Reviewed,
UniProtKB/Swiss-Prot Q14642 (I5P1_HUMAN)
Last modified
January 19, 2010.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Type I inositol-1,4,5-trisphosphate 5-phosphatase Short name=5PTase EC=3.1.3.56 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 412 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction. |
| Catalytic activity | D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate. 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| Subcellular location | |
| Tissue specificity | Brain; high level in Purkinje cells. |
| Sequence similarities | Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type I family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Molecular function | Hydrolase |
| PTM | Lipoprotein Prenylation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell communication Non-traceable author statement. Source: UniProtKB |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | PH domain binding Inferred from physical interaction. Source: UniProtKB inositol-polyphosphate 5-phosphatase activity Ref.4Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 412 | 412 | Type I inositol-1,4,5-trisphosphate 5-phosphatase | PRO_0000209719 | |||||
Amino acid modifications | |||||||||
| Lipidation | 409 | 1 | S-farnesyl cysteine Potential | ||||||
Natural variations | |||||||||
| Natural variant | 45 | 1 | K → R: dbSNP rs1133400. | VAR_034006 | |||||
Experimental info | |||||||||
| Sequence conflict | 152 – 172 | 21 | PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500. Ref.4 | ||||||
| Sequence conflict | 247 – 251 | 5 | CTKAT → SAKPP in CAA83500. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells." de Smedt F., Verjans B., Mailleux P., Erneux C. FEBS Lett. 347:69-72(1994) [PubMed: 8013665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase." Laxminarayan K.M., Chan B.K., Tetaz T., Bird P.I., Mitchell C.A. J. Biol. Chem. 269:17305-17310(1994) [PubMed: 8006039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-412. Tissue: Placenta. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X77567 mRNA. Translation: CAA54676.1. AL392043, AL356603, AL451069 Genomic DNA. Translation: CAI39945.1. AL451069, AL392043, AL356603 Genomic DNA. Translation: CAI14121.1. AL356603, AL451069, AL392043 Genomic DNA. Translation: CAI40942.1. BC096280 mRNA. Translation: AAH96280.1. Z31695 mRNA. Translation: CAA83500.1. |
| IPI | IPI00032262. |
| PIR | S45721. |
| RefSeq | NP_005530.3. |
| UniGene | Hs.523360 Hs.715308 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q14642. |
PTM databases | |
| PhosphoSite | Q14642. |
Proteomic databases | |
| PRIDE | Q14642. |
Genome annotation databases | |
| Ensembl | ENST00000368594; ENSP00000357583; ENSG00000068383; Homo sapiens. [Genome view] |
| GeneID | 3632. |
| KEGG | hsa:3632. |
| UCSC | uc001llp.1. human. |
Organism-specific databases | |
| CTD | 3632. |
| GeneCards | GC10P134201. |
| H-InvDB | HIX0035334. |
| HGNC | HGNC:6076. INPP5A. |
| HPA | HPA012285. |
| MIM | 600106. gene. |
| PharmGKB | PA29884. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG14931. |
| HOGENOM | HBG403108. |
| HOVERGEN | Q14642. |
| InParanoid | Q14642. |
| OMA | GRQYMNT. |
| OrthoDB | EOG9KSS46. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:ENSG00000068383-MONOMER. |
| BRENDA | 3.1.3.56. 247. |
Gene expression databases | |
| ArrayExpress | Q14642. |
| Bgee | Q14642. |
| CleanEx | HS_INPP5A. |
| Genevestigator | Q14642. |
| GermOnline | ENSG00000068383. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005135. Endo/exonuclease/phosphatase. IPR000300. IPPc. [Graphical view] |
| Pfam | PF03372. Exo_endo_phos. 1 hit. [Graphical view] |
| SMART | SM00128. IPPc. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 14213. |
| SOURCE | Search... |
Entry information
| Entry name | I5P1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q14642 Secondary accession number(s): Q14640, Q5JSF1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


