Q14643 (ITPR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 1,4,5-trisphosphate receptor type 1

Alternative name(s):
IP3 receptor isoform 1
Short name=IP3R 1
Short name=InsP3R1
Type 1 inositol 1,4,5-trisphosphate receptor
Short name=Type 1 InsP3 receptor

Gene names

Name:	ITPR1
Synonyms:	INSP3R1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2758 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways By similarity.
Subunit structure	Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with AHCYL1 By similarity. Interacts with MRVI1 and CABP1 (via N-terminus). Ref.7 Ref.8 Ref.9 Ref.11
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity	Widely expressed.
Domain	The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Post-translational modification	Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels By similarity. Ref.2 Phosphorylated on tyrosine residues. Ref.2 Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked By similarity.
Involvement in disease	Spinocerebellar ataxia 15 (SCA15) [MIM:606658]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12
Miscellaneous	Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.
Sequence similarities	Belongs to the InsP3 receptor family. Contains 5 MIR domains.
Caution	Alternative splice sites (AA 1053-1054) represent a non-canonical GA-AG donor-acceptor pair, but are well-supported by all available human transcripts, and by homologous transcripts in mouse, rat and cow.

Ontologies

Keywords
Biological process	Apoptosis Calcium transport Ion transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Neurodegeneration Spinocerebellar ataxia
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Ligand-gated ion channel Receptor
PTM	Glycoprotein Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase C activity Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome epidermal growth factor receptor signaling pathway Traceable author statement. Source: Reactome fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Inferred from sequence or structural similarity. Source: UniProtKB nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome platelet activation Traceable author statement. Source: Reactome regulation of insulin secretion Traceable author statement. Source: Reactome release of sequestered calcium ion into cytosol Inferred from sequence or structural similarity. Source: UniProtKB response to hypoxia Inferred from direct assay PubMed 19120137. Source: BHF-UCL small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW platelet dense granule membrane Inferred from direct assay PubMed 10828023. Source: BHF-UCL platelet dense tubular network membrane Traceable author statement. Source: Reactome
Molecular_function	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Inferred from sequence or structural similarity. Source: UniProtKB intracellular ligand-gated calcium channel activity Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: There is a combination of three alternatively spliced domains at site SI, SIII and site SII (A and C). Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q14643-1)

Also known as: SISIIISIIAC;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14643-2)

Also known as: SI-SIIISIIAC;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.

Isoform 3 (identifier: Q14643-3)

Also known as: SISIII-SII;

The sequence of this isoform differs from the canonical sequence as follows:
     919-927: Missing.
     1702-1725: Missing.
     1726-1740: Missing.

Isoform 4 (identifier: Q14643-4)

Also known as: SI-SIII-SII;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     919-927: Missing.
     1702-1725: Missing.
     1726-1740: Missing.

Isoform 5 (identifier: Q14643-5)

Also known as: SI-SIII-SIIAC;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     919-927: Missing.

Isoform 6 (identifier: Q14643-6)

Also known as: SISIIISIIA;

The sequence of this isoform differs from the canonical sequence as follows:
     1726-1740: Missing.

Isoform 7 (identifier: Q14643-7)

Also known as: SI-SIII-SIIA;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     1726-1740: Missing.

Isoform 8 (identifier: Q14643-8)

Also known as: SI-SIII-SIIA;

