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Protein

Type I inositol 1,4,5-trisphosphate 5-phosphatase

Gene

INPP5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

Catalytic activityi

D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS00936-MONOMER.
BRENDAi3.1.3.56. 2681.
ReactomeiR-HSA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.

Chemistry databases

SwissLipidsiSLP:000000952.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I inositol 1,4,5-trisphosphate 5-phosphatase (EC:3.1.3.56)
Short name:
5PTase
Gene namesi
Name:INPP5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000068383.18.
HGNCiHGNC:6076. INPP5A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3632.
OpenTargetsiENSG00000068383.
PharmGKBiPA29884.

Chemistry databases

ChEMBLiCHEMBL4243.
GuidetoPHARMACOLOGYi1453.

Polymorphism and mutation databases

BioMutaiINPP5A.
DMDMi3122245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097191 – 409Type I inositol 1,4,5-trisphosphate 5-phosphataseAdd BLAST409
PropeptideiPRO_0000396780410 – 412Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi408S-palmitoyl cysteineSequence analysis1
Modified residuei409Cysteine methyl esterSequence analysis1
Lipidationi409S-farnesyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiQ14642.
MaxQBiQ14642.
PaxDbiQ14642.
PeptideAtlasiQ14642.
PRIDEiQ14642.

PTM databases

DEPODiQ14642.
iPTMnetiQ14642.
PhosphoSitePlusiQ14642.
SwissPalmiQ14642.

Expressioni

Tissue specificityi

Brain; high level in Purkinje cells.

Gene expression databases

BgeeiENSG00000068383.
CleanExiHS_INPP5A.
ExpressionAtlasiQ14642. baseline and differential.
GenevisibleiQ14642. HS.

Organism-specific databases

HPAiHPA012285.
HPA066549.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLEKP085674EBI-8670520,EBI-2565501

GO - Molecular functioni

  • PH domain binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi109844. 15 interactors.
IntActiQ14642. 2 interactors.
STRINGi9606.ENSP00000357583.

Chemistry databases

BindingDBiQ14642.

Structurei

3D structure databases

ProteinModelPortaliQ14642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1976. Eukaryota.
ENOG410XNWI. LUCA.
GeneTreeiENSGT00390000015226.
HOGENOMiHOG000006583.
HOVERGENiHBG006102.
InParanoidiQ14642.
KOiK01106.
OMAiQGRQYMN.
OrthoDBiEOG091G0FF9.
PhylomeDBiQ14642.
TreeFamiTF314246.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiView protein in InterPro
IPR036691. Endo/exonu/phosph_ase_sf.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
PfamiView protein in Pfam
PF03372. Exo_endo_phos. 1 hit.
SMARTiView protein in SMART
SM00128. IPPc. 1 hit.
SUPFAMiSSF56219. SSF56219. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA
60 70 80 90 100
LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH
110 120 130 140 150
FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK
160 170 180 190 200
FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS
210 220 230 240 250
VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA
260 270 280 290 300
TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT
310 320 330 340 350
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR
360 370 380 390 400
ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK
410
PHAHVHKCCV VQ
Length:412
Mass (Da):47,820
Last modified:November 1, 1996 - v1
Checksum:iF55C0DFDDA01A850
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152 – 172PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500 (PubMed:8006039).CuratedAdd BLAST21
Sequence conflicti247 – 251CTKAT → SAKPP in CAA83500 (PubMed:8006039).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03400645K → R. Corresponds to variant dbSNP:rs1133400Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77567 mRNA. Translation: CAA54676.1.
AL392043 Genomic DNA. No translation available.
AL451069 Genomic DNA. No translation available.
AL356603 Genomic DNA. No translation available.
CH471211 Genomic DNA. Translation: EAW61306.1.
CH471211 Genomic DNA. Translation: EAW61307.1.
BC096280 mRNA. Translation: AAH96280.1.
Z31695 mRNA. Translation: CAA83500.1.
CCDSiCCDS7669.2.
PIRiS45721.
RefSeqiNP_001307971.1. NM_001321042.1.
NP_005530.3. NM_005539.4.
UniGeneiHs.523360.
Hs.715308.

Genome annotation databases

EnsembliENST00000368594; ENSP00000357583; ENSG00000068383.
GeneIDi3632.
KEGGihsa:3632.
UCSCiuc001llp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiI5P1_HUMAN
AccessioniPrimary (citable) accession number: Q14642
Secondary accession number(s): D3DXI3, Q14640, Q5JSF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families