Reviewed, UniProtKB/Swiss-Prot Q14642 (I5P1_HUMAN)

Names and origin

Protein names

Recommended name:
    Type I inositol-1,4,5-trisphosphate 5-phosphatase
      Short name=5PTase
    EC=3.1.3.56

Gene names

Name:

INPP5A

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
Catalytic activity	D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate. 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Subcellular location	Membrane; Lipid-anchor.
Tissue specificity	Brain; high level in Purkinje cells.
Sequence similarities	Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type I family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Molecular function	Hydrolase
PTM	Lipoprotein Prenylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell communication Non-traceable author statement. Source: UniProtKB
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	PH domain binding Inferred from physical interaction. Source: UniProtKB inositol-polyphosphate 5-phosphatase activity Ref.4 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	Type I inositol-1,4,5-trisphosphate 5-phosphatase		PRO_0000209719
Amino acid modifications
	Lipidation	409	1	S-farnesyl cysteine Potential
Natural variations
	Natural variant	45	1	K → R: dbSNP rs1133400.		VAR_034006
Experimental info
	Sequence conflict	152 – 172	21	PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500. Ref.4
	Sequence conflict	247 – 251	5	CTKAT → SAKPP in CAA83500. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q14642-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F55C0DFDDA01A850	FASTA	412	47,820
	10 20 30 40 50 60 MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN 70 80 90 100 110 120 YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH FTALGSFYFL HESLKNIYQF 130 140 150 160 170 180 DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFIRTR WCIADCAFDL 190 200 210 220 230 240 VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK 250 260 270 280 290 300 SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT 310 320 330 340 350 360 ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR ILMSPSAKEL 370 380 390 400 410 VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK PHAHVHKCCV VQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells." de Smedt F., Verjans B., Mailleux P., Erneux C. FEBS Lett. 347:69-72(1994) [PubMed: 8013665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase." Laxminarayan K.M., Chan B.K., Tetaz T., Bird P.I., Mitchell C.A. J. Biol. Chem. 269:17305-17310(1994) [PubMed: 8006039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-412. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X77567 mRNA. Translation: CAA54676.1. AL392043, AL356603, AL451069 Genomic DNA. Translation: CAI39945.1. AL451069, AL392043, AL356603 Genomic DNA. Translation: CAI14121.1. AL356603, AL451069, AL392043 Genomic DNA. Translation: CAI40942.1. BC096280 mRNA. Translation: AAH96280.1. Z31695 mRNA. Translation: CAA83500.1.
IPI	IPI00032262.
PIR	S45721.
RefSeq	NP_005530.3.
UniGene	Hs.523360 Hs.715308
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q14642.
PTM databases
PhosphoSite	Q14642.
Proteomic databases
PRIDE	Q14642.
Genome annotation databases
Ensembl	ENST00000368594; ENSP00000357583; ENSG00000068383; Homo sapiens. [Genome view]
GeneID	3632.
KEGG	hsa:3632.
UCSC	uc001llp.1. human.
Organism-specific databases
CTD	3632.
GeneCards	GC10P134201.
H-InvDB	HIX0035334.
HGNC	HGNC:6076. INPP5A.
HPA	HPA012285.
MIM	600106. gene.
PharmGKB	PA29884.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14931.
HOGENOM	HBG403108.
HOVERGEN	Q14642.
InParanoid	Q14642.
OMA	GRQYMNT.
OrthoDB	EOG9KSS46.
Enzyme and pathway databases
BioCyc	MetaCyc:ENSG00000068383-MONOMER.
BRENDA	3.1.3.56. 247.
Gene expression databases
ArrayExpress	Q14642.
Bgee	Q14642.
CleanEx	HS_INPP5A.
Genevestigator	Q14642.
GermOnline	ENSG00000068383. Homo sapiens.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. IPR000300. IPPc. [Graphical view]
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
SMART	SM00128. IPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	14213.
SOURCE	Search...

Entry information

Entry name

I5P1_HUMAN

Accession

Primary (citable) accession number: Q14642
Secondary accession number(s): Q14640, Q5JSF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.