The sequence of this isoform differs from the canonical sequence as follows:
     322-336: Missing.
     919-927: Missing.
     1726-1740: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2758	2758	Inositol 1,4,5-trisphosphate receptor type 1		PRO_0000153920
Regions
	Topological domain	1 – 2282	2282	Cytoplasmic Potential
	Transmembrane	2283 – 2303	21	Helical; Potential
	Topological domain	2304 – 2314	11	Lumenal Potential
	Transmembrane	2315 – 2335	21	Helical; Potential
	Topological domain	2336 – 2361	26	Cytoplasmic Potential
	Transmembrane	2362 – 2382	21	Helical; Potential
	Topological domain	2383 – 2405	23	Lumenal Potential
	Transmembrane	2406 – 2426	21	Helical; Potential
	Topological domain	2427 – 2448	22	Cytoplasmic Potential
	Transmembrane	2449 – 2469	21	Helical; Potential
	Topological domain	2470 – 2577	108	Lumenal Potential
	Transmembrane	2578 – 2598	21	Helical; Potential
	Topological domain	2599 – 2758	160	Cytoplasmic Potential
	Domain	112 – 166	55	MIR 1
	Domain	173 – 223	51	MIR 2
	Domain	231 – 287	57	MIR 3
	Domain	294 – 373	80	MIR 4
	Domain	379 – 435	57	MIR 5
	Region	265 – 269	5	Inositol 1,4,5-trisphosphate binding By similarity
	Region	508 – 511	4	Inositol 1,4,5-trisphosphate binding By similarity
	Region	567 – 569	3	Inositol 1,4,5-trisphosphate binding By similarity
	Region	2472 – 2537	66	Interaction with ERP44 By similarity
Amino acid modifications
	Modified residue	482	1	Phosphotyrosine Potential
	Modified residue	1598	1	Phosphoserine Ref.10 Ref.13 Ref.15
	Modified residue	1764	1	Phosphoserine Ref.13
	Modified residue	2664	1	Phosphotyrosine Potential
	Glycosylation	2512	1	N-linked (GlcNAc...) Ref.14
	Cross-link	917		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	972		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	1581		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	1780		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	1893		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	1894		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	1895		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	1910		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	1933		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	2127		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	2266		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Natural variations
	Alternative sequence	322 – 336	15	Missing in isoform 2, isoform 4, isoform 5, isoform 7 and isoform 8.		VSP_002687
	Alternative sequence	919 – 927	9	Missing in isoform 3, isoform 4, isoform 5 and isoform 8.		VSP_002688
	Alternative sequence	1702 – 1725	24	Missing in isoform 3 and isoform 4.		VSP_002689
	Alternative sequence	1726 – 1740	15	Missing in isoform 3, isoform 4, isoform 6, isoform 7 and isoform 8.		VSP_002690
	Natural variant	769	1	M → V. Corresponds to variant rs35789999 [ dbSNP | Ensembl ].		VAR_037005
	Natural variant	1430	1	I → V. Corresponds to variant rs3749383 [ dbSNP | Ensembl ].		VAR_037006
Experimental info
	Sequence conflict	1557 – 1581	25	AIAIP…SIVQK → HCHSRGPGQPSQQPLSQVPQ HCAE in AAD14386. Ref.6
	Sequence conflict	1722	1	S → A in U23850. Ref.4
	Sequence conflict	2302	1	F → L in AAB04947. Ref.2
	Sequence conflict	2305	1	F → L in AAB04947. Ref.2
	Sequence conflict	2448	1	S → A in U23850. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SISIIISIIAC) [UniParc]. Last modified November 2, 2001. Version 2. Checksum: 751AE722539530E3	FASTA	2,758	313,945
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 370 380 390 400 410 420 GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 430 440 450 460 470 480 SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 490 500 510 520 530 540 VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 550 560 570 580 590 600 LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 610 620 630 640 650 660 NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 670 680 690 700 710 720 NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF WRDSNKEIRS KSVRELAQDA 730 740 750 760 770 780 KEGQKEDRDV LSYYRYQLNL FARMCLDRQY LAINEISGQL DVDLILRCMS DENLPYDLRA 790 800 810 820 830 840 SFCRLMLHMH VDRDPQEQVT PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF 850 860 870 880 890 900 VEEYLRDVVC QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 910 920 930 940 950 960 VTTIFPISKM AKGEENKGNN DVEKLKSSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA 970 980 990 1000 1010 1020 PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQTSE 1030 1040 1050 1060 1070 1080 TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH 1090 1100 1110 1120 1130 1140 DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE 1150 1160 1170 1180 1190 1200 LWVYKGQGPD ETMDGASGEN EHKKTEEGNN KPQKHESTSS YNYRVVKEIL IRLSKLCVQE 1210 1220 1230 1240 1250 1260 SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ 1270 1280 1290 1300 1310 1320 NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK 1330 1340 1350 1360 1370 1380 FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP 1390 1400 1410 1420 1430 1440 LMYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY 1450 1460 1470 1480 1490 1500 VDTEVEMKEI YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF 1510 1520 1530 1540 1550 1560 SSPFSDQSTT LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI 1570 1580 1590 1600 1610 1620 PVDLDSQVNN LFLKSHSIVQ KTAMNWRLSA RNAARRDSVL AASRDYRNII ERLQDIVSAL 1630 1640 1650 1660 1670 1680 EDRLRPLVQA ELSVLVDVLH RPELLFPENT DARRKCESGG FICKLIKHTK QLLEENEEKL 1690 1700 1710 1720 1730 1740 CIKVLQTLRE MMTKDRGYGE KLISIDELDN AELPPAPDSE NSTEELEPSP