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Q14642

- I5P1_HUMAN

UniProt

Q14642 - I5P1_HUMAN

Protein

Type I inositol 1,4,5-trisphosphate 5-phosphatase

Gene

INPP5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

    Catalytic activityi

    D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.
    1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.

    GO - Molecular functioni

    1. inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
    2. inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
    3. inositol-polyphosphate 5-phosphatase activity Source: UniProtKB
    4. PH domain binding Source: BHF-UCL
    5. protein binding Source: IntAct

    GO - Biological processi

    1. inositol phosphate metabolic process Source: Reactome
    2. phosphatidylinositol dephosphorylation Source: InterPro
    3. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciMetaCyc:HS00936-MONOMER.
    BRENDAi3.1.3.56. 2681.
    ReactomeiREACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type I inositol 1,4,5-trisphosphate 5-phosphatase (EC:3.1.3.56)
    Short name:
    5PTase
    Gene namesi
    Name:INPP5A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:6076. INPP5A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29884.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Type I inositol 1,4,5-trisphosphate 5-phosphatasePRO_0000209719Add
    BLAST
    Propeptidei410 – 4123Removed in mature formSequence AnalysisPRO_0000396780

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi408 – 4081S-palmitoyl cysteineSequence Analysis
    Modified residuei409 – 4091Cysteine methyl esterSequence Analysis
    Lipidationi409 – 4091S-farnesyl cysteineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Methylation, Palmitate, Prenylation

    Proteomic databases

    MaxQBiQ14642.
    PaxDbiQ14642.
    PRIDEiQ14642.

    PTM databases

    PhosphoSiteiQ14642.

    Expressioni

    Tissue specificityi

    Brain; high level in Purkinje cells.

    Gene expression databases

    ArrayExpressiQ14642.
    BgeeiQ14642.
    CleanExiHS_INPP5A.
    GenevestigatoriQ14642.

    Organism-specific databases

    HPAiHPA012285.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PLEKP085674EBI-8670520,EBI-2565501

    Protein-protein interaction databases

    BioGridi109844. 3 interactions.
    IntActiQ14642. 1 interaction.
    STRINGi9606.ENSP00000357583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14642.
    SMRiQ14642. Positions 13-56, 159-238.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG288675.
    HOGENOMiHOG000006583.
    HOVERGENiHBG006102.
    InParanoidiQ14642.
    KOiK01106.
    OMAiQGRQYMN.
    OrthoDBiEOG70GMFC.
    PhylomeDBiQ14642.
    TreeFamiTF314246.

    Family and domain databases

    Gene3Di3.60.10.10. 1 hit.
    InterProiIPR005135. Endo/exonuclease/phosphatase.
    IPR000300. IPPc.
    [Graphical view]
    PfamiPF03372. Exo_endo_phos. 1 hit.
    [Graphical view]
    SMARTiSM00128. IPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56219. SSF56219. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14642-1 [UniParc]FASTAAdd to Basket

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    MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA    50
    LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH 100
    FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK 150
    FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS 200
    VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA 250
    TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT 300
    ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR 350
    ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK 400
    PHAHVHKCCV VQ 412
    Length:412
    Mass (Da):47,820
    Last modified:November 1, 1996 - v1
    Checksum:iF55C0DFDDA01A850
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 17221PQDYF…RTRWC → RRLLPRVQMVKKRLHPDEVV in CAA83500. (PubMed:8006039)CuratedAdd
    BLAST
    Sequence conflicti247 – 2515CTKAT → SAKPP in CAA83500. (PubMed:8006039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451K → R.
    Corresponds to variant rs1133400 [ dbSNP | Ensembl ].
    VAR_034006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77567 mRNA. Translation: CAA54676.1.
    AL392043, AL356603, AL451069 Genomic DNA. Translation: CAI39945.1.
    AL451069, AL392043, AL356603 Genomic DNA. Translation: CAI14121.1.
    AL356603, AL451069, AL392043 Genomic DNA. Translation: CAI40942.1.
    CH471211 Genomic DNA. Translation: EAW61306.1.
    CH471211 Genomic DNA. Translation: EAW61307.1.
    BC096280 mRNA. Translation: AAH96280.1.
    Z31695 mRNA. Translation: CAA83500.1.
    CCDSiCCDS7669.2.
    PIRiS45721.
    RefSeqiNP_005530.3. NM_005539.3.
    UniGeneiHs.523360.
    Hs.715308.

