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Protein

Type I inositol 1,4,5-trisphosphate 5-phosphatase

Gene

INPP5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

Catalytic activityi

D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS00936-MONOMER.
ZFISH:HS00936-MONOMER.
BRENDAi3.1.3.56. 2681.
ReactomeiR-HSA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.

Chemistry databases

SwissLipidsiSLP:000000952.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I inositol 1,4,5-trisphosphate 5-phosphatase (EC:3.1.3.56)
Short name:
5PTase
Gene namesi
Name:INPP5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:6076. INPP5A.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intracellular Source: GO_Central
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3632.
OpenTargetsiENSG00000068383.
PharmGKBiPA29884.

Chemistry databases

ChEMBLiCHEMBL4243.
GuidetoPHARMACOLOGYi1453.

Polymorphism and mutation databases

BioMutaiINPP5A.
DMDMi3122245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097191 – 409Type I inositol 1,4,5-trisphosphate 5-phosphataseAdd BLAST409
PropeptideiPRO_0000396780410 – 412Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi408S-palmitoyl cysteineSequence analysis1
Modified residuei409Cysteine methyl esterSequence analysis1
Lipidationi409S-farnesyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiQ14642.
MaxQBiQ14642.
PaxDbiQ14642.
PeptideAtlasiQ14642.
PRIDEiQ14642.

PTM databases

DEPODiQ14642.
iPTMnetiQ14642.
PhosphoSitePlusiQ14642.
SwissPalmiQ14642.

Expressioni

Tissue specificityi

Brain; high level in Purkinje cells.

Gene expression databases

BgeeiENSG00000068383.
CleanExiHS_INPP5A.
ExpressionAtlasiQ14642. baseline and differential.
GenevisibleiQ14642. HS.

Organism-specific databases

HPAiHPA012285.
HPA066549.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLEKP085674EBI-8670520,EBI-2565501

GO - Molecular functioni

  • PH domain binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi109844. 12 interactors.
IntActiQ14642. 1 interactor.
STRINGi9606.ENSP00000357583.

Chemistry databases

BindingDBiQ14642.

Structurei

3D structure databases

ProteinModelPortaliQ14642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1976. Eukaryota.
ENOG410XNWI. LUCA.
GeneTreeiENSGT00390000015226.
HOGENOMiHOG000006583.
HOVERGENiHBG006102.
InParanoidiQ14642.
KOiK01106.
OMAiQGRQYMN.
OrthoDBiEOG091G0FF9.
PhylomeDBiQ14642.
TreeFamiTF314246.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA
60 70 80 90 100
LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH
110 120 130 140 150
FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK
160 170 180 190 200
FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS
210 220 230 240 250
VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA
260 270 280 290 300
TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT
310 320 330 340 350
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR
360 370 380 390 400
ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK
410
PHAHVHKCCV VQ
Length:412
Mass (Da):47,820
Last modified:November 1, 1996 - v1
Checksum:iF55C0DFDDA01A850
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152 – 172PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500 (PubMed:8006039).CuratedAdd BLAST21
Sequence conflicti247 – 251CTKAT → SAKPP in CAA83500 (PubMed:8006039).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03400645K → R.Corresponds to variant rs1133400dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77567 mRNA. Translation: CAA54676.1.
AL392043, AL356603, AL451069 Genomic DNA. Translation: CAI39945.1.
AL451069, AL392043, AL356603 Genomic DNA. Translation: CAI14121.1.
AL356603, AL451069, AL392043 Genomic DNA. Translation: CAI40942.1.
CH471211 Genomic DNA. Translation: EAW61306.1.
CH471211 Genomic DNA. Translation: EAW61307.1.
BC096280 mRNA. Translation: AAH96280.1.
Z31695 mRNA. Translation: CAA83500.1.
CCDSiCCDS7669.2.
PIRiS45721.
RefSeqiNP_001307971.1. NM_001321042.1.
NP_005530.3. NM_005539.4.
UniGeneiHs.523360.
Hs.715308.

Genome annotation databases

EnsembliENST00000368594; ENSP00000357583; ENSG00000068383.
GeneIDi3632.
KEGGihsa:3632.
UCSCiuc001llp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77567 mRNA. Translation: CAA54676.1.
AL392043, AL356603, AL451069 Genomic DNA. Translation: CAI39945.1.
AL451069, AL392043, AL356603 Genomic DNA. Translation: CAI14121.1.
AL356603, AL451069, AL392043 Genomic DNA. Translation: CAI40942.1.
CH471211 Genomic DNA. Translation: EAW61306.1.
CH471211 Genomic DNA. Translation: EAW61307.1.
BC096280 mRNA. Translation: AAH96280.1.
Z31695 mRNA. Translation: CAA83500.1.
CCDSiCCDS7669.2.
PIRiS45721.
RefSeqiNP_001307971.1. NM_001321042.1.
NP_005530.3. NM_005539.4.
UniGeneiHs.523360.
Hs.715308.

3D structure databases

ProteinModelPortaliQ14642.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109844. 12 interactors.
IntActiQ14642. 1 interactor.
STRINGi9606.ENSP00000357583.

Chemistry databases

BindingDBiQ14642.
ChEMBLiCHEMBL4243.
GuidetoPHARMACOLOGYi1453.
SwissLipidsiSLP:000000952.

PTM databases

DEPODiQ14642.
iPTMnetiQ14642.
PhosphoSitePlusiQ14642.
SwissPalmiQ14642.

Polymorphism and mutation databases

BioMutaiINPP5A.
DMDMi3122245.

Proteomic databases

EPDiQ14642.
MaxQBiQ14642.
PaxDbiQ14642.
PeptideAtlasiQ14642.
PRIDEiQ14642.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368594; ENSP00000357583; ENSG00000068383.
GeneIDi3632.
KEGGihsa:3632.
UCSCiuc001llp.4. human.

Organism-specific databases

CTDi3632.
DisGeNETi3632.
GeneCardsiINPP5A.
HGNCiHGNC:6076. INPP5A.
HPAiHPA012285.
HPA066549.
MIMi600106. gene.
neXtProtiNX_Q14642.
OpenTargetsiENSG00000068383.
PharmGKBiPA29884.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1976. Eukaryota.
ENOG410XNWI. LUCA.
GeneTreeiENSGT00390000015226.
HOGENOMiHOG000006583.
HOVERGENiHBG006102.
InParanoidiQ14642.
KOiK01106.
OMAiQGRQYMN.
OrthoDBiEOG091G0FF9.
PhylomeDBiQ14642.
TreeFamiTF314246.

Enzyme and pathway databases

BioCyciMetaCyc:HS00936-MONOMER.
ZFISH:HS00936-MONOMER.
BRENDAi3.1.3.56. 2681.
ReactomeiR-HSA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

ChiTaRSiINPP5A. human.
GeneWikiiINPP5A.
GenomeRNAii3632.
PROiQ14642.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068383.
CleanExiHS_INPP5A.
ExpressionAtlasiQ14642. baseline and differential.
GenevisibleiQ14642. HS.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiI5P1_HUMAN
AccessioniPrimary (citable) accession number: Q14642
Secondary accession number(s): D3DXI3, Q14640, Q5JSF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.