PLRQLEDHKR 1750 1760 1770 1780 1790 1800 GEALRQVLVN RYYGNVRPSG RRESLTSFGN GPLSAGGPGK PGGGGGGSGS SSMSRGEMSL 1810 1820 1830 1840 1850 1860 AEVQCHLDKE GASNLVIDLI MNASSDRVFH ESILLAIALL EGGNTTIQHS FFCRLTEDKK 1870 1880 1890 1900 1910 1920 SEKFFKVFYD RMKVAQQEIK ATVTVNTSDL GNKKKDDEVD RDAPSRKKAK EPTTQITEEV 1930 1940 1950 1960 1970 1980 RDQLLEASAA TRKAFTTFRR EADPDDHYQP GEGTQATADK AKDDLEMSAV ITIMQPILRF 1990 2000 2010 2020 2030 2040 LQLLCENHNR DLQNFLRCQN NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINEKNVAL 2050 2060 2070 2080 2090 2100 INQTLESLTE YCQGPCHENQ NCIATHESNG IDIITALILN DINPLGKKRM DLVLELKNNA 2110 2120 2130 2140 2150 2160 SKLLLAIMES RHDSENAERI LYNMRPKELV EVIKKAYMQG EVEFEDGENG EDGAASPRNV 2170 2180 2190 2200 2210 2220 GHNIYILAHQ LARHNKELQS MLKPGGQVDG DEALEFYAKH TAQIEIVRLD RTMEQIVFPV 2230 2240 2250 2260 2270 2280 PSICEFLTKE SKLRIYYTTE RDEQGSKIND FFLRSEDLFN EMNWQKKLRA QPVLYWCARN 2290 2300 2310 2320 2330 2340 MSFWSSISFN LAVLMNLLVA FFYPFKGVRG GTLEPHWSGL LWTAMLISLA IVIALPKPHG 2350 2360 2370 2380 2390 2400 IRALIASTIL RLIFSVGLQP TLFLLGAFNV CNKIIFLMSF VGNCGTFTRG YRAMVLDVEF 2410 2420 2430 2440 2450 2460 LYHLLYLVIC AMGLFVHEFF YSLLLFDLVY REETLLNVIK SVTRNGRSII LTAVLALILV 2470 2480 2490 2500 2510 2520 YLFSIVGYLF FKDDFILEVD RLPNETAVPE TGESLASEFL FSDVCRVESG ENCSSPAPRE 2530 2540 2550 2560 2570 2580 ELVPAEETEQ DKEHTCETLL MCIVTVLSHG LRSGGGVGDV LRKPSKEEPL FAARVIYDLL 2590 2600 2610 2620 2630 2640 FFFMVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVTFEEHI 2650 2660 2670 2680 2690 2700 KEEHNMWHYL CFIVLVKVKD STEYTGPESY VAEMIKERNL DWFPRMRAMS LVSSDSEGEQ 2710 2720 2730 2740 2750 NELRNLQEKL ESTMKLVTNL SGQLSELKDQ MTEQRKQKQR IGLLGHPPHM NVNPQQPA
	Isoform 2 (SI-SIIISIIAC) [UniParc]. Checksum: 772B8DEC8259C0AF	FASTA	2,743	312,179
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE LAQDAKEGQK EDRDVLSYYR 730 740 750 760 770 780 YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP YDLRASFCRL MLHMHVDRDP 790 800 810 820 830 840 QEQVTPVKYA RLWSEIPSEI AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF 850 860 870 880 890 900 SDKEKNKLTF EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 910 920 930 940 950 960 NKGNNDVEKL KSSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV KQAEPEKEDI 970 980 990 1000 1010 1020 MVMDTKLKII EILQFILNVR LDYRISCLLC IFKREFDESN SQTSETSSGN SSQEGPSNVP 1030 1040 1050 1060 1070 1080 GALDFEHIEE QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR 1090 1100 1110 1120 1130 1140 HFSQRQEVLQ AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDETMDG 1150 1160 1170 1180 1190 1200 ASGENEHKKT EEGNNKPQKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL 1210 1220 1230 1240 1250 1260 RNMGAHAVVL ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL HKHINLFLNP 1270 1280 1290 1300 1310 1320 GILEAVTMQH IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK 1330 1340 1350 1360 1370 1380 CQDMVMAELV NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLMYHI HLVELLAVCT 1390 1400 1410 1420 1430 1440 EGKNVYTEIK CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH 1450 1460 1470 1480 1490 1500 MWKLFENFLV DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ 1510 1520 1530 1540 1550 1560 PVFVQLLQGV FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD SQVNNLFLKS 1570 1580 1590 1600 1610 1620 HSIVQKTAMN WRLSARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR PLVQAELSVL 1630 1640 1650 1660 1670 1680 VDVLHRPELL FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL QTLREMMTKD 1690 1700 1710 1720 1730 1740 RGYGEKLISI DELDNAELPP APDSENSTEE LEPSPPLRQL EDHKRGEALR QVLVNRYYGN 1750 1760 1770 1780 1790 1800 VRPSGRRESL TSFGNGPLSA GGPGKPGGGG GGSGSSSMSR GEMSLAEVQC HLDKEGASNL 1810 1820 1830 1840 1850 1860 VIDLIMNASS DRVFHESILL AIALLEGGNT TIQHSFFCRL TEDKKSEKFF KVFYDRMKVA 1870 1880 1890 1900 1910 1920 QQEIKATVTV NTSDLGNKKK DDEVDRDAPS RKKAKEPTTQ ITEEVRDQLL EASAATRKAF 1930 1940 1950 1960 1970 1980 TTFRREADPD DHYQPGEGTQ ATADKAKDDL EMSAVITIMQ PILRFLQLLC ENHNRDLQNF 1990 2000 2010 2020 2030 2040 LRCQNNKTNY NLVCETLQFL DCICGSTTGG LGLLGLYINE KNVALINQTL ESLTEYCQGP 2050 2060 2070 2080 2090 2100 CHENQNCIAT HESNGIDIIT ALILNDINPL GKKRMDLVLE LKNNASKLLL AIMESRHDSE 2110 2120 2130 2140 2150 2160 NAERILYNMR PKELVEVIKK AYMQGEVEFE DGENGEDGAA SPRNVGHNIY ILAHQLARHN 2170 2180 2190 2200 2210 2220 KELQSMLKPG GQVDGDEALE FYAKHTAQIE IVRLDRTMEQ IVFPVPSICE FLTKESKLRI 2230 2240 2250 2260 2270 2280 YYTTERDEQG SKINDFFLRS EDLFNEMNWQ KKLRAQPVLY WCARNMSFWS SISFNLAVLM 2290 2300 2310 2320 2330 2340 NLLVAFFYPF KGVRGGTLEP HWSGLLWTAM LISLAIVIAL PKPHGIRALI ASTILRLIFS 2350 2360 2370 2380 2390 2400 VGLQPTLFLL GAFNVCNKII FLMSFVGNCG TFTRGYRAMV LDVEFLYHLL YLVICAMGLF 2410 2420 2430 2440 2450 2460 VHEFFYSLLL FDLVYREETL LNVIKSVTRN GRSIILTAVL ALILVYLFSI VGYLFFKDDF 2470 2480 2490 2500 2510 2520 ILEVDRLPNE TAVPETGESL ASEFLFSDVC RVESGENCSS PAPREELVPA EETEQDKEHT 2530 2540 2550 2560 2570 2580 CETLLMCIVT VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV IIIVLNLIFG 2590 2600 2610 2620 2630 2640 VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKEEHN MWHYLCFIVL 2650 2660 2670 2680 2690 2700 VKVKDSTEYT GPESYVAEMI KERNLDWFPR MRAMSLVSSD SEGEQNELRN LQEKLESTMK 2710 2720 2730 2740 LVTNLSGQLS ELKDQMTEQR KQKQRIGLLG HPPHMNVNPQ QPA
	Isoform 3 (SISIII-SII) [UniParc]. Checksum: C24313548F4DCBFC	FASTA	2,710	308,539
