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Q14642

- I5P1_HUMAN

UniProt

Q14642 - I5P1_HUMAN

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Protein
Type I inositol 1,4,5-trisphosphate 5-phosphatase
Gene
INPP5A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

Catalytic activityi

D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.

GO - Molecular functioni

  1. PH domain binding Source: BHF-UCL
  2. inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
  3. inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
  4. inositol-polyphosphate 5-phosphatase activity Source: UniProtKB
  5. protein binding Source: IntAct

GO - Biological processi

  1. inositol phosphate metabolic process Source: Reactome
  2. phosphatidylinositol dephosphorylation Source: InterPro
  3. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS00936-MONOMER.
BRENDAi3.1.3.56. 2681.
ReactomeiREACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I inositol 1,4,5-trisphosphate 5-phosphatase (EC:3.1.3.56)
Short name:
5PTase
Gene namesi
Name:INPP5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:6076. INPP5A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Type I inositol 1,4,5-trisphosphate 5-phosphatase
PRO_0000209719Add
BLAST
Propeptidei410 – 4123Removed in mature form Reviewed prediction
PRO_0000396780

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi408 – 4081S-palmitoyl cysteine Reviewed prediction
Modified residuei409 – 4091Cysteine methyl ester Reviewed prediction
Lipidationi409 – 4091S-farnesyl cysteine Reviewed prediction

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiQ14642.
PaxDbiQ14642.
PRIDEiQ14642.

PTM databases

PhosphoSiteiQ14642.

Expressioni

Tissue specificityi

Brain; high level in Purkinje cells.

Gene expression databases

ArrayExpressiQ14642.
BgeeiQ14642.
CleanExiHS_INPP5A.
GenevestigatoriQ14642.

Organism-specific databases

HPAiHPA012285.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLEKP085674EBI-8670520,EBI-2565501

Protein-protein interaction databases

BioGridi109844. 3 interactions.
IntActiQ14642. 1 interaction.
STRINGi9606.ENSP00000357583.

Structurei

3D structure databases

ProteinModelPortaliQ14642.
SMRiQ14642. Positions 13-56, 159-238.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG288675.
HOGENOMiHOG000006583.
HOVERGENiHBG006102.
InParanoidiQ14642.
KOiK01106.
OMAiQGRQYMN.
OrthoDBiEOG70GMFC.
PhylomeDBiQ14642.
TreeFamiTF314246.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14642-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA    50
LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH 100
FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK 150
FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS 200
VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA 250
TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT 300
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR 350
ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK 400
PHAHVHKCCV VQ 412
Length:412
Mass (Da):47,820
Last modified:November 1, 1996 - v1
Checksum:iF55C0DFDDA01A850
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451K → R.
Corresponds to variant rs1133400 [ dbSNP | Ensembl ].
VAR_034006

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 17221PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500. 1 Publication
Add
BLAST
Sequence conflicti247 – 2515CTKAT → SAKPP in CAA83500. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77567 mRNA. Translation: CAA54676.1.
AL392043, AL356603, AL451069 Genomic DNA. Translation: CAI39945.1.
AL451069, AL392043, AL356603 Genomic DNA. Translation: CAI14121.1.
AL356603, AL451069, AL392043 Genomic DNA. Translation: CAI40942.1.
CH471211 Genomic DNA. Translation: EAW61306.1.
CH471211 Genomic DNA. Translation: EAW61307.1.
BC096280 mRNA. Translation: AAH96280.1.
Z31695 mRNA. Translation: CAA83500.1.
CCDSiCCDS7669.2.
PIRiS45721.
RefSeqiNP_005530.3. NM_005539.3.
UniGeneiHs.523360.
Hs.715308.

Genome annotation databases

EnsembliENST00000368594; ENSP00000357583; ENSG00000068383.
GeneIDi3632.
KEGGihsa:3632.
UCSCiuc001llp.3. human.

Polymorphism databases

DMDMi3122245.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77567 mRNA. Translation: CAA54676.1 .
AL392043 , AL356603 , AL451069 Genomic DNA. Translation: CAI39945.1 .
AL451069 , AL392043 , AL356603 Genomic DNA. Translation: CAI14121.1 .
AL356603 , AL451069 , AL392043 Genomic DNA. Translation: CAI40942.1 .
CH471211 Genomic DNA. Translation: EAW61306.1 .
CH471211 Genomic DNA. Translation: EAW61307.1 .
BC096280 mRNA. Translation: AAH96280.1 .
Z31695 mRNA. Translation: CAA83500.1 .
CCDSi CCDS7669.2.
PIRi S45721.
RefSeqi NP_005530.3. NM_005539.3.
UniGenei Hs.523360.
Hs.715308.

3D structure databases

ProteinModelPortali Q14642.
SMRi Q14642. Positions 13-56, 159-238.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109844. 3 interactions.
IntActi Q14642. 1 interaction.
STRINGi 9606.ENSP00000357583.

Chemistry

BindingDBi Q14642.
ChEMBLi CHEMBL4243.

PTM databases

PhosphoSitei Q14642.

Polymorphism databases

DMDMi 3122245.

Proteomic databases

MaxQBi Q14642.
PaxDbi Q14642.
PRIDEi Q14642.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368594 ; ENSP00000357583 ; ENSG00000068383 .
GeneIDi 3632.
KEGGi hsa:3632.
UCSCi uc001llp.3. human.

Organism-specific databases

CTDi 3632.
GeneCardsi GC10P134351.
HGNCi HGNC:6076. INPP5A.
HPAi HPA012285.
MIMi 600106. gene.
neXtProti NX_Q14642.
PharmGKBi PA29884.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288675.
HOGENOMi HOG000006583.
HOVERGENi HBG006102.
InParanoidi Q14642.
KOi K01106.
OMAi QGRQYMN.
OrthoDBi EOG70GMFC.
PhylomeDBi Q14642.
TreeFami TF314246.

Enzyme and pathway databases

BioCyci MetaCyc:HS00936-MONOMER.
BRENDAi 3.1.3.56. 2681.
Reactomei REACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

GeneWikii INPP5A.
GenomeRNAii 3632.
NextBioi 14213.
PROi Q14642.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14642.
Bgeei Q14642.
CleanExi HS_INPP5A.
Genevestigatori Q14642.

Family and domain databases

Gene3Di 3.60.10.10. 1 hit.
InterProi IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view ]
Pfami PF03372. Exo_endo_phos. 1 hit.
[Graphical view ]
SMARTi SM00128. IPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF56219. SSF56219. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells."
    de Smedt F., Verjans B., Mailleux P., Erneux C.
    FEBS Lett. 347:69-72(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase."
    Laxminarayan K.M., Chan B.K., Tetaz T., Bird P.I., Mitchell C.A.
    J. Biol. Chem. 269:17305-17310(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-412.
    Tissue: Placenta.

Entry informationi

Entry nameiI5P1_HUMAN
AccessioniPrimary (citable) accession number: Q14642
Secondary accession number(s): D3DXI3, Q14640, Q5JSF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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