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Protein

Type I inositol 1,4,5-trisphosphate 5-phosphatase

Gene

INPP5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

Catalytic activityi

D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.

GO - Molecular functioni

  1. inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
  2. inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
  3. inositol-polyphosphate 5-phosphatase activity Source: UniProtKB
  4. PH domain binding Source: BHF-UCL

GO - Biological processi

  1. inositol phosphate metabolic process Source: Reactome
  2. phosphatidylinositol dephosphorylation Source: InterPro
  3. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS00936-MONOMER.
BRENDAi3.1.3.56. 2681.
ReactomeiREACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I inositol 1,4,5-trisphosphate 5-phosphatase (EC:3.1.3.56)
Short name:
5PTase
Gene namesi
Name:INPP5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:6076. INPP5A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Type I inositol 1,4,5-trisphosphate 5-phosphatasePRO_0000209719Add
BLAST
Propeptidei410 – 4123Removed in mature formSequence AnalysisPRO_0000396780

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi408 – 4081S-palmitoyl cysteineSequence Analysis
Modified residuei409 – 4091Cysteine methyl esterSequence Analysis
Lipidationi409 – 4091S-farnesyl cysteineSequence Analysis

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiQ14642.
PaxDbiQ14642.
PRIDEiQ14642.

PTM databases

DEPODiQ14642.
PhosphoSiteiQ14642.

Expressioni

Tissue specificityi

Brain; high level in Purkinje cells.

Gene expression databases

BgeeiQ14642.
CleanExiHS_INPP5A.
ExpressionAtlasiQ14642. baseline and differential.
GenevestigatoriQ14642.

Organism-specific databases

HPAiHPA012285.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLEKP085674EBI-8670520,EBI-2565501

Protein-protein interaction databases

BioGridi109844. 8 interactions.
IntActiQ14642. 1 interaction.
STRINGi9606.ENSP00000357583.

Structurei

3D structure databases

ProteinModelPortaliQ14642.
SMRiQ14642. Positions 160-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG288675.
GeneTreeiENSGT00390000015226.
HOGENOMiHOG000006583.
HOVERGENiHBG006102.
InParanoidiQ14642.
KOiK01106.
OMAiQGRQYMN.
OrthoDBiEOG70GMFC.
PhylomeDBiQ14642.
TreeFamiTF314246.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA
60 70 80 90 100
LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH
110 120 130 140 150
FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK
160 170 180 190 200
FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS
210 220 230 240 250
VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA
260 270 280 290 300
TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT
310 320 330 340 350
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR
360 370 380 390 400
ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK
410
PHAHVHKCCV VQ
Length:412
Mass (Da):47,820
Last modified:November 1, 1996 - v1
Checksum:iF55C0DFDDA01A850
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 17221PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500 (PubMed:8006039).CuratedAdd
BLAST
Sequence conflicti247 – 2515CTKAT → SAKPP in CAA83500 (PubMed:8006039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451K → R.
Corresponds to variant rs1133400 [ dbSNP | Ensembl ].
VAR_034006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77567 mRNA. Translation: CAA54676.1.
AL392043, AL356603, AL451069 Genomic DNA. Translation: CAI39945.1.
AL451069, AL392043, AL356603 Genomic DNA. Translation: CAI14121.1.
AL356603, AL451069, AL392043 Genomic DNA. Translation: CAI40942.1.
CH471211 Genomic DNA. Translation: EAW61306.1.
CH471211 Genomic DNA. Translation: EAW61307.1.
BC096280 mRNA. Translation: AAH96280.1.
Z31695 mRNA. Translation: CAA83500.1.
CCDSiCCDS7669.2.
PIRiS45721.
RefSeqiNP_005530.3. NM_005539.3.
UniGeneiHs.523360.
Hs.715308.

Genome annotation databases

EnsembliENST00000368594; ENSP00000357583; ENSG00000068383.
GeneIDi3632.
KEGGihsa:3632.
UCSCiuc001llp.3. human.

Polymorphism databases

DMDMi3122245.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77567 mRNA. Translation: CAA54676.1.
AL392043, AL356603, AL451069 Genomic DNA. Translation: CAI39945.1.
AL451069, AL392043, AL356603 Genomic DNA. Translation: CAI14121.1.
AL356603, AL451069, AL392043 Genomic DNA. Translation: CAI40942.1.
CH471211 Genomic DNA. Translation: EAW61306.1.
CH471211 Genomic DNA. Translation: EAW61307.1.
BC096280 mRNA. Translation: AAH96280.1.
Z31695 mRNA. Translation: CAA83500.1.
CCDSiCCDS7669.2.
PIRiS45721.
RefSeqiNP_005530.3. NM_005539.3.
UniGeneiHs.523360.
Hs.715308.

3D structure databases

ProteinModelPortaliQ14642.
SMRiQ14642. Positions 160-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109844. 8 interactions.
IntActiQ14642. 1 interaction.
STRINGi9606.ENSP00000357583.

Chemistry

BindingDBiQ14642.
ChEMBLiCHEMBL4243.

PTM databases

DEPODiQ14642.
PhosphoSiteiQ14642.

Polymorphism databases

DMDMi3122245.

Proteomic databases

MaxQBiQ14642.
PaxDbiQ14642.
PRIDEiQ14642.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368594; ENSP00000357583; ENSG00000068383.
GeneIDi3632.
KEGGihsa:3632.
UCSCiuc001llp.3. human.

Organism-specific databases

CTDi3632.
GeneCardsiGC10P134351.
HGNCiHGNC:6076. INPP5A.
HPAiHPA012285.
MIMi600106. gene.
neXtProtiNX_Q14642.
PharmGKBiPA29884.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288675.
GeneTreeiENSGT00390000015226.
HOGENOMiHOG000006583.
HOVERGENiHBG006102.
InParanoidiQ14642.
KOiK01106.
OMAiQGRQYMN.
OrthoDBiEOG70GMFC.
PhylomeDBiQ14642.
TreeFamiTF314246.

Enzyme and pathway databases

BioCyciMetaCyc:HS00936-MONOMER.
BRENDAi3.1.3.56. 2681.
ReactomeiREACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

ChiTaRSiINPP5A. human.
GeneWikiiINPP5A.
GenomeRNAii3632.
NextBioi14213.
PROiQ14642.
SOURCEiSearch...

Gene expression databases

BgeeiQ14642.
CleanExiHS_INPP5A.
ExpressionAtlasiQ14642. baseline and differential.
GenevestigatoriQ14642.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells."
    de Smedt F., Verjans B., Mailleux P., Erneux C.
    FEBS Lett. 347:69-72(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase."
    Laxminarayan K.M., Chan B.K., Tetaz T., Bird P.I., Mitchell C.A.
    J. Biol. Chem. 269:17305-17310(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-412.
    Tissue: Placenta.

Entry informationi

Entry nameiI5P1_HUMAN
AccessioniPrimary (citable) accession number: Q14642
Secondary accession number(s): D3DXI3, Q14640, Q5JSF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.