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 370 380 390 400 410 420 GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 430 440 450 460 470 480 SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 490 500 510 520 530 540 VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 550 560 570 580 590 600 LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 610 620 630 640 650 660 NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 670 680 690 700 710 720 NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF WRDSNKEIRS KSVRELAQDA 730 740 750 760 770 780 KEGQKEDRDV LSYYRYQLNL FARMCLDRQY LAINEISGQL DVDLILRCMS DENLPYDLRA 790 800 810 820 830 840 SFCRLMLHMH VDRDPQEQVT PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF 850 860 870 880 890 900 VEEYLRDVVC QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 910 920 930 940 950 960 VTTIFPISKM AKGEENKGSN VMRSIHGVGE LMTQVVLRGG GFLPMTPMAA APEGNVKQAE 970 980 990 1000 1010 1020 PEKEDIMVMD TKLKIIEILQ FILNVRLDYR ISCLLCIFKR EFDESNSQTS ETSSGNSSQE 1030 1040 1050 1060 1070 1080 GPSNVPGALD FEHIEEQAEG IFGGSEENTP LDLDDHGGRT FLRVLLHLTM HDYPPLVSGA 1090 1100 1110 1120 1130 1140 LQLLFRHFSQ RQEVLQAFKQ VQLLVTSQDV DNYKQIKQDL DQLRSIVEKS ELWVYKGQGP 1150 1160 1170 1180 1190 1200 DETMDGASGE NEHKKTEEGN NKPQKHESTS SYNYRVVKEI LIRLSKLCVQ ESASVRKSRK 1210 1220 1230 1240 1250 1260 QQQRLLRNMG AHAVVLELLQ IPYEKAEDTK MQEIMRLAHE FLQNFCAGNQ QNQALLHKHI 1270 1280 1290 1300 1310 1320 NLFLNPGILE AVTMQHIFMN NFQLCSEINE RVVQHFVHCI ETHGRNVQYI KFLQTIVKAE 1330 1340 1350 1360 1370 1380 GKFIKKCQDM VMAELVNSGE DVLVFYNDRA SFQTLIQMMR SERDRMDENS PLMYHIHLVE 1390 1400 1410 1420 1430 1440 LLAVCTEGKN VYTEIKCNSL LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE 1450 1460 1470 1480 1490 1500 IYTSNHMWKL FENFLVDICR ACNNTSDRKH ADSILEKYVT EIVMSIVTTF FSSPFSDQST 1510 1520 1530 1540 1550 1560 TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA IPVDLDSQVN 1570 1580 1590 1600 1610 1620 NLFLKSHSIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI IERLQDIVSA LEDRLRPLVQ 1630 1640 1650 1660 1670 1680 AELSVLVDVL HRPELLFPEN TDARRKCESG GFICKLIKHT KQLLEENEEK LCIKVLQTLR 1690 1700 1710 1720 1730 1740 EMMTKDRGYG EKGEALRQVL VNRYYGNVRP SGRRESLTSF GNGPLSAGGP GKPGGGGGGS 1750 1760 1770 1780 1790 1800 GSSSMSRGEM SLAEVQCHLD KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ 1810 1820 1830 1840 1850 1860 HSFFCRLTED KKSEKFFKVF YDRMKVAQQE IKATVTVNTS DLGNKKKDDE VDRDAPSRKK 1870 1880 1890 1900 1910 1920 AKEPTTQITE EVRDQLLEAS AATRKAFTTF RREADPDDHY QPGEGTQATA DKAKDDLEMS 1930 1940 1950 1960 1970 1980 AVITIMQPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV CETLQFLDCI CGSTTGGLGL 1990 2000 2010 2020 2030 2040 LGLYINEKNV ALINQTLESL TEYCQGPCHE NQNCIATHES NGIDIITALI LNDINPLGKK 2050 2060 2070 2080 2090 2100 RMDLVLELKN NASKLLLAIM ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE 2110 2120 2130 2140 2150 2160 NGEDGAASPR NVGHNIYILA HQLARHNKEL QSMLKPGGQV DGDEALEFYA KHTAQIEIVR 2170 2180 2190 2200 2210 2220 LDRTMEQIVF PVPSICEFLT KESKLRIYYT TERDEQGSKI NDFFLRSEDL FNEMNWQKKL 2230 2240 2250 2260 2270 2280 RAQPVLYWCA RNMSFWSSIS FNLAVLMNLL VAFFYPFKGV RGGTLEPHWS GLLWTAMLIS 2290 2300 2310 2320 2330 2340 LAIVIALPKP HGIRALIAST ILRLIFSVGL QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT 2350 2360 2370 2380 2390 2400 RGYRAMVLDV EFLYHLLYLV ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRS 2410 2420 2430 2440 2450 2460 IILTAVLALI LVYLFSIVGY LFFKDDFILE VDRLPNETAV PETGESLASE FLFSDVCRVE 2470 2480 2490 2500 2510 2520 SGENCSSPAP REELVPAEET EQDKEHTCET LLMCIVTVLS HGLRSGGGVG DVLRKPSKEE 2530 2540 2550 2560 2570 2580 PLFAARVIYD LLFFFMVIII VLNLIFGVII DTFADLRSEK QKKEEILKTT CFICGLERDK 2590 2600 2610 2620 2630 2640 FDNKTVTFEE HIKEEHNMWH YLCFIVLVKV KDSTEYTGPE SYVAEMIKER NLDWFPRMRA 2650 2660 2670 2680 2690 2700 MSLVSSDSEG EQNELRNLQE KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP 2710 HMNVNPQQPA
	Isoform 4 (SI-SIII-SII) [UniParc]. Checksum: 92B35C092276D178	FASTA	2,695	306,773
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE LAQDAKEGQK EDRDVLSYYR 730 740 750 760 770 780 YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP YDLRASFCRL MLHMHVDRDP 790 800 810 820 830 840 QEQVTPVKYA RLWSEIPSEI AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF 850 860 870 880 890 900 SDKEKNKLTF EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 910 920 930 940 950 960 NKGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAAPEGN VKQAEPEKED IMVMDTKLKI 970 980 990 1000 1010 1020 IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG NSSQEGPSNV PGALDFEHIE 1030 1040 1050 1060 1070 1080 EQAEGIFGGS EENTPLDLDD HGGRTFLRVL LHLTMHDYPP LVSGALQLLF RHFSQRQEVL 1090 1100 1110 1120 1130 1140 QAFKQVQLLV TSQDVDNYKQ IKQDLDQLRS IVEKSELWVY KGQGPDETMD GASGENEHKK 1150 1160 1170 1180 1190 1200 TEEGNNKPQK HESTSSYNYR VVKEILIRLS KLCVQESASV RKSRKQQQRL LRNMGAHAVV 1210 1220 1230 1240 1250 1260 LELLQIPYEK AEDTKMQEIM RLAHEFLQNF CAGNQQNQAL LHKHINLFLN PGILEAVTMQ 1270 1280 1290 1300 1310 1320 HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT IVKAEGKFIK KCQDMVMAEL 1330 1340 1350 1360 1370 1380 VNSGEDVLVF YNDRASFQTL IQMMRSERDR MDENSPLMYH IHLVELLAVC TEGKNVYTEI 1390 1400 1410 1420 1430 1440 KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL 1450 1460 1470 1480 1490 1500 VDICRACNNT SDRKHADSIL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 1510 1520 1530 1540 1550 1560 VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK SHSIVQKTAM 1570 1580 1590 1600 1610 1620 NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV LVDVLHRPEL 1630 1640 1650 1660 1670 1680 LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK DRGYGEKGEA 1690 1700 1710 1720 1730 1740 LRQVLVNRYY GNVRPSGRRE SLTSFGNGPL SAGGPGKPGG GGGGSGSSSM SRGEMSLAEV 1750 1760 1770 1780 1790 1800 QCHLDKEGAS NLVIDLIMNA SSDRVFHESI LLAIALLEGG NTTIQHSFFC RLTEDKKSEK 1810 1820 1830 1840 1850 1860 FFKVFYDRMK VAQQEIKATV