHS_PLS1.
ExpressionAtlasiQ14651. baseline and differential.
GenevisibleiQ14651. HS.

Organism-specific databases

HPAiHPA055744.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

  • actin filament binding Source: ProtInc

Protein-protein interaction databases

BioGridi111371. 45 interactors.
IntActiQ14651. 4 interactors.
MINTiMINT-3029920.
STRINGi9606.ENSP00000336831.

Structurei

3D structure databases

ProteinModelPortaliQ14651.
SMRiQ14651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini108 – 380Actin-binding 1Add BLAST273
Domaini122 – 238CH 1PROSITE-ProRule annotationAdd BLAST117
Domaini266 – 376CH 2PROSITE-ProRule annotationAdd BLAST111
Domaini381 – 625Actin-binding 2Add BLAST245
Domaini395 – 504CH 3PROSITE-ProRule annotationAdd BLAST110
Domaini516 – 625CH 4PROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Contains 2 actin-binding domains.Curated
Contains 4 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiQ14651.
KOiK17275.
OMAiKREDLSY.
OrthoDBiEOG091G03YP.
PhylomeDBiQ14651.
TreeFamiTF300680.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
[Graphical view]
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSTTTISR EELEELQEAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY
60 70 80 90 100
KVREIVEKIL SVADSNKDGK ISFEEFVSLM QELKSKDISK TFRKIINKRE
110 120 130 140 150
GITAIGGTST ISSEGTQHSY SEEEKVAFVN WINKALENDP DCKHLIPMNP
160 170 180 190 200
NDDSLFKSLA DGILLCKMIN LSEPDTIDER AINKKKLTPF TISENLNLAL
210 220 230 240 250
NSASAIGCTV VNIGASDLKE GKPHLVLGLL WQIIKVGLFA DIEISRNEAL
260 270 280 290 300
IALLNEGEEL EELMKLSPEE LLLRWVNYHL TNAGWHTISN FSQDIKDSRA
310 320 330 340 350
YFHLLNQIAP KGGEDGPAIA IDLSGINETN DLKRAGLMLQ EADKLGCKQF
360 370 380 390 400
VTPADVVSGN PKLNLAFVAN LFNTYPCLHK PNNNDIDMNL LEGESKEERT
410 420 430 440 450
FRNWMNSLGV NPYINHLYSD LADALVIFQL YEMIRVPVNW SHVNKPPYPA
460 470 480 490 500
LGGNMKKIEN CNYAVELGKN KAKFSLVGIA GQDLNEGNST LTLALVWQLM
510 520 530 540 550
RRYTLNVLSD LGEGEKVNDE IIIKWVNQTL KSANKKTSIS SFKDKSISTS
560 570 580 590 600
LPVLDLIDAI APNAVRQEMI RRENLSDEDK LNNAKYAISV ARKIGARIYA
610 620
LPDDLVEVKP KMVMTVFACL MGKGLNRIK
Length:629
Mass (Da):70,253
Last modified:March 3, 2009 - v2
Checksum:iF904031933C2C323
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317P → L in BAF83005 (PubMed:14702039).Curated1
Sequence conflicti441S → R in AAH31083 (PubMed:15489334).Curated1
Sequence conflicti487G → R in AAA19869 (PubMed:8139549).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048660146I → M.Corresponds to variant rs35710125dbSNPEnsembl.1
Natural variantiVAR_048661216S → L.Corresponds to variant rs35435507dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20826 mRNA. Translation: AAA19869.1.
AK290316 mRNA. Translation: BAF83005.1.
CH471052 Genomic DNA. Translation: EAW78965.1.
CH471052 Genomic DNA. Translation: EAW78967.1.
BC031083 mRNA. Translation: AAH31083.1.
CCDSiCCDS3125.1.
PIRiA56536.
RefSeqiNP_001138791.1. NM_001145319.1.
NP_001165783.1. NM_001172312.1.
NP_002661.2. NM_002670.2.
XP_006713723.1. XM_006713660.3.
XP_011511202.1. XM_011512900.2.
XP_011511203.1. XM_011512901.1.
XP_011511205.1. XM_011512903.2.
XP_016862115.1. XM_017006626.1.
XP_016862116.1. XM_017006627.1.
UniGeneiHs.203637.

Genome annotation databases

EnsembliENST00000337777; ENSP00000336831; ENSG00000120756.
ENST00000457734; ENSP00000387890; ENSG00000120756.
ENST00000497002; ENSP00000418700; ENSG00000120756.
GeneIDi5357.
KEGGihsa:5357.
UCSCiuc003euz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20826 mRNA. Translation: AAA19869.1.
AK290316 mRNA. Translation: BAF83005.1.
CH471052 Genomic DNA. Translation: EAW78965.1.
CH471052 Genomic DNA. Translation: EAW78967.1.
BC031083 mRNA. Translation: AAH31083.1.
CCDSiCCDS3125.1.
PIRiA56536.
RefSeqiNP_001138791.1. NM_001145319.1.
NP_001165783.1. NM_001172312.1.
NP_002661.2. NM_002670.2.
XP_006713723.1. XM_006713660.3.
XP_011511202.1. XM_011512900.2.
XP_011511203.1. XM_011512901.1.
XP_011511205.1. XM_011512903.2.
XP_016862115.1. XM_017006626.1.
XP_016862116.1. XM_017006627.1.
UniGeneiHs.203637.

3D structure databases

ProteinModelPortaliQ14651.
SMRiQ14651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111371. 45 interactors.
IntActiQ14651. 4 interactors.
MINTiMINT-3029920.
STRINGi9606.ENSP00000336831.

PTM databases

iPTMnetiQ14651.
PhosphoSitePlusiQ14651.

Polymorphism and mutation databases

BioMutaiPLS1.
DMDMi224471848.

Proteomic databases

EPDiQ14651.
MaxQBiQ14651.
PaxDbiQ14651.
PeptideAtlasiQ14651.
PRIDEiQ14651.

Protocols and materials databases

DNASUi5357.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337777; ENSP00000336831; ENSG00000120756.
ENST00000457734; ENSP00000387890; ENSG00000120756.
ENST00000497002; ENSP00000418700; ENSG00000120756.
GeneIDi5357.
KEGGihsa:5357.
UCSCiuc003euz.4. human.

Organism-specific databases

CTDi5357.
DisGeNETi5357.
GeneCardsiPLS1.
H-InvDBHIX0003743.
HGNCiHGNC:9090. PLS1.
HPAiHPA055744.
MIMi602734. gene.
neXtProtiNX_Q14651.
OpenTargetsiENSG00000120756.
PharmGKBiPA33417.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiQ14651.
KOiK17275.
OMAiKREDLSY.
OrthoDBiEOG091G03YP.
PhylomeDBiQ14651.
TreeFamiTF300680.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120756-MONOMER.

Miscellaneous databases

GenomeRNAii5357.
PROiQ14651.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120756.
CleanExiHS_PLS1.
ExpressionAtlasiQ14651. baseline and differential.
GenevisibleiQ14651. HS.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
[Graphical view]
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLSI_HUMAN
AccessioniPrimary (citable) accession number: Q14651
Secondary accession number(s): A8K2Q1, D3DNG3, Q8NEG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.