    Genome annotation databases

    EnsembliENST00000368594; ENSP00000357583; ENSG00000068383.
    GeneIDi3632.
    KEGGihsa:3632.
    UCSCiuc001llp.3. human.

    Polymorphism databases

    DMDMi3122245.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77567 mRNA. Translation: CAA54676.1 .
    AL392043 , AL356603 , AL451069 Genomic DNA. Translation: CAI39945.1 .
    AL451069 , AL392043 , AL356603 Genomic DNA. Translation: CAI14121.1 .
    AL356603 , AL451069 , AL392043 Genomic DNA. Translation: CAI40942.1 .
    CH471211 Genomic DNA. Translation: EAW61306.1 .
    CH471211 Genomic DNA. Translation: EAW61307.1 .
    BC096280 mRNA. Translation: AAH96280.1 .
    Z31695 mRNA. Translation: CAA83500.1 .
    CCDSi CCDS7669.2.
    PIRi S45721.
    RefSeqi NP_005530.3. NM_005539.3.
    UniGenei Hs.523360.
    Hs.715308.

    3D structure databases

    ProteinModelPortali Q14642.
    SMRi Q14642. Positions 13-56, 159-238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109844. 3 interactions.
    IntActi Q14642. 1 interaction.
    STRINGi 9606.ENSP00000357583.

    Chemistry

    BindingDBi Q14642.
    ChEMBLi CHEMBL4243.

    PTM databases

    PhosphoSitei Q14642.

    Polymorphism databases

    DMDMi 3122245.

    Proteomic databases

    MaxQBi Q14642.
    PaxDbi Q14642.
    PRIDEi Q14642.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368594 ; ENSP00000357583 ; ENSG00000068383 .
    GeneIDi 3632.
    KEGGi hsa:3632.
    UCSCi uc001llp.3. human.

    Organism-specific databases

    CTDi 3632.
    GeneCardsi GC10P134351.
    HGNCi HGNC:6076. INPP5A.
    HPAi HPA012285.
    MIMi 600106. gene.
    neXtProti NX_Q14642.
    PharmGKBi PA29884.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288675.
    HOGENOMi HOG000006583.
    HOVERGENi HBG006102.
    InParanoidi Q14642.
    KOi K01106.
    OMAi QGRQYMN.
    OrthoDBi EOG70GMFC.
    PhylomeDBi Q14642.
    TreeFami TF314246.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS00936-MONOMER.
    BRENDAi 3.1.3.56. 2681.
    Reactomei REACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.

    Miscellaneous databases

    GeneWikii INPP5A.
    GenomeRNAii 3632.
    NextBioi 14213.
    PROi Q14642.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14642.
    Bgeei Q14642.
    CleanExi HS_INPP5A.
    Genevestigatori Q14642.

    Family and domain databases

    Gene3Di 3.60.10.10. 1 hit.
    InterProi IPR005135. Endo/exonuclease/phosphatase.
    IPR000300. IPPc.
    [Graphical view ]
    Pfami PF03372. Exo_endo_phos. 1 hit.
    [Graphical view ]
    SMARTi SM00128. IPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56219. SSF56219. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells."
      de Smedt F., Verjans B., Mailleux P., Erneux C.
      FEBS Lett. 347:69-72(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase."
      Laxminarayan K.M., Chan B.K., Tetaz T., Bird P.I., Mitchell C.A.
      J. Biol. Chem. 269:17305-17310(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-412.
      Tissue: Placenta.

    Entry informationi

    Entry nameiI5P1_HUMAN
    AccessioniPrimary (citable) accession number: Q14642
    Secondary accession number(s): D3DXI3, Q14640, Q5JSF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3