TVNTSDLGNK KKDDEVDRDA PSRKKAKEPT TQITEEVRDQ 1870 1880 1890 1900 1910 1920 LLEASAATRK AFTTFRREAD PDDHYQPGEG TQATADKAKD DLEMSAVITI MQPILRFLQL 1930 1940 1950 1960 1970 1980 LCENHNRDLQ NFLRCQNNKT NYNLVCETLQ FLDCICGSTT GGLGLLGLYI NEKNVALINQ 1990 2000 2010 2020 2030 2040 TLESLTEYCQ GPCHENQNCI ATHESNGIDI ITALILNDIN PLGKKRMDLV LELKNNASKL 2050 2060 2070 2080 2090 2100 LLAIMESRHD SENAERILYN MRPKELVEVI KKAYMQGEVE FEDGENGEDG AASPRNVGHN 2110 2120 2130 2140 2150 2160 IYILAHQLAR HNKELQSMLK PGGQVDGDEA LEFYAKHTAQ IEIVRLDRTM EQIVFPVPSI 2170 2180 2190 2200 2210 2220 CEFLTKESKL RIYYTTERDE QGSKINDFFL RSEDLFNEMN WQKKLRAQPV LYWCARNMSF 2230 2240 2250 2260 2270 2280 WSSISFNLAV LMNLLVAFFY PFKGVRGGTL EPHWSGLLWT AMLISLAIVI ALPKPHGIRA 2290 2300 2310 2320 2330 2340 LIASTILRLI FSVGLQPTLF LLGAFNVCNK IIFLMSFVGN CGTFTRGYRA MVLDVEFLYH 2350 2360 2370 2380 2390 2400 LLYLVICAMG LFVHEFFYSL LLFDLVYREE TLLNVIKSVT RNGRSIILTA VLALILVYLF 2410 2420 2430 2440 2450 2460 SIVGYLFFKD DFILEVDRLP NETAVPETGE SLASEFLFSD VCRVESGENC SSPAPREELV 2470 2480 2490 2500 2510 2520 PAEETEQDKE HTCETLLMCI VTVLSHGLRS GGGVGDVLRK PSKEEPLFAA RVIYDLLFFF 2530 2540 2550 2560 2570 2580 MVIIIVLNLI FGVIIDTFAD LRSEKQKKEE ILKTTCFICG LERDKFDNKT VTFEEHIKEE 2590 2600 2610 2620 2630 2640 HNMWHYLCFI VLVKVKDSTE YTGPESYVAE MIKERNLDWF PRMRAMSLVS SDSEGEQNEL 2650 2660 2670 2680 2690 RNLQEKLEST MKLVTNLSGQ LSELKDQMTE QRKQKQRIGL LGHPPHMNVN PQQPA
	Isoform 5 (SI-SIII-SIIAC) [UniParc]. Checksum: FAF0AD36939472A7	FASTA	2,734	311,151
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE LAQDAKEGQK EDRDVLSYYR 730 740 750 760 770 780 YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP YDLRASFCRL MLHMHVDRDP 790 800 810 820 830 840 QEQVTPVKYA RLWSEIPSEI AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF 850 860 870 880 890 900 SDKEKNKLTF EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 910 920 930 940 950 960 NKGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAAPEGN VKQAEPEKED IMVMDTKLKI 970 980 990 1000 1010 1020 IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG NSSQEGPSNV PGALDFEHIE 1030 1040 1050 1060 1070 1080 EQAEGIFGGS EENTPLDLDD HGGRTFLRVL LHLTMHDYPP LVSGALQLLF RHFSQRQEVL 1090 1100 1110 1120 1130 1140 QAFKQVQLLV TSQDVDNYKQ IKQDLDQLRS IVEKSELWVY KGQGPDETMD GASGENEHKK 1150 1160 1170 1180 1190 1200 TEEGNNKPQK HESTSSYNYR VVKEILIRLS KLCVQESASV RKSRKQQQRL LRNMGAHAVV 1210 1220 1230 1240 1250 1260 LELLQIPYEK AEDTKMQEIM RLAHEFLQNF CAGNQQNQAL LHKHINLFLN PGILEAVTMQ 1270 1280 1290 1300 1310 1320 HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT IVKAEGKFIK KCQDMVMAEL 1330 1340 1350 1360 1370 1380 VNSGEDVLVF YNDRASFQTL IQMMRSERDR MDENSPLMYH IHLVELLAVC TEGKNVYTEI 1390 1400 1410 1420 1430 1440 KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL 1450 1460 1470 1480 1490 1500 VDICRACNNT SDRKHADSIL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 1510 1520 1530 1540 1550 1560 VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK SHSIVQKTAM 1570 1580 1590 1600 1610 1620 NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV LVDVLHRPEL 1630 1640 1650 1660 1670 1680 LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK DRGYGEKLIS 1690 1700 1710 1720 1730 1740 IDELDNAELP PAPDSENSTE ELEPSPPLRQ LEDHKRGEAL RQVLVNRYYG NVRPSGRRES 1750 1760 1770 1780 1790 1800 LTSFGNGPLS AGGPGKPGGG GGGSGSSSMS RGEMSLAEVQ CHLDKEGASN LVIDLIMNAS 1810 1820 1830 1840 1850 1860 SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF FKVFYDRMKV AQQEIKATVT 1870 1880 1890 1900 1910 1920 VNTSDLGNKK KDDEVDRDAP SRKKAKEPTT QITEEVRDQL LEASAATRKA FTTFRREADP 1930 1940 1950 1960 1970 1980 DDHYQPGEGT QATADKAKDD LEMSAVITIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN 1990 2000 2010 2020 2030 2040 YNLVCETLQF LDCICGSTTG GLGLLGLYIN EKNVALINQT LESLTEYCQG PCHENQNCIA 2050 2060 2070 2080 2090 2100 THESNGIDII TALILNDINP LGKKRMDLVL ELKNNASKLL LAIMESRHDS ENAERILYNM 2110 2120 2130 2140 2150 2160 RPKELVEVIK KAYMQGEVEF EDGENGEDGA ASPRNVGHNI YILAHQLARH NKELQSMLKP 2170 2180 2190 2200 2210 2220 GGQVDGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC EFLTKESKLR IYYTTERDEQ 2230 2240 2250 2260 2270 2280 GSKINDFFLR SEDLFNEMNW QKKLRAQPVL YWCARNMSFW SSISFNLAVL MNLLVAFFYP 2290 2300 2310 2320 2330 2340 FKGVRGGTLE PHWSGLLWTA MLISLAIVIA LPKPHGIRAL IASTILRLIF SVGLQPTLFL 2350 2360 2370 2380 2390 2400 LGAFNVCNKI IFLMSFVGNC GTFTRGYRAM VLDVEFLYHL LYLVICAMGL FVHEFFYSLL 2410 2420 2430 2440 2450 2460 LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS IVGYLFFKDD FILEVDRLPN 2470 2480 2490 2500 2510 2520 ETAVPETGES LASEFLFSDV CRVESGENCS SPAPREELVP AEETEQDKEH TCETLLMCIV 2530 2540 2550 2560 2570 2580 TVLSHGLRSG GGVGDVLRKP SKEEPLFAAR VIYDLLFFFM VIIIVLNLIF GVIIDTFADL 2590 2600 2610 2620 2630 2640 RSEKQKKEEI LKTTCFICGL ERDKFDNKTV TFEEHIKEEH NMWHYLCFIV LVKVKDSTEY 2650 2660 2670 2680 2690 2700 TGPESYVAEM IKERNLDWFP RMRAMSLVSS DSEGEQNELR NLQEKLESTM KLVTNLSGQL 2710 2720 2730 SELKDQMTEQ RKQKQRIGLL GHPPHMNVNP QQPA
	Isoform 6 (SISIIISIIA) [UniParc]. Checksum: BD6539A4EFF21E7E	FASTA	2,743	312,148
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 370 380 390 400 410 420 GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 430 440 450 460 470 480 SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 490 500 510 520 530 540 VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 550 560 570 580 590 600 LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 610 620 630 640 650 660 NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 670 680 690 700 710 720 NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF WRDSNKEIRS KSVRELAQDA 730 740 750 760 770 780 KEGQKEDRDV LSYYRYQLNL FARMCLDRQY LAINEISGQL DVDLILRCMS DENLPYDLRA 790 800 810 820 830 840 SFCRLMLHMH VDRDPQEQVT PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF 850 860 870 880 890 900 VEEYLRDVVC QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 910 920 930 940 950 960 VTTIFPISKM AKGEENKGNN DVEKLKSSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA 970 980 990 1000 1010 1020 PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQTSE 1030 1040 1050 1060 1070 1080 TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH 1090 1100 1110 1120 1130 1140 DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE 1150 1160 1170 1180 1190 1200 LWVYKGQGPD ETMDGASGEN EHKKTEEGNN KPQKHESTSS YNYRVVKEIL IRLSKLCVQE 1210 1220 1230 1240 1250 1260 SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ 1270 1280 1290 1300 1310 1320 NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK 1330 1340 1350 1360 1370 1380 FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP 1390 1400 1410 1420 1430 1440 LMYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY 1450 1460 1470 1480 1490 1500 VDTEVEMKEI YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF 1510 1520 1530 1540 1550 1560 SSPFSDQSTT LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI 1570 1580 1590 1600 1610 1620 PVDLDSQVNN LFLKSHSIVQ KTAMNWRLSA RNAARRDSVL AASRDYRNII ERLQDIVSAL 1630 1640 1650 1660 1670 1680 EDRLRPLVQA ELSVLVDVLH RPELLFPENT DARRKCESGG FICKLIKHTK QLLEENEEKL 1690 1700 1710 1720 1730 1740 CIKVLQTLRE MMTKDRGYGE KLISIDELDN AELPPAPDSE NSTEEGEALR QVLVNRYYGN 1750 1760 1770 1780 1790 1800 VRPSGRRESL TSFGNGPLSA GGPGKPGGGG GGSGSSSMSR GEMSLAEVQC HLDKEGASNL 1810 1820 1830 1840 1850 1860 VIDLIMNASS DRVFHESILL AIALLEGGNT TIQHSFFCRL TEDKKSEKFF KVFYDRMKVA 1870 1880 1890 1900 1910 1920 QQEIKATVTV NTSDLGNKKK DDEVDRDAPS RKKAKEPTTQ ITEEVRDQLL EASAATRKAF 1930 1940 1950 1960 1970 1980 TTFRREADPD DHYQPGEGTQ ATADKAKDDL EMSAVITIMQ PILRFLQLLC ENHNRDLQNF 1990 2000 2010 2020 2030 2040 LRCQNNKTNY NLVCETLQFL DCICGSTTGG LGLLGLYINE KNVALINQTL ESLTEYCQGP 2050 2060 2070 2080 2090 2100 CHENQNCIAT HESNGIDIIT ALILNDINPL GKKRMDLVLE LKNNASKLLL AIMESRHDSE 2110 2120 2130 2140 2150 2160 NAERILYNMR PKELVEVIKK AYMQGEVEFE DGENGEDGAA SPRNVGHNIY ILAHQLARHN 2170 2180 2190 2200 2210 2220 KELQSMLKPG GQVDGDEALE FYAKHTAQIE IVRLDRTMEQ IVFPVPSICE FLTKESKLRI 2230 2240 2250 2260 2270 2280 YYTTERDEQG SKINDFFLRS EDLFNEMNWQ KKLRAQPVLY WCARNMSFWS SISFNLAVLM 2290 2300 2310 2320 2330 2340 NLLVAFFYPF KGVRGGTLEP HWSGLLWTAM LISLAIVIAL PKPHGIRALI ASTILRLIFS 2350 2360 2370 2380 2390 2400 VGLQPTLFLL GAFNVCNKII FLMSFVGNCG TFTRGYRAMV LDVEFLYHLL YLVICAMGLF 2410 2420 2430 2440 2450 2460 VHEFFYSLLL FDLVYREETL LNVIKSVTRN GRSIILTAVL ALILVYLFSI VGYLFFKDDF 2470 2480 2490 2500 2510 2520 ILEVDRLPNE TAVPETGESL ASEFLFSDVC RVESGENCSS PAPREELVPA EETEQDKEHT 2530 2540 2550 2560 2570 2580 CETLLMCIVT VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV IIIVLNLIFG 2590 2600 2610 2620 2630 2640 VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKEEHN MWHYLCFIVL 2650 2660 2670 2680 2690 2700 VKVKDSTEYT GPESYVAEMI KERNLDWFPR MRAMSLVSSD SEGEQNELRN LQEKLESTMK 2710 2720 2730 2740 LVTNLSGQLS ELKDQMTEQR KQKQRIGLLG HPPHMNVNPQ QPA
	Isoform 7 (SI-SIII-SIIA) [UniParc]. Checksum: 560A1170B33F71AB	FASTA	2,728	310,382
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE LAQDAKEGQK EDRDVLSYYR 730 740 750 760 770 780 YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP YDLRASFCRL MLHMHVDRDP 790 800 810 820 830 840 QEQVTPVKYA RLWSEIPSEI AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF 850 860 870 880 890 900 SDKEKNKLTF EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 910 920 930 940 950 960 NKGNNDVEKL KSSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV KQAEPEKEDI 970 980 990 1000 1010 1020 MVMDTKLKII EILQFILNVR LDYRISCLLC IFKREFDESN SQTSETSSGN SSQEGPSNVP 1030 1040 1050 1060 1070 1080 GALDFEHIEE QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR 1090 1100 1110 1120 1130 1140 HFSQRQEVLQ AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDETMDG 1150 1160 1170 1180 1190 1200 ASGENEHKKT EEGNNKPQKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL 1210 1220 1230 1240 1250 1260 RNMGAHAVVL ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL HKHINLFLNP 1270 1280 1290 1300 1310 1320 GILEAVTMQH IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK 1330 1340 1350 1360 1370 1380 CQDMVMAELV NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLMYHI HLVELLAVCT 1390 1400 1410 1420 1430 1440 EGKNVYTEIK CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH 1450 1460 1470 1480 1490 1500 MWKLFENFLV DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ 1510 1520 1530 1540 1550 1560 PVFVQLLQGV FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD SQVNNLFLKS 1570 1580 1590 1600 1610 1620 HSIVQKTAMN WRLSARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR PLVQAELSVL 1630 1640 1650 1660 1670 1680 VDVLHRPELL FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL QTLREMMTKD 1690 1700 1710 1720 1730 1740 RGYGEKLISI DELDNAELPP APDSENSTEE GEALRQVLVN RYYGNVRPSG RRESLTSFGN 1750 1760 1770 1780 1790 1800 GPLSAGGPGK PGGGGGGSGS SSMSRGEMSL AEVQCHLDKE GASNLVIDLI MNASSDRVFH 1810 1820 1830 1840 1850 1860 ESILLAIALL EGGNTTIQHS FFCRLTEDKK SEKFFKVFYD RMKVAQQEIK ATVTVNTSDL 1870 1880 1890 1900 1910 1920 GNKKKDDEVD RDAPSRKKAK EPTTQITEEV RDQLLEASAA TRKAFTTFRR EADPDDHYQP 1930 1940 1950 1960 1970 1980 GEGTQATADK AKDDLEMSAV ITIMQPILRF LQLLCENHNR DLQNFLRCQN NKTNYNLVCE 1990 2000 2010 2020 2030 2040 TLQFLDCICG STTGGLGLLG LYINEKNVAL INQTLESLTE YCQGPCHENQ NCIATHESNG 2050 2060 2070 2080 2090 2100 IDIITALILN DINPLGKKRM DLVLELKNNA SKLLLAIMES RHDSENAERI LYNMRPKELV 2110 2120 2130 2140 2150 2160 EVIKKAYMQG EVEFEDGENG EDGAASPRNV GHNIYILAHQ LARHNKELQS MLKPGGQVDG 2170 2180 2190 2200 2210 2220 DEALEFYAKH TAQIEIVRLD RTMEQIVFPV PSICEFLTKE SKLRIYYTTE RDEQGSKIND 2230 2240 2250 2260 2270 2280 FFLRSEDLFN EMNWQKKLRA QPVLYWCARN MSFWSSISFN LAVLMNLLVA FFYPFKGVRG 2290 2300 2310 2320 2330 2340 GTLEPHWSGL LWTAMLISLA IVIALPKPHG IRALIASTIL RLIFSVGLQP TLFLLGAFNV 2350 2360 2370 2380 2390 2400 CNKIIFLMSF VGNCGTFTRG YRAMVLDVEF LYHLLYLVIC AMGLFVHEFF YSLLLFDLVY 2410 2420 2430 2440 2450 2460 REETLLNVIK SVTRNGRSII LTAVLALILV YLFSIVGYLF FKDDFILEVD RLPNETAVPE 2470 2480 2490 2500 2510 2520 TGESLASEFL FSDVCRVESG ENCSSPAPRE ELVPAEETEQ DKEHTCETLL MCIVTVLSHG 2530 2540 2550 2560 2570 2580 LRSGGGVGDV LRKPSKEEPL FAARVIYDLL FFFMVIIIVL NLIFGVIIDT FADLRSEKQK 2590 2600 2610 2620 2630 2640 KEEILKTTCF ICGLERDKFD NKTVTFEEHI KEEHNMWHYL CFIVLVKVKD STEYTGPESY 2650 2660 2670 2680 2690 2700 VAEMIKERNL DWFPRMRAMS LVSSDSEGEQ NELRNLQEKL ESTMKLVTNL SGQLSELKDQ 2710 2720 MTEQRKQKQR IGLLGHPPHM NVNPQQPA
	Isoform 8 (SI-SIII-SIIA) [UniParc]. Checksum: 623E22696396D934	FASTA	2,719	309,354
	10 20 30 40 50 60 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 70 80 90 100 110 120 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 130 140 150 160 170 180 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 190 200 210 220 230 240 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 310 320 330 340 350 360 SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL 370 380 390 400 410 420 RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV 430 440 450 460 470 480 SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL 490 500 510 520 530 540 EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL 550 560 570 580 590 600 CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 610 620 630 640 650 660 DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF 670 680 690 700 710 720 EFEGVSSTGE NALEAGEDEE EVWLFWRDSN KEIRSKSVRE LAQDAKEGQK EDRDVLSYYR 730 740 750 760 770 780 YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP YDLRASFCRL MLHMHVDRDP 790 800 810 820 830 840 QEQVTPVKYA RLWSEIPSEI AIDDYDSSGA SKDEIKERFA QTMEFVEEYL RDVVCQRFPF 850 860 870 880 890 900 SDKEKNKLTF EVVNLARNLI YFGFYNFSDL LRLTKILLAI LDCVHVTTIF PISKMAKGEE 910 920 930 940 950 960 NKGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAAPEGN VKQAEPEKED IMVMDTKLKI 970 980 990 1000 1010 1020 IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG NSSQEGPSNV PGALDFEHIE 1030 1040 1050 1060 1070 1080 EQAEGIFGGS EENTPLDLDD HGGRTFLRVL LHLTMHDYPP LVSGALQLLF RHFSQRQEVL 1090 1100 1110 1120 1130 1140 QAFKQVQLLV TSQDVDNYKQ IKQDLDQLRS IVEKSELWVY KGQGPDETMD GASGENEHKK 1150 1160 1170 1180 1190 1200 TEEGNNKPQK HESTSSYNYR VVKEILIRLS KLCVQESASV RKSRKQQQRL LRNMGAHAVV 1210 1220 1230 1240 1250 1260 LELLQIPYEK AEDTKMQEIM RLAHEFLQNF CAGNQQNQAL LHKHINLFLN PGILEAVTMQ 1270 1280 1290 1300 1310 1320 HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT IVKAEGKFIK KCQDMVMAEL 1330 1340 1350 1360 1370 1380 VNSGEDVLVF YNDRASFQTL IQMMRSERDR MDENSPLMYH IHLVELLAVC TEGKNVYTEI 1390 1400 1410 1420 1430 1440 KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL 1450 1460 1470 1480 1490 1500 VDICRACNNT SDRKHADSIL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG 1510 1520 1530 1540 1550 1560 VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK SHSIVQKTAM 1570 1580 1590 1600 1610 1620 NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV LVDVLHRPEL 1630 1640 1650 1660 1670 1680 LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK DRGYGEKLIS 1690 1700 1710 1720 1730 1740 IDELDNAELP PAPDSENSTE EGEALRQVLV NRYYGNVRPS GRRESLTSFG NGPLSAGGPG 1750 1760 1770 1780 1790 1800 KPGGGGGGSG SSSMSRGEMS LAEVQCHLDK EGASNLVIDL IMNASSDRVF HESILLAIAL 1810 1820 1830 1840 1850 1860 LEGGNTTIQH SFFCRLTEDK KSEKFFKVFY DRMKVAQQEI KATVTVNTSD LGNKKKDDEV 1870 1880 1890 1900 1910 1920 DRDAPSRKKA KEPTTQITEE VRDQLLEASA ATRKAFTTFR READPDDHYQ PGEGTQATAD 1930 1940 1950 1960 1970 1980 KAKDDLEMSA VITIMQPILR FLQLLCENHN RDLQNFLRCQ NNKTNYNLVC ETLQFLDCIC 1990 2000 2010 2020 2030 2040 GSTTGGLGLL GLYINEKNVA LINQTLESLT EYCQGPCHEN QNCIATHESN GIDIITALIL 2050 2060 2070 2080 2090 2100 NDINPLGKKR MDLVLELKNN ASKLLLAIME SRHDSENAER ILYNMRPKEL VEVIKKAYMQ 2110 2120 2130 2140 2150 2160 GEVEFEDGEN GEDGAASPRN VGHNIYILAH QLARHNKELQ SMLKPGGQVD GDEALEFYAK 2170 2180 2190 2200 2210 2220 HTAQIEIVRL DRTMEQIVFP VPSICEFLTK ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF 2230 2240 2250 2260 2270 2280 NEMNWQKKLR AQPVLYWCAR NMSFWSSISF NLAVLMNLLV AFFYPFKGVR GGTLEPHWSG 2290 2300 2310 2320 2330 2340 LLWTAMLISL AIVIALPKPH GIRALIASTI LRLIFSVGLQ PTLFLLGAFN VCNKIIFLMS 2350 2360 2370 2380 2390 2400 FVGNCGTFTR GYRAMVLDVE FLYHLLYLVI CAMGLFVHEF FYSLLLFDLV YREETLLNVI 2410 2420 2430 2440 2450 2460 KSVTRNGRSI ILTAVLALIL VYLFSIVGYL FFKDDFILEV DRLPNETAVP ETGESLASEF 2470 2480 2490 2500 2510 2520 LFSDVCRVES GENCSSPAPR EELVPAEETE QDKEHTCETL LMCIVTVLSH GLRSGGGVGD 2530 2540 2550 2560 2570 2580 VLRKPSKEEP LFAARVIYDL LFFFMVIIIV LNLIFGVIID TFADLRSEKQ KKEEILKTTC 2590 2600 2610 2620 2630 2640 FICGLERDKF DNKTVTFEEH IKEEHNMWHY LCFIVLVKVK DSTEYTGPES YVAEMIKERN 2650 2660 2670 2680 2690 2700 LDWFPRMRAM SLVSSDSEGE QNELRNLQEK LESTMKLVTN LSGQLSELKD QMTEQRKQKQ 2710 RIGLLGHPPH MNVNPQQPA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization." Yamada N., Makino Y., Clark R.A., Pearson D.W., Mattei M.-G., Guenet J.-L., Ohama E., Fujino I., Miyawaki A., Furuichi T., Mikoshiba K. Biochem. J. 302:781-790(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Myeloid and Uterus.
[2]	"The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation." Harnick D.J., Jayaraman T., Ma Y., Mulieri P., Go L.O., Marks A.R. J. Biol. Chem. 270:2833-2840(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), PHOSPHORYLATION. Tissue: T-cell.
[3]	Marks A. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 431; 1012-1017; 1460; 1823; 2324; 2330; 2334; 2337; 2346; 2358; 2361; 2372; 2396; 2418; 2426; 2434 AND 2741.
[4]	"Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant." Nucifora F.C. Jr., Li S.-H., Danoff S., Ullrich A., Ross C.A. Brain Res. Mol. Brain Res. 32:291-296(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING. Tissue: Brain.
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[6]	"Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation." Yan J., Khanna K.K., Lavin M.F. Int. J. Radiat. Biol. 69:539-546(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1548-1723 (ISOFORMS 3 AND 4).
[7]	"Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels." Yang J., McBride S., Mak D.-O.D., Vardi N., Palczewski K., Haeseleer F., Foskett J.K. Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CABP1.
[8]	"Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins." Kasri N.N., Holmes A.M., Bultynck G., Parys J.B., Bootman M.D., Rietdorf K., Missiaen L., McDonald F., De Smedt H., Conway S.J., Holmes A.B., Berridge M.J., Roderick H.L. EMBO J. 23:312-321(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CABP1.
[9]	"Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44." Higo T., Hattori M., Nakamura T., Natsume T., Michikawa T., Mikoshiba K. Cell 120:85-98(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ERP44.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1598, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation." Antl M., von Bruehl M.-L., Eiglsperger C., Werner M., Konrad I., Kocher T., Wilm M., Hofmann F., Massberg S., Schlossmann J. Blood 109:552-559(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MRVI1.
[12]	"Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans." van de Leemput J., Chandran J., Knight M.A., Holtzclaw L.A., Scholz S., Cookson M.R., Houlden H., Gwinn-Hardy K., Fung H.-C., Lin X., Hernandez D., Simon-Sanchez J., Wood N.W., Giunti P., Rafferty I., Hardy J., Storey E., Gardner R.J.M. , Forrest S.M., Fisher E.M.C., Russell J.T., Cai H., Singleton A.B. PLoS Genet. 3:1076-1082(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SCA15.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1598 AND SER-1764, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2512, MASS SPECTROMETRY. Tissue: Liver.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1598, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D26070 mRNA. Translation: BAA05065.1. L38019 mRNA. Translation: AAB04947.2. U23850 mRNA. No translation available. AC018816 Genomic DNA. No translation available. AC024168 Genomic DNA. No translation available. AC069248 Genomic DNA. No translation available. AC090944 Genomic DNA. No translation available. S82269 mRNA. Translation: AAD14386.1.
IPI	IPI00218658. IPI00218659. IPI00218660. IPI00218661. IPI00218662. IPI00218664. IPI00333753. IPI00925443.
PIR	A55713. S54974.
RefSeq	NP_001093422.2. NM_001099952.2. NP_002213.5. NM_002222.5.
UniGene	Hs.567295. Hs.715765.
3D structure databases
ProteinModelPortal	Q14643.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29714N.
IntAct	Q14643. 3 interactions.
STRING	9606.ENSP00000405934.
PTM databases
PhosphoSite	Q14643.
Polymorphism databases
DMDM	17366467.
Proteomic databases
PaxDb	Q14643.
PRIDE	Q14643.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357086; ENSP00000349597; ENSG00000150995. ENST00000456211; ENSP00000397885; ENSG00000150995.
GeneID	3708.
KEGG	hsa:3708.
UCSC	uc021wsi.1. human. uc021wsj.1. human.
Organism-specific databases
CTD	3708.
GeneCards	GC03P004486.
HGNC	HGNC:6180. ITPR1.
HPA	HPA014765. HPA016487.
MIM	147265. gene. 606658. phenotype.
neXtProt	NX_Q14643.
Orphanet	98769. Spinocerebellar ataxia type 15. 98770. Spinocerebellar ataxia type 16.
PharmGKB	PA29978.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG280601.
HOGENOM	HOG000007660.
HOVERGEN	HBG052158.
InParanoid	Q14643.
KO	K04958.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_116125. Disease. REACT_604. Hemostasis. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q14643.
Bgee	Q14643.
CleanEx	HS_ITPR1.
Genevestigator	Q14643.
GermOnline	ENSG00000150995. Homo sapiens.
Family and domain databases
InterPro	IPR000699. Ca-rel_channel. IPR014821. Ins145_P3_rcpt. IPR000493. InsP3_rcpt-bd. IPR005821. Ion_trans_dom. IPR016093. MIR_motif. IPR013662. RIH_assoc-dom. IPR015925. Ryanodine_recept-rel. [Graphical view]
PANTHER	PTHR13715. PTHR13715. 1 hit.
Pfam	PF08709. Ins145_P3_rec. 1 hit. PF00520. Ion_trans. 1 hit. PF02815. MIR. 1 hit. PF08454. RIH_assoc. 1 hit. PF01365. RYDR_ITPR. 2 hits. [Graphical view]
PRINTS	PR00779. INSP3RECEPTR.
SMART	SM00472. MIR. 4 hits. [Graphical view]
SUPFAM	SSF82109. MIR. 2 hits.
PROSITE	PS50919. MIR. 5 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q14643.
ChEMBL	CHEMBL4046.
ChiTaRS	ITPR1. human.
GenomeRNAi	3708.
NextBio	14533.
SOURCE	Search...

Entry information

Entry name

ITPR1_HUMAN

Accession

Primary (citable) accession number: Q14643
Secondary accession number(s): Q14660, Q99897

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	November 2, 2001
Last modified:	May 1, 2013
This is version 148 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.